Lan Kluwe

Department of Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf

Affiliated withUniversity Medical Center Hamburg-Eppendorf

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 8	2016

Other Publications

Article	Year
Establishment and characterization of a schwannoma cell line from a patient with neurofibromatosis 2. International journal of oncology\| PubMed ID: 11836557	2002
Vestibular schwannoma growth in patients with neurofibromatosis Type 2: a longitudinal study. Journal of neurosurgery\| PubMed ID: 11838794	2002
Presymptomatic diagnosis for children of sporadic neurofibromatosis 2 patients: a method based on tumor analysis. Genetics in medicine : official journal of the American College of Medical Genetics\| PubMed ID: 11839955	2002
NF1 mutations in neurofibromatosis 1 patients with plexiform neurofibromas. Human mutation\| PubMed ID: 11857752	2002
Mutations in the LGI1/Epitempin gene on 10q24 cause autosomal dominant lateral temporal epilepsy. Human molecular genetics\| PubMed ID: 11978770	2002
Treatment of ADHD in neurofibromatosis type 1. Developmental medicine and child neurology\| PubMed ID: 12005317	2002
Polyneuropathy in neurofibromatosis 2: clinical findings, molecular genetics and neuropathological alterations in sural nerve biopsy specimens. Acta neuropathologica\| PubMed ID: 12111361	2002
Constitutional NF1 mutations in neurofibromatosis 1 patients with malignant peripheral nerve sheath tumors. Human mutation\| PubMed ID: 14517963	2003
Screening 500 unselected neurofibromatosis 1 patients for deletions of the NF1 gene. Human mutation\| PubMed ID: 14722914	2004
Sulindac derivatives inhibit cell growth and induce apoptosis in primary cells from malignant peripheral nerve sheath tumors of NF1-patients. Cancer cell international\| PubMed ID: 15147581	2004
Genetic and phenotypic characterization of tumor cells derived from malignant peripheral nerve sheath tumors of neurofibromatosis type 1 patients. Neurobiology of disease\| PubMed ID: 15207265	2004
Somatic mitochondrial DNA mutations in neurofibromatosis type 1-associated tumors. Molecular cancer research : MCR\| PubMed ID: 15328370	2004
Screening for large mutations of the NF2 gene. Genes, chromosomes & cancer\| PubMed ID: 15645494	2005
Prevalence of neurofibromatosis 1 in German children at elementary school enrollment. Archives of dermatology\| PubMed ID: 15655144	2005
Do hormonal contraceptives stimulate growth of neurofibromas? A survey on 59 NF1 patients. BMC cancer\| PubMed ID: 15703081	2005
Extensively high load of internal tumors determined by whole body MRI scanning in a patient with neurofibromatosis type 1 and a non-LCR-mediated 2-Mb deletion in 17q11.2. Human genetics\| PubMed ID: 15776250	2005
Malignant peripheral nerve sheath tumors (MPNST) in neurofibromatosis type 1 (NF1): diagnostic findings on magnetic resonance images and mutation analysis of the NF1 gene. Anticancer research\| PubMed ID: 16033085	2005
Unilateral vestibular schwannoma with other neurofibromatosis type 2-related tumors: clinical and molecular study of a unique phenotype. Journal of neurosurgery\| PubMed ID: 16509493	2006
Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues. Cancer research\| PubMed ID: 16510576	2006
Histopathology and clinical outcome of NF1-associated vs. sporadic malignant peripheral nerve sheath tumors. Journal of neuro-oncology\| PubMed ID: 17111191	2007
Conservation of hotspots for recombination in low-copy repeats associated with the NF1 microdeletion. Nature genetics\| PubMed ID: 17115058	2006
Germline and somatic NF1 gene mutation spectrum in NF1-associated malignant peripheral nerve sheath tumors (MPNSTs). Human mutation\| PubMed ID: 17960768	2008
Type 2 NF1 deletions are highly unusual by virtue of the absence of nonallelic homologous recombination hotspots and an apparent preference for female mitotic recombination. American journal of human genetics\| PubMed ID: 17999360	2007
Telomerase activity is a biomarker for high grade malignant peripheral nerve sheath tumors in neurofibromatosis type 1 individuals. Genes, chromosomes & cancer\| PubMed ID: 18069666	2008
Copy number variations in the NF1 gene region are infrequent and do not predispose to recurrent type-1 deletions. European journal of human genetics : EJHG\| PubMed ID: 18212816	2008
Absence of cutaneous neurofibromas in an NF1 patient with an atypical deletion partially overlapping the common 1.4 Mb microdeleted region. American journal of medical genetics. Part A\| PubMed ID: 18265407	2008
High-resolution DNA copy number profiling of malignant peripheral nerve sheath tumors using targeted microarray-based comparative genomic hybridization. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 18281533	2008
Germline and somatic NF1 gene mutations in plexiform neurofibromas. Human mutation\| PubMed ID: 18484666	2008
