Horst Kessler

Horst Kessler

Department of Chemistry, Technische Universität München

Affiliated withTechnische Universität München

Research Area

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JoVE Journal Publications

ArticleTotal : 1
Year
Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
Publication title

Cited by 2

2017

Other Publications

Article
Year
Solution structure and binding specificity of the p63 DNA binding domain.

Scientific reports| PubMed ID: 27225672

2016
2003
2003
2003
2004
2004
2004
Combination of an SRC kinase inhibitor with a novel pharmacological antagonist of the urokinase receptor diminishes in vitro colon cancer invasiveness.

Clinical cancer research : an official journal of the American Association for Cancer Research| PubMed ID: 14977859

2004
2004
2004
Activation of integrin function by nanopatterned adhesive interfaces.

Chemphyschem : a European journal of chemical physics and physical chemistry| PubMed ID: 15067875

2004
2004
Two-step methodology for high-yield routine radiohalogenation of peptides: (18)F-labeled RGD and octreotide analogs.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine| PubMed ID: 15136641

2004
First (18)F-labeled tracer suitable for routine clinical imaging of sst receptor-expressing tumors using positron emission tomography.

Clinical cancer research : an official journal of the American Association for Cancer Research| PubMed ID: 15173065

2004
2004
2004
A computational model of transmembrane integrin clustering.

Structure (London, England : 1993)| PubMed ID: 15274930

2004
Human integrin alphavbeta5: homology modeling and ligand binding.

Journal of medicinal chemistry| PubMed ID: 15293989

2004
2004
2004
2004
Improving implant materials by coating with nonpeptidic, highly specific integrin ligands.

Angewandte Chemie (International ed. in English)| PubMed ID: 15593169

2004
2005
2005
2005
2005
2005
2005
2005
2005
2005
2005
Diffusion NMR spectroscopy: folding and aggregation of domains in p53.

Chembiochem : a European journal of chemical biology| PubMed ID: 16138303

2005
Structure refinement of cyclosporin A in chloroform by using RDCs measured in a stretched PDMS-gel.

Chembiochem : a European journal of chemical biology| PubMed ID: 16138307

2005
Optimized selective N-methylation of peptides on solid support.

Journal of peptide science : an official publication of the European Peptide Society| PubMed ID: 16189816

2006
2005
3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors.

Bioorganic & medicinal chemistry letters| PubMed ID: 16236508

2006
Benzylprotected aromatic phosphonic acids for anchoring peptides on titanium.

Bioorganic & medicinal chemistry letters| PubMed ID: 16256349

2006
Photoswitched cell adhesion on surfaces with RGD peptides.

Journal of the American Chemical Society| PubMed ID: 16287297

2005
Molecular targeting with peptides or peptide-polymer conjugates: just a question of size?

Journal of nuclear medicine : official publication, Society of Nuclear Medicine| PubMed ID: 16330555

2005
2006
2006
Intrinsic inhibition of the Hsp90 ATPase activity.

The Journal of biological chemistry| PubMed ID: 16461354

2006
2006
2006
2006
Prokaryotic Kdp-ATPase: recent insights into the structure and function of KdpB.

Journal of molecular microbiology and biotechnology| PubMed ID: 16645309

2005
2006
2006
Synthesis and stereochemical assignment of DNA spore photoproduct analogues.

Chemistry (Weinheim an der Bergstrasse, Germany)| PubMed ID: 16789031

2006
2006
Positron emission tomography using [18F]Galacto-RGD identifies the level of integrin alpha(v)beta3 expression in man.

Clinical cancer research : an official journal of the American Association for Cancer Research| PubMed ID: 16818691

2006
2006
2006
p53--a natural cancer killer: structural insights and therapeutic concepts.

Angewandte Chemie (International ed. in English)| PubMed ID: 16983711

2006
2006
2007
N-methylated cyclic pentaalanine peptides as template structures.

Journal of the American Chemical Society| PubMed ID: 17117868

2006
2007
2007
2007
2007
2007
2007
2007
2007
2007
2007
Design and chemical synthesis of integrin ligands.

