Eric Gouaux

Vollum Institute, Oregon Health & Science University

Affiliated withOregon Health & Science University

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 15	2016

Other Publications

Article	Year
Insights into transport mechanism from LeuT engineered to transport tryptophan. The EMBO journal\| PubMed ID: 21952050	2012
A vibrational spectroscopic investigation of interactions of agonists with GluR0, a prokaryotic glutamate receptor. Biochemistry\| PubMed ID: 11814354	2002
Mechanism of glutamate receptor desensitization. Nature\| PubMed ID: 12015593	2002
Structure-based functional design of chemical ligands for AMPA-subtype glutamate receptors. Journal of molecular neuroscience : MN\| PubMed ID: 12212767	2002
Mechanism of activation and selectivity in a ligand-gated ion channel: structural and functional studies of GluR2 and quisqualate. Biochemistry\| PubMed ID: 12501192	2002
Beta-barrel membrane protein folding and structure viewed through the lens of alpha-hemolysin. Biochimica et biophysica acta\| PubMed ID: 12507754	2003
Competitive antagonism of AMPA receptors by ligands of different classes: crystal structure of ATPO bound to the GluR2 ligand-binding core, in comparison with DNQX. Journal of medicinal chemistry\| PubMed ID: 12519060	2003
Vibrio cholerae cytolysin is composed of an alpha-hemolysin-like core. Protein science : a publication of the Protein Society\| PubMed ID: 12538902	2003
Three-dimensional structure of the ligand-binding core of GluR2 in complex with the agonist (S)-ATPA: implications for receptor subunit selectivity. Journal of medicinal chemistry\| PubMed ID: 12593667	2003
Arresting and releasing Staphylococcal alpha-hemolysin at intermediate stages of pore formation by engineered disulfide bonds. Protein science : a publication of the Protein Society\| PubMed ID: 12717022	2003
Tuning activation of the AMPA-sensitive GluR2 ion channel by genetic adjustment of agonist-induced conformational changes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12730367	2003
Probing the function, conformational plasticity, and dimer-dimer contacts of the GluR2 ligand-binding core: studies of 5-substituted willardiines and GluR2 S1S2 in the crystal. Biochemistry\| PubMed ID: 12731861	2003
Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core. The EMBO journal\| PubMed ID: 12805203	2003
Structural basis for partial agonist action at ionotropic glutamate receptors. Nature neuroscience\| PubMed ID: 12872125	2003
Structural basis for modulation and agonist specificity of HCN pacemaker channels. Nature\| PubMed ID: 12968185	2003
Trimeric subunit stoichiometry of the glutamate transporters from Bacillus caldotenax and Bacillus stearothermophilus. Biochemistry\| PubMed ID: 14596613	2003
Structure and function of AMPA receptors. The Journal of physiology\| PubMed ID: 14645452	2004
High resolution crystallographic studies of alpha-hemolysin-phospholipid complexes define heptamer-lipid head group interactions: implication for understanding protein-lipid interactions. Protein science : a publication of the Protein Society\| PubMed ID: 15152085	2004
Structure of a glutamate transporter homologue from Pyrococcus horikoshii. Nature\| PubMed ID: 15483603	2004
AMPA receptor binding cleft mutations that alter affinity, efficacy, and recovery from desensitization. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15829627	2005
Crystal structure of the Vibrio cholerae cytolysin (VCC) pro-toxin and its assembly into a heptameric transmembrane pore. Journal of molecular biology\| PubMed ID: 15978620	2005
Mechanism of partial agonist action at the NR1 subunit of NMDA receptors. Neuron\| PubMed ID: 15996549	2005
Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters. Nature\| PubMed ID: 16041361	2005
Membrane proteins--pumping along. Current opinion in structural biology\| PubMed ID: 16043337	2005
Mechanism of positive allosteric modulators acting on AMPA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16192394	2005
Subunit arrangement and function in NMDA receptors. Nature\| PubMed ID: 16281028	2005
Principles of selective ion transport in channels and pumps. Science (New York, N.Y.)\| PubMed ID: 16322449	2005
Fluorescence-detection size-exclusion chromatography for precrystallization screening of integral membrane proteins. Structure (London, England : 1993)\| PubMed ID: 16615909	2006
Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor. Cell\| PubMed ID: 17018279	2006
Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter. Nature\| PubMed ID: 17230192	2007
Antidepressant binding site in a bacterial homologue of neurotransmitter transporters. Nature\| PubMed ID: 17687333	2007
Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH. Nature\| PubMed ID: 17882215	2007
Review. The molecular logic of sodium-coupled neurotransmitter transporters. Philosophical transactions of the Royal Society of London. Series B, Biological sciences\| PubMed ID: 18977735	2009
