Jacques Lapointe

Department of Surgery, McGill University

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 53	2016

Other Publications

Article	Year
ATP binding by glutamyl-tRNA synthetase is switched to the productive mode by tRNA binding. The EMBO journal\| PubMed ID: 12554668	2003
Gene expression profiling identifies clinically relevant subtypes of prostate cancer. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14711987	2004
Direct glutaminyl-tRNA biosynthesis and indirect asparaginyl-tRNA biosynthesis in Pseudomonas aeruginosa PAO1. Journal of bacteriology\| PubMed ID: 14729703	2004
The zinc-binding site of a class I aminoacyl-tRNA synthetase is a SWIM domain that modulates amino acid binding via the tRNA acceptor arm. European journal of biochemistry / FEBS\| PubMed ID: 14764088	2004
The Escherichia coli YadB gene product reveals a novel aminoacyl-tRNA synthetase like activity. Journal of molecular biology\| PubMed ID: 15003446	2004
An aminoacyl-tRNA synthetase-like protein encoded by the Escherichia coli yadB gene glutamylates specifically tRNAAsp. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15096594	2004
A minimalist glutamyl-tRNA synthetase dedicated to aminoacylation of the tRNAAsp QUC anticodon. Nucleic acids research\| PubMed ID: 15150343	2004
Crystal structure of chloramphenicol acetyltransferase B2 encoded by the multiresistance transposon Tn2424. Proteins\| PubMed ID: 15390264	2004
Genome-wide characterization of gene expression variations and DNA copy number changes in prostate cancer cell lines. The Prostate\| PubMed ID: 15486987	2005
Synthesis and aminoacyl-tRNA synthetase inhibitory activity of aspartyl adenylate analogs. Bioorganic & medicinal chemistry\| PubMed ID: 15582453	2005
Glutamylsulfamoyladenosine and pyroglutamylsulfamoyladenosine are competitive inhibitors of E. coli glutamyl-tRNA synthetase. Journal of enzyme inhibition and medicinal chemistry\| PubMed ID: 15895686	2005
Glu-Q-tRNA(Asp) synthetase coded by the yadB gene, a new paralog of aminoacyl-tRNA synthetase that glutamylates tRNA(Asp) anticodon. Biochimie\| PubMed ID: 16164993	2005
The retinoic acid synthesis gene ALDH1a2 is a candidate tumor suppressor in prostate cancer. Cancer research\| PubMed ID: 16166285	2005
Two residues in the anticodon recognition domain of the aspartyl-tRNA synthetase from Pseudomonas aeruginosa are individually implicated in the recognition of tRNAAsn. Journal of bacteriology\| PubMed ID: 16352843	2006
Synthesis of beta-ketophosphonate analogs of glutamyl and glutaminyl adenylate, and selective inhibition of the corresponding bacterial aminoacyl-tRNA synthetases. Bioorganic & medicinal chemistry\| PubMed ID: 17049867	2007
Application of genomic technologies to human prostate cancer. Omics : a journal of integrative biology\| PubMed ID: 17069507	2006
Structural bases of transfer RNA-dependent amino acid recognition and activation by glutamyl-tRNA synthetase. Structure (London, England : 1993)\| PubMed ID: 17161369	2006
A variant TMPRSS2 isoform and ERG fusion product in prostate cancer with implications for molecular diagnosis. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc\| PubMed ID: 17334351	2007
Inhibition by L-aspartol adenylate of a nondiscriminating aspartyl-tRNA synthetase reveals differences between the interactions of its active site with tRNA(Asp) and tRNA(Asn). Journal of enzyme inhibition and medicinal chemistry\| PubMed ID: 17373551	2007
E. coli glutamyl-tRNA synthetase is inhibited by anticodon stem-loop domains and a minihelix. RNA biology\| PubMed ID: 17671438	2007
Genomic profiling reveals alternative genetic pathways of prostate tumorigenesis. Cancer research\| PubMed ID: 17875689	2007
Mechanism of a GatCAB amidotransferase: aspartyl-tRNA synthetase increases its affinity for Asp-tRNA(Asn) and novel aminoacyl-tRNA analogues are competitive inhibitors. Biochemistry\| PubMed ID: 17929881	2007
hCAP-D3 expression marks a prostate cancer subtype with favorable clinical behavior and androgen signaling signature. The American journal of surgical pathology\| PubMed ID: 18223322	2008
Inhibition of Helicobacter pylori aminoacyl-tRNA amidotransferase by puromycin analogues. Journal of the American Chemical Society\| PubMed ID: 18293984	2008
Identification of candidate prostate cancer genes through comparative expression-profiling of seminal vesicle. The Prostate\| PubMed ID: 18500686	2008
Peculiar inhibition of human mitochondrial aspartyl-tRNA synthetase by adenylate analogs. Biochimie\| PubMed ID: 19254750	2009
A C-truncated glutamyl-tRNA synthetase specific for tRNA(Glu) is stimulated by its free complementary distal domain: mechanistic and evolutionary implications. Biochemistry\| PubMed ID: 19496540	2009
Inhibition of Helicobacter pylori aminoacyl-tRNA amidotransferase by chloramphenicol analogs. Bioorganic & medicinal chemistry\| PubMed ID: 20943400	2010
A tri-marker proliferation index predicts biochemical recurrence after surgery for prostate cancer. PloS one\| PubMed ID: 21629784	2011
Gln-tRNAGln synthesis in a dynamic transamidosome from Helicobacter pylori, where GluRS2 hydrolyzes excess Glu-tRNAGln. Nucleic acids research\| PubMed ID: 21813455	2011
The asparagine-transamidosome from Helicobacter pylori: a dual-kinetic mode in non-discriminating aspartyl-tRNA synthetase safeguards the genetic code. Nucleic acids research\| PubMed ID: 22362756	2012
Natural insertion of the bro-1 β-lactamase gene into the gatCAB operon affects Moraxella catarrhalis aspartyl-tRNA(Asn) amidotransferase activity. Microbiology (Reading, England)\| PubMed ID: 22745266	2012
PTEN genomic deletion predicts prostate cancer recurrence and is associated with low AR expression and transcriptional activity. BMC cancer\| PubMed ID: 23171135	2012
Magnetic interference of cardiac pacemakers from a surgical magnetic drape. Anesthesia and analgesia\| PubMed ID: 23400981	2013
The 16p13.3 (PDPK1) Genomic Gain in Prostate Cancer: A Potential Role in Disease Progression. Translational oncology\| PubMed ID: 23401739	2012
tRNAGlu increases the affinity of glutamyl-tRNA synthetase for its inhibitor glutamyl-sulfamoyl-adenosine, an analogue of the aminoacylation reaction intermediate glutamyl-AMP: mechanistic a... PloS one\| PubMed ID: 25860020	2015
Correction: tRNAGlu Increases the Affinity of Glutamyl-tRNA Synthetase for Its Inhibitor Glutamyl-Sulfamoyl-Adenosine, an Analogue of the Aminoacylation Reaction Intermediate Glutamyl-AMP: M... PloS one\| PubMed ID: 26039673	2015
Cyclic peptides identified by phage display are competitive inhibitors of the tRNA-dependent amidotransferase of Helicobacter pylori. Peptides\| PubMed ID: 26976271	2016
Interference between surgical magnetic drapes and pacemakers: an observational study comparing commercially available devices and a new magnetically isolated drape. Biomedical engineering online\| PubMed ID: 27430339	2016