Massimo Trucco

Institute of Cellular Therapeutics, Allegheny Health Network

Affiliated withAllegheny Health Network Carnegie Mellon University

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 10	2016

Other Publications

Article	Year
Molecular basis of evolutionary loss of the alpha 1,3-galactosyltransferase gene in higher primates. The Journal of biological chemistry\| PubMed ID: 11773054	2002
Indoleamine 2,3-dioxygenase expression in transplanted NOD Islets prolongs graft survival after adoptive transfer of diabetogenic splenocytes. Diabetes\| PubMed ID: 11812742	2002
Cellular environment and freedom of gene expression. Nature immunology\| PubMed ID: 11919570	2002
Pancreas and islet cell transplantation. Best practice & research. Clinical gastroenterology\| PubMed ID: 12079269	2002
Genes and engineered cells as drugs for type I and type II diabetes mellitus therapy and prevention. Current opinion in investigational drugs (London, England : 2000)\| PubMed ID: 12090547	2002
Distinct characteristics and features of allogeneic chimerism in the NOD mouse model of autoimmune diabetes. Cell transplantation\| PubMed ID: 12099635	2002
Y Chromosomal Sequences Identified in Gonadal Tissue of Two 45,X Patients with Turner Syndrome. Endocrine pathology\| PubMed ID: 12114813	1995
Preservation of human islet cell functional mass by anti-oxidative action of a novel SOD mimic compound. Diabetes\| PubMed ID: 12145171	2002
Immunosuppressive effects of glucosamine. The Journal of biological chemistry\| PubMed ID: 12176986	2002
Gene therapy strategies to prevent autoimmune disorders. Current gene therapy\| PubMed ID: 12189720	2002
Alternative core promoters regulate tissue-specific transcription from the autoimmune diabetes-related ICA1 (ICA69) gene locus. The Journal of biological chemistry\| PubMed ID: 12409289	2003
Monocytes are progressively activated in the circulation of pregnant women. Journal of leukocyte biology\| PubMed ID: 12429709	2002
Production of alpha 1,3-galactosyltransferase-deficient pigs. Science (New York, N.Y.)\| PubMed ID: 12493821	2003
Protection of islets by in situ peptide-mediated transduction of the Ikappa B kinase inhibitor Nemo-binding domain peptide. The Journal of biological chemistry\| PubMed ID: 12524423	2003
Gene transfer of manganese superoxide dismutase extends islet graft function in a mouse model of autoimmune diabetes. Diabetes\| PubMed ID: 12540612	2003
Expansion of specific alphabeta+ T-cell subsets in the myocardium of patients with myocarditis and idiopathic dilated cardiomyopathy associated with Coxsackievirus B infection. Human immunology\| PubMed ID: 12559622	2003
Regulation of FasL/Fas in human trophoblasts: possible implications for chorioamnionitis. Biology of reproduction\| PubMed ID: 12700199	2003
Tolerogenic immunosuppression for organ transplantation. Lancet (London, England)\| PubMed ID: 12737859	2003
Recovery of the endogenous beta cell function in the NOD model of autoimmune diabetes. Stem cells (Dayton, Ohio)\| PubMed ID: 12832692	2003
Gene therapy technology applied to disorders of glucose metabolism: promise, achievements, and prospects. BioTechniques\| PubMed ID: 12866413	2003
Four-color flow cytometric analysis of peripheral blood donor cell chimerism. Human immunology\| PubMed ID: 12878357	2003
Prevention of diabetes in NOD mice by administration of dendritic cells deficient in nuclear transcription factor-kappaB activity. Diabetes\| PubMed ID: 12882913	2003
Flexible management of enzymatic digestion improves human islet isolation outcome from sub-optimal donor pancreata. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 12919094	2003
Need for genetic education for type 1 diabetes. Archives of pediatrics & adolescent medicine\| PubMed ID: 12963603	2003
Body window-enabled in vivo multicolor imaging of transplanted mouse islets expressing an insulin-Timer fusion protein. BioTechniques\| PubMed ID: 14579736	2003
Current status and prospects for gene and cell therapeutics for type 1 diabetes mellitus. Reviews in endocrine & metabolic disorders\| PubMed ID: 14618022	2003
HLA class II DRB high resolution genotyping by pyrosequencing: comparison of group specific PCR and pyrosequencing primers. Human immunology\| PubMed ID: 14969771	2004
Islet/pancreas transplantation: challenges for pediatrics. Pediatric diabetes\| PubMed ID: 15016150	2002
Lessons of organ-induced tolerance learned from historical clinical experience. Transplantation\| PubMed ID: 15077039	2004
Islet cell autoimmunity in a triethnic adult population of the Third National Health and Nutrition Examination Survey. Diabetes\| PubMed ID: 15111499	2004
