Isabel Varela-Nieto

Instituto de Investigaciones Biomédicas (IIBm) Alberto Sols CSIC-UAM

Affiliated withInstituto de Investigaciones Biomédicas (IIBm) Alberto Sols CSIC-UAM Instituto de Salud Carlos III (ISCIII)Instituto de Investigación Sanitaria La Paz (IdiPAZ)

Research Area

Biology

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 15	2017

Other Publications

Article	Year
Serum deprivation increases ceramide levels and induces apoptosis in undifferentiated HN9.10e cells. Neurochemistry international\| PubMed ID: 11792463	2002
Liver cell proliferation requires methionine adenosyltransferase 2A mRNA up-regulation. Hepatology (Baltimore, Md.)\| PubMed ID: 12029623	2002
Cochlear abnormalities in insulin-like growth factor-1 mouse mutants. Hearing research\| PubMed ID: 12208536	2002
Expression and function of phospholipase A(2) in brain. FEBS letters\| PubMed ID: 12401195	2002
Programmed cell death in the developing inner ear is balanced by nerve growth factor and insulin-like growth factor I. Journal of cell science\| PubMed ID: 12508109	2003
Cell death in the nervous system: lessons from insulin and insulin-like growth factors. Molecular neurobiology\| PubMed ID: 14514984	2003
Growth factors and early development of otic neurons: interactions between intrinsic and extrinsic signals. Current topics in developmental biology\| PubMed ID: 14674481	2003
Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis. The Journal of clinical investigation\| PubMed ID: 15067322	2004
Jejunal microvilli atrophy and reduced nutrient transport in rats with advanced liver cirrhosis: improvement by Insulin-like Growth Factor I. BMC gastroenterology\| PubMed ID: 15196310	2004
Hematotesticular barrier is altered from early stages of liver cirrhosis: effect of insulin-like growth factor 1. World journal of gastroenterology\| PubMed ID: 15300898	2004
Trophic effects of insulin-like growth factor-I (IGF-I) in the inner ear. Hearing research\| PubMed ID: 15464297	2004
Phosphorylation of glycosyl-phosphatidylinositol by phosphatidylinositol 3-kinase changes its properties as a substrate for phospholipases. FEBS letters\| PubMed ID: 15620691	2005
Regulation of vertebrate sensory organ development: a scenario for growth hormone and insulin-like growth factors action. Advances in experimental medicine and biology\| PubMed ID: 16370141	2005
Anti-apoptotic actions of insulin-like growth factors: lessons from development and implications in neoplastic cell transformation. Current pharmaceutical design\| PubMed ID: 17346184	2007
A network of growth and transcription factors controls neuronal differentation and survival in the developing ear. The International journal of developmental biology\| PubMed ID: 17891717	2007
Spatial and temporal segregation of auditory and vestibular neurons in the otic placode. Developmental biology\| PubMed ID: 18674529	2008
RasGRF1 disruption causes retinal photoreception defects and associated transcriptomic alterations. Journal of neurochemistry\| PubMed ID: 19457086	2009
Melanin precursors prevent premature age-related and noise-induced hearing loss in albino mice. Pigment cell & melanoma research\| PubMed ID: 19843244	2010
Direct drug application to the round window: a comparative study of ototoxicity in rats. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery\| PubMed ID: 19861195	2009
RNA microarray analysis in prenatal mouse cochlea reveals novel IGF-I target genes: implication of MEF2 and FOXM1 transcription factors. PloS one\| PubMed ID: 20111592	2010
European scientific, ethical, and legal issues on human stem cell research and regenerative medicine. Stem cells (Dayton, Ohio)\| PubMed ID: 20533567	2010
A comparative study of age-related hearing loss in wild type and insulin-like growth factor I deficient mice. Frontiers in neuroanatomy\| PubMed ID: 20661454	2010
RAF kinase activity regulates neuroepithelial cell proliferation and neuronal progenitor cell differentiation during early inner ear development. PloS one\| PubMed ID: 21203386	2010
