Horst Kessler

Department of Chemistry, Technische Universität München

Affiliated withTechnische Universität München

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 2	2017

Other Publications

Article	Year
Solution structure and binding specificity of the p63 DNA binding domain. Scientific reports\| PubMed ID: 27225672	2016
Docking studies on alphavbeta3 integrin ligands: pharmacophore refinement and implications for drug design. Journal of medicinal chemistry\| PubMed ID: 14521404	2003
New oxazole-based peptidomimetics: useful building blocks for the synthesis of orthogonally protected macrocyclic scaffolds. Organic letters\| PubMed ID: 14627385	2003
Synthesis and structure-activity relationship of mannose-based peptidomimetics selectively blocking integrin alpha4beta7 binding to mucosal addressin cell adhesion molecule-1. Journal of medicinal chemistry\| PubMed ID: 14667228	2003
[18F]Galacto-RGD: synthesis, radiolabeling, metabolic stability, and radiation dose estimates. Bioconjugate chemistry\| PubMed ID: 14733584	2004
Evidence for hetero-association of transmembrane helices of integrins. FEBS letters\| PubMed ID: 14741377	2004
Expression of the GM2-activator protein in the methylotrophic yeast Pichia pastoris, purification, isotopic labeling, and biophysical characterization. Protein expression and purification\| PubMed ID: 14766311	2004
Combination of an SRC kinase inhibitor with a novel pharmacological antagonist of the urokinase receptor diminishes in vitro colon cancer invasiveness. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 14977859	2004
An easy and scalable method for the partial alignment of organic molecules for measuring residual dipolar couplings. Angewandte Chemie (International ed. in English)\| PubMed ID: 14983442	2004
Backbone 1H, 15N and 13C resonance assignments of alpha-ADT and beta-ADT. Journal of biomolecular NMR\| PubMed ID: 15014236	2004
Activation of integrin function by nanopatterned adhesive interfaces. Chemphyschem : a European journal of chemical physics and physical chemistry\| PubMed ID: 15067875	2004
NMR studies on the substrate-binding domains of the thermosome: structural plasticity in the protrusion region. Journal of molecular biology\| PubMed ID: 15095983	2004
Two-step methodology for high-yield routine radiohalogenation of peptides: (18)F-labeled RGD and octreotide analogs. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 15136641	2004
First (18)F-labeled tracer suitable for routine clinical imaging of sst receptor-expressing tumors using positron emission tomography. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 15173065	2004
A structural model of EmrE, a multi-drug transporter from Escherichia coli. Biophysical journal\| PubMed ID: 15189838	2004
1H, 13C and 15N resonance assignment of the nucleotide binding domain of KdpB from Escherichia coli. Journal of biomolecular NMR\| PubMed ID: 15213457	2004
A computational model of transmembrane integrin clustering. Structure (London, England : 1993)\| PubMed ID: 15274930	2004
Human integrin alphavbeta5: homology modeling and ligand binding. Journal of medicinal chemistry\| PubMed ID: 15293989	2004
Solution structure of Escherichia coli Par10: The prototypic member of the Parvulin family of peptidyl-prolyl cis/trans isomerases. Protein science : a publication of the Protein Society\| PubMed ID: 15322281	2004
Inter-domain motions of the N-domain of the KdpFABC complex, a P-type ATPase, are not driven by ATP-induced conformational changes. Journal of molecular biology\| PubMed ID: 15364580	2004
Stretched poly(dimethylsiloxane) gels as NMR alignment media for apolar and weakly polar organic solvents: an ideal tool for measuring RDCs at low molecular concentrations. Journal of the American Chemical Society\| PubMed ID: 15535672	2004
Improving implant materials by coating with nonpeptidic, highly specific integrin ligands. Angewandte Chemie (International ed. in English)\| PubMed ID: 15593169	2004
ADAM15 decreases integrin alphavbeta3/vitronectin-mediated ovarian cancer cell adhesion and motility in an RGD-dependent fashion. The international journal of biochemistry & cell biology\| PubMed ID: 15618016	2005
