Kunitada Shimotohno

Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine

Affiliated withNational Center for Global Health and Medicine

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 2	2017

Other Publications

Article	Year
RelA suppresses the Wnt/beta-catenin pathway without exerting trans-acting transcriptional ability. International journal of molecular medicine\| PubMed ID: 11956654	2002
Subgenomic replicon derived from a cell line infected with the hepatitis C virus. Biochemical and biophysical research communications\| PubMed ID: 12051758	2002
Hepatitis C virus and its roles in cell proliferation. Journal of gastroenterology\| PubMed ID: 12109666	2002
Wnt/beta-catenin signaling suppresses apoptosis in low serum medium and induces morphologic change in rodent fibroblasts. International journal of cancer\| PubMed ID: 12115501	2002
The interaction of HTLV-1 Tax with HDAC1 negatively regulates the viral gene expression. Oncogene\| PubMed ID: 12370815	2002
Gerbils of a seizure-sensitive strain have a mitochondrial inner membrane protein with different isoelectric points from those of a seizure-resistant strain. Electrophoresis\| PubMed ID: 12481273	2002
Distinct nuclear body components, PML and SMRT, regulate the trans-acting function of HTLV-1 Tax oncoprotein. Oncogene\| PubMed ID: 12642864	2003
Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene\| PubMed ID: 12761501	2003
p21(Waf1/Cip1/Sdi1) prevents apoptosis as well as stimulates growth in cells transformed or immortalized by human T-cell leukemia virus type 1-encoded tax. Journal of virology\| PubMed ID: 12805427	2003
Establishment of a hepatitis C virus subgenomic replicon derived from human hepatocytes infected in vitro. Biochemical and biophysical research communications\| PubMed ID: 12810084	2003
SR-related protein TAXREB803/SRL300 is an important cellular factor for the transactivational function of human T-cell lymphotropic virus type 1 Tax. Journal of virology\| PubMed ID: 12941912	2003
Hepatitis C virus non-structural proteins in the probable membranous compartment function in viral genome replication. The Journal of biological chemistry\| PubMed ID: 12963739	2003
Transforming growth factor-beta-mediated signaling via the p38 MAP kinase pathway activates Smad-dependent transcription through SUMO-1 modification of Smad4. The Journal of biological chemistry\| PubMed ID: 14514699	2003
[How can we improve the system to analyze HCV replication system?]. Uirusu\| PubMed ID: 14556507	2003
Modulation of retinoid signaling by a cytoplasmic viral protein via sequestration of Sp110b, a potent transcriptional corepressor of retinoic acid receptor, from the nucleus. Molecular and cellular biology\| PubMed ID: 14559998	2003
Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes. Hepatology (Baltimore, Md.)\| PubMed ID: 14578868	2003
The roles of hepatitis C virus proteins in modulation of cellular functions: a novel action mechanism of the HCV core protein on gene regulation by nuclear hormone receptors. Cancer science\| PubMed ID: 14611668	2003
Effect of interaction between hepatitis C virus NS5A and NS5B on hepatitis C virus RNA replication with the hepatitis C virus replicon. Journal of virology\| PubMed ID: 14990694	2004
Down-regulation of viral replication by adenoviral-mediated expression of siRNA against cellular cofactors for hepatitis C virus. Virology\| PubMed ID: 15003869	2004
Transcriptional activity of peroxisome proliferator-activated receptor gamma is modulated by SUMO-1 modification. The Journal of biological chemistry\| PubMed ID: 15123625	2004
Siah-1L, a novel transcript variant belonging to the human Siah family of proteins, regulates beta-catenin activity in a p53-dependent manner. Oncogene\| PubMed ID: 15326481	2004
Association of Ubc9, an E2 ligase for SUMO conjugation, with p53 is regulated by phosphorylation of p53. FEBS letters\| PubMed ID: 15327968	2004
