Hidde L. Ploegh

Whitehead Institute for Biomedical Research

Affiliated withWhitehead Institute for Biomedical Research Massachusetts Institute of Technology

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 10	2010

Other Publications

Article	Year
Membrane-specific, host-derived factors are required for US2- and US11-mediated degradation of major histocompatibility complex class I molecules. The Journal of biological chemistry\| PubMed ID: 11717308	2002
The cell biology of antigen presentation. Experimental cell research\| PubMed ID: 11740859	2002
A closer look at proteolysis and MHC-class-II-restricted antigen presentation. Current opinion in immunology\| PubMed ID: 11790528	2002
US2, a human cytomegalovirus-encoded type I membrane protein, contains a non-cleavable amino-terminal signal peptide. The Journal of biological chemistry\| PubMed ID: 11790769	2002
Specific role for cathepsin S in the generation of antigenic peptides in vivo. European journal of immunology\| PubMed ID: 11813165	2002
Uncoating ATPase Hsc70 is recruited by invariant chain and controls the size of endocytic compartments. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11818572	2002
Don Craig Wiley (1944-2001). Nature\| PubMed ID: 11823846	2002
Visualization of the ER-to-cytosol dislocation reaction of a type I membrane protein. The EMBO journal\| PubMed ID: 11867532	2002
Human cytomegalovirus gene products US2 and US11 differ in their ability to attack major histocompatibility class I heavy chains in dendritic cells. Journal of virology\| PubMed ID: 11967320	2002
Kaposi's sarcoma-associated herpesvirus K3 utilizes the ubiquitin-proteasome system in routing class major histocompatibility complexes to late endocytic compartments. Journal of virology\| PubMed ID: 11991980	2002
Neuronal loss and brain atrophy in mice lacking cathepsins B and L. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12048238	2002
The human cytomegalovirus US8 glycoprotein binds to major histocompatibility complex class I products. Journal of virology\| PubMed ID: 12050396	2002
Proteolysis and antigen presentation by MHC class II molecules. Advances in immunology\| PubMed ID: 12078484	2002
Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation. The Journal of experimental medicine\| PubMed ID: 12186844	2002
T-cell engagement of dendritic cells rapidly rearranges MHC class II transport. Nature\| PubMed ID: 12198548	2002
MHC class I antigen processing regulated by cytosolic proteolysis-short cuts that alter peptide generation. Molecular immunology\| PubMed ID: 12200049	2002
Lessons from viral manipulation of protein disposal pathways. The Journal of clinical investigation\| PubMed ID: 12370262	2002
Class I negative CD8 T cells reveal the confounding role of peptide-transfer onto CD8 T cells stimulated with soluble H2-Kb molecules. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12374858	2002
The human cytomegalovirus US10 gene product delays trafficking of major histocompatibility complex class I molecules. Journal of virology\| PubMed ID: 12388737	2002
Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family. Chemistry & biology\| PubMed ID: 12401499	2002
The ubiquitin-proteasome pathway in thymocyte apoptosis: caspase-dependent processing of the deubiquitinating enzyme USP7 (HAUSP). Molecular immunology\| PubMed ID: 12413694	2002
Invariant chain controls the activity of extracellular cathepsin L. The Journal of experimental medicine\| PubMed ID: 12417635	2002
Mouse MHC class I tetramers that are unable to bind to CD8 reveal the need for CD8 engagement in order to activate naive CD8 T cells. European journal of immunology\| PubMed ID: 12432573	2002
Zwitterionic polysaccharides stimulate T cells by MHC class II-dependent interactions. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12444118	2002
Protein unfolding is not a prerequisite for endoplasmic reticulum-to-cytosol dislocation. The Journal of biological chemistry\| PubMed ID: 12482753	2003
A role for N-glycanase in the cytosolic turnover of glycoproteins. The EMBO journal\| PubMed ID: 12606569	2003
The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites. The Journal of biological chemistry\| PubMed ID: 12815064	2003
Ubiquitinylation of the cytosolic domain of a type I membrane protein is not required to initiate its dislocation from the endoplasmic reticulum. The Journal of biological chemistry\| PubMed ID: 12832421	2003
Chemistry in living cells: detection of active proteasomes by a two-step labeling strategy. Angewandte Chemie (International ed. in English)\| PubMed ID: 12916032	2003