The role of insulin-like growth factor-I in the physiopathology of hearing. Frontiers in molecular neuroscience\| PubMed ID: 21845174	2011
Insulin receptor substrate 2 (IRS2)-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function. Molecular medicine (Cambridge, Mass.)\| PubMed ID: 22160220	2012
Drug delivery to the inner ear: strategies and their therapeutic implications for sensorineural hearing loss. Current drug delivery\| PubMed ID: 22283653	2012
AKT signaling mediates IGF-I survival actions on otic neural progenitors. PloS one\| PubMed ID: 22292041	2012
Early development of the vertebrate inner ear. Anatomical record (Hoboken, N.J. : 2007)\| PubMed ID: 23044927	2012
IGF-I deficiency and hearing loss: molecular clues and clinical implications. Pediatric endocrinology reviews : PER\| PubMed ID: 23957197	2013
Programmed cell senescence during mammalian embryonic development. Cell\| PubMed ID: 24238962	2013
Treatment with N- and C-terminal peptides of parathyroid hormone-related protein partly compensate the skeletal abnormalities in IGF-I deficient mice. PloS one\| PubMed ID: 24503961	2014
Autophagy during vertebrate development. Cells\| PubMed ID: 24710484	2012
Loss of lysophosphatidic acid receptor LPA1 alters oligodendrocyte differentiation and myelination in the mouse cerebral cortex. Brain structure & function\| PubMed ID: 25226845	2015
Differential organ phenotypes after postnatal Igf1r gene conditional deletion induced by tamoxifen in UBC-CreERT2; Igf1r fl/fl double transgenic mice. Transgenic research\| PubMed ID: 25238791	2015
Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 25384423	2015
Targeting cholesterol homeostasis to fight hearing loss: a new perspective. Frontiers in aging neuroscience\| PubMed ID: 25688206	2015
Swept-sine noise-induced damage as a hearing loss model for preclinical assays. Frontiers in aging neuroscience\| PubMed ID: 25762930	2015
Transforming growth factor β1 inhibition protects from noise-induced hearing loss. Frontiers in aging neuroscience\| PubMed ID: 25852546	2015
C-Raf deficiency leads to hearing loss and increased noise susceptibility. Cellular and molecular life sciences : CMLS\| PubMed ID: 25975225	2015
Corrigendum: Transforming growth factor β1 inhibition protects from noise-induced hearing loss. Frontiers in aging neuroscience\| PubMed ID: 26005416	2015
Corrigendum to: Swept-sine noise-induced damage as a hearing loss model for preclinical assays. Frontiers in aging neuroscience\| PubMed ID: 26029100	2015
Age-regulated function of autophagy in the mouse inner ear. Hearing research\| PubMed ID: 26235979	2015
Editorial: Aging, neurogenesis and neuroinflammation in hearing loss and protection. Frontiers in aging neuroscience\| PubMed ID: 26236234	2015
Long-term omega-3 fatty acid supplementation prevents expression changes in cochlear homocysteine metabolism and ameliorates progressive hearing loss in C57BL/6J mice. The Journal of nutritional biochemistry\| PubMed ID: 26321228	2015
Comparative gene expression study of the vestibular organ of the Igf1 deficient mouse using whole-transcript arrays. Hearing research\| PubMed ID: 26341476	2015
Public investment in biomedical research in Europe. Lancet (London, England)\| PubMed ID: 26460768	2015
Mild cognitive decline. A position statement of the Cognitive Decline Group of the European Innovation Partnership for Active and Healthy Ageing (EIPAHA). Maturitas\| PubMed ID: 26520249	2016
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy\| PubMed ID: 26799652	2016
Wbp2 is required for normal glutamatergic synapses in the cochlea and is crucial for hearing. EMBO molecular medicine\| PubMed ID: 26881968	2016
Frailty in mouse ageing: A conceptual approach. Mechanisms of ageing and development\| PubMed ID: 27443148	2016
Autophagy resolves early retinal inflammation in Igf1-deficient mice. Disease models & mechanisms\| PubMed ID: 27483352	2016
Long-Term Dietary Folate Deficiency Accelerates Progressive Hearing Loss on CBA/Ca Mice. Frontiers in aging neuroscience\| PubMed ID: 27630560	2016