Methods in enzymology| PubMed ID: 17697896

2007
Specific integrin labeling in living cells using functionalized nanocrystals.

Small (Weinheim an der Bergstrasse, Germany)| PubMed ID: 17705315

2007
2008
2007
Multiple N-methylation by a designed approach enhances receptor selectivity.

Journal of medicinal chemistry| PubMed ID: 17973471

2007
Conformational preference and potential templates of N-methylated cyclic pentaalanine peptides.

Chemistry (Weinheim an der Bergstrasse, Germany)| PubMed ID: 18080261

2008
2008
Improving oral bioavailability of peptides by multiple N-methylation: somatostatin analogues.

Angewandte Chemie (International ed. in English)| PubMed ID: 18297660

2008
Phosphorus NMR spectroscopy as a versatile tool for compound library screening.

Angewandte Chemie (International ed. in English)| PubMed ID: 18311739

2008
2008
The CLIP/CLAP-HSQC: pure absorptive spectra for the measurement of one-bond couplings.

Journal of magnetic resonance (San Diego, Calif. : 1997)| PubMed ID: 18411067

2008
2008
2008
Rational design of highly active and selective ligands for the alpha5beta1 integrin receptor.

Chembiochem : a European journal of chemical biology| PubMed ID: 18481343

2008
2008
2008
N-methylation of peptides: a new perspective in medicinal chemistry.

Accounts of chemical research| PubMed ID: 18636716

2008
2008
The structure of a folding intermediate provides insight into differences in immunoglobulin amyloidogenicity.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 18768806

2008
2008
Can N-methylated amino acids serve as substitutes for prolines in conformational design of cyclic pentapeptides?

Journal of peptide science : an official publication of the European Peptide Society| PubMed ID: 18985637

2009
Deuterated polymer gels for measuring anisotropic NMR parameters with strongly reduced artefacts.

Chemical communications (Cambridge, England)| PubMed ID: 19009060

2008
The state of the art of chemical biology.

Chembiochem : a European journal of chemical biology| PubMed ID: 19115274

2009
Perspectives on NMR in drug discovery: a technique comes of age.

Nature reviews. Drug discovery| PubMed ID: 19172689

2008
2009
2009
2009
2009
N-methylated cyclic pentapeptides as template structures.

Advances in experimental medicine and biology| PubMed ID: 19400115

2009
2009
2009
Highly selective cyclic hexapeptides antagonist of GPIIb-IIIa by multiple N-methylation.

Advances in experimental medicine and biology| PubMed ID: 19400163

2009
New perspective in peptide chemistry by N-alkylation.

Advances in experimental medicine and biology| PubMed ID: 19400173

2009
2009
2009
Ligands for mapping alphavbeta3-integrin expression in vivo.

Accounts of chemical research| PubMed ID: 19489579

2009
2009
2009
The transmembrane structure of integrin alphaIIbbeta3: significance for signal transduction.

Angewandte Chemie (International ed. in English)| PubMed ID: 19598189

2009
2009
2010
2010
The impact of amino acid side chain mutations in conformational design of peptides and proteins.

Chemistry (Weinheim an der Bergstrasse, Germany)| PubMed ID: 20358563

2010
2010
2010
2010
Polymeric substrates with tunable elasticity and nanoscopically controlled biomolecule presentation.

Langmuir : the ACS journal of surfaces and colloids| PubMed ID: 20831282

2010
Conformational control of integrin-subtype selectivity in isoDGR peptide motifs: a biological switch.

Angewandte Chemie (International ed. in English)| PubMed ID: 20957712

2010
2010
Stimulation of cell adhesion at nanostructured teflon interfaces.

Advanced materials (Deerfield Beach, Fla.)| PubMed ID: 20972983

2010
2011
NCO-sP(EO-stat-PO) surface coatings preserve biochemical properties of RGD peptides.

International journal of molecular medicine| PubMed ID: 21069259

2011
Stable functionalized PEGylated quantum dots micelles with a controlled stoichiometry.

Chemical communications (Cambridge, England)| PubMed ID: 21103558

2011
2010
2011
2011
PET Imaging of Integrin αVβ3 Expression.