Dislocation of a type I membrane protein requires interactions between membrane-spanning segments within the lipid bilayer. Molecular biology of the cell\| PubMed ID: 12972557	2003
Functional proteomics of the active cysteine protease content in Drosophila S2 cells. Molecular & cellular proteomics : MCP\| PubMed ID: 13130081	2003
A single protease, Apg4B, is specific for the autophagy-related ubiquitin-like proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L. The Journal of biological chemistry\| PubMed ID: 14530254	2003
Elimination in vivo of developing T cells by natural killer cells. The Journal of experimental medicine\| PubMed ID: 14568980	2003
The ER-lumenal domain of the HHV-7 immunoevasin U21 directs class I MHC molecules to lysosomes. Traffic (Copenhagen, Denmark)\| PubMed ID: 14617346	2003
Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins. Molecular and cellular biology\| PubMed ID: 14673145	2004
Thymic selection and peripheral activation of CD8 T cells by the same class I MHC/peptide complex. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 14688383	2004
Yeast N-glycanase distinguishes between native and non-native glycoproteins. EMBO reports\| PubMed ID: 14726951	2004
Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity. The Biochemical journal\| PubMed ID: 14748687	2004
A glycosylated type I membrane protein becomes cytosolic when peptide: N-glycanase is compromised. The EMBO journal\| PubMed ID: 14749736	2004
Dissection of the dislocation pathway for type I membrane proteins with a new small molecule inhibitor, eeyarestatin. Molecular biology of the cell\| PubMed ID: 14767067	2004
Control of cross-presentation during dendritic cell maturation. European journal of immunology\| PubMed ID: 14768044	2004
Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14982996	2004
Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15070758	2004
Chemistry-based functional proteomics: mechanism-based activity-profiling tools for ubiquitin and ubiquitin-like specific proteases. Journal of proteome research\| PubMed ID: 15113103	2004
Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases. Bioorganic & medicinal chemistry letters\| PubMed ID: 15149659	2004
Immunology. Nothing 'gainst time's scythe can make defense... Science (New York, N.Y.)\| PubMed ID: 15166355	2004
A membrane protein required for dislocation of misfolded proteins from the ER. Nature\| PubMed ID: 15215855	2004
Translating cell biology in vitro to immunity in vivo. Nature\| PubMed ID: 15241425	2004
Preferred in vivo ubiquitination sites. Bioinformatics (Oxford, England)\| PubMed ID: 15256413	2004
Mice deficient in invariant-chain and MHC class II exhibit a normal mature B2 cell compartment. European journal of immunology\| PubMed ID: 15259020	2004
Identification of proteins associated with murine cytomegalovirus virions. Journal of virology\| PubMed ID: 15452238	2004
Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate. The Journal of biological chemistry\| PubMed ID: 15531586	2005
Using a small molecule inhibitor of peptide: N-glycanase to probe its role in glycoprotein turnover. Chemistry & biology\| PubMed ID: 15610852	2004
Cotranslational endoplasmic reticulum assembly of FcepsilonRI controls the formation of functional IgE-binding receptors. The Journal of experimental medicine\| PubMed ID: 15642744	2005
Small-molecule inhibitors and probes for ubiquitin- and ubiquitin-like-specific proteases. Chembiochem : a European journal of chemical biology\| PubMed ID: 15651044	2005
CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science (New York, N.Y.)\| PubMed ID: 15653504	2005
Human cytomegalovirus protein US11 provokes an unfolded protein response that may facilitate the degradation of class I major histocompatibility complex products. Journal of virology\| PubMed ID: 15708995	2005
Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib. Nature methods\| PubMed ID: 15846363	2005
Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15905550	2005
Cellular internalization of cytolethal distending toxin: a new end to a known pathway. Cellular microbiology\| PubMed ID: 15953025	2005
A molecule's right to choose: how diabetogenic class II MHC products bind peptides. The Journal of clinical investigation\| PubMed ID: 16075053	2005
XBP-1 specifically promotes IgM synthesis and secretion, but is dispensable for degradation of glycoproteins in primary B cells. The Journal of experimental medicine\| PubMed ID: 16103408	2005
A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family Herpesviridae. Molecular cell\| PubMed ID: 16109378	2005
Effects of PS-341 on the activity and composition of proteasomes in multiple myeloma cells. Cancer research\| PubMed ID: 16140960	2005