Assessment of benign tumor burden by whole-body MRI in patients with neurofibromatosis 1. Neuro-oncology\| PubMed ID: 18559970	2008
Mechanisms of loss of heterozygosity in neurofibromatosis type 1-associated plexiform neurofibromas. The Journal of investigative dermatology\| PubMed ID: 18800150	2009
Correlation of nonsense and frameshift mutations with severity of retinal abnormalities in neurofibromatosis 2. Archives of ophthalmology (Chicago, Ill. : 1960)\| PubMed ID: 18852415	2008
The spectrum of somatic and germline NF1 mutations in NF1 patients with spinal neurofibromas. Neurogenetics\| PubMed ID: 19221814	2009
Ral overactivation in malignant peripheral nerve sheath tumors. Molecular and cellular biology\| PubMed ID: 19414599	2009
Genome-wide high-resolution analysis of DNA copy number alterations in NF1-associated malignant peripheral nerve sheath tumors using 32K BAC array. Genes, chromosomes & cancer\| PubMed ID: 19603524	2009
Imatinib mesylate (Glivec) inhibits Schwann cell viability and reduces the size of human plexiform neurofibroma in a xenograft model. Journal of neuro-oncology\| PubMed ID: 19921098	2010
Large intragenic deletions of the NF2 gene: breakpoints and associated phenotypes. Genes, chromosomes & cancer\| PubMed ID: 19924781	2010
Extended runs of homozygosity at 17q11.2: an association with type-2 NF1 deletions? Human mutation\| PubMed ID: 20052761	2010
Analysis of NF1 somatic mutations in cutaneous neurofibromas from patients with high tumor burden. Neurogenetics\| PubMed ID: 20358387	2010
A novel third type of recurrent NF1 microdeletion mediated by nonallelic homologous recombination between LRRC37B-containing low-copy repeats in 17q11.2. Human mutation\| PubMed ID: 20506354	2010
Intrachromosomal mitotic nonallelic homologous recombination is the major molecular mechanism underlying type-2 NF1 deletions. Human mutation\| PubMed ID: 20725927	2010
Gene expression analysis identifies potential biomarkers of neurofibromatosis type 1 including adrenomedullin. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 20739432	2010
Effects of splicing mutations on NF2-transcripts: transcript analysis and information theoretic predictions. Genes, chromosomes & cancer\| PubMed ID: 21563229	2011
Monozygotic twins discordant for neurofibromatosis type 1 due to a postzygotic NF1 gene mutation. Human mutation\| PubMed ID: 21618341	2011
Plexiform neurofibromas in children with neurofibromatosis type 1: frequency and associated clinical deficits. The Journal of pediatrics\| PubMed ID: 21621223	2011
Cancer stem cell-like cells derived from malignant peripheral nerve sheath tumors. PloS one\| PubMed ID: 21695156	2011
MIA is a potential biomarker for tumour load in neurofibromatosis type 1. BMC medicine\| PubMed ID: 21726432	2011
Atypical neurofibromas in neurofibromatosis type 1 are premalignant tumors. Genes, chromosomes & cancer\| PubMed ID: 21987445	2011
Characterization of the nonallelic homologous recombination hotspot PRS3 associated with type-3 NF1 deletions. Human mutation\| PubMed ID: 22045503	2012
Delineation of the clinical phenotype associated with non-mosaic type-2 NF1 deletions: two case reports. Journal of medical case reports\| PubMed ID: 22151963	2011
Tissue-specific differences in the proportion of mosaic large NF1 deletions are suggestive of a selective growth advantage of hematopoietic del(+/-) stem cells. Human mutation\| PubMed ID: 22190464	2012
Chinese herb mix Tiáo-Gēng-Tāng possesses antiaging and antioxidative effects and upregulates expression of estrogen receptors alpha and beta in ovariectomized rats. BMC complementary and alternative medicine\| PubMed ID: 22206438	2011
Allelic drop-out, allele imbalance, or loss of heterozygosity? Genes, chromosomes & cancer\| PubMed ID: 22294435	2012
Internal tumor burden in neurofibromatosis Type I patients with large NF1 deletions. Genes, chromosomes & cancer\| PubMed ID: 22294457	2012
Ferritin light chain and squamous cell carcinoma antigen 1 are coreceptors for cellular attachment and entry of hepatitis B virus. International journal of nanomedicine\| PubMed ID: 22359459	2012
Clinical presentation, immunohistochemistry and electron microscopy indicate neurofibromatosis type 2-associated gliomas to be spinal ependymomas. Neuropathology : official journal of the Japanese Society of Neuropathology\| PubMed ID: 22394059	2012
Dissecting the clinical phenotype associated with mosaic type-2 NF1 microdeletions. Neurogenetics\| PubMed ID: 22581253	2012
Growth dynamics of plexiform neurofibromas: a retrospective cohort study of 201 patients with neurofibromatosis 1. Orphanet journal of rare diseases\| PubMed ID: 23035791	2012
Non-coding RNA ANRIL and the number of plexiform neurofibromas in patients with NF1 microdeletions. BMC medical genetics\| PubMed ID: 23101500	2012