Stretched poly(vinyl acetate) gels as NMR alignment media for the measurement of residual dipolar couplings in polar organic solvents. Angewandte Chemie (International ed. in English)\| PubMed ID: 15624159	2005
NMR studies reveal structural differences between the gallium and yttrium complexes of DOTA-D-Phe1-Tyr3-octreotide. Journal of medicinal chemistry\| PubMed ID: 15743193	2005
Noninvasive visualization of the activated alphavbeta3 integrin in cancer patients by positron emission tomography and [18F]Galacto-RGD. PLoS medicine\| PubMed ID: 15783258	2005
Structure-activity relationship studies optimizing the antiproliferative activity of novel cyclic somatostatin analogues containing a restrained cyclic beta-amino acid. Journal of medicinal chemistry\| PubMed ID: 15828830	2005
Stretched gelatin gels as chiral alignment media for the discrimination of enantiomers by NMR spectroscopy. Angewandte Chemie (International ed. in English)\| PubMed ID: 15834848	2005
Orientational properties of stretched polystyrene gels in organic solvents and the suppression of their residual 1H NMR signals. Journal of the American Chemical Society\| PubMed ID: 15853354	2005
Convenient synthesis of N-methylamino acids compatible with Fmoc solid-phase peptide synthesis. The Journal of organic chemistry\| PubMed ID: 15960522	2005
Ligand binding analysis for human alpha5beta1 integrin: strategies for designing new alpha5beta1 integrin antagonists. Journal of medicinal chemistry\| PubMed ID: 15974570	2005
Cooperative binding of p53 to DNA: regulation by protein-protein interactions through a double salt bridge. Angewandte Chemie (International ed. in English)\| PubMed ID: 16035029	2005
Diffusion NMR spectroscopy: folding and aggregation of domains in p53. Chembiochem : a European journal of chemical biology\| PubMed ID: 16138303	2005
Structure refinement of cyclosporin A in chloroform by using RDCs measured in a stretched PDMS-gel. Chembiochem : a European journal of chemical biology\| PubMed ID: 16138307	2005
Optimized selective N-methylation of peptides on solid support. Journal of peptide science : an official publication of the European Peptide Society\| PubMed ID: 16189816	2006
Titanium implant materials with improved biocompatibility through coating with phosphonate-anchored cyclic RGD peptides. Chembiochem : a European journal of chemical biology\| PubMed ID: 16206226	2005
3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors. Bioorganic & medicinal chemistry letters\| PubMed ID: 16236508	2006
Benzylprotected aromatic phosphonic acids for anchoring peptides on titanium. Bioorganic & medicinal chemistry letters\| PubMed ID: 16256349	2006
Photoswitched cell adhesion on surfaces with RGD peptides. Journal of the American Chemical Society\| PubMed ID: 16287297	2005
Molecular targeting with peptides or peptide-polymer conjugates: just a question of size? Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 16330555	2005
The holo-form of the nucleotide binding domain of the KdpFABC complex from Escherichia coli reveals a new binding mode. The Journal of biological chemistry\| PubMed ID: 16354672	2006
WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization. The Journal of biological chemistry\| PubMed ID: 16443602	2006
Intrinsic inhibition of the Hsp90 ATPase activity. The Journal of biological chemistry\| PubMed ID: 16461354	2006
Cellular unbinding forces of initial adhesion processes on nanopatterned surfaces probed with magnetic tweezers. Nano letters\| PubMed ID: 16522030	2006
Lateral spacing of integrin ligands influences cell spreading and focal adhesion assembly. European journal of cell biology\| PubMed ID: 16546564	2006
Characterization of human saposins by NMR spectroscopy. Biochemistry\| PubMed ID: 16618109	2006
Prokaryotic Kdp-ATPase: recent insights into the structure and function of KdpB. Journal of molecular microbiology and biotechnology\| PubMed ID: 16645309	2005
