Nir Qvit

Nir Qvit

Department of Chemical and Systems Biology, Stanford University School of Medicine

Affiliated withStanford University School of MedicineBar Ilan UniversityBar-Ilan University

Research Area

Biography

Nir Qvit is an Associate Professor in the Faculty of Medicine, Bar-Ilan University, Israel. He received his undergraduate and a Ph.D. in organic chemistry developing different strategies for the synthesis of small molecules and peptides, in solution and on a solid support, for various therapeutic applications from the Hebrew University of Jerusalem, Israel. Dr. Qvit overcame challenging synthesis and developed an innovative procedure for generating novel and highly bioactive protein-protein interaction inhibitors and was awarded the prestigious Kaye Innovation Award for demonstrating extraordinary creativity as a medicinal chemist.

During Dr. Qvit’s training, he developed a keen focus on research that encompasses the maintenance of mitochondrial homeostasis and cell fate. As a post-doctoral fellow (2008 to 2016) in Daria Mochly-Rosen’s lab at the Department of Chemical and System Biology in Stanford School of Medicine, Stanford, CA, USA, He developed and studied the roles of inhibitors that selectively regulates the protein-protein interactions between a kinase and its specific substrate among many, and he developed specific inhibitors of large GTPase to modulate excessive mitochondrial fission. These inhibitors are highly active in models of neurodegenerative disease and cardiovascular disease, and one molecule has been licensed to a biopharmaceutical company.

Dr. Qvit served as a chairman for multiple sessions of several conferences and was the Chair of the first: “Gordon Research Seminar: The Future of Peptides in Chemistry and Biology, 2012”. He received the prestigious Kaye Innovation Award for demonstrating extraordinary creativity as a medicinal chemist, the Burroughs Wellcome Fund Collaborative Research Grant, and the European Molecular Biology Organization (EMBO) Fellowship, and in 2017 he was recruited as faculty at Bar-Ilan University. His research focuses on the development of novel tools to regulate protein-protein interactions in a highly specific manner for basic research and for therapeutic applications.

JoVE Journal Publications

ArticleTotal : 2
Year
Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
Publication title

Cited by 10

2016
2022

Other Publications

Article
Year
Synthesis of a novel macrocyclic library: discovery of an IGF-1R inhibitor.

Journal of combinatorial chemistry| PubMed ID: 18271560

2008
2008
2009
Rationally designed peptide regulators of protein kinase C.

Trends in endocrinology and metabolism: TEM| PubMed ID: 19056296

2009
Design and synthesis of backbone cyclic phosphopeptides: the IkappaB model.

Advances in experimental medicine and biology| PubMed ID: 19400129

2009
Highly Specific Modulators of Protein Kinase C Localization: Applications to Heart Failure.

Drug discovery today. Disease mechanisms| PubMed ID: 21151743

2010
2013
Microwave-assisted synthesis of cyclic phosphopeptide on solid support.

Chemical biology & drug design| PubMed ID: 25042903

2015
The many hats of protein kinase Cδ: one enzyme with many functions.

Biochemical Society transactions| PubMed ID: 25399565

2014
2015
Backbone-Cyclized Peptides: A Critical Review.

Current topics in medicinal chemistry| PubMed ID: 29773062

2018
2018
Cyclic Peptides for Protein-Protein Interaction Targets.

Current topics in medicinal chemistry| PubMed ID: 30014801

2018
2018
Approach for comparing protein structures and origami models.

Biochimica et biophysica acta. Biomembranes| PubMed ID: 31738904

2020
An Approach to comparing protein structures and origami models - Part 2. Multi-domain proteins.

Biochimica et biophysica acta. Biomembranes| PubMed ID: 32710853

2020
2020
2020
2020
2022