A competitive inhibitor traps LeuT in an open-to-out conformation. Science (New York, N.Y.)\| PubMed ID: 19074341	2008
Unlocking the molecular secrets of sodium-coupled transporters. Nature\| PubMed ID: 19458710	2009
Crystal structure and association behaviour of the GluR2 amino-terminal domain. The EMBO journal\| PubMed ID: 19461580	2009
Structure and mechanism of a Na+-independent amino acid transporter. Science (New York, N.Y.)\| PubMed ID: 19608859	2009
Crystal structure of the ATP-gated P2X(4) ion channel in the closed state. Nature\| PubMed ID: 19641588	2009
Pore architecture and ion sites in acid-sensing ion channels and P2X receptors. Nature\| PubMed ID: 19641589	2009
X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor. Nature\| PubMed ID: 19946266	2009
Molecular bases of cyclodextrin adapter interactions with engineered protein nanopores. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20400691	2010
The New York Consortium on Membrane Protein Structure (NYCOMPS): a high-throughput platform for structural genomics of integral membrane proteins. Journal of structural and functional genomics\| PubMed ID: 20690043	2010
Dynamic superresolution imaging of endogenous proteins on living cells at ultra-high density. Biophysical journal\| PubMed ID: 20713016	2010
Neurotransmitter/sodium symporter orthologue LeuT has a single high-affinity substrate site. Nature\| PubMed ID: 21179170	2010
Amino terminal domains of the NMDA receptor are organized as local heterodimers. PloS one\| PubMed ID: 21544205	2011
Principles of activation and permeation in an anion-selective Cys-loop receptor. Nature\| PubMed ID: 21572436	2011
X-ray structures of LeuT in substrate-free outward-open and apo inward-open states. Nature\| PubMed ID: 22230955	2012
Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context. Nature structural & molecular biology\| PubMed ID: 22245965	2012
Molecular mechanism of ATP binding and ion channel activation in P2X receptors. Nature\| PubMed ID: 22535247	2012
Substrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologue. EMBO reports\| PubMed ID: 22836580	2012
Structural plasticity and dynamic selectivity of acid-sensing ion channel-spider toxin complexes. Nature\| PubMed ID: 22842900	2012
A fluorescence-detection size-exclusion chromatography-based thermostability assay for membrane protein precrystallization screening. Structure (London, England : 1993)\| PubMed ID: 22884106	2012
Unanticipated parallels in architecture and mechanism between ATP-gated P2X receptors and acid sensing ion channels. Current opinion in structural biology\| PubMed ID: 23628284	2013
How LeuT shapes our understanding of the mechanisms of sodium-coupled neurotransmitter transporters. The Journal of physiology\| PubMed ID: 23878376	2014
Novel dicarboxylate selectivity in an insect glutamate transporter homolog. PloS one\| PubMed ID: 23951049	2013
X-ray structure of dopamine transporter elucidates antidepressant mechanism. Nature\| PubMed ID: 24037379	2013
Structural basis for action by diverse antidepressants on biogenic amine transporters. Nature\| PubMed ID: 24121440	2013
X-ray structure of acid-sensing ion channel 1-snake toxin complex reveals open state of a Na(+)-selective channel. Cell\| PubMed ID: 24507937	2014
NMDA receptor structures reveal subunit arrangement and pore architecture. Nature\| PubMed ID: 25008524	2014
X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism. Science (New York, N.Y.)\| PubMed ID: 25103405	2014
Structure and dynamics of AMPA receptor GluA2 in resting, pre-open, and desensitized states. Cell\| PubMed ID: 25109876	2014
X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors. Nature\| PubMed ID: 25143115	2014
Screening and large-scale expression of membrane proteins in mammalian cells for structural studies. Nature protocols\| PubMed ID: 25299155	2014
X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine. Nature structural & molecular biology\| PubMed ID: 25961798	2015
Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature\| PubMed ID: 25970245	2015
Glycine receptor mechanism elucidated by electron cryo-microscopy. Nature\| PubMed ID: 26344198	2015
Thermostabilization of the Human Serotonin Transporter in an Antidepressant-Bound Conformation. PloS one\| PubMed ID: 26695939	2015
X-ray structures and mechanism of the human serotonin transporter. Nature\| PubMed ID: 27049939	2016
Mechanism of NMDA Receptor Inhibition and Activation. Cell\| PubMed ID: 27062927	2016
Architecture of fully occupied GluA2 AMPA receptor-TARP complex elucidated by cryo-EM. Nature\| PubMed ID: 27368053	2016
X-ray structures define human P2X3 receptor gating cycle and antagonist action. Nature\| PubMed ID: 27626375	2016
Structure and symmetry inform gating principles of ionotropic glutamate receptors. Neuropharmacology\| PubMed ID: 27663701	2017
[4] Membrane protein crystallization: Application of sparse matrices to the α-hemolysin heptamer. Methods in enzymology\| PubMed ID: 27799118	1997