Growth promoting in vitro effect of synthetic cyclic RGD-peptides on human osteoblast-like cells attached to cancellous bone. International journal of molecular medicine\| PubMed ID: 16685410	2006
Solid-phase synthesis of 1,3-azole-based peptides and peptidomimetics. Organic letters\| PubMed ID: 16706540	2006
Synthesis and stereochemical assignment of DNA spore photoproduct analogues. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 16789031	2006
Binding of small mono- and oligomeric integrin ligands to membrane-embedded integrins monitored by surface plasmon-enhanced fluorescence spectroscopy. Analytical chemistry\| PubMed ID: 16808462	2006
Positron emission tomography using [18F]Galacto-RGD identifies the level of integrin alpha(v)beta3 expression in man. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 16818691	2006
Inter-domain orientation and motions in VAT-N explored by residual dipolar couplings and 15N backbone relaxation. Magnetic resonance in chemistry : MRC\| PubMed ID: 16826545	2006
Efficient enantioselective synthesis of condensed and aromatic-ring-substituted tyrosine derivatives. The Journal of organic chemistry\| PubMed ID: 16839142	2006
p53--a natural cancer killer: structural insights and therapeutic concepts. Angewandte Chemie (International ed. in English)\| PubMed ID: 16983711	2006
The conformation of cyclo(-D-Pro-Ala4-) as a model for cyclic pentapeptides of the DL4 type. Journal of the American Chemical Society\| PubMed ID: 17044709	2006
Influence of the internal disulfide bridge on the folding pathway of the CL antibody domain. Journal of molecular biology\| PubMed ID: 17112539	2007
N-methylated cyclic pentaalanine peptides as template structures. Journal of the American Chemical Society\| PubMed ID: 17117868	2006
J-Spectroscopy in the presence of residual dipolar couplings: determination of one-bond coupling constants and scalable resolution. Journal of biomolecular NMR\| PubMed ID: 17235497	2007
Cell spreading and focal adhesion dynamics are regulated by spacing of integrin ligands. Biophysical journal\| PubMed ID: 17277192	2007
Probing integrin selectivity: rational design of highly active and selective ligands for the alpha5beta1 and alphavbeta3 integrin receptor. Angewandte Chemie (International ed. in English)\| PubMed ID: 17394271	2007
Mimicking cellular environments by nanostructured soft interfaces. Nano letters\| PubMed ID: 17394372	2007
Synthesis and biological evaluation of phosphino dipeptide isostere inhibitor of human beta-secretase (BACE1). Bioorganic & medicinal chemistry\| PubMed ID: 17433698	2007
Synthesis of novel 1,4,7,10-tetraazacyclodecane-1,4,7,10-tetraacetic acid (DOTA) derivatives for chemoselective attachment to unprotected polyfunctionalized compounds. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 17503419	2007
The RGD motif in fibronectin is essential for development but dispensable for fibril assembly. The Journal of cell biology\| PubMed ID: 17591922	2007
NMR-based screening: a powerful tool in fragment-based drug discovery. The Analyst\| PubMed ID: 17657909	2007
Development of a peptidomimetic ligand for efficient isolation and purification of factor VIII via affinity chromatography. Journal of medicinal chemistry\| PubMed ID: 17691762	2007
Protein repellent properties of covalently attached PEG coatings on nanostructured SiO(2)-based interfaces. Biomaterials\| PubMed ID: 17697710	2007
Design and chemical synthesis of integrin ligands. Methods in enzymology\| PubMed ID: 17697896	2007
Specific integrin labeling in living cells using functionalized nanocrystals. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 17705315	2007
Development and evaluation of peptidic ligands targeting tumour-associated urokinase plasminogen activator receptor (uPAR) for use in alpha-emitter therapy for disseminated ovarian cancer. European journal of nuclear medicine and molecular imaging\| PubMed ID: 17891393	2008
J-ONLY-TOCSY: efficient suppression of RDC-induced transfer in homonuclear TOCSY experiments using JESTER-1-derived multiple pulse sequences. Journal of magnetic resonance (San Diego, Calif. : 1997)\| PubMed ID: 17936049	2007