Establishment of hepatitis C virus replicon cell lines possessing interferon-resistant phenotype. Biochemical and biophysical research communications\| PubMed ID: 15351737	2004
[Gene organization of hepatitis C virus and its sequence diversity]. Nihon rinsho. Japanese journal of clinical medicine\| PubMed ID: 15359758	2004
[Processing of HCV precursor polyprotein]. Nihon rinsho. Japanese journal of clinical medicine\| PubMed ID: 15359763	2004
Enhanced activation of tax-dependent transcription of human T-cell leukemia virus type I (HTLV-I) long terminal repeat by TORC3. The Journal of biological chemistry\| PubMed ID: 15466468	2004
cDNA microarray analysis to compare HCV subgenomic replicon cells with their cured cells. Virus research\| PubMed ID: 15567036	2005
The role of notch signaling in the development of intrahepatic bile ducts. Gastroenterology\| PubMed ID: 15578515	2004
HTLV-1 HBZ suppresses AP-1 activity by impairing both the DNA-binding ability and the stability of c-Jun protein. Oncogene\| PubMed ID: 15592508	2005
Suppression of hepatitis C virus replicon by TGF-beta. Virology\| PubMed ID: 15629783	2005
p21WAF1 modulates NF-kappaB signaling and induces anti-apoptotic protein Bcl-2 in Tax-expressing rat fibroblast. Virology\| PubMed ID: 15661157	2005
Interaction of HTLV-1 Tax and methyl-CpG-binding domain 2 positively regulates the gene expression from the hypermethylated LTR. Oncogene\| PubMed ID: 15674330	2005
Centrosomal P4.1-associated protein is a new member of transcriptional coactivators for nuclear factor-kappaB. The Journal of biological chemistry\| PubMed ID: 15687488	2005
Genetic variation and dynamics of hepatitis C virus replicons in long-term cell culture. The Journal of general virology\| PubMed ID: 15722525	2005
Role of cyclophilin B in activation of interferon regulatory factor-3. The Journal of biological chemistry\| PubMed ID: 15764595	2005
Analysis of the 5' end structure of HCV subgenomic RNA replicated in a Huh7 cell line. Intervirology\| PubMed ID: 15812182	2005
Exploiting cis-acting replication elements to direct hepatitis C virus-dependent transgene expression. Journal of virology\| PubMed ID: 15857978	2005
Identification of a novel p300-specific-associating protein, PRS1 (phosphoribosylpyrophosphate synthetase subunit 1). The Biochemical journal\| PubMed ID: 15943588	2005
Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase. Molecular cell\| PubMed ID: 15989969	2005
Enhancement of internal ribosome entry site-mediated translation and replication of hepatitis C virus by PD98059. Virology\| PubMed ID: 16005928	2005
Inhibition of hepatitis C virus replication by pol III-directed overexpression of RNA decoys corresponding to stem-loop structures in the NS5B coding region. Virology\| PubMed ID: 16139319	2005
Interferon resistance of hepatitis C virus replicon-harbouring cells is caused by functional disruption of type I interferon receptors. The Journal of general virology\| PubMed ID: 16186233	2005
[Current approaches for developing new anti-HCV agents and analyses of HCV replication using anti-HCV agents]. Uirusu\| PubMed ID: 16308536	2005
High-throughput screening of low molecular weight NS3-NS4A protease inhibitors using a fluorescence resonance energy transfer substrate. Antiviral chemistry & chemotherapy\| PubMed ID: 16329285	2005
Effect of hepatitis C virus (HCV) NS5B-nucleolin interaction on HCV replication with HCV subgenomic replicon. Journal of virology\| PubMed ID: 16537600	2006
Epigenetic silencing of interferon-inducible genes is implicated in interferon resistance of hepatitis C virus replicon-harboring cells. Journal of hepatology\| PubMed ID: 16545484	2006
Evaluation of the anti-hepatitis C virus effects of cyclophilin inhibitors, cyclosporin A, and NIM811. Biochemical and biophysical research communications\| PubMed ID: 16564500	2006
Inhibition of hepatitis C virus RNA replication by short hairpin RNA synthesized by T7 RNA polymerase in hepatitis C virus subgenomic replicons. Biochemical and biophysical research communications\| PubMed ID: 16566896	2006