Genomic imbalance of HMMR/RHAMM regulates the sensitivity and response of malignant peripheral nerve sheath tumour cells to aurora kinase inhibition. Oncotarget\| PubMed ID: 23328114	2013
Efficacy and side effects of chinese herbal medicine for menopausal symptoms: a critical review. Evidence-based complementary and alternative medicine : eCAM\| PubMed ID: 23365599	2012
P53 immunohistochemical expression does not correlate with clinical features in 207 carcinomas of the oral cavity and in the head and neck region. Clinical oral investigations\| PubMed ID: 23404560	2014
Sensitivity of malignant peripheral nerve sheath tumor cells to TRAIL is augmented by loss of NF1 through modulation of MYC/MAD and is potentiated by curcumin through induction of ROS. PloS one\| PubMed ID: 23437333	2013
Amplification of the PPFIA1 gene region on 11q13 in oral squamous cell carcinomas (OSCC). Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery\| PubMed ID: 23453270	2013
Serum biomarkers for neurofibromatosis type 1 and early detection of malignant peripheral nerve-sheath tumors. BMC medicine\| PubMed ID: 23618374	2013
Immunohistochemical analysis of p16 expression, HPV infection and its prognostic utility in oral squamous cell carcinoma. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology\| PubMed ID: 23721566	2013
Immunohistochemical and FISH analysis of EGFR and its prognostic value in patients with oral squamous cell carcinoma. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology\| PubMed ID: 24020871	2014
Postoperative bleeding risk for cutaneous surgery in the head and neck region with continued phenprocoumon therapy. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery\| PubMed ID: 24103463	2014
Efficacy and selectivity of nilotinib on NF1-associated tumors in vitro. Journal of neuro-oncology\| PubMed ID: 24173684	2014
Prognostic relevance of circulating tumor cells in blood and disseminated tumor cells in bone marrow of patients with squamous cell carcinoma of the oral cavity. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 24218516	2014
B-scan ultrasonographic monitoring of orthotopic xenografted plexiform neurofibroma in mice. In vivo (Athens, Greece)\| PubMed ID: 24292574	2013
Lack of evidence for predictive and prognostic value of cyclin D1 gene polymorphism CCND1 G870A for oral squamous cell carcinoma. Anticancer research\| PubMed ID: 24403468	2014
Fractal dimension of time-resolved autofluorescence discriminates tumour from healthy tissues in the oral cavity. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery\| PubMed ID: 24444757	2014
Differences of 25-hydroxyvitamin D3 concentrations in children and adults with neurofibromatosis type 1. Clinical biochemistry\| PubMed ID: 24613576	2014
Lack of evidence for increased risk of postoperative bleeding after cutaneous surgery in the head and neck in patients taking aspirin. The British journal of oral & maxillofacial surgery\| PubMed ID: 24703383	2014
Nilotinib is more potent than imatinib for treating plexiform neurofibroma in vitro and in vivo. PloS one\| PubMed ID: 25340526	2014
Lack of evidence for increased postoperative bleeding risk for dental osteotomy with continued aspirin therapy. Oral surgery, oral medicine, oral pathology and oral radiology\| PubMed ID: 25442244	2015
Efficacy and side-effects of a semi-individualized Chinese herb mixture "Tiáo Gēng Tāng" for menopausal syndrome in China. In vivo (Athens, Greece)\| PubMed ID: 25600538	2015
Postoperative bleeding risk for oral surgery under continued clopidogrel antiplatelet therapy. BioMed research international\| PubMed ID: 25632402	2015
Is immediate bony microsurgical reconstruction after head and neck tumor ablation associated with a higher rate of local recurrence? Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery\| PubMed ID: 25701393	2015
Preclinical assessment of the anticancer drug response of plexiform neurofibroma tissue using primary cultures. Journal of clinical neurology (Seoul, Korea)\| PubMed ID: 25851896	2015
Quantitative associations of scalp and body subcutaneous neurofibromas with internal plexiform tumors in neurofibromatosis 1. American journal of medical genetics. Part A\| PubMed ID: 25900062	2015
Optimized in vitro procedure for assessing the cytocompatibility of magnesium-based biomaterials. Acta biomaterialia\| PubMed ID: 26073090	2015
Increased Postoperative Bleeding Risk among Patients with Local Flap Surgery under Continued Clopidogrel Therapy. BioMed research international\| PubMed ID: 26345612	2015
Postoperative bleeding risk for oral surgery under continued rivaroxaban anticoagulant therapy. Clinical oral investigations\| PubMed ID: 26498769	2015
A novel genetic- and cell-based tool for assessing the efficacy and toxicity of anticancer drugs in vitro. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia\| PubMed ID: 26558359	2015