Multiple N-methylation by a designed approach enhances receptor selectivity. Journal of medicinal chemistry\| PubMed ID: 17973471	2007
Conformational preference and potential templates of N-methylated cyclic pentaalanine peptides. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 18080261	2008
Assessment of alphavbeta3 integrin expression after myocardial infarction by positron emission tomography. Cardiovascular research\| PubMed ID: 18256073	2008
Improving oral bioavailability of peptides by multiple N-methylation: somatostatin analogues. Angewandte Chemie (International ed. in English)\| PubMed ID: 18297660	2008
Phosphorus NMR spectroscopy as a versatile tool for compound library screening. Angewandte Chemie (International ed. in English)\| PubMed ID: 18311739	2008
Chemical conjugation of linear and cyclic RGD moieties to a recombinant elastin-mimetic polypeptide--a versatile approach towards bioactive protein hydrogels. Macromolecular bioscience\| PubMed ID: 18350537	2008
The CLIP/CLAP-HSQC: pure absorptive spectra for the measurement of one-bond couplings. Journal of magnetic resonance (San Diego, Calif. : 1997)\| PubMed ID: 18411067	2008
Biophysics: the sweetest candy for the virus. Nature\| PubMed ID: 18421340	2008
Isothiocyanate-functionalized RGD peptides for tailoring cell-adhesive surface patterns. Biomaterials\| PubMed ID: 18433862	2008
Rational design of highly active and selective ligands for the alpha5beta1 integrin receptor. Chembiochem : a European journal of chemical biology\| PubMed ID: 18481343	2008
Induction of cell polarization and migration by a gradient of nanoscale variations in adhesive ligand spacing. Nano letters\| PubMed ID: 18558788	2008
Cell adhesion and polarisation on molecularly defined spacing gradient surfaces of cyclic RGDfK peptide patches. European journal of cell biology\| PubMed ID: 18572273	2008
N-methylation of peptides: a new perspective in medicinal chemistry. Accounts of chemical research\| PubMed ID: 18636716	2008
Cooperativity in adhesion cluster formation during initial cell adhesion. Biophysical journal\| PubMed ID: 18689459	2008
The structure of a folding intermediate provides insight into differences in immunoglobulin amyloidogenicity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18768806	2008
The solution structure of BMPR-IA reveals a local disorder-to-order transition upon BMP-2 binding. Biochemistry\| PubMed ID: 18937504	2008
Can N-methylated amino acids serve as substitutes for prolines in conformational design of cyclic pentapeptides? Journal of peptide science : an official publication of the European Peptide Society\| PubMed ID: 18985637	2009
Deuterated polymer gels for measuring anisotropic NMR parameters with strongly reduced artefacts. Chemical communications (Cambridge, England)\| PubMed ID: 19009060	2008
The state of the art of chemical biology. Chembiochem : a European journal of chemical biology\| PubMed ID: 19115274	2009
Perspectives on NMR in drug discovery: a technique comes of age. Nature reviews. Drug discovery\| PubMed ID: 19172689	2008
Interaction of human heat shock protein 70 with tumor-associated peptides. Biological chemistry\| PubMed ID: 19199830	2009
Impact of order and disorder in RGD nanopatterns on cell adhesion. Nano letters\| PubMed ID: 19206508	2009
Breaking the dogma of the metal-coordinating carboxylate group in integrin ligands: introducing hydroxamic acids to the MIDAS to tune potency and selectivity. Angewandte Chemie (International ed. in English)\| PubMed ID: 19343753	2009
Solid-phase synthesis of phosphinic dipepetide isosteres and beta amino acids via activated N-terminal acrylamides. Advances in experimental medicine and biology\| PubMed ID: 19400072	2009
N-methylated cyclic pentapeptides as template structures. Advances in experimental medicine and biology\| PubMed ID: 19400115	2009
Development of a small molecule peptidomimetic affinity ligand for efficient purification of the large protein factor VIII. Advances in experimental medicine and biology\| PubMed ID: 19400135	2009