Diverse effects of cyclosporine on hepatitis C virus strain replication. Journal of virology\| PubMed ID: 16611911	2006
Ubiquitination and proteasome-dependent degradation of human eukaryotic translation initiation factor 4E. The Journal of biological chemistry\| PubMed ID: 16720573	2006
Maintenance of self-renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b. Genes to cells : devoted to molecular & cellular mechanisms\| PubMed ID: 16824199	2006
Inhibition of hcv replication in HCV replicon by shRNAs. Nucleosides, nucleotides & nucleic acids\| PubMed ID: 16898418	2006
High expression of APOBEC3G in patients infected with hepatitis C virus. Journal of molecular histology\| PubMed ID: 17036163	2006
Helper virus-independent trans-replication of hepatitis C virus-derived minigenome. Biochemical and biophysical research communications\| PubMed ID: 17112469	2007
Serum-derived hepatitis C virus infectivity in interferon regulatory factor-7-suppressed human primary hepatocytes. Journal of hepatology\| PubMed ID: 17112629	2007
RNAi expression mediated inhibition of HCV replication. Nucleic acids symposium series (2004)\| PubMed ID: 17150601	2004
Suppression of HCV RNA replication by baculovirus-mediated shRNA expression. Nucleic acids symposium series (2004)\| PubMed ID: 17150772	2005
The expression of phosphatidic acid phosphatase 2a, which hydrolyzes lipids to generate diacylglycerol, is regulated by p73, a member of the p53 family. Biochemical and biophysical research communications\| PubMed ID: 17169329	2007
In vitro infection of immortalized primary hepatocytes by HCV genotype 4a and inhibition of virus replication by cyclosporin. Microbiology and immunology\| PubMed ID: 17237608	2007
Chemical genetics approach to hepatitis C virus replication: cyclophilin as a target for anti-hepatitis C virus strategy. Reviews in medical virology\| PubMed ID: 17299803	2007
Identification of new immunogenic peptides in conserved regions of hepatitis C virus (HCV) 1b with the potentiality to generate cytotoxic T lymphocytes in HCV1b(+) HLA-A24(+) patients. Hepatology research : the official journal of the Japan Society of Hepatology\| PubMed ID: 17362301	2007
Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17460044	2007
BCL3 acts as a negative regulator of transcription from the human T-cell leukemia virus type 1 long terminal repeat through interactions with TORC3. The Journal of biological chemistry\| PubMed ID: 17644518	2007
Anti-hepatitis C virus activity of tamoxifen reveals the functional association of estrogen receptor with viral RNA polymerase NS5B. The Journal of biological chemistry\| PubMed ID: 17704057	2007
UbcH8 regulates ubiquitin and ISG15 conjugation to RIG-I. Molecular immunology\| PubMed ID: 17719635	2008
The lipid droplet is an important organelle for hepatitis C virus production. Nature cell biology\| PubMed ID: 17721513	2007
Up-regulation of hepatitis C virus replication by human T cell leukemia virus type I-encoded Tax protein. Virology\| PubMed ID: 17765943	2007
5'-O-masked 2'-deoxyadenosine analogues as lead compounds for hepatitis C virus (HCV) therapeutic agents. Bioorganic & medicinal chemistry\| PubMed ID: 17766124	2007
Suppression of subgenomic hepatitis C virus replication by 5'-O-masked analogues of 6-chloropurine-2'-deoxyriboside. Nucleic acids symposium series (2004)\| PubMed ID: 18029775	2007
Suppression of hepatitis C virus core protein by short hairpin RNA expression vectors in the core protein expression Huh-7 cells. Nucleosides, nucleotides & nucleic acids\| PubMed ID: 18066906	2007
Possible molecular mechanism of the relationship between NS5B polymorphisms and early clearance of hepatitis C virus during interferon plus ribavirin treatment. Journal of medical virology\| PubMed ID: 18297719	2008
Isolation and gene analysis of interferon alpha-resistant cell clones of the hepatitis C virus subgenome. Virology\| PubMed ID: 18353417	2008
