Christopher S. Chen

Department of Bioengineering, University of Pennsylvania

Affiliated withUniversity of Pennsylvania

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 16	2007

Other Publications

Article	Year
Fabrication of aligned microstructures with a single elastomeric stamp. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11842197	2002
Patterning the cellular microenvironment. IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society\| PubMed ID: 11935995	2002
Cell-cell signaling by direct contact increases cell proliferation via a PI3K-dependent signal. FEBS letters\| PubMed ID: 11943158	2002
Engineering cellular microenvironments to improve cell-based drug testing. Drug discovery today\| PubMed ID: 12047872	2002
Cells lying on a bed of microneedles: an approach to isolate mechanical force. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12552122	2003
Cell shape provides global control of focal adhesion assembly. Biochemical and biophysical research communications\| PubMed ID: 12859964	2003
VE-cadherin simultaneously stimulates and inhibits cell proliferation by altering cytoskeletal structure and tension. Journal of cell science\| PubMed ID: 12876221	2003
Repositioning of cells by mechanotaxis on surfaces with micropatterned Young's modulus. Journal of biomedical materials research. Part A\| PubMed ID: 12918044	2003
Dielectrophoretic registration of living cells to a microelectrode array. Biosensors & bioelectronics\| PubMed ID: 14709396	2004
Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Developmental cell\| PubMed ID: 15068789	2004
Vascular endothelial-cadherin regulates cytoskeletal tension, cell spreading, and focal adhesions by stimulating RhoA. Molecular biology of the cell\| PubMed ID: 15075376	2004
Dielectrophoretic registration of living cells to a microelectrode array. Biosensors & bioelectronics\| PubMed ID: 15198083	2004
Mechanotransduction at cell-matrix and cell-cell contacts. Annual review of biomedical engineering\| PubMed ID: 15255771	2004
Simple approach to micropattern cells on common culture substrates by tuning substrate wettability. Tissue engineering\| PubMed ID: 15265304	2004
Characterization of the nuclear deformation caused by changes in endothelial cell shape. Journal of biomechanical engineering\| PubMed ID: 15648807	2004
Facile modification of collagen directed by collagen mimetic peptides. Journal of the American Chemical Society\| PubMed ID: 15783169	2005
Optimization of yield in magnetic cell separations using nickel nanowires of different lengths. Biotechnology progress\| PubMed ID: 15801791	2005
Nanopattern-induced changes in morphology and motility of smooth muscle cells. Biomaterials\| PubMed ID: 15814139	2005
Strategies for engineering the adhesive microenvironment. Journal of mammary gland biology and neoplasia\| PubMed ID: 15838609	2004
Assembly of multicellular constructs and microarrays of cells using magnetic nanowires. Lab on a chip\| PubMed ID: 15915251	2005
T cell-to-T cell clustering enhances NF-kappaB activity by a PI3K signal mediated by Cbl-b and Rho. Biochemical and biophysical research communications\| PubMed ID: 15922296	2005
Emergent patterns of growth controlled by multicellular form and mechanics. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16049098	2005
Finite-element analysis of the adhesion-cytoskeleton-nucleus mechanotransduction pathway during endothelial cell rounding: axisymmetric model. Journal of biomechanical engineering\| PubMed ID: 16121529	2005
Nanotechnology for cell-substrate interactions. Annals of biomedical engineering\| PubMed ID: 16525764	2006
E-cadherin engagement stimulates proliferation via Rac1. The Journal of cell biology\| PubMed ID: 16682529	2006
Shear force at the cell-matrix interface: enhanced analysis for microfabricated post array detectors. Mechanics & chemistry of biosystems : MCB\| PubMed ID: 16708468	2005
Heparin binding directs activation of T cells against adeno-associated virus serotype 2 capsid. Nature medicine\| PubMed ID: 16845388	2006
An inhibitory role for FAK in regulating proliferation: a link between limited adhesion and RhoA-ROCK signaling. The Journal of cell biology\| PubMed ID: 16847103	2006
Using microenvironment to engineer stem cell function. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference\| PubMed ID: 17271427	2004
Separate but not equal: differential mechanical roles for Myosin isoforms. Biophysical journal\| PubMed ID: 17325018	2007
Manipulation of cell-cell adhesion using bowtie-shaped microwells. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 17416983	2007
Bait and switch: synthetic GEFs divert an input signal to diverse cellular responses. Developmental cell\| PubMed ID: 17609105	2007
Microfabricated silicone elastomeric post arrays for measuring traction forces of adherent cells. Methods in cell biology\| PubMed ID: 17613314	2007
Activation of ROCK by RhoA is regulated by cell adhesion, shape, and cytoskeletal tension. Experimental cell research\| PubMed ID: 17673200	2007
Cadherins, RhoA, and Rac1 are differentially required for stretch-mediated proliferation in endothelial versus smooth muscle cells. Circulation research\| PubMed ID: 17712140	2007
Magnetic microposts as an approach to apply forces to living cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17804810	2007
Cellular and multicellular form and function. Advanced drug delivery reviews\| PubMed ID: 17884241	2007
Versatile, fully automated, microfluidic cell culture system. Analytical chemistry\| PubMed ID: 17953452	2007
Rac-dependent cyclin D1 gene expression regulated by cadherin- and integrin-mediated adhesion. Journal of cell science\| PubMed ID: 18187454	2008