Antisense oligonucleotides down-regulating costimulation confer diabetes-preventive properties to nonobese diabetic mouse dendritic cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15383562	2004
Response of human islets to isolation stress and the effect of antioxidant treatment. Diabetes\| PubMed ID: 15448084	2004
Gene combination transfer to block autoimmune damage in transplanted islets of Langerhans. Experimental diabesity research\| PubMed ID: 15512788	2004
Stem cells and diabetes. Pediatric diabetes\| PubMed ID: 15601368	2004
Regeneration of the pancreatic beta cell. The Journal of clinical investigation\| PubMed ID: 15630433	2005
SOP3: a web-based tool for selection of oligonucleotide primers for single nucleotide polymorphism analysis by Pyrosequencing. BioTechniques\| PubMed ID: 15679090	2005
Gene transfer of constitutively active Akt markedly improves human islet transplant outcomes in diabetic severe combined immunodeficient mice. Diabetes\| PubMed ID: 15919787	2005
Footer: a quantitative comparative genomics method for efficient recognition of cis-regulatory elements. Genome research\| PubMed ID: 15930494	2005
SOP3v2: web-based selection of oligonucleotide primer trios for genotyping of human and mouse polymorphisms. Nucleic acids research\| PubMed ID: 15980532	2005
Harmful delayed effects of exogenous isolation enzymes on isolated human islets: relevance to clinical transplantation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 16212626	2005
Gene therapy for type 1 diabetes: a proposal to move to the next level. Current opinion in molecular therapeutics\| PubMed ID: 16248282	2005
Gene therapy for type 1 diabetes. American journal of therapeutics\| PubMed ID: 16280645	2005
A look to the future: prediction, prevention, and cure including islet transplantation and stem cell therapy. Pediatric clinics of North America\| PubMed ID: 16301093	2005
Multifaceted therapeutic approaches for a multigenic disease. Diabetes\| PubMed ID: 16306345	2005
Facilitating physiologic self-regeneration: a step beyond islet cell replacement. Pharmaceutical research\| PubMed ID: 16323065	2006
Interleukin-7 is a survival factor for CD4+ CD25+ T-cells and is expressed by diabetes-suppressive dendritic cells. Diabetes\| PubMed ID: 16380489	2006
Cytoplasmic islet cell antibodies remain valuable in defining risk of progression to type 1 diabetes in subjects with other islet autoantibodies. Pediatric diabetes\| PubMed ID: 16390386	2005
HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16493087	2006
Widespread and stable pancreatic gene transfer by adeno-associated virus vectors via different routes. Diabetes\| PubMed ID: 16567506	2006
Is facilitating pancreatic beta cell regeneration a valid option for clinical therapy? Cell transplantation\| PubMed ID: 16826799	2006
Rehabilitation of adaptive immunity and regeneration of beta cells. Trends in biotechnology\| PubMed ID: 16963140	2006
Induction of diabetes in cynomolgus monkeys with high-dose streptozotocin: adverse effects and early responses. Pancreas\| PubMed ID: 17003651	2006
Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17015713	2006
Modulatory role of DR4- to DQ8-restricted CD4 T-cell responses and type 1 diabetes susceptibility. Diabetes\| PubMed ID: 17130492	2006
Web-based primer design software for genome-scale genotyping by pyrosequencing. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 17185755	2007
Pyrosequencing-based strategies for improved allele typing of human leukocyte antigen loci. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 17185762	2007
Functionally important glycosyltransferase gain and loss during catarrhine primate emergence. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17194757	2007
Disruption of innate-mediated proinflammatory cytokine and reactive oxygen species third signal leads to antigen-specific hyporesponsiveness. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17202352	2007
Isolation outcome and functional characteristics of young and adult pig pancreatic islets for transplantation studies. Xenotransplantation\| PubMed ID: 17214707	2007
Reduction of early graft loss after intraportal porcine islet transplantation in monkeys. Transplantation\| PubMed ID: 17264817	2007
To be DR8 or not to be DQ8, that is the question. Pediatric diabetes\| PubMed ID: 17341284	2007
Suppression of memory CD8 T cell generation and function by tryptophan catabolism. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17371982	2007
Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity. Annals of the New York Academy of Sciences\| PubMed ID: 17376822	2007
