Craig A. Simmons

Department of Mechanical and Industrial Engineering, University of Toronto

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 3	2010

Other Publications

Article	Year
Cyclic strain enhances matrix mineralization by adult human mesenchymal stem cells via the extracellular signal-regulated kinase (ERK1/2) signaling pathway. Journal of biomechanics\| PubMed ID: 12831733	2003
Effects of a bone-like mineral film on phenotype of adult human mesenchymal stem cells in vitro. Biomaterials\| PubMed ID: 15262472	2005
Dual growth factor delivery and controlled scaffold degradation enhance in vivo bone formation by transplanted bone marrow stromal cells. Bone\| PubMed ID: 15268909	2004
Aortic valve: turning over a new leaf(let) in endothelial phenotypic heterogeneity. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 15297285	2004
Mechanical stimulation and mitogen-activated protein kinase signaling independently regulate osteogenic differentiation and mineralization by calcifying vascular cells. Journal of biomechanics\| PubMed ID: 15336928	2004
A rapid, reliable method to isolate high quality endothelial RNA from small spatially-defined locations. Annals of biomedical engineering\| PubMed ID: 15535062	2004
Spatial heterogeneity of endothelial phenotypes correlates with side-specific vulnerability to calcification in normal porcine aortic valves. Circulation research\| PubMed ID: 15761200	2005
Methylglyoxal inhibits the binding step of collagen phagocytosis. The Journal of biological chemistry\| PubMed ID: 17229729	2007
Matrix-dependent adhesion of vascular and valvular endothelial cells in microfluidic channels. Lab on a chip\| PubMed ID: 18030398	2007
Substrate architecture and fluid-induced shear stress during chondrocyte seeding: role of alpha5beta1 integrin. Biomaterials\| PubMed ID: 18314188	2008
Mechanobiology of the aortic heart valve. The Journal of heart valve disease\| PubMed ID: 18365571	2008
Augmenting microgel flow via receptor-ligand binding in the constrained geometries of microchannels. Lab on a chip\| PubMed ID: 19107286	2009
Techniques for isolating and purifying porcine aortic valve endothelial cells. The Journal of heart valve disease\| PubMed ID: 19137801	2008
Identification and characterization of aortic valve mesenchymal progenitor cells with robust osteogenic calcification potential. The American journal of pathology\| PubMed ID: 19218344	2009
Calcification by valve interstitial cells is regulated by the stiffness of the extracellular matrix. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 19304575	2009
Aortic valve mechanics: an emerging role for the endothelium. Journal of the American College of Cardiology\| PubMed ID: 19371830	2009
Integrating polyurethane culture substrates into poly(dimethylsiloxane) microdevices. Biomaterials\| PubMed ID: 19545891	2009
Comparison of analytical and inverse finite element approaches to estimate cell viscoelastic properties by micropipette aspiration. Journal of biomechanics\| PubMed ID: 19765713	2009
Boning up on Wolff's Law: mechanical regulation of the cells that make and maintain bone. Journal of biomechanics\| PubMed ID: 19818443	2010
A microfabricated platform for high-throughput unconfined compression of micropatterned biomaterial arrays. Biomaterials\| PubMed ID: 19819010	2010
Molecular markers of early orthodontic tooth movement. The Angle orthodontist\| PubMed ID: 19852601	2009
Influence of substrate stiffness on the phenotype of heart cells. Biotechnology and bioengineering\| PubMed ID: 20014437	2010
Integration of statistical modeling and high-content microscopy to systematically investigate cell-substrate interactions. Biomaterials\| PubMed ID: 20034663	2010
Effects of scleral stiffness properties on optic nerve head biomechanics. Annals of biomedical engineering\| PubMed ID: 20039133	2010
Technique for real-time measurements of endothelial permeability in a microfluidic membrane chip using laser-induced fluorescence detection. Analytical chemistry\| PubMed ID: 20050596	2010
Macro- and microscale fluid flow systems for endothelial cell biology. Lab on a chip\| PubMed ID: 20066241	2010
Microfabricated arrays for high-throughput screening of cellular response to cyclic substrate deformation. Lab on a chip\| PubMed ID: 20066251	2010
A circular cross-section PDMS microfluidics system for replication of cardiovascular flow conditions. Biomaterials\| PubMed ID: 20167361	2010
Biaxial mechanical testing of human sclera. Journal of biomechanics\| PubMed ID: 20399430	2010
Methylglyoxal-modified collagen promotes myofibroblast differentiation. Matrix biology : journal of the International Society for Matrix Biology\| PubMed ID: 20423729	2010
A study of vascular smooth muscle cell function under cyclic mechanical loading in a polyurethane scaffold with optimized porosity. Acta biomaterialia\| PubMed ID: 20601230	2010
Osteocyte apoptosis is mechanically regulated and induces angiogenesis in vitro. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 20979141	2010
Single cell deposition and patterning with a robotic system. PloS one\| PubMed ID: 21042403	2010
Measurement of layer-specific mechanical properties in multilayered biomaterials by micropipette aspiration. Acta biomaterialia\| PubMed ID: 21056128	2011
Î²-catenin mediates mechanically regulated, transforming growth factor-Î²1-induced myofibroblast differentiation of aortic valve interstitial cells. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 21127288	2011
Lessons from (patho)physiological tissue stiffness and their implications for drug screening, drug delivery and regenerative medicine. Advanced drug delivery reviews\| PubMed ID: 21241759	2011
The aortic valve microenvironment and its role in calcific aortic valve disease. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology\| PubMed ID: 21256052	2011
Osteocyte apoptosis is mechanically regulated and induces angiogenesis in vitro. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 21337392	2011
Functional characterization of human coronary artery smooth muscle cells under cyclic mechanical strain in a degradable polyurethane scaffold. Biomaterials\| PubMed ID: 21463894	2011
A microfluidic membrane device to mimic critical components of the vascular microenvironment. Biomicrofluidics\| PubMed ID: 21522499	2011
Inhibition of pathological differentiation of valvular interstitial cells by C-type natriuretic peptide. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 21617139	2011
Cell-matrix interactions in the pathobiology of calcific aortic valve disease: critical roles for matricellular, matricrine, and matrix mechanics cues. Circulation research\| PubMed ID: 21659654	2011
Animal models of calcific aortic valve disease. International journal of inflammation\| PubMed ID: 21826258	2011
(Micro)managing the mechanical microenvironment. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 21931883	2011
Osteocyte apoptosis regulates osteoclast precursor adhesion via osteocytic IL-6 secretion and endothelial ICAM-1 expression. Bone\| PubMed ID: 21986000	2012
Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executi... Circulation\| PubMed ID: 22007101	2011
An improved texture correlation algorithm to measure substrate-cytoskeletal network strain transfer under large compressive strain. Journal of biomechanics\| PubMed ID: 22030122	2012
A digital microfluidic platform for primary cell culture and analysis. Lab on a chip\| PubMed ID: 22094822	2012
The elastic properties of valve interstitial cells undergoing pathological differentiation. Journal of biomechanics\| PubMed ID: 22189247	2011