Thomas Douglas

Biogeochemical Sciences Branch, US Army Engineer Research & Development Center, Fairbanks, AK

Affiliated withUS Army Engineer Research & Development Center, Fairbanks, AK

Research Area

Biography

Thomas Douglas has not added Biography.
If you are Thomas Douglas and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 8	2016

Other Publications

Article	Year
Direct real-time evaluation of nitration with green fluorescent protein in solution and within human cells reveals the impact of nitrogen dioxide vs. peroxynitrite mechanisms. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11904413	2002
Further evidence for distinct reactive intermediates from nitroxyl and peroxynitrite: effects of buffer composition on the chemistry of Angeli's salt and synthetic peroxynitrite. Archives of biochemistry and biophysics\| PubMed ID: 12054463	2002
A chemical perspective on the interplay between NO, reactive oxygen species, and reactive nitrogen oxide species. Annals of the New York Academy of Sciences\| PubMed ID: 12076975	2002
Focusing of nitric oxide mediated nitrosation and oxidative nitrosylation as a consequence of reaction with superoxide. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12177414	2002
Ingress and reactive chemistry of nitroxyl-derived species within human cells. Free radical biology & medicine\| PubMed ID: 12208370	2002
Protein nitration is mediated by heme and free metals through Fenton-type chemistry: an alternative to the NO/O2- reaction. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12226478	2002
Guide for the use of nitric oxide (NO) donors as probes of the chemistry of NO and related redox species in biological systems. Methods in enzymology\| PubMed ID: 12481562	2002
Comparison of the reactivity of nitric oxide and nitroxyl with heme proteins. A chemical discussion of the differential biological effects of these redox related products of NOS. Journal of inorganic biochemistry\| PubMed ID: 12538052	2003
Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: a novel redox paradigm. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 12855429	2003
A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12865500	2003
Heme proteins and nitric oxide (NO): the neglected, eloquent chemistry in NO redox signaling and regulation. Antioxidants & redox signaling\| PubMed ID: 12880485	2003
Viral-associated trichodysplasia in patients who are immunocompromised. Journal of the American Academy of Dermatology\| PubMed ID: 14726896	2004
The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations. Biological chemistry\| PubMed ID: 14977040	2004
Hypoxic inducible factor 1alpha, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15178764	2004
The chemical dynamics of NO and reactive nitrogen oxides: a practical guide. Current molecular medicine\| PubMed ID: 15579020	2004
Mechanism of aerobic decomposition of Angeli's salt (sodium trioxodinitrate) at physiological pH. Journal of the American Chemical Society\| PubMed ID: 15643898	2005
Pili trianguli et canaliculi is a defect of inner root sheath keratinization: ultrastructural observations of anomalous tonofilament organization in a case. The American Journal of dermatopathology\| PubMed ID: 15900128	2005
Nitric oxide regulates angiogenesis through a functional switch involving thrombospondin-1. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16141331	2005
Guanylyl cyclase-dependent chemotaxis of endothelial cells in response to nitric oxide gradients. Free radical biology & medicine\| PubMed ID: 16540398	2006
Discriminating formation of HNO from other reactive nitrogen oxide species. Free radical biology & medicine\| PubMed ID: 16540401	2006
Superoxide fluxes limit nitric oxide-induced signaling. The Journal of biological chemistry\| PubMed ID: 16829532	2006
Phosphine-olefin ligands: a facile dehydrogenative route to catalytically active rhodium complexes. Chemical communications (Cambridge, England)\| PubMed ID: 16896477	2006
The biphasic nature of nitric oxide responses in tumor biology. Antioxidants & redox signaling\| PubMed ID: 16910780	2006
The activation of metabolites of nitric oxide synthase by metals is both redox and oxygen dependent: a new feature of nitrogen oxide signaling. Antioxidants & redox signaling\| PubMed ID: 16910783	2006
Peroxynitrite and myocardial contractility: in vivo versus in vitro effects. Free radical biology & medicine\| PubMed ID: 17045928	2006
Inflammation and IGF-I activate the Akt pathway in breast cancer. International journal of cancer\| PubMed ID: 17096325	2007
The role of halogenated carborane monoanions in olefin hydrogenation catalysed by cationic iridium phosphine complexes. Dalton transactions (Cambridge, England : 2003)\| PubMed ID: 17117219	2006
Asbestos redirects nitric oxide signaling through rapid catalytic conversion to nitrite. Cancer research\| PubMed ID: 17178853	2006
Phylogenetic analysis of bacteria preserved in a permafrost ice wedge for 25,000 years. Applied and environmental microbiology\| PubMed ID: 17293514	2007
Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17942699	2007
