Carl Nathan

Departments of Microbiology & Immunology, Weill Cornell Medical College

Affiliated withWeill Cornell Medical College

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 10	2016

Other Publications

Article	Year
Peptide methionine sulfoxide reductase: structure, mechanism of action, and biological function. Archives of biochemistry and biophysics\| PubMed ID: 11795868	2002
Nonredundant antioxidant defense by multiple two-cysteine peroxiredoxins in human prostate cancer cells. Molecular medicine (Cambridge, Mass.)\| PubMed ID: 12080185	2002
Inducible nitric oxide synthase in the tuberculous human lung. American journal of respiratory and critical care medicine\| PubMed ID: 12119220	2002
Immunology. Catalytic antibody bridges innate and adaptive immunity. Science (New York, N.Y.)\| PubMed ID: 12481124	2002
Points of control in inflammation. Nature\| PubMed ID: 12490957	2002
Critical role of the carboxyl terminus of proline-rich tyrosine kinase (Pyk2) in the activation of human neutrophils by tumor necrosis factor: separation of signals for the respiratory burst... The Journal of experimental medicine\| PubMed ID: 12515814	2003
Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair. Cell\| PubMed ID: 12526812	2002
Specificity of a third kind: reactive oxygen and nitrogen intermediates in cell signaling. The Journal of clinical investigation\| PubMed ID: 12639979	2003
Immunology: Oxygen and the inflammatory cell. Nature\| PubMed ID: 12700748	2003
Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment. The Journal of experimental medicine\| PubMed ID: 12953091	2003
MyD88 primes macrophages for full-scale activation by interferon-gamma yet mediates few responses to Mycobacterium tuberculosis. The Journal of experimental medicine\| PubMed ID: 14517275	2003
The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide. Science (New York, N.Y.)\| PubMed ID: 14671303	2003
Identification of Mycobacterium tuberculosis counterimmune (cim) mutants in immunodeficient mice by differential screening. Infection and immunity\| PubMed ID: 15322028	2004
Antibiotics at the crossroads. Nature\| PubMed ID: 15496893	2004
The moving frontier in nitric oxide-dependent signaling. Science's STKE : signal transduction knowledge environment\| PubMed ID: 15523044	2004
S-nitroso proteome of Mycobacterium tuberculosis: Enzymes of intermediary metabolism and antioxidant defense. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15626759	2005
Characterization of a Mycobacterium tuberculosis proteasomal ATPase homologue. Molecular microbiology\| PubMed ID: 15659170	2005
A glutamate-alanine-leucine (EAL) domain protein of Salmonella controls bacterial survival in mice, antioxidant defence and killing of macrophages: role of cyclic diGMP. Molecular microbiology\| PubMed ID: 15882417	2005
Mycobacterium tuberculosis and the host response. The Journal of experimental medicine\| PubMed ID: 15939785	2005
Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of alpha-ketoglutarate decarboxylase. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16027371	2005
Role for nucleotide excision repair in virulence of Mycobacterium tuberculosis. Infection and immunity\| PubMed ID: 16040969	2005
Calcium-sensing soluble adenylyl cyclase mediates TNF signal transduction in human neutrophils. The Journal of experimental medicine\| PubMed ID: 16043520	2005
Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Molecular microbiology\| PubMed ID: 16045627	2005
Crystal structure and functional analysis of lipoamide dehydrogenase from Mycobacterium tuberculosis. The Journal of biological chemistry\| PubMed ID: 16093239	2005
Progress and new directions in genetics of tuberculosis: an NHLBI working group report. American journal of respiratory and critical care medicine\| PubMed ID: 16192449	2005
Outlook: the profit problem in antibiotic R&D. Nature reviews. Drug discovery\| PubMed ID: 16247440	2005
Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase. The Journal of experimental medicine\| PubMed ID: 16260491	2005