Theranostics| PubMed ID: 21547152

2011
2009
2011
2011
2011
2011
2011
Increasing αvβ3 selectivity of the anti-angiogenic drug cilengitide by N-methylation.

Angewandte Chemie (International ed. in English)| PubMed ID: 21948451

2011
PET of CXCR4 expression by a (68)Ga-labeled highly specific targeted contrast agent.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine| PubMed ID: 22045709

2011
Synthesis and conformational analysis of efrapeptins.

Chemistry (Weinheim an der Bergstrasse, Germany)| PubMed ID: 22147615

2012
2012
2011
2012
2012
Synthesis of N-methylated cyclic peptides.

Nature protocols| PubMed ID: 22322216

2012
2012
2012
Cyclic aza-peptide integrin ligand synthesis and biological activity.

The Journal of organic chemistry| PubMed ID: 22582818

2012
2012
2012
Intestinal permeability of cyclic peptides: common key backbone motifs identified.

Journal of the American Chemical Society| PubMed ID: 22737969

2012
A conformationally frozen peptoid boosts CXCR4 affinity and anti-HIV activity.

Angewandte Chemie (International ed. in English)| PubMed ID: 22760863

2012
Improvement of drug-like properties of peptides: the somatostatin paradigm.

Expert opinion on drug discovery| PubMed ID: 22823205

2010
2013
In support of the BMRB.

Nature structural & molecular biology| PubMed ID: 22955930

2012
2013
N-methylation of peptides and proteins: an important element for modulating biological functions.

Angewandte Chemie (International ed. in English)| PubMed ID: 23161799

2013
2013
2013
2013
2013
A cyclen-based tetraphosphinate chelator for the preparation of radiolabeled tetrameric bioconjugates.

Chemistry (Weinheim an der Bergstrasse, Germany)| PubMed ID: 23613345

2013
2013
2013
2013
2013
Tumor Targeting via Integrin Ligands.

Frontiers in oncology| PubMed ID: 24010121

2013
Integrin modulators: a patent review.

Expert opinion on therapeutic patents| PubMed ID: 24050747

2013
Selective imaging of the angiogenic relevant integrins α5β1 and αvβ3.

Angewandte Chemie (International ed. in English)| PubMed ID: 24115324

2013
2014
2014
2014
2014
2014
2014
2014
2011
2014
Protein folding by interaction.

Structure (London, England : 1993)| PubMed ID: 25007223

2014
2014
2014
2015
2015
2014
2015
2015
Enantiomeric cyclic peptides with different Caco-2 permeability suggest carrier-mediated transport.

Chemistry (Weinheim an der Bergstrasse, Germany)| PubMed ID: 25917866

2015
2015
2015
Minimal synthetic cells to study integrin-mediated adhesion.

Angewandte Chemie (International ed. in English)| PubMed ID: 26257266

2015
cis-Peptide Bonds: A Key for Intestinal Permeability of Peptides? .

Chemistry (Weinheim an der Bergstrasse, Germany)| PubMed ID: 26337831

2015
2015
In vivo biokinetic and metabolic characterization of the ⁶⁸Ga-labelled α5β1-selective peptidomimetic FR366.

European journal of nuclear medicine and molecular imaging| PubMed ID: 26497698

2016
Complementary, Selective PET Imaging of Integrin Subtypes α5β1 and αvβ3 Using 68Ga-Aquibeprin and 68Ga-Avebetrin.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine| PubMed ID: 26635338

2016
Stable Peptides Instead of Stapled Peptides: Highly Potent αvβ6-Selective Integrin Ligands.

Angewandte Chemie (International ed. in English)| PubMed ID: 26663660

2016
2016
2016
2016
2016
2016
2016
αvβ3- or α5β1-Integrin-Selective Peptidomimetics for Surface Coating.

Angewandte Chemie (International ed. in English)| PubMed ID: 27258759

2016
2016
2017
In Vivo PET Imaging of the Cancer Integrin αvβ6 Using (68)Ga-Labeled Cyclic RGD Nonapeptides.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine| PubMed ID: 27980050

2017
2017