Alessio Fasano

Mucosal Immunology and Biology Research Center, Massachusetts General Hospital for Children

Affiliated withMassachusetts General Hospital for Children

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 20	2016

Other Publications

Article	Year
Zonula occludin toxin, a microtubule binding protein. World journal of gastroenterology\| PubMed ID: 11819591	2000
Zonula occludens toxin (Zot) interferes with the induction of nasal tolerance to gliadin. Immunology letters\| PubMed ID: 11947928	2002
New developments in childhood celiac disease. Current gastroenterology reports\| PubMed ID: 12010625	2002
Ganglioside reactive antibodies in the neuropathy associated with celiac disease. Journal of neuroimmunology\| PubMed ID: 12044986	2002
Structural and functional alterations of the gastrointestinal tract following radiation-induced injury in the rhesus monkey. Digestive diseases and sciences\| PubMed ID: 12141804	2002
Infectious diarrhea in children: Working Group Report of the First World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition. Journal of pediatric gastroenterology and nutrition\| PubMed ID: 12192183	2002
Host-dependent zonulin secretion causes the impairment of the small intestine barrier function after bacterial exposure. Gastroenterology\| PubMed ID: 12404235	2002
Effect of the biologically active fragment of zonula occludens toxin, delta G, on the intestinal paracellular transport and oral absorption of mannitol. International journal of pharmaceutics\| PubMed ID: 12527181	2003
Zonula occludens toxin increases the permeability of molecular weight markers and chemotherapeutic agents across the bovine brain microvessel endothelial cells. Journal of pharmaceutical sciences\| PubMed ID: 12532391	2003
Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study. Archives of internal medicine\| PubMed ID: 12578508	2003
Zonula occludens toxin acts as an adjuvant through different mucosal routes and induces protective immune responses. Infection and immunity\| PubMed ID: 12654806	2003
Bioterrorism and biological warfare: not only a respiratory affair. Journal of pediatric gastroenterology and nutrition\| PubMed ID: 12669708	2003
Celiac disease--how to handle a clinical chameleon. The New England journal of medicine\| PubMed ID: 12815143	2003
Intestinal epithelial tight junctions as targets for enteric bacteria-derived toxins. Advanced drug delivery reviews\| PubMed ID: 15063590	2004
The effect of delta G on the transport and oral absorption of macromolecules. Journal of pharmaceutical sciences\| PubMed ID: 15067707	2004
Intestinal infections and environmental enteropathy: Working Group report of the second World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition. Journal of pediatric gastroenterology and nutrition\| PubMed ID: 15184767	2004
Celiac disease as a cause of growth retardation in childhood. Current opinion in pediatrics\| PubMed ID: 15273508	2004
The impact of DeltaG on the oral bioavailability of low bioavailable therapeutic agents. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 15448170	2005
Relationship of HLA-DQ8 and severity of celiac disease: comparison of New York and Parisian cohorts. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association\| PubMed ID: 15476152	2004
Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. Journal of pediatric gastroenterology and nutrition\| PubMed ID: 15625418	2005
Dual sugar gut-permeability testing on blood drop in animal models. Clinica chimica acta; international journal of clinical chemistry\| PubMed ID: 15653114	2005
Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15710870	2005
Permeability, zonulin production, and enteropathy in dermatitis herpetiformis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association\| PubMed ID: 15822038	2005
Clinical presentation of celiac disease in the pediatric population. Gastroenterology\| PubMed ID: 15825129	2005
Seeing the light with celiac. Clinical immunology (Orlando, Fla.)\| PubMed ID: 15893690	2005
Coeliac disease in children. Best practice & research. Clinical gastroenterology\| PubMed ID: 15925850	2005
Secreted autotransporter toxin produced by a diffusely adhering Escherichia coli strain causes intestinal damage in animal model assays. FEMS microbiology letters\| PubMed ID: 16098687	2005