Making double-minded peptides strong-willed? The side chain impact on the backbone conformation of N-methylated cyclic pentapeptides. Advances in experimental medicine and biology\| PubMed ID: 19400138	2009
Highly selective cyclic hexapeptides antagonist of GPIIb-IIIa by multiple N-methylation. Advances in experimental medicine and biology\| PubMed ID: 19400163	2009
New perspective in peptide chemistry by N-alkylation. Advances in experimental medicine and biology\| PubMed ID: 19400173	2009
Imaging of integrin alpha(v)beta(3) expression in patients with malignant glioma by [18F] Galacto-RGD positron emission tomography. Neuro-oncology\| PubMed ID: 19401596	2009
The HSP90 binding mode of a radicicol-like E-oxime determined by docking, binding free energy estimations, and NMR 15N chemical shifts. Biophysical chemistry\| PubMed ID: 19482409	2009
Ligands for mapping alphavbeta3-integrin expression in vivo. Accounts of chemical research\| PubMed ID: 19489579	2009
Prolonged stability by cyclization: Macrocyclic phosphino dipeptide isostere inhibitors of beta-secretase (BACE1). Bioorganic & medicinal chemistry letters\| PubMed ID: 19523824	2009
An unfolded CH1 domain controls the assembly and secretion of IgG antibodies. Molecular cell\| PubMed ID: 19524537	2009
The transmembrane structure of integrin alphaIIbbeta3: significance for signal transduction. Angewandte Chemie (International ed. in English)\| PubMed ID: 19598189	2009
Hsp90 is regulated by a switch point in the C-terminal domain. EMBO reports\| PubMed ID: 19696785	2009
BclxL changes conformation upon binding to wild-type but not mutant p53 DNA binding domain. The Journal of biological chemistry\| PubMed ID: 19955567	2010
Asymmetric activation of the hsp90 dimer by its cochaperone aha1. Molecular cell\| PubMed ID: 20159554	2010
The impact of amino acid side chain mutations in conformational design of peptides and proteins. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 20358563	2010
A conserved spider silk domain acts as a molecular switch that controls fibre assembly. Nature\| PubMed ID: 20463741	2010
Multiple N-methylation of MT-II backbone amide bonds leads to melanocortin receptor subtype hMC1R selectivity: pharmacological and conformational studies. Journal of the American Chemical Society\| PubMed ID: 20496895	2010
Hsp12 is an intrinsically unstructured stress protein that folds upon membrane association and modulates membrane function. Molecular cell\| PubMed ID: 20797624	2010
Polymeric substrates with tunable elasticity and nanoscopically controlled biomolecule presentation. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 20831282	2010
Conformational control of integrin-subtype selectivity in isoDGR peptide motifs: a biological switch. Angewandte Chemie (International ed. in English)\| PubMed ID: 20957712	2010
Optimized measurement temperature gives access to the solution structure of a 49 kDa homohexameric β-propeller. Journal of the American Chemical Society\| PubMed ID: 20961124	2010
Stimulation of cell adhesion at nanostructured teflon interfaces. Advanced materials (Deerfield Beach, Fla.)\| PubMed ID: 20972983	2010
pH-dependent dimerization and salt-dependent stabilization of the N-terminal domain of spider dragline silk--implications for fiber formation. Angewandte Chemie (International ed. in English)\| PubMed ID: 21064058	2011
NCO-sP(EO-stat-PO) surface coatings preserve biochemical properties of RGD peptides. International journal of molecular medicine\| PubMed ID: 21069259	2011
Stable functionalized PEGylated quantum dots micelles with a controlled stoichiometry. Chemical communications (Cambridge, England)\| PubMed ID: 21103558	2011
Cilengitide: the first anti-angiogenic small molecule drug candidate design, synthesis and clinical evaluation. Anti-cancer agents in medicinal chemistry\| PubMed ID: 21269250	2010
The effect of multiple N-methylation on intestinal permeability of cyclic hexapeptides. Molecular pharmaceutics\| PubMed ID: 21375270	2011
Impact of local versus global ligand density on cellular adhesion. Nano letters\| PubMed ID: 21425841	2011
PET Imaging of Integrin αVβ3 Expression. Theranostics\| PubMed ID: 21547152	2011
