Karen M. Vasquez

Division of Pharmacology and Toxicology, The University of Texas at Austin

Affiliated withThe University of Texas at Austin

Research Area

Biography

Karen M. Vasquez has not added Biography.
If you are Karen M. Vasquez and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2016

Other Publications

Article	Year
Non-B DNA-forming sequences and WRN deficiency independently increase the frequency of base substitution in human cells. The Journal of biological chemistry\| PubMed ID: 21285356	2011
Human XPA and RPA DNA repair proteins participate in specific recognition of triplex-induced helical distortions. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11972036	2002
Triplex-forming oligonucleotides: principles and applications. Quarterly reviews of biophysics\| PubMed ID: 11997982	2002
Site-directed recombination via bifunctional PNA-DNA conjugates. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12461167	2002
Critical DNA damage recognition functions of XPC-hHR23B and XPA-RPA in nucleotide excision repair. Molecular carcinogenesis\| PubMed ID: 12949838	2003
Mutation frequencies in murine keratinocytes as a function of carcinogenic status. Molecular carcinogenesis\| PubMed ID: 15170817	2004
Naturally occurring H-DNA-forming sequences are mutagenic in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15342911	2004
Interplay between human high mobility group protein 1 and replication protein A on psoralen-cross-linked DNA. Biochemistry\| PubMed ID: 15766246	2005
Mismatch repair participates in error-free processing of DNA interstrand crosslinks in human cells. EMBO reports\| PubMed ID: 15891767	2005
Human XPC-hHR23B interacts with XPA-RPA in the recognition of triplex-directed psoralen DNA interstrand crosslinks. Nucleic acids research\| PubMed ID: 15914671	2005
Repair of genome destabilizing lesions. Radiation research\| PubMed ID: 16187737	2005
Z-DNA-forming sequences generate large-scale deletions in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16473937	2006
Non-B DNA structure-induced genetic instability. Mutation research\| PubMed ID: 16516932	2006
Targeting oncogenes to improve breast cancer chemotherapy. Cancer research\| PubMed ID: 16618728	2006
A web-based search engine for triplex-forming oligonucleotide target sequences. Oligonucleotides\| PubMed ID: 16764543	2006
High-affinity triplex-forming oligonucleotide target sequences in mammalian genomes. Molecular carcinogenesis\| PubMed ID: 17013831	2007
Therapeutic effect of rapamycin on gallbladder cancer in a transgenic mouse model. Cancer research\| PubMed ID: 17440093	2007
Z-DNA, an active element in the genome. Frontiers in bioscience : a journal and virtual library\| PubMed ID: 17485386	2007
A triplex-forming sequence from the human c-MYC promoter interferes with DNA transcription. The Journal of biological chemistry\| PubMed ID: 17785457	2007
DNA triple helices: biological consequences and therapeutic potential. Biochimie\| PubMed ID: 18331847	2008
Inhibitory effect of a short Z-DNA forming sequence on transcription elongation by T7 RNA polymerase. Nucleic acids research\| PubMed ID: 18400779	2008
Targeted generation of DNA strand breaks using pyrene-conjugated triplex-forming oligonucleotides. Biochemistry\| PubMed ID: 18473480	2008
Processing of triplex-directed psoralen DNA interstrand crosslinks by recombination mechanisms. Nucleic acids research\| PubMed ID: 18628293	2008
High mobility group protein B1 enhances DNA repair and chromatin modification after DNA damage. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18650382	2008
Human MLH1 protein participates in genomic damage checkpoint signaling in response to DNA interstrand crosslinks, while MSH2 functions in DNA repair. PLoS genetics\| PubMed ID: 18787700	2008
Efficient processing of TFO-directed psoralen DNA interstrand crosslinks by the UvrABC nuclease. Nucleic acids research\| PubMed ID: 18996898	2008
DNA structure-induced genomic instability in vivo. Journal of the National Cancer Institute\| PubMed ID: 19066276	2008
Role of TLS DNA polymerases eta and kappa in processing naturally occurring structured DNA in human cells. Molecular carcinogenesis\| PubMed ID: 19117014	2009
Models for chromosomal replication-independent non-B DNA structure-induced genetic instability. Molecular carcinogenesis\| PubMed ID: 19123200	2009
Methods to determine DNA structural alterations and genetic instability. Methods (San Diego, Calif.)\| PubMed ID: 19245837	2009
Intrinsic genomic instability from naturally occurring DNA structures: An introduction to the special issue. Molecular carcinogenesis\| PubMed ID: 19306307	2009
HMGB1: the jack-of-all-trades protein is a master DNA repair mechanic. Molecular carcinogenesis\| PubMed ID: 19360789	2009