Current concepts in the evaluation, diagnosis and management of acute infectious diarrhea. Current opinion in pharmacology\| PubMed ID: 16207535	2005
Mechanisms of disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases. Nature clinical practice. Gastroenterology & hepatology\| PubMed ID: 16265432	2005
Enhancement of brain distribution of anticancer agents using DeltaG, the 12 kDa active fragment of ZOT. International journal of pharmaceutics\| PubMed ID: 16274945	2005
VSL#3 probiotic preparation has the capacity to hydrolyze gliadin polypeptides responsible for Celiac Sprue. Biochimica et biophysica acta\| PubMed ID: 16311022	2006
Celiac disease: is the atypical really typical? Summary of the recent National Institutes of Health Consensus Conference and latest advances. Current gastroenterology reports\| PubMed ID: 16313875	2005
Gliadin stimulation of murine macrophage inflammatory gene expression and intestinal permeability are MyD88-dependent: role of the innate immune response in Celiac disease. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16456012	2006
Tight junction modulation and its relationship to drug delivery. Advanced drug delivery reviews\| PubMed ID: 16517003	2006
Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines. Scandinavian journal of gastroenterology\| PubMed ID: 16635908	2006
Celiac disease in the pediatric population. Pediatric annals\| PubMed ID: 16637556	2006
Zonulin upregulation is associated with increased gut permeability in subjects with type 1 diabetes and their relatives. Diabetes\| PubMed ID: 16644703	2006
Zonula occludens toxin synthetic peptide derivative AT1002 enhances in vitro and in vivo intestinal absorption of low molecular weight heparin. Journal of drug targeting\| PubMed ID: 16882552	2006
Latest developments in the pathogenesis and treatment of celiac disease. The Journal of pediatrics\| PubMed ID: 16939736	2006
Systemic autoimmune disorders in celiac disease. Current opinion in gastroenterology\| PubMed ID: 17053448	2006
A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease. The American journal of clinical nutrition\| PubMed ID: 17209192	2007
Detection of Celiac disease in primary care: a multicenter case-finding study in North America. The American journal of gastroenterology\| PubMed ID: 17355413	2007
Screening for celiac disease in family members: is follow-up testing necessary? Digestive diseases and sciences\| PubMed ID: 17380406	2007
Mechanisms of disease: protease functions in intestinal mucosal pathobiology. Nature clinical practice. Gastroenterology & hepatology\| PubMed ID: 17607295	2007
Effect of the six-mer synthetic peptide (AT1002) fragment of zonula occludens toxin on the intestinal absorption of cyclosporin A. International journal of pharmaceutics\| PubMed ID: 17954018	2008
Enhanced nasal absorption of hydrophilic markers after dosing with AT1002, a tight junction modulator. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 18039562	2008
Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3. Gastroenterology\| PubMed ID: 18485912	2008
Analysis of proteinase-activated receptor 2 and TLR4 signal transduction: a novel paradigm for receptor cooperativity. The Journal of biological chemistry\| PubMed ID: 18622013	2008
Is this really celiac disease? Pitfalls in diagnosis. Current gastroenterology reports\| PubMed ID: 18799121	2008
Cutting edge: IL-1 controls the IL-23 response induced by gliadin, the etiologic agent in celiac disease. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18802048	2008
Physiological, pathological, and therapeutic implications of zonulin-mediated intestinal barrier modulation: living life on the edge of the wall. The American journal of pathology\| PubMed ID: 18832585	2008
Celiac disease. Current opinion in gastroenterology\| PubMed ID: 19122516	2008
Isolation, identification, and characterization of small bioactive peptides from Lactobacillus GG conditional media that exert both anti-Gram-negative and Gram-positive bactericidal activity... Journal of pediatric gastroenterology and nutrition\| PubMed ID: 19465870	2009
Prevalence of celiac disease and gluten sensitivity in the United States clinical antipsychotic trials of intervention effectiveness study population. Schizophrenia bulletin\| PubMed ID: 19494248	2011