Cell interactions with hierarchically structured nano-patterned adhesive surfaces. Soft matter\| PubMed ID: 21686049	2009
PET imaging of CXCR4 receptors in cancer by a new optimized ligand. ChemMedChem\| PubMed ID: 21780290	2011
Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart. Circulation research\| PubMed ID: 21799151	2011
Introducing lasso peptides as molecular scaffolds for drug design: engineering of an integrin antagonist. Angewandte Chemie (International ed. in English)\| PubMed ID: 21812076	2011
Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53. Nature structural & molecular biology\| PubMed ID: 21892170	2011
Design, synthesis, and functionalization of dimeric peptides targeting chemokine receptor CXCR4. Journal of medicinal chemistry\| PubMed ID: 21905730	2011
Increasing αvβ3 selectivity of the anti-angiogenic drug cilengitide by N-methylation. Angewandte Chemie (International ed. in English)\| PubMed ID: 21948451	2011
PET of CXCR4 expression by a (68)Ga-labeled highly specific targeted contrast agent. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 22045709	2011
Synthesis and conformational analysis of efrapeptins. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 22147615	2012
Tailoring of integrin ligands: probing the charge capability of the metal ion-dependent adhesion site. Journal of medicinal chemistry\| PubMed ID: 22185640	2012
Spectroscopically well-characterized RGD optical probe as a prerequisite for lifetime-gated tumor imaging. Molecular imaging\| PubMed ID: 22201538	2011
The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop. The EMBO journal\| PubMed ID: 22227520	2012
Polymer-free immobilization of a cyclic RGD peptide on a nitinol stent promotes integrin-dependent endothelial coverage of strut surfaces. Journal of biomedical materials research. Part B, Applied biomaterials\| PubMed ID: 22278946	2012
Synthesis of N-methylated cyclic peptides. Nature protocols\| PubMed ID: 22322216	2012
Solid-phase-assisted synthesis of targeting peptide-PEG-oligo(ethane amino)amides for receptor-mediated gene delivery. Organic & biomolecular chemistry\| PubMed ID: 22407126	2012
68Ga-NODAGA-RGD is a suitable substitute for (18)F-Galacto-RGD and can be produced with high specific activity in a cGMP/GRP compliant automated process. Nuclear medicine and biology\| PubMed ID: 22444238	2012
Cyclic aza-peptide integrin ligand synthesis and biological activity. The Journal of organic chemistry\| PubMed ID: 22582818	2012
Guiding plant virus particles to integrin-displaying cells. Nanoscale\| PubMed ID: 22585108	2012
Cell adhesion and proliferation on RGD-modified recombinant spider silk proteins. Biomaterials\| PubMed ID: 22727466	2012
Intestinal permeability of cyclic peptides: common key backbone motifs identified. Journal of the American Chemical Society\| PubMed ID: 22737969	2012
A conformationally frozen peptoid boosts CXCR4 affinity and anti-HIV activity. Angewandte Chemie (International ed. in English)\| PubMed ID: 22760863	2012
Improvement of drug-like properties of peptides: the somatostatin paradigm. Expert opinion on drug discovery\| PubMed ID: 22823205	2010
Behavior of primary human osteoblasts on trimmed and sandblasted Ti6Al4V surfaces functionalized with integrin αvβ3-selective cyclic RGD peptides. Journal of biomedical materials research. Part A\| PubMed ID: 22826207	2013
In support of the BMRB. Nature structural & molecular biology\| PubMed ID: 22955930	2012
The regulatory domain stabilizes the p53 tetramer by intersubunit contacts with the DNA binding domain. Journal of molecular biology\| PubMed ID: 23103206	2013
N-methylation of peptides and proteins: an important element for modulating biological functions. Angewandte Chemie (International ed. in English)\| PubMed ID: 23161799	2013
Orthogonally protected artificial amino acid as tripod ligand for automated peptide synthesis and labeling with [(99m)Tc(OH(2))(3)(CO)(3)](+). Bioconjugate chemistry\| PubMed ID: 23237229	2013