Viral modulation of antigen presentation: manipulation of cellular targets in the ER and beyond. Immunological reviews\| PubMed ID: 16181332	2005
Cathepsin L is essential for onset of autoimmune diabetes in NOD mice. The Journal of clinical investigation\| PubMed ID: 16184198	2005
Ubiquitin--conserved protein or selfish gene? Trends in biochemical sciences\| PubMed ID: 16185873	2005
Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16186509	2005
Loss of Usp14 results in reduced levels of ubiquitin in ataxia mice. Journal of neurochemistry\| PubMed ID: 16190881	2005
A deubiquitinating activity is conserved in the large tegument protein of the herpesviridae. Journal of virology\| PubMed ID: 16306630	2005
Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein response. The Journal of biological chemistry\| PubMed ID: 16332684	2006
Mechanism-based proteomics tools based on ubiquitin and ubiquitin-like proteins: crystallography, activity profiling, and protease identification. Methods in enzymology\| PubMed ID: 16338352	2005
Mechanism-based proteomics tools based on ubiquitin and ubiquitin-like proteins: synthesis of active site-directed probes. Methods in enzymology\| PubMed ID: 16338376	2005
Behavioral responses of epidermal Langerhans cells in situ to local pathological stimuli. The Journal of investigative dermatology\| PubMed ID: 16439974	2006
Monovalent ligation of the B cell receptor induces receptor activation but fails to promote antigen presentation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16492756	2006
Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome. Structure (London, England : 1993)\| PubMed ID: 16531229	2006
Regulation of monoubiquitinated PCNA by DUB autocleavage. Nature cell biology\| PubMed ID: 16531995	2006
A microengraving method for rapid selection of single cells producing antigen-specific antibodies. Nature biotechnology\| PubMed ID: 16699501	2006
High-molecular-weight protein (pUL48) of human cytomegalovirus is a competent deubiquitinating protease: mutant viruses altered in its active-site cysteine or histidine are viable. Journal of virology\| PubMed ID: 16731939	2006
Signal peptide peptidase is required for dislocation from the endoplasmic reticulum. Nature\| PubMed ID: 16738546	2006
Development of intravital intermittent confocal imaging system for studying Langerhans cell turnover. The Journal of investigative dermatology\| PubMed ID: 16794586	2006
Chlamydia trachomatis-derived deubiquitinating enzymes in mammalian cells during infection. Molecular microbiology\| PubMed ID: 16824101	2006
Immune-privileged embryonic Swiss mouse STO and STO cell-derived progenitor cells: major histocompatibility complex and cell differentiation antigen expression patterns resemble those of hum... Immunology\| PubMed ID: 16836618	2006
Murine polyomavirus requires the endoplasmic reticulum protein Derlin-2 to initiate infection. Journal of virology\| PubMed ID: 16912321	2006
Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum. Molecular microbiology\| PubMed ID: 16925553	2006
SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER. The Journal of cell biology\| PubMed ID: 17043138	2006
Recruitment of CD63 to Cryptococcus neoformans phagosomes requires acidification. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17043215	2006
Viral interference with B7-1 costimulation: a new role for murine cytomegalovirus fc receptor-1. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17142739	2006
Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions. Advances in immunology\| PubMed ID: 17145306	2006
Mechanism-based probe for the analysis of cathepsin cysteine proteases in living cells. ACS chemical biology\| PubMed ID: 17184136	2006
AID-/-mus-/- mice are agammaglobulinemic and fail to maintain B220-CD138+ plasma cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17277124	2007
Chemical probes for the rapid detection of Fatty-acylated proteins in Mammalian cells. Journal of the American Chemical Society\| PubMed ID: 17305342	2007
Structure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymes. Molecular cell\| PubMed ID: 17349955	2007
ElaD, a Deubiquitinating protease expressed by E. coli. PloS one\| PubMed ID: 17440617	2007
The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling. The Journal of cell biology\| PubMed ID: 17452530	2007
The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance. The EMBO journal\| PubMed ID: 17491588	2007
Tubulation of class II MHC compartments is microtubule dependent and involves multiple endolysosomal membrane proteins in primary dendritic cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17513769	2007
