exergaming-older-people-living-with-hiv-improves-balance-mobility

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty

Approximately 1.2 million people in the United States live with HIV infection. Medical advancements have increased the life expectancy and this cohort is ...

College of Medicine, University of Arizona

The low affinity IgE receptor, FcepsilonRII (CD23), is both a positive and negative regulator of IgE synthesis. The proteinase activity that converts the membrane-bound form of CD23 into a soluble species (sCD23) is an important regulator of the function of CD23 and may be an important therapeutic target for the control of allergy and inflammation. We have characterized the catalytic activity of ADAM (a disintegrin and metalloproteinase) 10 toward human CD23. We found that ADAM10 efficiently catalyzes the cleavage of peptides derived from two distinct cleavage sites in the CD23 backbone. Tissue inhibitors of metalloproteinases and a specific prodomain-based inhibitor of ADAM10 perturb the release of endogenously produced CD23 from human leukemia cell lines as well as primary cultures of human B-cells. Expression of a mutant metalloproteinase-deficient construct of ADAM10 partially inhibited the production of sCD23. Similarly, small inhibitory RNA knockdown of ADAM10 partially inhibited CD23 release and resulted in the accumulation of the membrane-bound form of CD23 on the cells. ADAM10 contributes to CD23 shedding and thus could be considered a potential therapeutic target for the treatment of allergic disease.

The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10.

Injurious falls are a prevalent and serious problem faced by a growing elderly population. Accurate assessment and long-term monitoring of falls-risk could prove useful in the prevention of falls, by identifying those at risk of falling early so targeted intervention may be prescribed. Previous studies have demonstrated the feasibility of using triaxial accelerometry to estimate the risk of a person falling in the near future, by characterizing their movement as they execute a restricted sequence of predefined movements in an unsupervised environment, termed a directed routine. This study presents an improvement on this previously published system, which relied explicitly on time-domain features extracted from the accelerometry signals. The proposed improvement incorporates features derived from spectral analysis of the same accelerometry signals; in particular the harmonic ratios between signal harmonics and the fundamental frequency component are used. Employing these additional frequency-domain features, in combination with the previously reported time-domain features, an increase in the observed correlation with the clinical gold-standard risk of falling, from = 0:81 to = 0:96, was achieved when using manually annotated event segmentation markers; using an automated algorithm to segment the signals gave corresponding results of = 0:73 and = 0:99, before and after the inclusion of spectral features. The strong correlation with falls-risk observed in this preliminary study further supports the feasibility of using an unsupervised assessment of falls-risk in the home environment.

Article	Year
The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10. The Journal of biological chemistry\| PubMed ID: 17389606	2007
Spectral analysis of accelerometry signals from a directed-routine for falls-risk estimation. IEEE transactions on bio-medical engineering\| PubMed ID: 21550876	2011

Fernando Blumenkron

Biography

JoVE Journal Publications

Other Publications