FOSL1 controls the assembly of endothelial cells into capillary tubes by direct repression of αv and β3 integrin transcription. Molecular and cellular biology\| PubMed ID: 23319049	2013
Functionalizing αvβ3- or α5β1-selective integrin antagonists for surface coating: a method to discriminate integrin subtypes in vitro. Angewandte Chemie (International ed. in English)\| PubMed ID: 23345131	2013
Biselectivity of isoDGR peptides for fibronectin binding integrin subtypes α5β1 and αvβ6: conformational control through flanking amino acids. Journal of medicinal chemistry\| PubMed ID: 23362923	2013
A cyclen-based tetraphosphinate chelator for the preparation of radiolabeled tetrameric bioconjugates. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 23613345	2013
Comparison of cyclic RGD peptides for αvβ3 integrin detection in a rat model of myocardial infarction. EJNMMI research\| PubMed ID: 23663426	2013
The glycophorin A transmembrane sequence within integrin αvβ3 creates a non-signaling integrin with low basal affinity that is strongly adhesive under force. Journal of molecular biology\| PubMed ID: 23727145	2013
A molecular toolkit for the functionalization of titanium-based biomaterials that selectively control integrin-mediated cell adhesion. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 23744802	2013
Hydrogel micropillars with integrin selective peptidomimetic functionalized nanopatterned tops: a new tool for the measurement of cell traction forces transmitted through αvβ3- or α5β1-integ... Advanced materials (Deerfield Beach, Fla.)\| PubMed ID: 23913640	2013
Tumor Targeting via Integrin Ligands. Frontiers in oncology\| PubMed ID: 24010121	2013
Integrin modulators: a patent review. Expert opinion on therapeutic patents\| PubMed ID: 24050747	2013
Selective imaging of the angiogenic relevant integrins α5β1 and αvβ3. Angewandte Chemie (International ed. in English)\| PubMed ID: 24115324	2013
The cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: A proof-of-concept study using the integrin-binding RGD motif. Chembiochem : a European journal of chemical biology\| PubMed ID: 24382674	2014
PET/CT imaging of integrin αvβ3 expression in human carotid atherosclerosis. JACC. Cardiovascular imaging\| PubMed ID: 24412187	2014
Investigation of early cell-surface interactions of human mesenchymal stem cells on nanopatterned β-type titanium-niobium alloy surfaces. Interface focus\| PubMed ID: 24501674	2014
Pharmacophoric modifications lead to superpotent αvβ3 integrin ligands with suppressed α5β1 activity. Journal of medicinal chemistry\| PubMed ID: 24654918	2014
Benefits of NOPO as chelator in gallium-68 peptides, exemplified by preclinical characterization of (68)Ga-NOPO-c(RGDfK). Molecular pharmaceutics\| PubMed ID: 24669840	2014
The integrin ligand c(RGDf(NMe)Nal) reduces neointimal hyperplasia in a polymer-free drug-eluting stent system. ChemMedChem\| PubMed ID: 24706601	2014
Single cell tracking assay reveals an opposite effect of selective small non-peptidic α5β1 or αvβ3/β5 integrin antagonists in U87MG glioma cells. Biochimica et biophysica acta\| PubMed ID: 24810979	2014
N-Methylated sst2 Selective Somatostatin Cyclic Peptide Analogue as a Potent Candidate for Treating Neurogenic Inflammation. ACS medicinal chemistry letters\| PubMed ID: 24900340	2011
Rational improvement of the affinity and selectivity of integrin binding of grafted lasso peptides. Journal of medicinal chemistry\| PubMed ID: 24949551	2014
Protein folding by interaction. Structure (London, England : 1993)\| PubMed ID: 25007223	2014
Cytoplasmic salt bridge formation in integrin αvß3 stabilizes its inactive state affecting integrin-mediated cell biological effects. Cellular signalling\| PubMed ID: 25041847	2014
Receptor-bound conformation of cilengitide better represented by its solution-state structure than the solid-state structure. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 25251673	2014
Direct prediction of residual dipolar couplings of small molecules in a stretched gel by stochastic molecular dynamics simulations. Magnetic resonance in chemistry : MRC\| PubMed ID: 25612077	2015
