Rachael Natrajan

The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research

Affiliated withThe Institute of Cancer Research

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 20	2016

Other Publications

Article	Year
High-resolution deletion mapping of 15q13.2-q21.1 in transitional cell carcinoma of the bladder. Cancer research\| PubMed ID: 14633686	2003
Prognostic classification of relapsing favorable histology Wilms tumor using cDNA microarray expression profiling and support vector machines. Genes, chromosomes & cancer\| PubMed ID: 15236318	2004
Array CGH using whole genome amplification of fresh-frozen and formalin-fixed, paraffin-embedded tumor DNA. Genomics\| PubMed ID: 16271290	2006
Unlocking pathology archives for molecular genetic studies: a reliable method to generate probes for chromogenic and fluorescent in situ hybridization. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 16446704	2006
Blastemal expression of type I insulin-like growth factor receptor in Wilms' tumors is driven by increased copy number and correlates with relapse. Cancer research\| PubMed ID: 17145858	2006
Amplification and overexpression of CACNA1E correlates with relapse in favorable histology Wilms' tumors. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 17189400	2006
Delineation of a 1Mb breakpoint region at 1p13 in Wilms tumors by fine-tiling oligonucleotide array CGH. Genes, chromosomes & cancer\| PubMed ID: 17370329	2007
Getting it right: designing microarray (and not 'microawry') comparative genomic hybridization studies for cancer research. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 17558419	2007
Chromogenic and fluorescent in situ hybridization in breast cancer. Human pathology\| PubMed ID: 17640550	2007
Multifaceted dysregulation of the epidermal growth factor receptor pathway in clear cell sarcoma of the kidney. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 17646270	2007
Resistance to therapy caused by intragenic deletion in BRCA2. Nature\| PubMed ID: 18264088	2008
Genomic analysis of the HER2/TOP2A amplicon in breast cancer and breast cancer cell lines. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 18332872	2008
ESR1 gene amplification in breast cancer: a common phenomenon? Nature genetics\| PubMed ID: 18583966	2008
Loss of 16q in high grade breast cancer is associated with estrogen receptor status: Evidence for progression in tumors with a luminal phenotype? Genes, chromosomes & cancer\| PubMed ID: 19156836	2009
PPM1D is a potential therapeutic target in ovarian clear cell carcinomas. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 19293255	2009
Tiling path genomic profiling of grade 3 invasive ductal breast cancers. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 19318498	2009
CD44 is overexpressed in basal-like breast cancers but is not a driver of 11p13 amplification. Breast cancer research and treatment\| PubMed ID: 19350388	2010
Integrated functional, gene expression and genomic analysis for the identification of cancer targets. PloS one\| PubMed ID: 19357772	2009
Mixed micropapillary-ductal carcinomas of the breast: a genomic and immunohistochemical analysis of morphologically distinct components. The Journal of pathology\| PubMed ID: 19479727	2009
An integrative genomic and transcriptomic analysis reveals molecular pathways and networks regulated by copy number aberrations in basal-like, HER2 and luminal cancers. Breast cancer research and treatment\| PubMed ID: 19688261	2010
Loss of heterozygosity at 2q37 in sporadic Wilms' tumor: putative role for miR-562. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 19789318	2009
The molecular underpinning of lobular histological growth pattern: a genome-wide transcriptomic analysis of invasive lobular carcinomas and grade- and molecular subtype-matched invasive duct... The Journal of pathology\| PubMed ID: 19877120	2010
Microglandular adenosis or microglandular adenoma? A molecular genetic analysis of a case associated with atypia and invasive carcinoma. Histopathology\| PubMed ID: 19922592	2009
Complex landscapes of somatic rearrangement in human breast cancer genomes. Nature\| PubMed ID: 20033038	2009
Molecular analysis reveals a genetic basis for the phenotypic diversity of metaplastic breast carcinomas. The Journal of pathology\| PubMed ID: 20099298	2010
FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer. Cancer research\| PubMed ID: 20179196	2010
Breast cancer molecular profiling with single sample predictors: a retrospective analysis. The Lancet. Oncology\| PubMed ID: 20181526	2010
Cortactin gene amplification and expression in breast cancer: a chromogenic in situ hybridisation and immunohistochemical study. Breast cancer research and treatment\| PubMed ID: 20213079	2010
Genomic and immunohistochemical analysis of adenosquamous carcinoma of the breast. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc\| PubMed ID: 20453835	2010
DNA amplifications in breast cancer: genotypic-phenotypic correlations. Future oncology (London, England)\| PubMed ID: 20528234	2010
PPM1D gene amplification and overexpression in breast cancer: a qRT-PCR and chromogenic in situ hybridization study. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc\| PubMed ID: 20543821	2010
Transcriptomic analysis of tubular carcinomas of the breast reveals similarities and differences with molecular subtype-matched ductal and lobular carcinomas. The Journal of pathology\| PubMed ID: 20593406	2010
BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells. Cell stem cell\| PubMed ID: 20804975	2010
Mucinous carcinoma of the breast is genomically distinct from invasive ductal carcinomas of no special type. The Journal of pathology\| PubMed ID: 20815046	2010
Down-regulation of the miRNA master regulators Drosha and Dicer is associated with specific subgroups of breast cancer. European journal of cancer (Oxford, England : 1990)\| PubMed ID: 20832293	2011
PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors. Science translational medicine\| PubMed ID: 20944090	2010
β-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc\| PubMed ID: 21076461	2011
Enhanced RAD21 cohesin expression confers poor prognosis and resistance to chemotherapy in high grade luminal, basal and HER2 breast cancers. Breast cancer research : BCR\| PubMed ID: 21255398	2011
Genomic analysis reveals the molecular heterogeneity of ovarian clear cell carcinomas. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 21411445	2011
Microarray-based class discovery for molecular classification of breast cancer: analysis of interobserver agreement. Journal of the National Cancer Institute\| PubMed ID: 21421860	2011
Genomic profiling of mitochondrion-rich breast carcinoma: chromosomal changes may be relevant for mitochondria accumulation and tumour biology. Breast cancer research and treatment\| PubMed ID: 21509527	2012
Next-generation sequencing applied to molecular diagnostics. Expert review of molecular diagnostics\| PubMed ID: 21545259	2011
FGFR signaling promotes the growth of triple-negative and basal-like breast cancer cell lines both in vitro and in vivo. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 21712446	2011
Functional characterization of EMSY gene amplification in human cancers. The Journal of pathology\| PubMed ID: 21735447	2011
High-throughput detection of fusion genes in cancer using the Sequenom MassARRAY platform. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 21808235	2011
Molecular profiling reveals frequent gain of MYCN and anaplasia-specific loss of 4q and 14q in Wilms tumor. Genes, chromosomes & cancer\| PubMed ID: 21882282	2011
Identification of a disease-defining gene fusion in epithelioid hemangioendothelioma. Science translational medicine\| PubMed ID: 21885404	2011
Non-existence of caveolin-1 gene mutations in human breast cancer. Breast cancer research and treatment\| PubMed ID: 21909981	2012
Functional viability profiles of breast cancer. Cancer discovery\| PubMed ID: 21984977	2011
Adenoid cystic carcinomas constitute a genomically distinct subgroup of triple-negative and basal-like breast cancers. The Journal of pathology\| PubMed ID: 22015727	2012
Immunophenotypic and genomic characterization of papillary carcinomas of the breast. The Journal of pathology\| PubMed ID: 22025283	2012
Identification of gene fusion transcripts by transcriptome sequencing in BRCA1-mutated breast cancers and cell lines. BMC medical genomics\| PubMed ID: 22032724	2011
Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer. Nature medicine\| PubMed ID: 22101766	2011