Empty class II major histocompatibility complex created by peptide photolysis establishes the role of DM in peptide association. The Journal of biological chemistry\| PubMed ID: 17525157	2007
TLRs bent into shape. Nature immunology\| PubMed ID: 17579642	2007
Sequence and structure evolved separately in a ribosomal ubiquitin variant. The EMBO journal\| PubMed ID: 17599068	2007
A functional ubiquitin-specific protease embedded in the large tegument protein (ORF64) of murine gammaherpesvirus 68 is active during the course of infection. Journal of virology\| PubMed ID: 17634221	2007
A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum. Nature\| PubMed ID: 17653186	2007
Screen for ISG15-crossreactive deubiquitinases. PloS one\| PubMed ID: 17653289	2007
Differential priming of CD8 and CD4 T-cells in animal models of autoimmune hepatitis and cholangitis. Hepatology (Baltimore, Md.)\| PubMed ID: 17657820	2007
The peptide cargo of class I molecules: not just passive passengers. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17878322	2007
Sortagging: a versatile method for protein labeling. Nature chemical biology\| PubMed ID: 17891153	2007
Mechanisms, biology and inhibitors of deubiquitinating enzymes. Nature chemical biology\| PubMed ID: 17948018	2007
N-linked glycosylation does not impair proteasomal degradation but affects class I major histocompatibility complex presentation. The Journal of biological chemistry\| PubMed ID: 17951257	2008
Bridging B cell and T cell recognition of antigen. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18025158	2007
Discovery of CD8+ T cell epitopes in Chlamydia trachomatis infection through use of caged class I MHC tetramers. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18245382	2008
Lysosomal cysteine and aspartic proteases are heterogeneously expressed and act redundantly to initiate human invariant chain degradation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18292509	2008
UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes. Nature\| PubMed ID: 18305481	2008
The known unknowns of antigen processing and presentation. Nature reviews. Immunology\| PubMed ID: 18641646	2008
Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies. Clinical immunology (Orlando, Fla.)\| PubMed ID: 18675591	2008
Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth. PloS one\| PubMed ID: 18698347	2008
SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18711132	2008
Parasite stage-specific recognition of endogenous Toxoplasma gondii-derived CD8+ T cell epitopes. The Journal of infectious diseases\| PubMed ID: 18922097	2008
The CD8 T-cell response against murine gammaherpesvirus 68 is directed toward a broad repertoire of epitopes from both early and late antigens. Journal of virology\| PubMed ID: 18922872	2008
Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9. Nature immunology\| PubMed ID: 18931679	2008
Lipid modification of proteins through sortase-catalyzed transpeptidation. Journal of the American Chemical Society\| PubMed ID: 18989959	2008
Profiling antibody responses by multiparametric analysis of primary B cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19004776	2008
A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19017811	2008
Substrate filtering by the active site crossover loop in UCHL3 revealed by sortagging and gain-of-function mutations. The Journal of biological chemistry\| PubMed ID: 19047059	2009
Ubiquitin C-terminal electrophiles are activity-based probes for identification and mechanistic study of ubiquitin conjugating machinery. ACS chemical biology\| PubMed ID: 19256548	2009
A straight path to circular proteins. The Journal of biological chemistry\| PubMed ID: 19359246	2009
Site-specific protein labeling via sortase-mediated transpeptidation. Current protocols in protein science / editorial board, John E. Coligan ... [et al.]\| PubMed ID: 19365788	2009
XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells. The EMBO journal\| PubMed ID: 19407814	2009
Ubiquitination, ubiquitin-like modifiers, and deubiquitination in viral infection. Cell host & microbe\| PubMed ID: 19527883	2009
Cathepsin S regulates class II MHC processing in human CD4+ HLA-DR+ T cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19553543	2009
Site-specific N- and C-terminal labeling of a single polypeptide using sortases of different specificity. Journal of the American Chemical Society\| PubMed ID: 19610623	2009
A gammaherpesvirus ubiquitin-specific protease is involved in the establishment of murine gammaherpesvirus 68 infection. Journal of virology\| PubMed ID: 19706716	2009