Mimicking bone extracellular matrix: integrin-binding peptidomimetics enhance osteoblast-like cells adhesion, proliferation, and differentiation on titanium. Colloids and surfaces. B, Biointerfaces\| PubMed ID: 25637448	2015
Interface Immobilization Chemistry of cRGD-based Peptides Regulates Integrin Mediated Cell Adhesion. Advanced functional materials\| PubMed ID: 25810710	2014
Disclosing the CXCR4 expression in lymphoproliferative diseases by targeted molecular imaging. Theranostics\| PubMed ID: 25825601	2015
Hsp90 regulates the dynamics of its cochaperone Sti1 and the transfer of Hsp70 between modules. Nature communications\| PubMed ID: 25851214	2015
Enantiomeric cyclic peptides with different Caco-2 permeability suggest carrier-mediated transport. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 25917866	2015
Segregation versus colocalization: orthogonally functionalized binary micropatterned substrates regulate the molecular distribution in focal adhesions. Advanced materials (Deerfield Beach, Fla.)\| PubMed ID: 25981929	2015
Systematic Backbone Conformational Constraints on a Cyclic Melanotropin Ligand Leads to Highly Selective Ligands for Multiple Melanocortin Receptors. Journal of medicinal chemistry\| PubMed ID: 26218460	2015
Minimal synthetic cells to study integrin-mediated adhesion. Angewandte Chemie (International ed. in English)\| PubMed ID: 26257266	2015
cis-Peptide Bonds: A Key for Intestinal Permeability of Peptides? . Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 26337831	2015
Caveolin-1-negative head and neck squamous cell carcinoma primary tumors display increased epithelial to mesenchymal transition and prometastatic properties. Oncotarget\| PubMed ID: 26474461	2015
In vivo biokinetic and metabolic characterization of the ⁶⁸Ga-labelled α5β1-selective peptidomimetic FR366. European journal of nuclear medicine and molecular imaging\| PubMed ID: 26497698	2016
Complementary, Selective PET Imaging of Integrin Subtypes α5β1 and αvβ3 Using 68Ga-Aquibeprin and 68Ga-Avebetrin. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 26635338	2016
Stable Peptides Instead of Stapled Peptides: Highly Potent αvβ6-Selective Integrin Ligands. Angewandte Chemie (International ed. in English)\| PubMed ID: 26663660	2016
Small Cause, Great Impact: Modification of the Guanidine Group in the RGD Motif Controls Integrin Subtype Selectivity. Angewandte Chemie (International ed. in English)\| PubMed ID: 26663700	2016
Substrate engagement of integrins α5β1 and αvβ3 is necessary, but not sufficient, for high directional persistence in migration on fibronectin. Scientific reports\| PubMed ID: 26987342	2016
Selective binding and lateral clustering of α5β1 and αvβ3 integrins: Unraveling the spatial requirements for cell spreading and focal adhesion assembly. Cell adhesion & migration\| PubMed ID: 27003228	2016
Non-invasive assessment of inter-and intrapatient variability of integrin expression in metastasized prostate cancer by PET. Oncotarget\| PubMed ID: 27058620	2016
The influence of different metal-chelate conjugates of pentixafor on the CXCR4 affinity. EJNMMI research\| PubMed ID: 27112767	2016
Variation of Specific Activities of 68Ga-Aquibeprin and 68Ga-Avebetrin Enables Selective PET Imaging of Different Expression Levels of Integrins α5β1 and αvβ3. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 27151985	2016
αvβ3- or α5β1-Integrin-Selective Peptidomimetics for Surface Coating. Angewandte Chemie (International ed. in English)\| PubMed ID: 27258759	2016
Rational Design of Cyclic Peptide Inhibitors of U2AF Homology Motif (UHM) Domains To Modulate Pre-mRNA Splicing. Journal of medicinal chemistry\| PubMed ID: 27753493	2016
Integrin-Targeted Hybrid Fluorescence Molecular Tomography/X-ray Computed Tomography for Imaging Tumor Progression and Early Response in Non-Small Cell Lung Cancer. Neoplasia (New York, N.Y.)\| PubMed ID: 27940248	2017
In Vivo PET Imaging of the Cancer Integrin αvβ6 Using (68)Ga-Labeled Cyclic RGD Nonapeptides. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 27980050	2017
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