a-simple-mechanical-procedure-to-create-limbal-stem-cell-deficiency

A Simple Mechanical Procedure to Create Limbal Stem Cell Deficiency in Mouse

Limbal stem cell deficiency (LSCD) is a state of malfunction or loss of limbal epithelial stem cells, after which the corneal epithelium is replaced with ...

University of Illinois at Chicago

To describe the prevalence and types of glaucoma in Yazd, central Iran.

A population-based survey of the prevalence and types of glaucoma in central Iran: the Yazd eye study.

To explore the correlation between clinical manifestations of primary congenital glaucoma (PCG) and CYP1B1 mutations.

Phenotype and Genotype Correlation in Iranian Primary Congenital Glaucoma Patients.

To compare the visual outcomes and complications of three different types of phakic intraocular lenses (PIOLs), for correction of moderate to high myopia.

Comparison of three phakic intraocular lenses for correction of myopia.

To determine whether adjunctive mitomycin C (MMC) or amniotic membrane transplantation (AMT) improve the outcomes of Ahmed glaucoma valve (AGV) implantation.

Adjunctive Mitomycin C or Amniotic Membrane Transplantation for Ahmed Glaucoma Valve Implantation: A Randomized Clinical Trial.

To compare biometric changes measured with contact and noncontact methods after mitomycin-C-augmented trabeculectomy.

Biometric Changes After Trabeculectomy with Contact and Non-contact Biometry.

To investigate the effects of topical administration of a selective Rho-associated kinase (ROCK) inhibitor, fasudil 0.5% and 1.2% in glaucomatous patients. In this interventional case series study, 4 eyes of 4 patients with unilateral end-stage primary open-angle glaucoma and no light perception vision were assigned to receive topical fasudil 0.5% (in 3 eyes) or 1.2% (in 1 eye) ophthalmic solution twice daily for 8 weeks. At weeks 1, 2, 3, 4, and 8, intraocular pressure (IOP) and adverse events were evaluated. Baseline mean IOP was 53.5 ± 3.4 mm Hg and mean IOP reductions of the last visit were -8.25 ± 1.2 mm Hg at 2 hours and -8.75 ± 2.2 mm Hg at 4 hours. Mean IOP reductions were clinically and statistically significant with 0.5% and 1.2% fasudil and peak effects occurred 2-4 hours after application (P = 0.0002). The largest IOP reductions were produced by 1.2% fasudil (up to -12 mm Hg). Conjunctival hyperemia was found in 1 patient with 1.2% fasudil. Topical administration of fasudil in end-stage primary open-angle glaucoma patients, caused reduction in IOP and was well tolerated. ROCK inhibitors could be considered as a candidate for glaucoma therapy in future.

The Ocular Hypotensive Efficacy of Topical Fasudil, a Rho-Associated Protein Kinase Inhibitor, in Patients With End-Stage Glaucoma.

To compare trabeculectomy with mitomycin-C (MMC) application before versus after scleral flap dissection in terms of corneal endothelial cell loss and surgical outcomes.

Mitomycin-C Application Before versus After Scleral Flap Dissection in Trabeculectomy; a Randomized Clinical Trial.

To evaluate changes in peripapillary retinal nerve fiber layer (RNFL) thickness as determined by spectral domain optical coherence tomography (SD-OCT) after panretinal photocoagulation (PRP) for proliferative diabetic retinopathy (PDR).

Peripapillary RNFL Thickness Changes after Panretinal Photocoagulation.

Methanol-induced optic neuropathy (MTON) is frequently seen in countries where alcohol consumption is banned or poorly regulated. MTON frequently results in blindness and there is no empirically validated treatment.

Erythropoietin as an adjunctive treatment for methanol-induced toxic optic neuropathy.

Trabeculectomy is the most common surgical procedure for the management of glaucoma, which may significantly influence ocular biometry. Axial length and anterior chamber depth tend to decrease, while crystalline lens and choroidal thickness increase post-operatively. An increase in with-the-rule astigmatism is also observed after the procedure. Such biometric changes affect intraocular lens power calculation even years after the procedure. Non-contact biometric methods and postponing cataract surgery after trabeculectomy could reduce calculation errors associated with surgically induced alterations in ocular biometrics.

Post-trabeculectomy ocular biometric changes.

To determine the distribution of intraocular pressure (IOP), central corneal thickness (CCT) and vertical cup-to-disc ratio (VCDR) in the healthy Iranian population.

Article	Year
A population-based survey of the prevalence and types of glaucoma in central Iran: the Yazd eye study. Ophthalmology\| PubMed ID: 23664464	2013
Phenotype and Genotype Correlation in Iranian Primary Congenital Glaucoma Patients. Journal of glaucoma\| PubMed ID: 25580891	2016
Comparison of three phakic intraocular lenses for correction of myopia. Journal of ophthalmic & vision research\| PubMed ID: 25709766	2014
Adjunctive Mitomycin C or Amniotic Membrane Transplantation for Ahmed Glaucoma Valve Implantation: A Randomized Clinical Trial. Journal of glaucoma\| PubMed ID: 25967528	2016
Biometric Changes After Trabeculectomy with Contact and Non-contact Biometry. Optometry and vision science : official publication of the American Academy of Optometry\| PubMed ID: 26583799	2016
The Ocular Hypotensive Efficacy of Topical Fasudil, a Rho-Associated Protein Kinase Inhibitor, in Patients With End-Stage Glaucoma. American journal of therapeutics\| PubMed ID: 26825486	2016
Mitomycin-C Application Before versus After Scleral Flap Dissection in Trabeculectomy; a Randomized Clinical Trial. Journal of ophthalmic & vision research\| PubMed ID: 27051483	2015
Peripapillary RNFL Thickness Changes after Panretinal Photocoagulation. Optometry and vision science : official publication of the American Academy of Optometry\| PubMed ID: 27232898	2016
Erythropoietin as an adjunctive treatment for methanol-induced toxic optic neuropathy. The American journal of drug and alcohol abuse\| PubMed ID: 27463192	2016
Post-trabeculectomy ocular biometric changes. Clinical & experimental optometry\| PubMed ID: 27686794	2016
Distribution of intraocular pressure, central corneal thickness and vertical cup-to-disc ratio in a healthy Iranian population: the Yazd Eye Study. Acta ophthalmologica\| PubMed ID: 27778447	2016

Elham Ghahari

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