Antidiabetic sulfonylurea stimulates insulin secretion independently of plasma membrane KATP channels. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 17405830	2007
Immunoregulatory dendritic cells to prevent and reverse new-onset Type 1 diabetes mellitus. Expert opinion on biological therapy\| PubMed ID: 17665986	2007
Immunomodulation by adenoviral-mediated SCD40-Ig gene therapy for mouse allogeneic islet transplantation. Transplantation\| PubMed ID: 17700153	2007
Increased Expression of Monocyte CD11b (Mac-1) in Overweight Recent-Onset Type 1 Diabetic Children. The review of diabetic studies : RDS\| PubMed ID: 17823696	2007
Navigating pathways affecting type 1 diabetic kidney disease. Pediatric diabetes\| PubMed ID: 17850474	2007
Indoleamine 2,3-dioxygenase gene transfer prolongs cardiac allograft survival. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 17933973	2007
Induction of immune tolerance to facilitate beta cell regeneration in type 1 diabetes. Advanced drug delivery reviews\| PubMed ID: 18053613	2008
A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene. Clinical immunology (Orlando, Fla.)\| PubMed ID: 18096436	2008
On the use of general control samples for genome-wide association studies: genetic matching highlights causal variants. American journal of human genetics\| PubMed ID: 18252225	2008
Human proinsulin C-peptide reduces high glucose-induced proliferation and NF-kappaB activation in vascular smooth muscle cells. Atherosclerosis\| PubMed ID: 18294642	2008
A microsphere-based vaccine prevents and reverses new-onset autoimmune diabetes. Diabetes\| PubMed ID: 18316361	2008
Identification of novel IGRP epitopes targeted in type 1 diabetes patients. Clinical immunology (Orlando, Fla.)\| PubMed ID: 18358785	2008
Renal diseases as targets of gene therapy. Contributions to nephrology\| PubMed ID: 18391581	2008
Toward a cure for type 1 diabetes mellitus: diabetes-suppressive dendritic cells and beyond. Pediatric diabetes\| PubMed ID: 18540865	2008
Dendritic cell mediated therapy for immunoregulation of type 1 diabetes mellitus. Pediatric endocrinology reviews : PER\| PubMed ID: 18552749	2008
AAV8-mediated gene transfer of interleukin-4 to endogenous beta-cells prevents the onset of diabetes in NOD mice. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 18560422	2008
Proteomic analysis of fructose-induced fatty liver in hamsters. Metabolism: clinical and experimental\| PubMed ID: 18640390	2008
The role of external and matrix pH in mitochondrial reactive oxygen species generation. The Journal of biological chemistry\| PubMed ID: 18687689	2008
Multiplex HLA-typing by pyrosequencing. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 18839107	2009
Recovery of endogenous beta-cell function in nonhuman primates after chemical diabetes induction and islet transplantation. Diabetes\| PubMed ID: 19001183	2009
Suppression of autoimmune diabetes by soluble galectin-1. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19234158	2009
Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism. The Journal of biological chemistry\| PubMed ID: 19460757	2009
Thymus-specific deletion of insulin induces autoimmune diabetes. The EMBO journal\| PubMed ID: 19680229	2009
Breakthrough in diabetes therapy ... Just around the corner? The review of diabetic studies : RDS\| PubMed ID: 19806236	2009
Anti-inflammatory properties of C-Peptide. The review of diabetic studies : RDS\| PubMed ID: 20039006	2009
Bistability of mitochondrial respiration underlies paradoxical reactive oxygen species generation induced by anoxia. PLoS computational biology\| PubMed ID: 20041200	2009
Phagocytosis of enterovirus-infected pancreatic beta-cells triggers innate immune responses in human dendritic cells. Diabetes\| PubMed ID: 20071599	2010
Screen and clean: a tool for identifying interactions in genome-wide association studies. Genetic epidemiology\| PubMed ID: 20088021	2010
Humoral autoimmunity against the extracellular domain of the neuroendocrine autoantigen IA-2 heightens the risk of type 1 diabetes. Endocrinology\| PubMed ID: 20382696	2010
Redox modulation protects islets from transplant-related injury. Diabetes\| PubMed ID: 20413509	2010
Dendritic cell-based therapy in Type 1 diabetes mellitus. Expert review of clinical immunology\| PubMed ID: 20477010	2009
Gene-environment interaction in type 1 diabetes mellitus. Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion\| PubMed ID: 20542231	2009
Gene-environment interaction in type 1 diabetes mellitus. Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición\| PubMed ID: 20629235	2009
Beta-cell regeneration: from science fiction to challenging reality. Pediatric diabetes\| PubMed ID: 20646239	2010