Intramolecular alkyl phosphine dehydrogenation in cationic rhodium complexes of tris(cyclopentylphosphine). Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 17992682	2008
Reversible addition of water to the high-hydride-content cluster [Rh6(PiPr3)6H12][BArF4]2. Synthesis and Structure of [Rh6PiPr3)6H11(OH)][BArF4]2. Inorganic chemistry\| PubMed ID: 18181618	2008
The chemical biology of nitric oxide: implications in cellular signaling. Free radical biology & medicine\| PubMed ID: 18439435	2008
Influence of snow and ice crystal formation and accumulation on mercury deposition to the Arctic. Environmental science & technology\| PubMed ID: 18441801	2008
Molecular mechanisms for discrete nitric oxide levels in cancer. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society\| PubMed ID: 18472020	2008
Amine-borane sigma-complexes of rhodium. relevance to the catalytic dehydrogenation of amine-boranes. Journal of the American Chemical Society\| PubMed ID: 18844358	2008
Consequentialism and the death penalty. The American journal of bioethics : AJOB\| PubMed ID: 19003713	2008
Medical injury compensation: beyond 'no-fault'. Medical law review\| PubMed ID: 19095721	2009
Moral Enhancement. Journal of applied philosophy\| PubMed ID: 19132138	2008
Glaciibacter superstes gen. nov., sp. nov., a novel member of the family Microbacteriaceae isolated from a permafrost ice wedge. International journal of systematic and evolutionary microbiology\| PubMed ID: 19244426	2009
A time series investigation of the stability of nitramine and nitroaromatic explosives in surface water samples at ambient temperature. Chemosphere\| PubMed ID: 19329139	2009
Destroying unwanted embryos in research. Talking Point on morality and human embryo research. EMBO reports\| PubMed ID: 19337299	2009
Comparing the chemical biology of NO and HNO. Archives of pharmacal research\| PubMed ID: 19727606	2009
Enhancement in Sport, and Enhancement outside Sport. Studies in ethics, law, and technology\| PubMed ID: 19750128	2007
Monomeric and oligomeric amine-borane sigma-complexes of rhodium. intermediates in the catalytic dehydrogenation of amine-boranes. Journal of the American Chemical Society\| PubMed ID: 19785431	2009
Absence of significant dissent should be sufficient for deceased donor organ procurement in New Zealand. Australian and New Zealand journal of public health\| PubMed ID: 19811481	2009
Investigating the fate of nitroaromatic (TNT) and nitramine (RDX and HMX) explosives in fractured and pristine soils. Journal of environmental quality\| PubMed ID: 19875785	2009
Tomitella biformata gen. nov., sp. nov., a new member of the suborder Corynebacterineae isolated from a permafrost ice wedge. International journal of systematic and evolutionary microbiology\| PubMed ID: 20081023	2010
Nitric oxide and cancer therapy: the emperor has NO clothes. Current pharmaceutical design\| PubMed ID: 20236067	2010
Resisting Sparrow's sexy reductio: selection principles and the social good. The American journal of bioethics : AJOB\| PubMed ID: 20582820	2010
Australian attitudes to early and late abortion. The Medical journal of Australia\| PubMed ID: 20618106	2010
Synthetic biology and the ethics of knowledge. Journal of medical ethics\| PubMed ID: 20935316	2010
Desorption of nitramine and nitroaromatic explosive residues from soils detonated under controlled conditions. Environmental toxicology and chemistry / SETAC\| PubMed ID: 21038362	2011
SHOULD INSTITUTIONS PRIORITIZE RECTIFICATION OVER AID? The Philosophical quarterly\| PubMed ID: 21423857	2010
Intertemporal Disagreement and Empirical Slippery Slope Arguments. Utilitas\| PubMed ID: 21516214	2010
Dissolution and sorption of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and 2,4,6-trinitrotoluene (TNT) residues from detonated mineral surfaces. Chemosphere\| PubMed ID: 21601233	2011
Dinitrosyliron complexes are the most abundant nitric oxide-derived cellular adduct: biological parameters of assembly and disappearance. Free radical biology & medicine\| PubMed ID: 21787861	2011
Nitric oxide suppresses tumor cell migration through N-Myc downstream-regulated gene-1 (NDRG1) expression: role of chelatable iron. The Journal of biological chemistry\| PubMed ID: 21976667	2011
Moral enhancement via direct emotion modulation: a reply to John Harris. Bioethics\| PubMed ID: 22092503	2013
Self-serving bias and the structure of moral status. Journal of medical ethics\| PubMed ID: 22174328	2012
Is S-nitrosocysteine a true surrogate for nitric oxide? Antioxidants & redox signaling\| PubMed ID: 22304688	2012
Is NICE ageist? Highlights from this issue. Journal of medical ethics\| PubMed ID: 22518054	2012
S-nitrosation: current concepts and new developments. Antioxidants & redox signaling\| PubMed ID: 22530975	2012
Engineering and ethical perspectives in synthetic biology. Rigorous, robust and predictable designs, public engagement and a modern ethical framework are vital to the continued success of sy... EMBO reports\| PubMed ID: 22699939	2012
The harms of status enhancement could be compensated or outweighed: a response to Agar. Journal of medical ethics\| PubMed ID: 23047835	2013