XBP-1-deficient plasmablasts show normal protein folding but altered glycosylation and lipid synthesis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19710472	2009
Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes. The Journal of experimental medicine\| PubMed ID: 19808260	2009
The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER. Molecular cell\| PubMed ID: 19818707	2009
Haploid genetic screens in human cells identify host factors used by pathogens. Science (New York, N.Y.)\| PubMed ID: 19965467	2009
A structural element within the HUWE1 HECT domain modulates self-ubiquitination and substrate ubiquitination activities. The Journal of biological chemistry\| PubMed ID: 20007713	2010
Characterization and structural studies of the Plasmodium falciparum ubiquitin and Nedd8 hydrolase UCHL3. The Journal of biological chemistry\| PubMed ID: 20042598	2010
The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc. Cell\| PubMed ID: 20211139	2010
Differential regulation of effector- and central-memory responses to Toxoplasma gondii Infection by IL-12 revealed by tracking of Tgd057-specific CD8+ T cells. PLoS pathogens\| PubMed ID: 20333242	2010
Transnuclear mice with predefined T cell receptor specificities against Toxoplasma gondii obtained via SCNT. Science (New York, N.Y.)\| PubMed ID: 20378817	2010
The transmembrane segment of a tail-anchored protein determines its degradative fate through dislocation from the endoplasmic reticulum. The Journal of biological chemistry\| PubMed ID: 20435896	2010
Quality and quantity control at the endoplasmic reticulum. Current opinion in cell biology\| PubMed ID: 20570125	2010
The HCMV membrane glycoprotein US10 selectively targets HLA-G for degradation. The Journal of experimental medicine\| PubMed ID: 20713594	2010
The tetraspanin CD82 is specifically recruited to fungal and bacterial phagosomes prior to acidification. Infection and immunity\| PubMed ID: 21149584	2011
Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21209336	2011
Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes. Molecular and cellular biology\| PubMed ID: 21220515	2011
Sortase-catalyzed transformations that improve the properties of cytokines. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21297034	2011
Enzymatic blockade of the ubiquitin-proteasome pathway. PLoS biology\| PubMed ID: 21468303	2011
Granulin is a soluble cofactor for toll-like receptor 9 signaling. Immunity\| PubMed ID: 21497117	2011
Sortase A as a tool for high-yield histatin cyclization. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 21525488	2011
Ubiquitin-dependent control of class II MHC localization is dispensable for antigen presentation and antibody production. PloS one\| PubMed ID: 21533087	2011
Making and breaking peptide bonds: protein engineering using sortase. Angewandte Chemie (International ed. in English)\| PubMed ID: 21538739	2011
Helicobacter pylori cytotoxin-associated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21562218	2011
Global gene disruption in human cells to assign genes to phenotypes by deep sequencing. Nature biotechnology\| PubMed ID: 21623355	2011
Competition by inhibitory oligonucleotides prevents binding of CpG to C-terminal TLR9. European journal of immunology\| PubMed ID: 21766476	2011
Fungal recognition is mediated by the association of dectin-1 and galectin-3 in macrophages. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21825168	2011
Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control. The Journal of biological chemistry\| PubMed ID: 21857022	2011
CD8Î±(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites. Immunity\| PubMed ID: 21867928	2011
Determinants of GBP recruitment to Toxoplasma gondii vacuoles and the parasitic factors that control it. PloS one\| PubMed ID: 21931713	2011
Protein quality control in the ER: balancing the ubiquitin checkbook. Trends in cell biology\| PubMed ID: 22055166	2012
Road to ruin: targeting proteins for degradation in the endoplasmic reticulum. Science (New York, N.Y.)\| PubMed ID: 22116878	2011
Identification of host cell factors required for intoxication through use of modified cholera toxin. The Journal of cell biology\| PubMed ID: 22123862	2011
BAT3 guides misfolded glycoproteins out of the endoplasmic reticulum. PloS one\| PubMed ID: 22174835	2011
Class II MHC Self-Antigen Presentation in Human B and T Lymphocytes. PloS one\| PubMed ID: 22299025	2012
Accessory molecules for Toll-like receptors and their function. Nature reviews. Immunology\| PubMed ID: 22301850	2012
Cholera toxin activates nonconventional adjuvant pathways that induce protective CD8 T-cell responses after epicutaneous vaccination. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22308317	2012