Regenerative medicine for diabetes treatment. Discovery medicine\| PubMed ID: 20704900	2005
Using ancestry matching to combine family-based and unrelated samples for genome-wide association studies. Statistics in medicine\| PubMed ID: 20862653	2010
Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages: implications for inflammatory mediated diseases. PloS one\| PubMed ID: 21072211	2010
HLA matching and the point system. Clinical transplantation\| PubMed ID: 21151745	1993
Global deficits in development, function, and gene expression in the endocrine pancreas in a deletion mouse model of Prader-Willi syndrome. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 21343540	2011
Phosphatidylinositol-3-kinase activity during in vitro dendritic cell generation determines suppressive or stimulatory capacity. Immunologic research\| PubMed ID: 21476100	2011
Reactive oxygen species production by forward and reverse electron fluxes in the mitochondrial respiratory chain. PLoS computational biology\| PubMed ID: 21483483	2011
Hemoglobin A1C Percentage in Nonhuman Primates: A Useful Tool to Monitor Diabetes before and after Porcine Pancreatic Islet Xenotransplantation. Journal of transplantation\| PubMed ID: 21559266	2011
The Role of Cell Migration and Chimerism in Organ Transplant Acceptance and Tolerance Induction. Transplantation science\| PubMed ID: 21572595	1993
Kidney/Bone Marrow Transplantation. Dialysis & transplantation\| PubMed ID: 21625353	1996
Phase I (safety) study of autologous tolerogenic dendritic cells in type 1 diabetic patients. Diabetes care\| PubMed ID: 21680720	2011
A multivalent vaccine for type 1 diabetes skews T cell subsets to Th2 phenotype in NOD mice. Immunologic research\| PubMed ID: 21717080	2011
Current state of type 1 diabetes immunotherapy: incremental advances, huge leaps, or more of the same? Clinical & developmental immunology\| PubMed ID: 21785616	2011
Pig-to-nonhuman primates pancreatic islet xenotransplantation: an overview. Current diabetes reports\| PubMed ID: 21805400	2011
Immunotherapy-based strategies for the treatment of autoimmune diabetes: searching for the cure. Current pharmaceutical design\| PubMed ID: 21864264	2011
C-peptide reduces pro-inflammatory cytokine secretion in LPS-stimulated U937 monocytes in condition of hyperglycemia. Inflammation research : official journal of the European Histamine Research Society ... [et al.]\| PubMed ID: 21947415	2012
Clinical xenotransplantation: the next medical revolution? Lancet (London, England)\| PubMed ID: 22019026	2012
An improved intracellular staining protocol for efficient detection of nuclear proteins in YFP-expressing cells. BioTechniques\| PubMed ID: 22150333	2011
Essential roles of insulin expression in Aire+ tolerogenic dendritic cells in maintaining peripheral self-tolerance of islet β-cells. Cellular immunology\| PubMed ID: 22297234	2012
Sequence variation in promoter of Ica1 gene, which encodes protein implicated in type 1 diabetes, causes transcription factor autoimmune regulator (AIRE) to increase its binding and down-reg... The Journal of biological chemistry\| PubMed ID: 22447927	2012
Isolation of human islets for autologous islet transplantation in children and adolescents with chronic pancreatitis. Journal of transplantation\| PubMed ID: 22461976	2012
FOXO1 mediates the autocrine effect of endothelin-1 on endothelial cell survival. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 22570335	2012
Modulation of redox balance leaves murine diabetogenic TH1 T cells "LAG-3-ing" behind. Diabetes\| PubMed ID: 22586584	2012
Cytokine and chemokine production by human pancreatic islets upon enterovirus infection. Diabetes\| PubMed ID: 22596052	2012
A role for tolerogenic dendritic cell-induced B-regulatory cells in type 1 diabetes mellitus. Current opinion in endocrinology, diabetes, and obesity\| PubMed ID: 22760513	2012
Early islet damage after direct exposure of pig islets to blood: has humoral immunity been underestimated? Cell transplantation\| PubMed ID: 22776064	2012
Multistationary and oscillatory modes of free radicals generation by the mitochondrial respiratory chain revealed by a bifurcation analysis. PLoS computational biology\| PubMed ID: 23028295	2012
Treg cells in pancreatic lymph nodes: the possible role in diabetogenesis and β cell regeneration in a T1D model. Cellular & molecular immunology\| PubMed ID: 23042535	2012
Dendritic cell therapy for Type 1 diabetes suppression. Immunotherapy\| PubMed ID: 23148758	2012
Clinical islet xenotransplantation: how close are we? Diabetes\| PubMed ID: 23172951	2012
