Aik-Choon Tan

Medicine, University of Colorado Denver Anschutz Medical Campus

Affiliated withUniversity of Colorado Denver Anschutz Medical Campus

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 23	2016

Other Publications

Article	Year
Ensemble machine learning on gene expression data for cancer classification. Applied bioinformatics\| PubMed ID: 15130820	2003
MSAT: a multiple sequence alignment tool based on TOPS. Applied bioinformatics\| PubMed ID: 15693740	2004
Multi-class protein fold classification using a new ensemble machine learning approach. Genome informatics. International Conference on Genome Informatics\| PubMed ID: 15706535	2003
Simple decision rules for classifying human cancers from gene expression profiles. Bioinformatics (Oxford, England)\| PubMed ID: 16105897	2005
Robust prostate cancer marker genes emerge from direct integration of inter-study microarray data. Bioinformatics (Oxford, England)\| PubMed ID: 16131522	2005
Allele-specific expression in the germline of patients with familial pancreatic cancer: an unbiased approach to cancer gene discovery. Cancer biology & therapy\| PubMed ID: 18059179	2008
Merging microarray data from separate breast cancer studies provides a robust prognostic test. BMC bioinformatics\| PubMed ID: 18304324	2008
Coordinated epidermal growth factor receptor pathway gene overexpression predicts epidermal growth factor receptor inhibitor sensitivity in pancreatic cancer. Cancer research\| PubMed ID: 18413752	2008
Antitumor activity and molecular effects of the novel heat shock protein 90 inhibitor, IPI-504, in pancreatic cancer. Molecular cancer therapeutics\| PubMed ID: 18852131	2008
Identification of novel serological biomarkers for inflammatory bowel disease using Escherichia coli proteome chip. Molecular & cellular proteomics : MCP\| PubMed ID: 19357087	2009
Characterizing DNA methylation patterns in pancreatic cancer genome. Molecular oncology\| PubMed ID: 19497796	2009
Antitumor effects and biomarkers of activity of AZD0530, a Src inhibitor, in pancreatic cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 19509160	2009
Efficacy and pharmacodynamic effects of bosutinib (SKI-606), a Src/Abl inhibitor, in freshly generated human pancreas cancer xenografts. Molecular cancer therapeutics\| PubMed ID: 19509264	2009
A resource for analysis of microRNA expression and function in pancreatic ductal adenocarcinoma cells. Cancer biology & therapy\| PubMed ID: 20037478	2009
Novel agents in the treatment of metastatic colorectal cancer. Cancer journal (Sudbury, Mass.)\| PubMed ID: 20526106	2010
Development of an integrated genomic classifier for a novel agent in colorectal cancer: approach to individualized therapy in early development. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 20530704	2010
Gene array and fluorescence in situ hybridization biomarkers of activity of saracatinib (AZD0530), a Src inhibitor, in a preclinical model of colorectal cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 20682712	2010
Identification of predictive markers of response to the MEK1/2 inhibitor selumetinib (AZD6244) in K-ras-mutated colorectal cancer. Molecular cancer therapeutics\| PubMed ID: 20923857	2010
The insulin-like growth factor I receptor/insulin receptor tyrosine kinase inhibitor PQIP exhibits enhanced antitumor effects in combination with chemotherapy against colorectal cancer model... Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 20943761	2010
Optimizing the detection of lung cancer patients harboring anaplastic lymphoma kinase (ALK) gene rearrangements potentially suitable for ALK inhibitor treatment. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 21062932	2010
A survey of statistical software for analysing RNA-seq data. Human genomics\| PubMed ID: 21106489	2010
Quantitative proteomic analysis of ovarian cancer cells identified mitochondrial proteins associated with Paclitaxel resistance. Proteomics. Clinical applications\| PubMed ID: 21113235	2009
Confident predictability: identifying reliable gene expression patterns for individualized tumor classification using a local minimax kernel algorithm. BMC medical genomics\| PubMed ID: 21261972	2011
A short survey of computational analysis methods in analysing ChIP-seq data. Human genomics\| PubMed ID: 21296745	2011