Genomic and mutational profiling of ductal carcinomas in situ and matched adjacent invasive breast cancers reveals intra-tumour genetic heterogeneity and clonal selection. The Journal of pathology\| PubMed ID: 22252965	2012
APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer. The EMBO journal\| PubMed ID: 22293751	2012
A whole-genome massively parallel sequencing analysis of BRCA1 mutant oestrogen receptor-negative and -positive breast cancers. The Journal of pathology\| PubMed ID: 22362584	2012
Functional characterization of the 19q12 amplicon in grade III breast cancers. Breast cancer research : BCR\| PubMed ID: 22433433	2012
Molecular evidence in support of the neoplastic and precursor nature of microglandular adenosis. Histopathology\| PubMed ID: 22486256	2012
Cross-platform pathway-based analysis identifies markers of response to the PARP inhibitor olaparib. Breast cancer research and treatment\| PubMed ID: 22875744	2012
Mutation profiling of adenoid cystic carcinomas from multiple anatomical sites identifies mutations in the RAS pathway, but no KIT mutations. Histopathology\| PubMed ID: 23398044	2013
From integrative genomics to therapeutic targets. Cancer research\| PubMed ID: 23740772	2013
Genomic profiling of histological special types of breast cancer. Breast cancer research and treatment\| PubMed ID: 24162157	2013
Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity. Cancer research\| PubMed ID: 24240700	2014
Characterization of the genomic features and expressed fusion genes in micropapillary carcinomas of the breast. The Journal of pathology\| PubMed ID: 24395524	2014
Integrative genomic and transcriptomic characterization of papillary carcinomas of the breast. Molecular oncology\| PubMed ID: 25041824	2014
Unbiased analysis of potential targets of breast cancer susceptibility loci by Capture Hi-C. Genome research\| PubMed ID: 25122612	2014
Metaplastic breast carcinomas display genomic and transcriptomic heterogeneity [corrected]. . Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc\| PubMed ID: 25412848	2015
SF3B1 mutations constitute a novel therapeutic target in breast cancer. The Journal of pathology\| PubMed ID: 25424858	2015
Robust BRCA1-like classification of copy number profiles of samples repeated across different datasets and platforms. Molecular oncology\| PubMed ID: 25825120	2015
Corrigendum: metastatic breast carcinomas display genomic and transcriptomic heterogeneity. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc\| PubMed ID: 25836989	2015
Breast cancer heterogeneity: parallel evolution or conscious uncoupling? The Journal of pathology\| PubMed ID: 25953517	2015
Intra-tumor genetic heterogeneity and alternative driver genetic alterations in breast cancers with heterogeneous HER2 gene amplification. Genome biology\| PubMed ID: 25994018	2015
Genomic landscape of adenoid cystic carcinoma of the breast. The Journal of pathology\| PubMed ID: 26095796	2015
An ecological measure of immune-cancer colocalization as a prognostic factor for breast cancer. Breast cancer research : BCR\| PubMed ID: 26395345	2015
The status of epidermal growth factor receptor in borderline ovarian tumours. Oncotarget\| PubMed ID: 26870997	2016
Microenvironmental Heterogeneity Parallels Breast Cancer Progression: A Histology-Genomic Integration Analysis. PLoS medicine\| PubMed ID: 26881778	2016
Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines. Cell reports\| PubMed ID: 26947069	2016
Risk Stratification and Intrinsic Subtype Classification of Breast Cancer: a Multi-Parameter Test to Rule Them All? Journal of the National Cancer Institute\| PubMed ID: 27130931	2016
Three-dimensional modelling identifies novel genetic dependencies associated with breast cancer progression in the isogenic MCF10 model. The Journal of pathology\| PubMed ID: 27512948	2016
Systematic analysis of tumour cell-extracellular matrix adhesion identifies independent prognostic factors in breast cancer. Oncotarget\| PubMed ID: 27556857	2016
Comparative proteomic assessment of matrisome enrichment methodologies. The Biochemical journal\| PubMed ID: 27589945	2016
Dual Targeting of PDGFRα and FGFR1 Displays Synergistic Efficacy in Malignant Rhabdoid Tumors. Cell reports\| PubMed ID: 27783942	2016