A concise argument: on the wrongness of killing. Journal of medical ethics\| PubMed ID: 23247758	2013
Procreative beneficence and in vitro gametogenesis. Monash bioethics review\| PubMed ID: 23409535	2012
Biosecurity and the division of cognitive labour. Journal of medical ethics\| PubMed ID: 23508647	2013
Nitric oxide modifies global histone methylation by inhibiting Jumonji C domain-containing demethylases. The Journal of biological chemistry\| PubMed ID: 23546878	2013
Human enhancement and supra-personal moral status. Philosophical studies\| PubMed ID: 23576821	2013
Is the creation of artificial life morally significant? Studies in history and philosophy of biological and biomedical sciences\| PubMed ID: 23810562	2013
Coercion, incarceration, and chemical castration: an argument from autonomy. Journal of bioethical inquiry\| PubMed ID: 23813324	2013
Procreative altruism: beyond individualism in reproductive selection. The Journal of medicine and philosophy\| PubMed ID: 23856478	2013
Oxygen dependence of nitric oxide-mediated signaling. Redox biology\| PubMed ID: 24024154	2013
Regulation of devices for cognitive enhancement. Lancet (London, England)\| PubMed ID: 24034296	2013
Convective forcing of mercury and ozone in the Arctic boundary layer induced by leads in sea ice. Nature\| PubMed ID: 24429521	2014
Inhibition of extracellular HMGB1 attenuates hyperoxia-induced inflammatory acute lung injury. Redox biology\| PubMed ID: 24563849	2014
Enhancing Moral Conformity and Enhancing Moral Worth. Neuroethics\| PubMed ID: 24600486	2014
Stocking the genetic supermarket: reproductive genetic technologies and collective action problems. Bioethics\| PubMed ID: 24720568	2015
Moral bioenhancement, freedom and reasoning. Journal of medical ethics\| PubMed ID: 24840918	2014
Enhancement and Civic Virtue. Social theory and practice\| PubMed ID: 24882886	2014
The Relationship Between Effort and Moral Worth: Three Amendments to Sorensen's Model. Ethical theory and moral practice : an international forum\| PubMed ID: 24991189	2014
The compromise of macrophage functions by hyperoxia is attenuated by ethacrynic acid via inhibition of NF-κB-mediated release of high-mobility group box-1. American journal of respiratory cell and molecular biology\| PubMed ID: 24992505	2015
Criminal Rehabilitation Through Medical Intervention: Moral Liability and the Right to Bodily Integrity. The journal of ethics\| PubMed ID: 25009441	2014
Insights into the diverse effects of nitric oxide on tumor biology. Vitamins and hormones\| PubMed ID: 25189391	2014
The regulation of cognitive enhancement devices: extending the medical model. Journal of law and the biosciences\| PubMed ID: 25243073	2014
Stem cell-derived gametes, iterated in vitro reproduction, and genetic parenthood. Journal of medical ethics\| PubMed ID: 25332370	2014
The dual-use problem, scientific isolationism and the division of moral labour. Monash bioethics review\| PubMed ID: 25434066	2014
The harms of enhancement and the conclusive reasons view. Cambridge quarterly of healthcare ethics : CQ : the international journal of healthcare ethics committees\| PubMed ID: 25473855	2015
The dual-use problem, scientific isolationism and the division of moral labour. Monash bioethics review\| PubMed ID: 25507664	2014
Are You Morally Modified?: The Moral Effects of Widely Used Pharmaceuticals. Philosophy, psychiatry, & psychology : PPP\| PubMed ID: 25892904	2014
Proximity of arteries to the anterior ulna with changing flexion. Orthopedics\| PubMed ID: 25901616	2015
Breathing new life into nitric oxide signaling: A brief overview of the interplay between oxygen and nitric oxide. Redox biology\| PubMed ID: 26056766	2015
Sex Offenders Seeking Treatment for Sexual Dysfunction--Ethics, Medicine, and the Law. The journal of sexual medicine\| PubMed ID: 26060942	2015
The moral imperative to continue gene editing research on human embryos. Protein & cell\| PubMed ID: 26113289	2015
Signaling and stress: The redox landscape in NOS2 biology. Free radical biology & medicine\| PubMed ID: 26117324	2015
Substituted judgment, procreative beneficence, and the Ashley treatment. Journal of medical ethics\| PubMed ID: 26304130	2015
Nitric Oxide Regulates Gene Expression in Cancers by Controlling Histone Posttranslational Modifications. Cancer research\| PubMed ID: 26542213	2015
CRISPR: A path through the thicket. Nature\| PubMed ID: 26560284	2015
Genome Editing Technologies and Human Germline Genetic Modification: The Hinxton Group Consensus Statement. The American journal of bioethics : AJOB\| PubMed ID: 26632362	2015
Methadone for prisoners. Lancet (London, England)\| PubMed ID: 26842294	2016
Why is Cognitive Enhancement Deemed Unacceptable? The Role of Fairness, Deservingness, and Hollow Achievements. Frontiers in psychology\| PubMed ID: 26925027	2016
Duties to rescue: individual, professional and institutional. Journal of medical ethics\| PubMed ID: 27004742	2016
Ascorbic Acid Attenuates Hyperoxia-Compromised Host Defense Against Pulmonary Bacterial Infection. American journal of respiratory cell and molecular biology\| PubMed ID: 27120084	2016