MIR29B regulates expression of MLLT11 (AF1Q), an MLL fusion partner, and low MIR29B expression associates with adverse cytogenetics and poor overall survival in AML. British journal of haematology\| PubMed ID: 21496004	2011
A DNA methylation fingerprint of 1628 human samples. Genome research\| PubMed ID: 21613409	2012
Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy. Nature medicine\| PubMed ID: 21725296	2011
Tumor engraftment in nude mice and enrichment in stroma- related gene pathways predict poor survival and resistance to gemcitabine in patients with pancreatic cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 21742805	2011
Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2. Nature medicine\| PubMed ID: 21822285	2011
Host response transcriptional profiling reveals extracellular components and ABC (ATP-binding cassette) transporters gene enrichment in typhoid fever-infected Nigerian children. BMC infectious diseases\| PubMed ID: 21914192	2011
Maintenance of hormone responsiveness in luminal breast cancers by suppression of Notch. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21969591	2012
Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells. Cell research\| PubMed ID: 22105488	2012
Employing gene set top scoring pairs to identify deregulated pathway-signatures in dilated cardiomyopathy from integrated microarray gene expression data. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22130892	2012
BiNGS!SL-seq: a bioinformatics pipeline for the analysis and interpretation of deep sequencing genome-wide synthetic lethal screen. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22130895	2012
Preclinical activity of the rational combination of selumetinib (AZD6244) in combination with vorinostat in KRAS-mutant colorectal cancer models. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 22173548	2012
Patient-derived tumour xenografts as models for oncology drug development. Nature reviews. Clinical oncology\| PubMed ID: 22508028	2012
ALDH+ tumor-initiating cells exhibiting gain in NOTCH1 gene copy number have enhanced regrowth sensitivity to a γ-secretase inhibitor and irinotecan in colorectal cancer. Molecular oncology\| PubMed ID: 22521243	2012
Common PIK3CA mutants and a novel 3' UTR mutation are associated with increased sensitivity to saracatinib. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 22553375	2012
ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53. Nature chemical biology\| PubMed ID: 22660439	2012
Tankyrase and the canonical Wnt pathway protect lung cancer cells from EGFR inhibition. Cancer research\| PubMed ID: 22738915	2012
Predictive biomarkers of sensitivity to the aurora and angiogenic kinase inhibitor ENMD-2076 in preclinical breast cancer models. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 23136197	2013
Obesity and overfeeding affecting both tumor and systemic metabolism activates the progesterone receptor to contribute to postmenopausal breast cancer. Cancer research\| PubMed ID: 23222299	2012
Biomarker-driven trial in metastatic pancreas cancer: feasibility in a multicenter study of saracatinib, an oral Src inhibitor, in previously treated pancreatic cancer. Cancer medicine\| PubMed ID: 23342270	2012
A receptor tyrosine kinase network composed of fibroblast growth factor receptors, epidermal growth factor receptor, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, and hepatocyte... Molecular pharmacology\| PubMed ID: 23371912	2013
Genomic signatures of pregnancy-associated breast cancer epithelia and stroma and their regulation by estrogens and progesterone. Hormones & cancer\| PubMed ID: 23479404	2013
Tumor P-Glycoprotein Correlates with Efficacy of PF-3758309 in in vitro and in vivo Models of Colorectal Cancer. Frontiers in pharmacology\| PubMed ID: 23524533	2013
Association of the epithelial-to-mesenchymal transition phenotype with responsiveness to the p21-activated kinase inhibitor, PF-3758309, in colon cancer models. Frontiers in pharmacology\| PubMed ID: 23543898	2013
MERTK receptor tyrosine kinase is a therapeutic target in melanoma. The Journal of clinical investigation\| PubMed ID: 23585477	2013
A patient tumor transplant model of squamous cell cancer identifies PI3K inhibitors as candidate therapeutics in defined molecular bins. Molecular oncology\| PubMed ID: 23607916	2013