Tight junctions, intestinal permeability, and autoimmunity: celiac disease and type 1 diabetes paradigms. Annals of the New York Academy of Sciences\| PubMed ID: 19538307	2009
Pediatric celiac disease. Current opinion in pediatrics\| PubMed ID: 19606042	2009
Surprises from celiac disease. Scientific American\| PubMed ID: 19634568	2009
Should we screen for coeliac disease? Yes. BMJ (Clinical research ed.)\| PubMed ID: 19762413	2009
Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19805376	2009
Differential mucosal IL-17 expression in two gliadin-induced disorders: gluten sensitivity and the autoimmune enteropathy celiac disease. International archives of allergy and immunology\| PubMed ID: 19940509	2010
Membrane-anchored serine protease matriptase regulates epithelial barrier formation and permeability in the intestine. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20142489	2010
Monocytes differentiated with IL-15 support Th17 and Th1 responses to wheat gliadin: implications for celiac disease. Clinical immunology (Orlando, Fla.)\| PubMed ID: 20153259	2010
Commentary on "anti-pituitary antibodies in children with newly diagnosed celiac disease: a novel finding contributing to linear growth". The American journal of gastroenterology\| PubMed ID: 20203647	2010
Celiac disease diagnosis: simple rules are better than complicated algorithms. The American journal of medicine\| PubMed ID: 20670718	2010
The active Zot domain (aa 288-293) increases ZO-1 and myosin 1C serine/threonine phosphorylation, alters interaction between ZO-1 and its binding partners, and induces tight junction disasse... FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 20852064	2011
Natural history of celiac disease autoimmunity in a USA cohort followed since 1974. Annals of medicine\| PubMed ID: 20868314	2010
Identification of a novel immunomodulatory gliadin peptide that causes interleukin-8 release in a chemokine receptor CXCR3-dependent manner only in patients with coeliac disease. Immunology\| PubMed ID: 21091908	2011
Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer. Physiological reviews\| PubMed ID: 21248165	2011
Enteric pathogens and gut function: Role of cytokines and STATs. Gut microbes\| PubMed ID: 21327040	2010
Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity. BMC medicine\| PubMed ID: 21392369	2011
Engineering of a multicellular organotypic model of the human intestinal mucosa. Gastroenterology\| PubMed ID: 21723866	2011
Increased bacterial translocation in gluten-sensitive mice is independent of small intestinal paracellular permeability defect. Digestive diseases and sciences\| PubMed ID: 21822909	2012
Neurologic and psychiatric manifestations of celiac disease and gluten sensitivity. The Psychiatric quarterly\| PubMed ID: 21877216	2012
The expression of caspases is enhanced in peripheral blood mononuclear cells of autism spectrum disorder patients. Journal of autism and developmental disorders\| PubMed ID: 21969075	2012
Early feeding practices and their impact on development of celiac disease. Nestlé Nutrition workshop series. Paediatric programme\| PubMed ID: 22044901	2011
Matriptase protects against experimental colitis and promotes intestinal barrier recovery. Inflammatory bowel diseases\| PubMed ID: 22081509	2012
Leaky gut and autoimmune diseases. Clinical reviews in allergy & immunology\| PubMed ID: 22109896	2012
Spectrum of gluten-related disorders: consensus on new nomenclature and classification. BMC medicine\| PubMed ID: 22313950	2012
The Oslo definitions for coeliac disease and related terms. Gut\| PubMed ID: 22345659	2013
Proof of concept of microbiome-metabolome analysis and delayed gluten exposure on celiac disease autoimmunity in genetically at-risk infants. PloS one\| PubMed ID: 22432018	2012
The cannabinoid receptor type 2 Q63R variant increases the risk of celiac disease: implication for a novel molecular biomarker and future therapeutic intervention. Pharmacological research\| PubMed ID: 22465144	2012
Increased prevalence of transglutaminase 6 antibodies in sera from schizophrenia patients. Schizophrenia bulletin\| PubMed ID: 22516148	2013
Timing of introduction of gluten and celiac disease risk. Annals of nutrition & metabolism\| PubMed ID: 22555186	2012
Association analysis of the extended MHC region in celiac disease implicates multiple independent susceptibility loci. PloS one\| PubMed ID: 22615847	2012