[Strategy of HCV proliferation]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme\| PubMed ID: 18409561	2008
Synthesis and evaluation of 5'-modified 2'-deoxyadenosine analogues as anti-hepatitis C virus agents. Bioorganic & medicinal chemistry letters\| PubMed ID: 18644724	2008
Human T-cell leukemia virus type 1 Tax modulates interferon-alpha signal transduction through competitive usage of the coactivator CBP/p300. Virology\| PubMed ID: 18678383	2008
Human T-cell leukemia virus type 1 HBZ protein bypasses the targeting function of ubiquitination. The Journal of biological chemistry\| PubMed ID: 18805793	2008
3D cultured immortalized human hepatocytes useful to develop drugs for blood-borne HCV. Biochemical and biophysical research communications\| PubMed ID: 19103167	2009
Regulation of viral recognition signaling by ubiquitin modification. Uirusu\| PubMed ID: 19122388	2008
Regulation of the hepatitis C virus genome replication by miR-199a. Journal of hepatology\| PubMed ID: 19144437	2009
Heat-shock protein 90 is essential for stabilization of the hepatitis C virus nonstructural protein NS3. The Journal of biological chemistry\| PubMed ID: 19150985	2009
TORC2, a coactivator of cAMP-response element-binding protein, promotes Epstein-Barr virus reactivation from latency through interaction with viral BZLF1 protein. The Journal of biological chemistry\| PubMed ID: 19164291	2009
Genetic analysis of hepatitis C virus with defective genome and its infectivity in vitro. Journal of virology\| PubMed ID: 19369330	2009
Strain-dependent viral dynamics and virus-cell interactions in a novel in vitro system supporting the life cycle of blood-borne hepatitis C virus. Hepatology (Baltimore, Md.)\| PubMed ID: 19489071	2009
Hepatitis C virus utilizes lipid droplet for production of infectious virus. Proceedings of the Japan Academy. Series B, Physical and biological sciences\| PubMed ID: 19644222	2009
Identification of cellular and viral factors related to anti-hepatitis C virus activity of cyclophilin inhibitor. Cancer science\| PubMed ID: 19659609	2009
Synthesis and anti-HCV activity of 2',5'-deoxy-5'-phenacyladenosine analogs. Nucleic acids symposium series (2004)\| PubMed ID: 19749281	2009
Anti-bovine viral diarrhoea virus and hepatitis C virus activity of the cyclooxygenase inhibitor SC-560. Antiviral chemistry & chemotherapy\| PubMed ID: 19794231	2009
Combination therapy for hepatitis C virus with heat-shock protein 90 inhibitor 17-AAG and proteasome inhibitor MG132. Antiviral chemistry & chemotherapy\| PubMed ID: 20231781	2010
HTLV-1 basic leucine-zipper factor, HBZ, interacts with MafB and suppresses transcription through a Maf recognition element. Journal of cellular biochemistry\| PubMed ID: 20506502	2010
Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20724660	2010
Lipoprotein lipase and hepatic triglyceride lipase reduce the infectivity of hepatitis C virus (HCV) through their catalytic activities on HCV-associated lipoproteins. Virology\| PubMed ID: 20822787	2010
Infectivity of hepatitis C virus is influenced by association with apolipoprotein E isoforms. Journal of virology\| PubMed ID: 20826689	2010
Sphingomyelin activates hepatitis C virus RNA polymerase in a genotype-specific manner. Journal of virology\| PubMed ID: 20844041	2010
Hepatic microRNA expression is associated with the response to interferon treatment of chronic hepatitis C. BMC medical genomics\| PubMed ID: 20969775	2010
Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction. PloS one\| PubMed ID: 21170385	2010
The progression of liver fibrosis is related with overexpression of the miR-199 and 200 families. PloS one\| PubMed ID: 21283674	2011
Cyclosporin A associated helicase-like protein facilitates the association of hepatitis C virus RNA polymerase with its cellular cyclophilin B. PloS one\| PubMed ID: 21559518	2011