Spatial patterning of gene expression using surface-immobilized recombinant adenovirus. Biomedical microdevices\| PubMed ID: 18246428	2008
Magnetic microposts for mechanical stimulation of biological cells: fabrication, characterization, and analysis. The Review of scientific instruments\| PubMed ID: 18447536	2008
Myofibrillar architecture in engineered cardiac myocytes. Circulation research\| PubMed ID: 18635822	2008
Engineering amount of cell-cell contact demonstrates biphasic proliferative regulation through RhoA and the actin cytoskeleton. Experimental cell research\| PubMed ID: 18652824	2008
Biotechnology: remote control of living cells. Nature nanotechnology\| PubMed ID: 18654443	2008
Emergence of patterned stem cell differentiation within multicellular structures. Stem cells (Dayton, Ohio)\| PubMed ID: 18703661	2008
Immobilization of growth factors on collagen scaffolds mediated by polyanionic collagen mimetic peptides and its effect on endothelial cell morphogenesis. Biomacromolecules\| PubMed ID: 18816098	2008
Mechanotransduction - a field pulling together? Journal of cell science\| PubMed ID: 18843115	2008
Cell traction forces direct fibronectin matrix assembly. Biophysical journal\| PubMed ID: 19167317	2009
Mechanotransduction in development: a growing role for contractility. Nature reviews. Molecular cell biology\| PubMed ID: 19197330	2009
Using self-assembled monolayers to pattern ECM proteins and cells on substrates. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19247618	2009
Cell polarity triggered by cell-cell adhesion via E-cadherin. Journal of cell science\| PubMed ID: 19258396	2009
Microfabricated tissue gauges to measure and manipulate forces from 3D microtissues. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19541627	2009
Control of stem cell fate by physical interactions with the extracellular matrix. Cell stem cell\| PubMed ID: 19570510	2009
Cytoskeleton-based forecasting of stem cell lineage fates. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20080726	2010
Stem cell shape regulates a chondrogenic versus myogenic fate through Rac1 and N-cadherin. Stem cells (Dayton, Ohio)\| PubMed ID: 20082286	2010
Bioactive hydrogels made from step-growth derived PEG-peptide macromers. Biomaterials\| PubMed ID: 20138664	2010
Geometrically controlled endothelial tubulogenesis in micropatterned gels. Tissue engineering. Part A\| PubMed ID: 20180698	2010
Mechanical tugging force regulates the size of cell-cell junctions. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20463286	2010
Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics. Nature\| PubMed ID: 20613844	2010
Mechanical regulation of cell function with geometrically modulated elastomeric substrates. Nature methods\| PubMed ID: 20676108	2010
Decoupling diffusional from dimensional control of signaling in 3D culture reveals a role for myosin in tubulogenesis. Journal of cell science\| PubMed ID: 20682635	2010
Mechanical Forces in Endothelial Cells during Firm Adhesion and Early Transmigration of Human Monocytes. Cellular and molecular bioengineering\| PubMed ID: 20862208	2010
Micropatterned dynamically adhesive substrates for cell migration. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 20886900	2010
Engineered materials and the cellular microenvironment: a strengthening interface between cell biology and bioengineering. Trends in cell biology\| PubMed ID: 20965727	2010
Measurement of mechanical tractions exerted by cells in three-dimensional matrices. Nature methods\| PubMed ID: 21076420	2010
几何调制刚性测定干细胞美国超微型弹性衬底上。 Nature protocols\| PubMed ID: 21293460	2011
Subcellular spatial segregation of integrin subtypes by patterned multicomponent surfaces. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 21298148	2011
Cell shape and substrate rigidity both regulate cell stiffness. Biophysical journal\| PubMed ID: 21354386	2011
The Cdc42 guanine nucleotide exchange factor FGD1 regulates osteogenesis in human mesenchymal stem cells. The American journal of pathology\| PubMed ID: 21356349	2011
Measurement and analysis of traction force dynamics in response to vasoactive agonists. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 21445393	2011
Decreased cell adhesion promotes angiogenesis in a Pyk2-dependent manner. Experimental cell research\| PubMed ID: 21640103	2011
A hitchhiker's guide to mechanobiology. Developmental cell\| PubMed ID: 21763607	2011
Repressor transcription factor 7-like 1 promotes adipogenic competency in precursor cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21914845	2011
Bone Morphogenetic Protein-2-Induced Signaling and Osteogenesis Is Regulated by Cell Shape, RhoA/ROCK, and Cytoskeletal Tension. Stem cells and development\| PubMed ID: 21967638	2011
Bioresponsive mesoporous silica nanoparticles for triggered drug release. Journal of the American Chemical Society\| PubMed ID: 21981330	2011
A Microfabricated Platform to Measure and Manipulate the Mechanics of Engineered Cardiac Microtissues. Tissue engineering. Part A\| PubMed ID: 22092279	2012
Matrix rigidity regulates a switch between TGF-Î²1-induced apoptosis and epithelial-mesenchymal transition. Molecular biology of the cell\| PubMed ID: 22238361	2012
Probing cellular traction forces with magnetic nanowires and microfabricated force sensor arrays. Nanotechnology\| PubMed ID: 22260885	2012
Measuring traction forces of motile dendritic cells on micropost arrays. Biophysical journal\| PubMed ID: 22261049	2011
miR-125b is an Adhesion-Regulated microRNA that Protects Mesenchymal Stem Cells from Anoikis. Stem cells (Dayton, Ohio)\| PubMed ID: 22331826	2012