Increased yield and improved transplantation outcome of mouse islets with bovine serum albumin. Journal of transplantation\| PubMed ID: 23304445	2012
Toward clinical islet xenotransplantation - are revisions to the IXA guidelines warranted? Xenotransplantation\| PubMed ID: 23320741	2013
Intestinal γδ T-cell lymphomas are most frequently of type II enteropathy-associated T-cell type. Human pathology\| PubMed ID: 23332928	2013
Clustering and alignment of polymorphic sequences for HLA-DRB1 genotyping. PloS one\| PubMed ID: 23555798	2013
Mn porphyrin regulation of aerobic glycolysis: implications on the activation of diabetogenic immune cells. Antioxidants & redox signaling\| PubMed ID: 23682840	2013
In vivo delivery of nucleic acid-formulated microparticles as a potential tolerogenic vaccine for type 1 diabetes. The review of diabetic studies : RDS\| PubMed ID: 23804272	2012
The potential of genetically-engineered pigs in providing an alternative source of organs and cells for transplantation. Journal of biomedical research\| PubMed ID: 23885264	2013
Islet xenotransplantation from genetically engineered pigs. Current opinion in organ transplantation\| PubMed ID: 24126804	2013
It's time to bring dendritic cell therapy to type 1 diabetes. Diabetes\| PubMed ID: 24357690	2014
Involvement of suppressive B-lymphocytes in the mechanism of tolerogenic dendritic cell reversal of type 1 diabetes in NOD mice. PloS one\| PubMed ID: 24465383	2014
Compromised central tolerance of ICA69 induces multiple organ autoimmunity. Journal of autoimmunity\| PubMed ID: 25088457	2014
Islet xenotransplantation: what is the optimal age of the islet-source pig? Xenotransplantation\| PubMed ID: 25130196	2015
Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease. Science (New York, N.Y.)\| PubMed ID: 25146295	2014
Obesity, islet cell autoimmunity, and cardiovascular risk factors in youth at onset of type 1 autoimmune diabetes. The Journal of clinical endocrinology and metabolism\| PubMed ID: 25250632	2015
Streptozotocin-associated lymphopenia in cynomolgus monkeys. Islets\| PubMed ID: 25322828	2014
Glucose metabolism in pigs expressing human genes under an insulin promoter. Xenotransplantation\| PubMed ID: 25382150	2015
Neuronal T-cell autoreactivity is amplified in overweight children with new-onset insulin-requiring diabetes. Diabetes care\| PubMed ID: 25414154	2015
Evolution of hepatic steatosis to fibrosis and adenoma formation in liver-specific growth hormone receptor knockout mice. Frontiers in endocrinology\| PubMed ID: 25566190	2014
Cellular therapies based on stem cells and their insulin-producing surrogates: a 2015 reality check. Pediatric diabetes\| PubMed ID: 25652322	2015
Generation of antigen-specific Foxp3+ regulatory T-cells in vivo following administration of diabetes-reversing tolerogenic microspheres does not require provision of antigen in the formulat... Clinical immunology (Orlando, Fla.)\| PubMed ID: 25773782	2015
Factors associated with islet yield and insulin independence after total pancreatectomy and islet cell autotransplantation in patients with chronic pancreatitis utilizing off-site islet isol... The Journal of clinical endocrinology and metabolism\| PubMed ID: 25781357	2015
Bioengineering mini functional thymic units with EAK16-II/EAKIIH6 self-assembling hydrogel. Clinical immunology (Orlando, Fla.)\| PubMed ID: 25805654	2015
A brief glimpse over the horizon for type 1 diabetes nanotherapeutics. Clinical immunology (Orlando, Fla.)\| PubMed ID: 25817545	2015
Bioengineering Thymus Organoids to Restore Thymic Function and Induce Donor-Specific Immune Tolerance to Allografts. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 25903472	2015
Clinical implementation of islet transplantation: A current assessment. Pediatric diabetes\| PubMed ID: 26084669	2015
Author Response to Letter by Delibasi T., et al. The Journal of clinical endocrinology and metabolism\| PubMed ID: 26151405	2015
In vitro exposure of pig neonatal isletlike cell clusters to human blood. Xenotransplantation\| PubMed ID: 26179209	2015
Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β Cell Proliferation. Cell metabolism\| PubMed ID: 26626461	2016
Use of genetically-engineered pig donors in islet transplantation. World journal of transplantation\| PubMed ID: 26722651	2015
A Multicenter Study: North American Islet Donor Score in Donor Pancreas Selection for Human Islet Isolation for Transplantation. Cell transplantation\| PubMed ID: 26922947	2016
Inherent ER stress in pancreatic islet β cells causes self-recognition by autoreactive T cells in type 1 diabetes. Journal of autoimmunity\| PubMed ID: 27173406	2016