Hassan Y. Naim

Department of Physiological Chemistry, University of Veterinary Medicine Hannover

Affiliated withUniversity of Veterinary Medicine Hannover University of Veterinary Medicine Hannover

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 5	2017

Other Publications

Article	Year
The prosequence of human lactase-phlorizin hydrolase modulates the folding of the mature enzyme. The Journal of biological chemistry\| PubMed ID: 11751874	2002
Intestinal dipeptidyl peptidase IV is efficiently sorted to the apical membrane through the concerted action of N- and O-glycans as well as association with lipid microdomains. The Journal of biological chemistry\| PubMed ID: 11773049	2002
Sucrase is an intramolecular chaperone located at the C-terminal end of the sucrase-isomaltase enzyme complex. The Journal of biological chemistry\| PubMed ID: 12055199	2002
Cloning and characterization of the mammalian-specific nicolin 1 gene (NICN1) encoding a nuclear 24 kDa protein. European journal of biochemistry\| PubMed ID: 12392556	2002
Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans. European journal of nutrition\| PubMed ID: 12594539	2003
A glutamine to proline exchange at amino acid residue 1098 in sucrase causes a temperature-sensitive arrest of sucrase-isomaltase in the endoplasmic reticulum and cis-Golgi. The Journal of biological chemistry\| PubMed ID: 12624106	2003
Distinct cytoskeletal tracks direct individual vesicle populations to the apical membrane of epithelial cells. Current biology : CB\| PubMed ID: 12676094	2003
Annexin II is required for apical transport in polarized epithelial cells. The Journal of biological chemistry\| PubMed ID: 14670963	2004
Congenital sucrase-isomaltase deficiency because of an accumulation of the mutant enzyme in the endoplasmic reticulum. Gastroenterology\| PubMed ID: 14724820	2003
Antigen transport and cytoskeletal characteristics of a distinct enterocyte population in inflammatory bowel diseases. The American journal of pathology\| PubMed ID: 15277217	2004
A novel sorting signal for intracellular localization is present in the S protein of a porcine coronavirus but absent from severe acute respiratory syndrome-associated coronavirus. The Journal of biological chemistry\| PubMed ID: 15304515	2004
Binding of Par-4 to the actin cytoskeleton is essential for Par-4/Dlk-mediated apoptosis. Experimental cell research\| PubMed ID: 15817164	2005
Trafficking pathways of Cx49-GFP in living mammalian cells. Biological chemistry\| PubMed ID: 15843159	2005
Alpha-kinase 1, a new component in apical protein transport. The Journal of biological chemistry\| PubMed ID: 15883161	2005
A phenylalanine-based folding determinant in intestinal sucrase-isomaltase that functions in the context of a quality control mechanism beyond the endoplasmic reticulum. Journal of cell science\| PubMed ID: 15944403	2005
Impaired trafficking of mutants of lysosomal glucocerebrosidase in Gaucher's disease. The international journal of biochemistry & cell biology\| PubMed ID: 15982918	2005
Apical transport and folding of prostate-specific membrane antigen occurs independent of glycan processing. The Journal of biological chemistry\| PubMed ID: 16221666	2006
A novel type of detergent-resistant membranes may contribute to an early protein sorting event in epithelial cells. The Journal of biological chemistry\| PubMed ID: 16230359	2005
Novel mutations in the human sucrase-isomaltase gene (SI) that cause congenital carbohydrate malabsorption. Human mutation\| PubMed ID: 16329100	2006
A mutation in aminopeptidase N (CD13) isolated from a patient suffering from leukemia leads to an arrest in the endoplasmic reticulum. The Journal of biological chemistry\| PubMed ID: 16469741	2006
Requirement for galectin-3 in apical protein sorting. Current biology : CB\| PubMed ID: 16488876	2006
Ex vivo biochemical analysis of CFTR in human rectal biopsies. Biochimica et biophysica acta\| PubMed ID: 16504487	2006
Altered folding, turnover, and polarized sorting act in concert to define a novel pathomechanism of congenital sucrase-isomaltase deficiency. The Journal of biological chemistry\| PubMed ID: 16543230	2006
Analysis of ACE2 in polarized epithelial cells: surface expression and function as receptor for severe acute respiratory syndrome-associated coronavirus. The Journal of general virology\| PubMed ID: 16690935	2006
Transcoronary delivery of bone marrow cells to the infarcted murine myocardium: feasibility, cellular kinetics, and improvement in cardiac function. Basic research in cardiology\| PubMed ID: 16705471	2006