Dysregulation of IFN system can lead to poor response to pegylated interferon and ribavirin therapy in chronic hepatitis C. PloS one\| PubMed ID: 21603632	2011
Will there be an HCV meeting in 2020? Summary of the 17th international meeting on hepatitis C virus and related viruses. Gastroenterology\| PubMed ID: 21620847	2011
Development of mouse hepatocyte lines permissive for hepatitis C virus (HCV). PloS one\| PubMed ID: 21731692	2011
Cyclophilin and viruses: cyclophilin as a cofactor for viral infection and possible anti-viral target. Drug target insights\| PubMed ID: 21901058	2007
The interaction between human initiation factor eIF3 subunit c and heat-shock protein 90: a necessary factor for translation mediated by the hepatitis C virus internal ribosome entry site. Virus research\| PubMed ID: 22016036	2012
In vitro models for analysis of the hepatitis C virus life cycle. Microbiology and immunology\| PubMed ID: 22145950	2012
Detergent-induced activation of the hepatitis C virus genotype 1b RNA polymerase. Gene\| PubMed ID: 22306265	2012
Lipoprotein component associated with hepatitis C virus is essential for virus infectivity. Current opinion in virology\| PubMed ID: 22440563	2011
Self-enhancement of hepatitis C virus replication by promotion of specific sphingolipid biosynthesis. PLoS pathogens\| PubMed ID: 22916015	2012
Different mechanisms of hepatitis C virus RNA polymerase activation by cyclophilin A and B in vitro. Biochimica et biophysica acta\| PubMed ID: 22954804	2012
PML tumor suppressor protein is required for HCV production. Biochemical and biophysical research communications\| PubMed ID: 23219818	2013
Hepatitis C virus infection induces inflammatory cytokines and chemokines mediated by the cross talk between hepatocytes and stellate cells. Journal of virology\| PubMed ID: 23678168	2013
Thromboxane A2 synthase inhibitors prevent production of infectious hepatitis C virus in mice with humanized livers. Gastroenterology\| PubMed ID: 23684750	2013
Critical role of interferon-α constitutively produced in human hepatocytes in response to RNA virus infection. PloS one\| PubMed ID: 24587086	2014
Interferon-mediated ISG15 conjugation restricts dengue virus 2 replication. Biochemical and biophysical research communications\| PubMed ID: 24769207	2014
The J6JFH1 strain of hepatitis C virus infects human B-cells with low replication efficacy. Viral immunology\| PubMed ID: 24853207	2014
The RNA-editing enzyme APOBEC1 requires heterogeneous nuclear ribonucleoprotein Q isoform 6 for efficient interaction with interleukin-8 mRNA. The Journal of biological chemistry\| PubMed ID: 25100733	2014
Hepatitis C virus NS5A protein enhances gluconeogenesis through upregulation of Akt-/JNK-PEPCK signalling pathways. Liver international : official journal of the International Association for the Study of the Liver\| PubMed ID: 25360475	2014
Murine Herc6 Plays a Critical Role in Protein ISGylation In Vivo and Has an ISGylation-Independent Function in Seminal Vesicles. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research\| PubMed ID: 25406959	2015
A new role for PGA1 in inhibiting hepatitis C virus-IRES-mediated translation by targeting viral translation factors. Antiviral research\| PubMed ID: 25666760	2015
Apolipoprotein E, but Not Apolipoprotein B, Is Essential for Efficient Cell-to-Cell Transmission of Hepatitis C Virus. Journal of virology\| PubMed ID: 26202245	2015
Novel reporter system to monitor early stages of the hepatitis B virus life cycle. Cancer science\| PubMed ID: 26310603	2015
Hepatitis C virus utilizes VLDLR as a novel entry pathway. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26699506	2016
Human induced pluripotent stem cell-derived hepatic cell lines as a new model for host interaction with hepatitis B virus. Scientific reports\| PubMed ID: 27386799	2016
Long noncoding RNA #32 contributes to antiviral responses by controlling interferon-stimulated gene expression. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27582466	2016