A genetic screen identifies TCF3/E2A and TRIAP1 as pathway-specific regulators of the cellular response to p53 activation. Cell reports\| PubMed ID: 23684607	2013
Rational combination of a MEK inhibitor, selumetinib, and the Wnt/calcium pathway modulator, cyclosporin A, in preclinical models of colorectal cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 23757356	2013
Collagen architecture in pregnancy-induced protection from breast cancer. Journal of cell science\| PubMed ID: 23843613	2013
Mer receptor tyrosine kinase is a therapeutic target in pre-B-cell acute lymphoblastic leukemia. Blood\| PubMed ID: 23861246	2013
The dual pathway inhibitor rigosertib is effective in direct patient tumor xenografts of head and neck squamous cell carcinomas. Molecular cancer therapeutics\| PubMed ID: 23873848	2013
Plasma-based circulating MicroRNA biomarkers for Parkinson's disease. Journal of Parkinson's disease\| PubMed ID: 23938262	2012
Overcoming IGF1R/IR resistance through inhibition of MEK signaling in colorectal cancer models. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 24045180	2013
From bench to bedside: lessons learned in translating preclinical studies in cancer drug development. Journal of the National Cancer Institute\| PubMed ID: 24052618	2013
K-Map: connecting kinases with therapeutics for drug repurposing and development. Human genomics\| PubMed ID: 24060470	2013
BEReX: Biomedical Entity-Relationship eXplorer. Bioinformatics (Oxford, England)\| PubMed ID: 24149052	2014
DNA methylation profiling revealed promoter hypermethylation-induced silencing of p16, DDAH2 and DUSP1 in primary oral squamous cell carcinoma. International journal of medical sciences\| PubMed ID: 24155659	2013
Resistance to ROS1 inhibition mediated by EGFR pathway activation in non-small cell lung cancer. PloS one\| PubMed ID: 24349229	2013
Automatic context-specific subnetwork discovery from large interaction networks. PloS one\| PubMed ID: 24392115	2014
Thioredoxin interacting protein (TXNIP) is a novel tumor suppressor in thyroid cancer. Molecular cancer\| PubMed ID: 24645981	2014
FGFR1 mRNA and protein expression, not gene copy number, predict FGFR TKI sensitivity across all lung cancer histologies. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 24771645	2014
Bioinformatics-driven discovery of rational combination for overcoming EGFR-mutant lung cancer resistance to EGFR therapy. Bioinformatics (Oxford, England)\| PubMed ID: 24812339	2014
Potent antitumor activity of cabozantinib, a c-MET and VEGFR2 inhibitor, in a colorectal cancer patient-derived tumor explant model. International journal of cancer\| PubMed ID: 25242168	2015
Homeoprotein Six2 promotes breast cancer metastasis via transcriptional and epigenetic control of E-cadherin expression. Cancer research\| PubMed ID: 25348955	2014
Antitumor activity of the MEK inhibitor TAK-733 against melanoma cell lines and patient-derived tumor explants. Molecular cancer therapeutics\| PubMed ID: 25376610	2015
Long term storage of dry versus frozen RNA for next generation molecular studies. PloS one\| PubMed ID: 25380187	2014
Dual pharmacological targeting of the MAP kinase and PI3K/mTOR pathway in preclinical models of colorectal cancer. PloS one\| PubMed ID: 25401499	2014
Contrasting roles for C/EBPα and Notch in irradiation-induced multipotent hematopoietic progenitor cell defects. Stem cells (Dayton, Ohio)\| PubMed ID: 25546133	2015
TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation. Cancer research\| PubMed ID: 25716682	2015
Systems biology approaches for advancing the discovery of effective drug combinations. Journal of cheminformatics\| PubMed ID: 25741385	2015
p53 Family Members Regulate Phenotypic Response to Aurora Kinase A Inhibition in Triple-Negative Breast Cancer. Molecular cancer therapeutics\| PubMed ID: 25758253	2015
RIP1 negatively regulates basal autophagic flux through TFEB to control sensitivity to apoptosis. EMBO reports\| PubMed ID: 25908842	2015
An Inducible TGF-β2-TGFβR Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases. PloS one\| PubMed ID: 25946135	2015
DSigDB: drug signatures database for gene set analysis. Bioinformatics (Oxford, England)\| PubMed ID: 25990557	2015
FGFR1 Expression Levels Predict BGJ398 Sensitivity of FGFR1-Dependent Head and Neck Squamous Cell Cancers. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 26015511	2015