Chemical inhibitors of TNF signal transduction in human neutrophils point to distinct steps in cell activation. Journal of leukocyte biology\| PubMed ID: 16275893	2006
Abrupt expression of TLR4 in TLR4-deficient macrophages imposes a selective disadvantage: genetic evidence for TLR4-dependent responses to endogenous, nonmicrobial stimuli. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16394008	2006
Mycobacterium tuberculosis prcBA genes encode a gated proteasome with broad oligopeptide specificity. Molecular microbiology\| PubMed ID: 16468985	2006
Structure of the Mycobacterium tuberculosis proteasome and mechanism of inhibition by a peptidyl boronate. Molecular microbiology\| PubMed ID: 16468986	2006
Cytosolic phospholipase A2 enzymes are not required by mouse bone marrow-derived macrophages for the control of Mycobacterium tuberculosis in vitro. Infection and immunity\| PubMed ID: 16495548	2006
Neutrophils and immunity: challenges and opportunities. Nature reviews. Immunology\| PubMed ID: 16498448	2006
Role of iNOS in human host defense. Science (New York, N.Y.)\| PubMed ID: 16809512	2006
Man is not a mouse: reply. Journal of leukocyte biology\| PubMed ID: 17332374	2007
Aligning pharmaceutical innovation with medical need. Nature medicine\| PubMed ID: 17342145	2007
MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival. The Journal of experimental medicine\| PubMed ID: 17724133	2007
New approaches to filling the gap in tuberculosis drug discovery. PLoS medicine\| PubMed ID: 17988169	2007
Selective killing of nonreplicating mycobacteria. Cell host & microbe\| PubMed ID: 18329613	2008
Epidemic inflammation: pondering obesity. Molecular medicine (Cambridge, Mass.)\| PubMed ID: 18431463	2008
Metchnikoff's Legacy in 2008. Nature immunology\| PubMed ID: 18563074	2008
A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis. Nature medicine\| PubMed ID: 18641659	2008
Identification of a copper-binding metallothionein in pathogenic mycobacteria. Nature chemical biology\| PubMed ID: 18724363	2008
Pulmonary nodules in an infliximab-treated rheumatoid arthritis patient: a clinical pathology conference held by the Division of Rheumatology at Hospital for Special Surgery. HSS journal : the musculoskeletal journal of Hospital for Special Surgery\| PubMed ID: 18751782	2007
A philosophy of anti-infectives as a guide in the search for new drugs for tuberculosis. Tuberculosis (Edinburgh, Scotland)\| PubMed ID: 18762150	2008
Distinct specificities of Mycobacterium tuberculosis and mammalian proteasomes for N-acetyl tripeptide substrates. The Journal of biological chemistry\| PubMed ID: 18829465	2008
Acid-susceptible mutants of Mycobacterium tuberculosis share hypersusceptibility to cell wall and oxidative stress and to the host environment. Journal of bacteriology\| PubMed ID: 19011036	2009
Microbiology. An antibiotic mimics immunity. Science (New York, N.Y.)\| PubMed ID: 19039126	2008
Mycobacterium tuberculosis expresses methionine sulphoxide reductases A and B that protect from killing by nitrite and hypochlorite. Molecular microbiology\| PubMed ID: 19040639	2009
Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer's disease. Journal of neurochemistry\| PubMed ID: 19200343	2009
Taming tuberculosis: a challenge for science and society. Cell host & microbe\| PubMed ID: 19286131	2009
Acid resistance in Mycobacterium tuberculosis. Journal of bacteriology\| PubMed ID: 19465648	2009
Nitazoxanide kills replicating and nonreplicating Mycobacterium tuberculosis and evades resistance. Journal of medicinal chemistry\| PubMed ID: 19736929	2009
Inhibitors selective for mycobacterial versus human proteasomes. Nature\| PubMed ID: 19759536	2009
Structural insights on the Mycobacterium tuberculosis proteasomal ATPase Mpa. Structure (London, England : 1993)\| PubMed ID: 19836337	2009
N-iminoethyl-L-lysine improves memory and reduces amyloid pathology in a transgenic mouse model of amyloid deposition. Neurochemistry international\| PubMed ID: 19914323	2010
Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice. The Journal of experimental medicine\| PubMed ID: 20026663	2010
