John Arcaroli

Medicine, University of Colorado Denver Anschutz Medical Campus

Affiliated withUniversity of Colorado Denver Anschutz Medical Campus

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 23	2016

Other Publications

Article	Year
Antitumor activity of the aurora a selective kinase inhibitor, alisertib, against preclinical models of colorectal cancer. Oncotarget\| PubMed ID: 27385211	2016
Lipopolysaccharide-induced neutrophil gene expression under in vivo or in vitro conditions. Chest\| PubMed ID: 11893694	2002
Effects of catecholamines on kinase activation in lung neutrophils after hemorrhage or endotoxemia. Journal of leukocyte biology\| PubMed ID: 12223526	2002
Involvement of phosphatidylinositol 3-kinase gamma in neutrophil apoptosis. Cellular signalling\| PubMed ID: 12464394	2003
Evidence for extracellular superoxide dismutase as a mediator of hemorrhage-induced lung injury. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 12618426	2003
Activation of gene expression in human neutrophils by high mobility group box 1 protein. American journal of physiology. Cell physiology\| PubMed ID: 12620891	2003
Early alterations in neutrophil activation are associated with outcome in acute lung injury. American journal of respiratory and critical care medicine\| PubMed ID: 12626346	2003
Urokinase-type plasminogen activator potentiates lipopolysaccharide-induced neutrophil activation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12759445	2003
Modulation of bone marrow-derived neutrophil signaling by H2O2: disparate effects on kinases, NF-kappaB, and cytokine expression. American journal of physiology. Cell physiology\| PubMed ID: 14656721	2004
Hemorrhage-induced acute lung injury is TLR-4 dependent. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 15072965	2004
Genetic polymorphisms and sepsis. Shock (Augusta, Ga.)\| PubMed ID: 16205313	2005
Variant IRAK-1 haplotype is associated with increased nuclear factor-kappaB activation and worse outcomes in sepsis. American journal of respiratory and critical care medicine\| PubMed ID: 16528020	2006
HMGB1 and LPS induce distinct patterns of gene expression and activation in neutrophils from patients with sepsis-induced acute lung injury. Intensive care medicine\| PubMed ID: 17581740	2007
Association between urokinase haplotypes and outcome from infection-associated acute lung injury. Intensive care medicine\| PubMed ID: 17994220	2008
Extracellular superoxide dismutase haplotypes are associated with acute lung injury and mortality. American journal of respiratory and critical care medicine\| PubMed ID: 18948423	2009
Gene array and fluorescence in situ hybridization biomarkers of activity of saracatinib (AZD0530), a Src inhibitor, in a preclinical model of colorectal cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 20682712	2010
Identification of predictive markers of response to the MEK1/2 inhibitor selumetinib (AZD6244) in K-ras-mutated colorectal cancer. Molecular cancer therapeutics\| PubMed ID: 20923857	2010
Association between IL-32 genotypes and outcome in infection-associated acute lung injury. Critical care (London, England)\| PubMed ID: 21649914	2011
Preclinical activity of the rational combination of selumetinib (AZD6244) in combination with vorinostat in KRAS-mutant colorectal cancer models. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 22173548	2012
Similarity-based multimarker association tests for continuous traits. Annals of human genetics\| PubMed ID: 22497480	2012
Patient-derived tumour xenografts as models for oncology drug development. Nature reviews. Clinical oncology\| PubMed ID: 22508028	2012
ALDH+ tumor-initiating cells exhibiting gain in NOTCH1 gene copy number have enhanced regrowth sensitivity to a γ-secretase inhibitor and irinotecan in colorectal cancer. Molecular oncology\| PubMed ID: 22521243	2012
Common PIK3CA mutants and a novel 3' UTR mutation are associated with increased sensitivity to saracatinib. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 22553375	2012
Phase I pharmacokinetic and pharmacodynamic study of cetuximab, irinotecan and sorafenib in advanced colorectal cancer. Investigational new drugs\| PubMed ID: 22615057	2013
Stromal cell-derived factor 1α mediates resistance to mTOR-directed therapy in pancreatic cancer. Neoplasia (New York, N.Y.)\| PubMed ID: 22952422	2012
Biomarker-driven trial in metastatic pancreas cancer: feasibility in a multicenter study of saracatinib, an oral Src inhibitor, in previously treated pancreatic cancer. Cancer medicine\| PubMed ID: 23342270	2012
Association of the epithelial-to-mesenchymal transition phenotype with responsiveness to the p21-activated kinase inhibitor, PF-3758309, in colon cancer models. Frontiers in pharmacology\| PubMed ID: 23543898	2013
A patient tumor transplant model of squamous cell cancer identifies PI3K inhibitors as candidate therapeutics in defined molecular bins. Molecular oncology\| PubMed ID: 23607916	2013
Rational combination of a MEK inhibitor, selumetinib, and the Wnt/calcium pathway modulator, cyclosporin A, in preclinical models of colorectal cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 23757356	2013
hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression. Biology open\| PubMed ID: 23862015	2013
A phase II study of the gamma secretase inhibitor RO4929097 in patients with previously treated metastatic pancreatic adenocarcinoma. Investigational new drugs\| PubMed ID: 24668033	2014
Potent antitumor activity of cabozantinib, a c-MET and VEGFR2 inhibitor, in a colorectal cancer patient-derived tumor explant model. International journal of cancer\| PubMed ID: 25242168	2015
An improved high yield total synthesis and cytotoxicity study of the marine alkaloid neoamphimedine: an ATP-competitive inhibitor of topoisomerase IIα and potent anticancer agent. Marine drugs\| PubMed ID: 25244109	2014
Dual pharmacological targeting of the MAP kinase and PI3K/mTOR pathway in preclinical models of colorectal cancer. PloS one\| PubMed ID: 25401499	2014
ALDH1B1 Is Crucial for Colon Tumorigenesis by Modulating Wnt/β-Catenin, Notch and PI3K/Akt Signaling Pathways. PloS one\| PubMed ID: 25950950	2015
Combined inhibition of MEK and Aurora A kinase in KRAS/PIK3CA double-mutant colorectal cancer models. Frontiers in pharmacology\| PubMed ID: 26136684	2015
A NOTCH1 gene copy number gain is a prognostic indicator of worse survival and a predictive biomarker to a Notch1 targeting antibody in colorectal cancer. International journal of cancer\| PubMed ID: 26152787	2016
Targeting the WNT Signaling Pathway in Cancer Therapeutics. The oncologist\| PubMed ID: 26306903	2015
Antitumor activity of a potent MEK inhibitor, TAK-733, against colorectal cancer cell lines and patient derived xenografts. Oncotarget\| PubMed ID: 26439693	2015
Aldehyde Dehydrogenase 1B1 as a Modulator of Pancreatic Adenocarcinoma. Pancreas\| PubMed ID: 26566217	2016
The novel tankyrase inhibitor (AZ1366) enhances irinotecan activity in tumors that exhibit elevated tankyrase and irinotecan resistance. Oncotarget\| PubMed ID: 27070088	2016
Regulation of Head and Neck Squamous Cancer Stem Cells by PI3K and SOX2. Journal of the National Cancer Institute\| PubMed ID: 27634934	2017