Comparative Haploid Genetic Screens Reveal Divergent Pathways in the Biogenesis and Trafficking of Glycophosphatidylinositol-Anchored Proteins. Cell reports\| PubMed ID: 26074080	2015
Combined inhibition of MEK and Aurora A kinase in KRAS/PIK3CA double-mutant colorectal cancer models. Frontiers in pharmacology\| PubMed ID: 26136684	2015
iCOSSY: An Online Tool for Context-Specific Subnetwork Discovery from Gene Expression Data. PloS one\| PubMed ID: 26147457	2015
A NOTCH1 gene copy number gain is a prognostic indicator of worse survival and a predictive biomarker to a Notch1 targeting antibody in colorectal cancer. International journal of cancer\| PubMed ID: 26152787	2016
Identifying kinase dependency in cancer cells by integrating high-throughput drug screening and kinase inhibition data. Bioinformatics (Oxford, England)\| PubMed ID: 26206305	2015
Kinome RNAi Screens Reveal Synergistic Targeting of MTOR and FGFR1 Pathways for Treatment of Lung Cancer and HNSCC. Cancer research\| PubMed ID: 26359452	2015
Antitumor activity of a potent MEK inhibitor, TAK-733, against colorectal cancer cell lines and patient derived xenografts. Oncotarget\| PubMed ID: 26439693	2015
Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors. The Journal of clinical investigation\| PubMed ID: 26551682	2015
Expanding the computational toolbox for interrogating cancer kinomes. Pharmacogenomics\| PubMed ID: 26666839	2016
An integrated bioinformatics analysis to dissect kinase dependency in triple negative breast cancer. BMC genomics\| PubMed ID: 26681397	2015
The Six1 oncoprotein downregulates p53 via concomitant regulation of RPL26 and microRNA-27a-3p. Nature communications\| PubMed ID: 26687066	2015
A pilot study of cetuximab and the hedgehog inhibitor IPI-926 in recurrent/metastatic head and neck squamous cell carcinoma. Oral oncology\| PubMed ID: 26705064	2016
PKCδ regulates integrin αVβ3 expression and transformed growth of K-ras dependent lung cancer cells. Oncotarget\| PubMed ID: 26918447	2016
IMPACT: a whole-exome sequencing analysis pipeline for integrating molecular profiles with actionable therapeutics in clinical samples. Journal of the American Medical Informatics Association : JAMIA\| PubMed ID: 27026619	2016
Genetically-defined novel oral squamous cell carcinoma cell lines for the development of molecular therapies. Oncotarget\| PubMed ID: 27050151	2016
BRONCO: Biomedical entity Relation ONcology COrpus for extracting gene-variant-disease-drug relations. Database : the journal of biological databases and curation\| PubMed ID: 27074804	2016
The Mitogen-Activated Protein Kinase Pathway Facilitates Resistance to the Src Inhibitor Dasatinib in Thyroid Cancer. Molecular cancer therapeutics\| PubMed ID: 27222538	2016
Integrating heterogeneous drug sensitivity data from cancer pharmacogenomic studies. Oncotarget\| PubMed ID: 27322211	2016
Antitumor activity of the aurora a selective kinase inhibitor, alisertib, against preclinical models of colorectal cancer. Oncotarget\| PubMed ID: 27385211	2016
Exploiting receptor tyrosine kinase co-activation for cancer therapy. Drug discovery today\| PubMed ID: 27452454	2016
HiPub: translating PubMed and PMC texts to networks for knowledge discovery. Bioinformatics (Oxford, England)\| PubMed ID: 27485446	2016
Barasertib (AZD1152), a Small Molecule Aurora B Inhibitor, Inhibits the Growth of SCLC Cell Lines In Vitro and In Vivo. Molecular cancer therapeutics\| PubMed ID: 27496133	2016
Systematic analysis of tumour cell-extracellular matrix adhesion identifies independent prognostic factors in breast cancer. Oncotarget\| PubMed ID: 27556857	2016
Treating experimental arthritis with the innate immune inhibitor interleukin-37 reduces joint and systemic inflammation. Rheumatology (Oxford, England)\| PubMed ID: 27567100	2016
Big Data Mining and Adverse Event Pattern Analysis in Clinical Drug Trials. Assay and drug development technologies\| PubMed ID: 27631620	2016
Regulation of Head and Neck Squamous Cancer Stem Cells by PI3K and SOX2. Journal of the National Cancer Institute\| PubMed ID: 27634934	2017
AZ1366: An inhibitor of tankyrase and the canonical Wnt pathway that limits the persistence of non-small cell lung cancer cells following EGFR inhibition. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 27663586	2016