Prevalence and natural history of potential celiac disease in at-family-risk infants prospectively investigated from birth. The Journal of pediatrics\| PubMed ID: 22704250	2012
Zonulin, regulation of tight junctions, and autoimmune diseases. Annals of the New York Academy of Sciences\| PubMed ID: 22731712	2012
A gluten-free diet in people with schizophrenia and anti-tissue transglutaminase or anti-gliadin antibodies. Schizophrenia research\| PubMed ID: 22771303	2012
Intestinal permeability and its regulation by zonulin: diagnostic and therapeutic implications. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association\| PubMed ID: 22902773	2012
Major signaling pathways in intestinal stem cells. Biochimica et biophysica acta\| PubMed ID: 22922290	2013
Presentation of celiac disease. Gastrointestinal endoscopy clinics of North America\| PubMed ID: 23083982	2012
Novel therapeutic/integrative approaches for celiac disease and dermatitis herpetiformis. Clinical & developmental immunology\| PubMed ID: 23093980	2012
Gastrointestinal conditions in children with autism spectrum disorder: developing a research agenda. Pediatrics\| PubMed ID: 23118247	2012
Chromosomal and plasmid-encoded factors of Shigella flexneri induce secretogenic activity ex vivo. PloS one\| PubMed ID: 23166804	2012
Might gluten traces in wheat substitutes pose a risk in patients with celiac disease? A population-based probabilistic approach to risk estimation. The American journal of clinical nutrition\| PubMed ID: 23193005	2013
Clinical practice. Celiac disease. The New England journal of medicine\| PubMed ID: 23252527	2012
Microbiota and gut-liver axis: their influences on obesity and obesity-related liver disease. Journal of pediatric gastroenterology and nutrition\| PubMed ID: 23287807	2013
Helicobacter pylori-induced disruption of monolayer permeability and proinflammatory cytokine secretion in polarized human gastric epithelial cells. Infection and immunity\| PubMed ID: 23297384	2013
World Gastroenterology Organisation global guidelines on celiac disease. Journal of clinical gastroenterology\| PubMed ID: 23314668	2013
Novel advances in dermatitis herpetiformis. Clinical & developmental immunology\| PubMed ID: 23316253	2012
In vitro Intestinal Mucosal Epithelial Responses to Wild-Type Salmonella Typhi and Attenuated Typhoid Vaccines. Frontiers in immunology\| PubMed ID: 23408152	2013
Progress and pitfalls in Shigella vaccine research. Nature reviews. Gastroenterology & hepatology\| PubMed ID: 23419287	2013
Trace gluten contamination may play a role in mucosal and clinical recovery in a subgroup of diet-adherent non-responsive celiac disease patients. BMC gastroenterology\| PubMed ID: 23448408	2013
Markers of Inflammation and Lineage on Exfoliated Colonic Cells In Pediatric Inflammatory Bowel Disease. Journal of gastrointestinal & digestive system\| PubMed ID: 23519721	2011
Zonulin as prehaptoglobin2 regulates lung permeability and activates the complement system. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 23564505	2013
Cannabinoid receptor type 2, but not type 1, is up-regulated in peripheral blood mononuclear cells of children affected by autistic disorders. Journal of autism and developmental disorders\| PubMed ID: 23585028	2013
Gut microbiota, tight junction protein expression, intestinal resistance, bacterial translocation and mortality following cholestasis depend on the genetic background of the host. Gut microbes\| PubMed ID: 23652772	2013
Antibodies against food antigens in patients with autistic spectrum disorders. BioMed research international\| PubMed ID: 23984403	2013
Non-Celiac Gluten sensitivity: the new frontier of gluten related disorders. Nutrients\| PubMed ID: 24077239	2013
Effect of wild-type Shigella species and attenuated Shigella vaccine candidates on small intestinal barrier function, antigen trafficking, and cytokine release. PloS one\| PubMed ID: 24416363	2014
Prediction of celiac disease at endoscopy. Endoscopy\| PubMed ID: 24477366	2014
Analytical and clinical comparison of two fully automated immunoassay systems for the diagnosis of celiac disease. Journal of immunology research\| PubMed ID: 24741592	2014