Both cleavage products of the mCLCA3 protein are secreted soluble proteins. The Journal of biological chemistry\| PubMed ID: 16895902	2006
Neuropeptide Y (NPY) cleaving enzymes: structural and functional homologues of dipeptidyl peptidase 4. Peptides\| PubMed ID: 17223229	2007
A genetically engineered prime-boost vaccination strategy for oculonasal delivery with poly(D,L-lactic-co-glycolic acid) microparticles against infection of turkeys with avian Metapneumoviru... Vaccine\| PubMed ID: 17920166	2007
Different glycoforms of prostate-specific membrane antigen are intracellularly transported through their association with distinct detergent-resistant membranes. The Biochemical journal\| PubMed ID: 17935484	2008
Mosaic pattern of sucrase isomaltase deficiency in two brothers. Pediatric research\| PubMed ID: 18043509	2008
Ex vivo expanded hematopoietic progenitor cells improve cardiac function after myocardial infarction: role of beta-catenin transduction and cell dose. Journal of molecular and cellular cardiology\| PubMed ID: 18671980	2008
Importance of cholesterol-rich membrane microdomains in the interaction of the S protein of SARS-coronavirus with the cellular receptor angiotensin-converting enzyme 2. Virology\| PubMed ID: 18814896	2008
Association of a GPI-anchored protein with detergent-resistant membranes facilitates its trafficking through the early secretory pathway. Experimental cell research\| PubMed ID: 19022244	2009
The influence of linoleic and linolenic acid on the activity and intracellular localisation of phospholipase D in COS-1 cells. Biological chemistry\| PubMed ID: 19090716	2009
Compound heterozygous mutations affect protein folding and function in patients with congenital sucrase-isomaltase deficiency. Gastroenterology\| PubMed ID: 19121318	2009
Impaired trafficking and subcellular localization of a mutant lactase associated with congenital lactase deficiency. Gastroenterology\| PubMed ID: 19208354	2009
The prostate specific membrane antigen regulates the expression of IL-6 and CCL5 in prostate tumour cells by activating the MAPK pathways. PloS one\| PubMed ID: 19242540	2009
Impact of glycosylation and detergent-resistant membranes on the function of intestinal sucrase-isomaltase. Biological chemistry\| PubMed ID: 19426137	2009
Toxic peptides in Frazer's fraction interact with the actin cytoskeleton and affect the targeting and function of intestinal proteins. Experimental cell research\| PubMed ID: 19576210	2009
Domains in biological membranes. Experimental cell research\| PubMed ID: 19632223	2009
Glycoprotein analysis of porcine bronchoalveolar lavage fluid reveals potential biomarkers corresponding to resistance to Actinobacillus pleuropneumoniae infection. Veterinary research\| PubMed ID: 19638268	2009
Endocytotic segregation of gliadin peptide 31-49 in enterocytes. Gut\| PubMed ID: 19654123	2010
Congenital and putatively acquired forms of sucrase-isomaltase deficiency in infancy: effects of sacrosidase therapy. Journal of pediatric gastroenterology and nutrition\| PubMed ID: 19680155	2009
Structural hierarchy of regulatory elements in the folding and transport of an intestinal multidomain protein. The Journal of biological chemistry\| PubMed ID: 19955176	2010
Protocadherin of the liver, kidney, and colon associates with detergent-resistant membranes during cellular differentiation. The Journal of biological chemistry\| PubMed ID: 20159971	2010
Structural basis for substrate selectivity in human maltase-glucoamylase and sucrase-isomaltase N-terminal domains. The Journal of biological chemistry\| PubMed ID: 20356844	2010
A modified lipid composition in Fabry disease leads to an intracellular block of the detergent-resistant membrane-associated dipeptidyl peptidase IV. Journal of inherited metabolic disease\| PubMed ID: 20495958	2010
TGFα-associated MUC2 and MUC3 expression of the gastric epithelium in Menetrier's disease during remission of ulcerative colitis. Gut\| PubMed ID: 21303913	2011
The dual role of annexin II in targeting of brush border proteins and in intestinal cell polarity. Differentiation; research in biological diversity\| PubMed ID: 21330046	2011
Demonstration of free fatty acids in the integument of semi-aquatic and aquatic mammals. Acta histochemica\| PubMed ID: 21524787	2012
Impairment of protein trafficking by direct interaction of gliadin peptides with actin. Experimental cell research\| PubMed ID: 21663741	2011