Triazaspirodimethoxybenzoyls as selective inhibitors of mycobacterial lipoamide dehydrogenase . Biochemistry\| PubMed ID: 20078138	2010
Nonresolving inflammation. Cell\| PubMed ID: 20303877	2010
SnapShot: Reactive Oxygen Intermediates (ROI). Cell\| PubMed ID: 20303882	2010
Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase. Chemistry & biology\| PubMed ID: 20416504	2010
Killing of non-replicating Mycobacterium tuberculosis by 8-hydroxyquinoline. The Journal of antimicrobial chemotherapy\| PubMed ID: 20435781	2010
Fellutamide B is a potent inhibitor of the Mycobacterium tuberculosis proteasome. Archives of biochemistry and biophysics\| PubMed ID: 20558127	2010
Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 20667979	2010
Induction of ER stress in macrophages of tuberculosis granulomas. PloS one\| PubMed ID: 20856677	2010
A protecting group-free synthesis of deazathiamine: a step toward inhibitor design. Bioorganic & medicinal chemistry letters\| PubMed ID: 20943392	2010
Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates. Chemistry & biology\| PubMed ID: 21035735	2010
Genome-wide screen for Mycobacterium tuberculosis genes that regulate host immunity. PloS one\| PubMed ID: 21170273	2010
Identification of a chemical that inhibits the mycobacterial UvrABC complex in nucleotide excision repair. Biochemistry\| PubMed ID: 21235228	2011
Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes. Cell host & microbe\| PubMed ID: 21238944	2011
Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends in microbiology\| PubMed ID: 21561773	2011
Making space for anti-infective drug discovery. Cell host & microbe\| PubMed ID: 21575903	2011
Identification of new inhibitors of protein kinase R guided by statistical modeling. Bioorganic & medicinal chemistry letters\| PubMed ID: 21632247	2011
Mycobacterium tuberculosis gene Rv2136c is dispensable for acid resistance and virulence in mice. Tuberculosis (Edinburgh, Scotland)\| PubMed ID: 21778115	2011
In vitro differentiation of human macrophages with enhanced antimycobacterial activity. The Journal of clinical investigation\| PubMed ID: 21911939	2011
Is iNOS beginning to smoke? Cell\| PubMed ID: 22000003	2011
Nitazoxanide Disrupts Membrane Potential and Intrabacterial pH Homeostasis of Mycobacterium tuberculosis. ACS medicinal chemistry letters\| PubMed ID: 22096616	2011
Remembering Ralph Steinman. The Journal of experimental medicine\| PubMed ID: 22216461	2011
Improved control of tuberculosis and activation of macrophages in mice lacking protein kinase R. PloS one\| PubMed ID: 22359543	2012
Secretory products of macrophages: twenty-five years on. The Journal of clinical investigation\| PubMed ID: 22570864	2012
dSarm/Sarm1 is required for activation of an injury-induced axon death pathway. Science (New York, N.Y.)\| PubMed ID: 22678360	2012
Fresh approaches to anti-infective therapies. Science translational medicine\| PubMed ID: 22745440	2012
Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23012453	2012
Efficacy of nitazoxanide against clinical isolates of Mycobacterium tuberculosis. Antimicrobial agents and chemotherapy\| PubMed ID: 23507275	2013
Beyond oxidative stress: an immunologist's guide to reactive oxygen species. Nature reviews. Immunology\| PubMed ID: 23618831	2013
SARM Is Required for Neuronal Injury and Cytokine Production in Response to Central Nervous System Viral Infection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23749635	2013
Influence of allosteric regulators on individual steps in the reaction catalyzed by Mycobacterium tuberculosis 2-hydroxy-3-oxoadipate synthase. The Journal of biological chemistry\| PubMed ID: 23760263	2013
N,C-Capped dipeptides with selectivity for mycobacterial proteasome over human proteasomes: role of S3 and S1 binding pockets. Journal of the American Chemical Society\| PubMed ID: 23782398	2013
Whole cell screen for inhibitors of pH homeostasis in Mycobacterium tuberculosis. PloS one\| PubMed ID: 23935911	2013
Nitrite impacts the survival of Mycobacterium tuberculosis in response to isoniazid and hydrogen peroxide. MicrobiologyOpen\| PubMed ID: 24019302	2013