Human HMGB1 directly facilitates interactions between nucleotide excision repair proteins on triplex-directed psoralen interstrand crosslinks. DNA repair\| PubMed ID: 19446504	2009
Mismatch repair and nucleotide excision repair proteins cooperate in the recognition of DNA interstrand crosslinks. Nucleic acids research\| PubMed ID: 19468048	2009
Cruciform-forming inverted repeats appear to have mediated many of the microinversions that distinguish the human and chimpanzee genomes. Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology\| PubMed ID: 19475482	2009
Targeted gene conversion induced by triplex-directed psoralen interstrand crosslinks in mammalian cells. Nucleic acids research\| PubMed ID: 19726585	2009
Non-B DNA structure-induced genetic instability and evolution. Cellular and molecular life sciences : CMLS\| PubMed ID: 19727556	2010
2,6-Dithiopurine blocks toxicity and mutagenesis in human skin cells exposed to sulfur mustard analogues, 2-chloroethyl ethyl sulfide and 2-chloroethyl methyl sulfide. Chemical research in toxicology\| PubMed ID: 20050631	2010
Targeting and processing of site-specific DNA interstrand crosslinks. Environmental and molecular mutagenesis\| PubMed ID: 20196133	2010
Pathways for double-strand break repair in genetically unstable Z-DNA-forming sequences. Journal of molecular biology\| PubMed ID: 20347845	2010
DNA interstrand crosslinks: repair, cell signaling, and therapeutic implications. Environmental and molecular mutagenesis\| PubMed ID: 20577999	2010
Human DHX9 helicase unwinds triple-helical DNA structures. Biochemistry\| PubMed ID: 20669935	2010
Triplex technology in studies of DNA damage, DNA repair, and mutagenesis. Biochimie\| PubMed ID: 21501652	2011
On the sequence-directed nature of human gene mutation: the role of genomic architecture and the local DNA sequence environment in mediating gene mutations underlying human inherited disease... Human mutation\| PubMed ID: 21853507	2011
2,6-Dithiopurine, a nucleophilic scavenger, protects against mutagenesis in mouse skin treated in vivo with 2-(chloroethyl) ethyl sulfide, a mustard gas analog. Toxicology and applied pharmacology\| PubMed ID: 22732900	2012
The yin and yang of repair mechanisms in DNA structure-induced genetic instability. Mutation research\| PubMed ID: 23219604	2013
Direct and inverted repeats elicit genetic instability by both exploiting and eluding DNA double-strand break repair systems in mycobacteria. PloS one\| PubMed ID: 23251422	2012
FANCM and FAAP24 maintain genome stability via cooperative as well as unique functions. Molecular cell\| PubMed ID: 23333308	2013
Triplex-forming oligonucleotides targeting c-MYC potentiate the anti-tumor activity of gemcitabine in a mouse model of human cancer. Molecular carcinogenesis\| PubMed ID: 23681918	2014
DNA structure matters. Genome medicine\| PubMed ID: 23796271	2013
Methods to detect replication-dependent and replication-independent DNA structure-induced genetic instability. Methods (San Diego, Calif.)\| PubMed ID: 23954565	2013
DHX9 helicase is involved in preventing genomic instability induced by alternatively structured DNA in human cells. Nucleic acids research\| PubMed ID: 24049074	2013
Guanine holes are prominent targets for mutation in cancer and inherited disease. PLoS genetics\| PubMed ID: 24086153	2013
Mechanisms of base substitution mutagenesis in cancer genomes. Genes\| PubMed ID: 24705290	2014
Impact of alternative DNA structures on DNA damage, DNA repair, and genetic instability. DNA repair\| PubMed ID: 24767258	2014
Short Inverted Repeats Are Hotspots for Genetic Instability: Relevance to Cancer Genomes. Cell reports\| PubMed ID: 25772355	2015
Local DNA dynamics shape mutational patterns of mononucleotide repeats in human genomes. Nucleic acids research\| PubMed ID: 25897114	2015
The somatic autosomal mutation matrix in cancer genomes. Human genetics\| PubMed ID: 26001532	2015
Erratum to: The somatic autosomal mutation matrix in cancer genomes. Human genetics\| PubMed ID: 26071096	2015
Long non-coding RNA: A new paradigm for lung cancer. Molecular carcinogenesis\| PubMed ID: 26332907	2015
HMGB1 interacts with XPA to facilitate the processing of DNA interstrand crosslinks in human cells. Nucleic acids research\| PubMed ID: 26578599	2016
New Perspectives on DNA and RNA Triplexes As Effectors of Biological Activity. PLoS genetics\| PubMed ID: 26700634	2015
Translocation and deletion breakpoints in cancer genomes are associated with potential non-B DNA-forming sequences. Nucleic acids research\| PubMed ID: 27084947	2016
Detection of cis- and trans-acting Factors in DNA Structure-Induced Genetic Instability Using In silico and Cellular Approaches. Frontiers in genetics\| PubMed ID: 27532010	2016