Mapping the intestinal alpha-glucogenic enzyme specificities of starch digesting maltase-glucoamylase and sucrase-isomaltase. Bioorganic & medicinal chemistry\| PubMed ID: 21669536	2011
Unexpected high digestion rate of cooked starch by the Ct-maltase-glucoamylase small intestine mucosal α-glucosidase subunit. PloS one\| PubMed ID: 22563462	2012
Cadherin-related protein 24 induces morphological changes and partial cell polarization by facilitating direct cell-cell interactions. Biological chemistry\| PubMed ID: 22628312	2012
A novel role for the transcription factor HIF-1α in the formation of mast cell extracellular traps. The Biochemical journal\| PubMed ID: 22738198	2012
β-Glucan protects neutrophil extracellular traps against degradation by Aeromonas hydrophila in carp (Cyprinus carpio). Fish & shellfish immunology\| PubMed ID: 22959188	2012
Miglustat-induced intestinal carbohydrate malabsorption is due to the inhibition of α-glucosidases, but not β-galactosidases. Journal of inherited metabolic disease\| PubMed ID: 22976762	2012
Starch source influences dietary glucose generation at the mucosal α-glucosidase level. The Journal of biological chemistry\| PubMed ID: 22988246	2012
Research progress reported at the 50th Anniversary of the Discovery of Congenital Sucrase-Isomaltase Deficiency Workshop. Journal of pediatric gastroenterology and nutrition\| PubMed ID: 23103641	2012
Congenital sucrase-isomaltase deficiency: heterogeneity of inheritance, trafficking, and function of an intestinal enzyme complex. Journal of pediatric gastroenterology and nutrition\| PubMed ID: 23103643	2012
Investigations of the structures and inhibitory properties of intestinal maltase glucoamylase and sucrase isomaltase. Journal of pediatric gastroenterology and nutrition\| PubMed ID: 23103645	2012
Congenital sucrase-isomaltase deficiency: summary of an evaluation in one family. Journal of pediatric gastroenterology and nutrition\| PubMed ID: 23103651	2012
Transient sucrose and starch intolerance. Journal of pediatric gastroenterology and nutrition\| PubMed ID: 23103653	2012
Retinal glycoprotein enrichment by concanavalin a enabled identification of novel membrane autoantigen synaptotagmin-1 in equine recurrent uveitis. PloS one\| PubMed ID: 23236410	2012
Cloning and characterization of canine prostate-specific membrane antigen. The Prostate\| PubMed ID: 23359458	2013
Discriminatory Role of Detergent-Resistant Membranes in the Dimerization and Endocytosis of Prostate-Specific Membrane Antigen. PloS one\| PubMed ID: 23840421	2013
Isolation and analysis of membrane lipids and lipid rafts in common carp (Cyprinus carpio L.). Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology\| PubMed ID: 24326265	2014
The effect of β-glucan on formation and functionality of neutrophil extracellular traps in carp (Cyprinus carpio L.). Developmental and comparative immunology\| PubMed ID: 24434196	2014
Drug-induced trafficking of p-glycoprotein in human brain capillary endothelial cells as demonstrated by exposure to mitomycin C. PloS one\| PubMed ID: 24505408	2014
Enrofloxacin enhances the formation of neutrophil extracellular traps in bovine granulocytes. Journal of innate immunity\| PubMed ID: 24642685	2014
Lidocaine effect on flotillin-2 distribution in detergent-resistant membranes of equine jejunal smooth muscle in vitro. Veterinary journal (London, England : 1997)\| PubMed ID: 24680669	2014
Long term differential consequences of miglustat therapy on intestinal disaccharidases. Journal of inherited metabolic disease\| PubMed ID: 24863482	2014
Novel role of the antimicrobial peptide LL-37 in the protection of neutrophil extracellular traps against degradation by bacterial nucleases. Journal of innate immunity\| PubMed ID: 25012862	2014
Canine epidermal lipid sampling by skin scrub revealed variations between different body sites and normal and atopic dogs. BMC veterinary research\| PubMed ID: 25012966	2014
Lipid alterations in human blood-derived neutrophils lead to formation of neutrophil extracellular traps. European journal of cell biology\| PubMed ID: 25172775	2014
The antimicrobial peptide LL-37 facilitates the formation of neutrophil extracellular traps. The Biochemical journal\| PubMed ID: 25181554	2014
Genetic reporter analysis reveals an expandable reservoir of OCT4+ cells in adult skin. Cell regeneration (London, England)\| PubMed ID: 25408888	2014