A journey in science: promise, purpose, privilege. Molecular medicine (Cambridge, Mass.)\| PubMed ID: 24089245	2013
Perspective: Graduation time. Nature\| PubMed ID: 24108080	2013
Nitrite produced by Mycobacterium tuberculosis in human macrophages in physiologic oxygen impacts bacterial ATP consumption and gene expression. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24145454	2013
Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24248369	2013
Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase. Biochemistry\| PubMed ID: 24251446	2013
Drug-resistant tuberculosis: a new shot on goal. Nature medicine\| PubMed ID: 24504402	2014
Benzimidazole-based compounds kill Mycobacterium tuberculosis. European journal of medicinal chemistry\| PubMed ID: 24556148	2014
Synthetic calanolides with bactericidal activity against replicating and nonreplicating Mycobacterium tuberculosis. Journal of medicinal chemistry\| PubMed ID: 24694175	2014
Oxathiazolones Selectively Inhibit the Human Immunoproteasome over the Constitutive Proteasome. ACS medicinal chemistry letters\| PubMed ID: 24900849	2014
Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis. Nature communications\| PubMed ID: 24978671	2014
Antibiotic resistance--problems, progress, and prospects. The New England journal of medicine\| PubMed ID: 25271470	2014
Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis. ACS chemical biology\| PubMed ID: 25457457	2015
Stressed mycobacteria use the chaperone ClpB to sequester irreversibly oxidized proteins asymmetrically within and between cells. Cell host & microbe\| PubMed ID: 25620549	2015
Video podcast: Tuberculosis. Immunological reviews\| PubMed ID: 25703547	2015
What can immunology contribute to the control of the world's leading cause of death from bacterial infection? Immunological reviews\| PubMed ID: 25703548	2015
TB drug development: immunology at the table. Immunological reviews\| PubMed ID: 25703568	2015
A multi-stress model for high throughput screening against non-replicating Mycobacterium tuberculosis. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 25779324	2015
Identification of Rv3852 as an Agrimophol-Binding Protein in Mycobacterium tuberculosis. PloS one\| PubMed ID: 25978362	2015
Rapid, Semiquantitative Assay To Discriminate among Compounds with Activity against Replicating or Nonreplicating Mycobacterium tuberculosis. Antimicrobial agents and chemotherapy\| PubMed ID: 26239979	2015
Cooperative development of antimicrobials: looking back to look ahead. Nature reviews. Microbiology\| PubMed ID: 26373373	2015
E1 of α-ketoglutarate dehydrogenase defends Mycobacterium tuberculosis against glutamate anaplerosis and nitroxidative stress. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26430237	2015
IMMUNOLOGY. From transient infection to chronic disease. Science (New York, N.Y.)\| PubMed ID: 26450196	2015
Comparison of transposon and deletion mutants in Mycobacterium tuberculosis: The case of rv1248c, encoding 2-hydroxy-3-oxoadipate synthase. Tuberculosis (Edinburgh, Scotland)\| PubMed ID: 26547230	2015
Human studies at JEM: Immunology and beyond. The Journal of experimental medicine\| PubMed ID: 26976629	2016
Novel Cephalosporins Selectively Active on Nonreplicating Mycobacterium tuberculosis. Journal of medicinal chemistry\| PubMed ID: 27144688	2016
N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27432954	2016
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. PLoS pathogens\| PubMed ID: 27467575	2016
Immunoproteasome β5i-Selective Dipeptidomimetic Inhibitors. ChemMedChem\| PubMed ID: 27561172	2016
Identification of Novel Anti-mycobacterial Compounds by Screening a Pharmaceutical Small-Molecule Library against Nonreplicating Mycobacterium tuberculosis. ACS infectious diseases\| PubMed ID: 27623055	2015
Macrophages' Choice: Take It In or Keep It Out. Immunity\| PubMed ID: 27760333	2016
Reconstitution of a Mycobacterium tuberculosis proteostasis network highlights essential cofactor interactions with chaperone DnaK. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27872278	2016