Celiac disease: past, present, and future challenges: dedicated to the memory of our friend and colleague, Prof David Branski (1944-2013). Journal of pediatric gastroenterology and nutrition\| PubMed ID: 24840514	2014
The new epidemiology of celiac disease. Journal of pediatric gastroenterology and nutrition\| PubMed ID: 24979197	2014
Genome-wide association study of celiac disease in North America confirms FRMD4B as new celiac locus. PloS one\| PubMed ID: 24999842	2014
Coeliac disease. The debate on coeliac disease screening--are we there yet? Nature reviews. Gastroenterology & hepatology\| PubMed ID: 25001972	2014
Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4. Immunity\| PubMed ID: 25065623	2014
Introduction of gluten, HLA status, and the risk of celiac disease in children. The New England journal of medicine\| PubMed ID: 25271602	2014
Genetics and celiac disease: the importance of screening. Expert review of gastroenterology & hepatology\| PubMed ID: 25294637	2015
Gluten sensitivity and relationship to psychiatric symptoms in people with schizophrenia. Schizophrenia research\| PubMed ID: 25311778	2014
Duodenal lymphocytosis with no or minimal enteropathy: much ado about nothing? Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc\| PubMed ID: 25560597	2015
Nonceliac gluten sensitivity. Gastroenterology\| PubMed ID: 25583468	2015
Mammalian gastrointestinal tract parameters modulating the integrity, surface properties, and absorption of food-relevant nanomaterials. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology\| PubMed ID: 25641962	2015
Effect of gliadin on permeability of intestinal biopsy explants from celiac disease patients and patients with non-celiac gluten sensitivity. Nutrients\| PubMed ID: 25734566	2015
Diagnosis of Non-Celiac Gluten Sensitivity (NCGS): The Salerno Experts' Criteria. Nutrients\| PubMed ID: 26096570	2015
Remission of Refractory Celiac Disease With Infliximab in a Pediatric Patient. ACG case reports journal\| PubMed ID: 26157934	2015
Gluten Introduction, Breastfeeding, and Celiac Disease: Back to the Drawing Board. The American journal of gastroenterology\| PubMed ID: 26259710	2016
Extraintestinal manifestations of coeliac disease. Nature reviews. Gastroenterology & hepatology\| PubMed ID: 26260366	2015
The Role of Gluten in Celiac Disease and Type 1 Diabetes. Nutrients\| PubMed ID: 26343710	2015
Gliadin Induces Neutrophil Migration via Engagement of the Formyl Peptide Receptor, FPR1. PloS one\| PubMed ID: 26378785	2015
Celiac Disease Genomic, Environmental, Microbiome, and Metabolomic (CDGEMM) Study Design: Approach to the Future of Personalized Prevention of Celiac Disease. Nutrients\| PubMed ID: 26569299	2015
Celiac Disease Histopathology Recapitulates Hedgehog Downregulation, Consistent with Wound Healing Processes Activation. PloS one\| PubMed ID: 26649570	2015
Gut microbiome and necrotising enterocolitis: time for intervention? Lancet (London, England)\| PubMed ID: 26969092	2016
The microbiome as a possible target to prevent celiac disease. Expert review of gastroenterology & hepatology\| PubMed ID: 26999627	2016
NASPGHAN Clinical Report on the Diagnosis and Treatment of Gluten-related Disorders. Journal of pediatric gastroenterology and nutrition\| PubMed ID: 27035374	2016
Free and complexed-secretory immunoglobulin A triggers distinct intestinal epithelial responses. Clinical and experimental immunology\| PubMed ID: 27084834	2016
CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 14-2016. A 37-Year-Old Woman with Adult-Onset Psychosis. The New England journal of medicine\| PubMed ID: 27168437	2016
Mechanisms Involved in the Development of the Chronic Gastrointestinal Syndrome in Nonhuman Primates after Total-Body Irradiation with Bone Marrow Shielding. Radiation research\| PubMed ID: 27223826	2016
Emergency Department Utilization Report to Decrease Visits by Pediatric Gastroenterology Patients. Pediatrics\| PubMed ID: 27287727	2016
[Design of a genomic, environmental, microbial and metabolomic study on celiac disease: an approach to the future of personalized prevention of celiac disease]. Recenti progressi in medicina\| PubMed ID: 27362724	2016
Celiac disease diagnosis still significantly delayed - Doctor's but not patients' delay responsive for the increased total delay in women. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver\| PubMed ID: 27401607	2016