Precision-cut intestinal slices as a culture system to analyze the infection of differentiated intestinal epithelial cells by avian influenza viruses. Journal of virological methods\| PubMed ID: 25445801	2015
Identification of a novel DNase of Streptococcus suis (EndAsuis) important for neutrophil extracellular trap degradation during exponential growth. Microbiology (Reading, England)\| PubMed ID: 25667008	2015
Congenital lactose intolerance is triggered by severe mutations on both alleles of the lactase gene. BMC gastroenterology\| PubMed ID: 25881162	2015
Central Nervous System Demyelination and Remyelination is Independent from Systemic Cholesterol Level in Theiler's Murine Encephalomyelitis. Brain pathology (Zurich, Switzerland)\| PubMed ID: 25959295	2016
Cholesterol-rich lipid rafts play an important role in the Cyprinid herpesvirus 3 replication cycle. Veterinary microbiology\| PubMed ID: 26059657	2015
The Pathobiochemistry of Gastrointestinal Symptoms in a Patient with Niemann-Pick Type C Disease. JIMD reports\| PubMed ID: 26122626	2016
The Diverse Forms of Lactose Intolerance and the Putative Linkage to Several Cancers. Nutrients\| PubMed ID: 26343715	2015
In vitro activity of human and animal cathelicidins against livestock-associated methicillin-resistant Staphylococcus aureus. Veterinary microbiology\| PubMed ID: 26453316	2016
Yersinia enterocolitica-mediated degradation of neutrophil extracellular traps (NETs). FEMS microbiology letters\| PubMed ID: 26459885	2015
A Novel SLC27A4 Splice Acceptor Site Mutation in Great Danes with Ichthyosis. PloS one\| PubMed ID: 26506231	2015
Hypoxia Decreases Invasin-Mediated Yersinia enterocolitica Internalization into Caco-2 Cells. PloS one\| PubMed ID: 26731748	2016
What to do with high autofluorescence background in pancreatic tissues - an efficient Sudan black B quenching method for specific immunofluorescence labelling. Histopathology\| PubMed ID: 26802460	2016
The multiple roles of sucrase-isomaltase in the intestinal physiology. Molecular and cellular pediatrics\| PubMed ID: 26812950	2016
Endocytosis in enterocytes. Wiener medizinische Wochenschrift (1946)\| PubMed ID: 26993488	2016
The impact of hypoxia on intestinal epithelial cell functions: consequences for invasion by bacterial pathogens. Molecular and cellular pediatrics\| PubMed ID: 27002817	2016
Effects of SecDF on the antimicrobial functions of cathelicidins against Staphylococcus aureus. Veterinary microbiology\| PubMed ID: 27062479	2017
Iron-chelating agent desferrioxamine stimulates formation of neutrophil extracellular traps (NETs) in human blood-derived neutrophils. Bioscience reports\| PubMed ID: 27129288	2016
Intercellular transfer of P-glycoprotein in human blood-brain barrier endothelial cells is increased by histone deacetylase inhibitors. Scientific reports\| PubMed ID: 27375084	2016
Cross-talk between intestinal epithelial cells and immune cells in inflammatory bowel disease. Scientific reports\| PubMed ID: 27417573	2016
Molecular biology of the gut. Molecular and cellular pediatrics\| PubMed ID: 27518572	2016
Guarea kunthiana Bark Extract Enhances the Antimicrobial Activities of Human and Bovine Neutrophils. Natural product communications\| PubMed ID: 27534112	2016
Alterations in membrane trafficking and pathophysiological implications in lysosomal storage disorders. Biochimie\| PubMed ID: 27664461	2016
Prostate-specific membrane antigen (PSMA) assembles a macromolecular complex regulating growth and survival of prostate cancer cells "in vitro" and correlating with progression "in vivo". Oncotarget\| PubMed ID: 27713116	2016
Structural determinants for transport of lactase phlorizin-hydrolase in the early secretory pathway as a multi-domain membrane glycoprotein. Biochimica et biophysica acta\| PubMed ID: 27773655	2017
Measuring oxygen levels in Caco-2 cultures. Hypoxia (Auckland, N.Z.)\| PubMed ID: 27774482	2015
Functional variants in the sucrase-isomaltase gene associate with increased risk of irritable bowel syndrome. Gut\| PubMed ID: 27872184	2016
Formation of Neutrophil Extracellular Traps under Low Oxygen Level. Frontiers in immunology\| PubMed ID: 27933059	2016
Molecular pathogenicity of novel sucrase-isomaltase mutations found in congenital sucrase-isomaltase deficiency patients. Biochimica et biophysica acta\| PubMed ID: 28062276	2017
Antimicrobial activity of HL-60 cells compared to primary blood-derived neutrophils against Staphylococcus aureus. Journal of negative results in biomedicine\| PubMed ID: 28214466	2017