Martin Hauer-Jensen

Division of Radiation Health, University of Arkansas for Medical Sciences

Affiliated withUniversity of Arkansas for Medical Sciences Central Arkansas Veterans Healthcare System

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 3	2016
Publication title Cited by 5	2017

Other Publications

Article	Year
Short-term inhibition of ADP-induced platelet aggregation by clopidogrel ameliorates radiation-induced toxicity in rat small intestine. Thrombosis and haemostasis\| PubMed ID: 11848440	2002
Deficiency of microvascular thrombomodulin and up-regulation of protease-activated receptor-1 in irradiated rat intestine: possible link between endothelial dysfunction and chronic radiation... The American journal of pathology\| PubMed ID: 12057911	2002
The radiotherapeutic injury--a complex 'wound'. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology\| PubMed ID: 12063002	2002
Clinical significance of increased gelatinolytic activity in the rectal mucosa during external beam radiation therapy of prostate cancer. International journal of radiation oncology, biology, physics\| PubMed ID: 12095558	2002
Hyperhomocysteinemia leads to adverse cardiac remodeling in hypertensive rats. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 12388235	2002
Alterations in endothelial thrombomodulin expression in zymosan-induced lung injury. The Journal of trauma\| PubMed ID: 12707536	2003
Hyperhomocysteinemia leads to pathological ventricular hypertrophy in normotensive rats. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 12730062	2003
Normal tissue effects: reporting and analysis. Seminars in radiation oncology\| PubMed ID: 12903009	2003
Bowel injury: current and evolving management strategies. Seminars in radiation oncology\| PubMed ID: 12903023	2003
Statins increase thrombomodulin expression and function in human endothelial cells by a nitric oxide-dependent mechanism and counteract tumor necrosis factor alpha-induced thrombomodulin dow... Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis\| PubMed ID: 12960612	2003
Up-regulation and activation of proteinase-activated receptor 2 in early and delayed radiation injury in the rat intestine: influence of biological activators of proteinase-activated recepto... Radiation research\| PubMed ID: 14565830	2003
Gastrointestinal mucositis. Seminars in oncology nursing\| PubMed ID: 15038516	2004
Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer\| PubMed ID: 15108222	2004
Radiation injury and the protein C pathway. Critical care medicine\| PubMed ID: 15118539	2004
Cardiac function in hearts isolated from a rat model deficient in mast cells. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 15388501	2005
Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003. Radiation research\| PubMed ID: 15548121	2004
Protective role of mast cells in homocysteine-induced cardiac remodeling. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 15591099	2005
Influence of mast cells on structural and functional manifestations of radiation-induced heart disease. Cancer research\| PubMed ID: 15833839	2005
Modulation of the intestinal response to ionizing radiation by anticoagulant and non-anticoagulant heparins. Thrombosis and haemostasis\| PubMed ID: 16366003	2005
Comparative expression profiling in primary and immortalized endothelial cells: changes in gene expression in response to hydroxy methylglutaryl-coenzyme A reductase inhibition. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis\| PubMed ID: 16575254	2006
Regulation of early and delayed radiation responses in rat small intestine by capsaicin-sensitive nerves. International journal of radiation oncology, biology, physics\| PubMed ID: 16580503	2006
Acute dilatory and negative inotropic effects of homocysteine are inhibited by an adenosine blocker. Clinical and experimental pharmacology & physiology\| PubMed ID: 16620298	2006
Calcitonin gene-related peptide and substance P regulate the intestinal radiation response. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 16818712	2006
Orazipone, a locally acting immunomodulator, ameliorates intestinal radiation injury: a preclinical study in a novel rat model. International journal of radiation oncology, biology, physics\| PubMed ID: 16965997	2006
Comparison of mortality rates in statin users versus nonstatin users in a United States veteran population. The American journal of cardiology\| PubMed ID: 16996875	2006
Radiation responses in skin and connective tissues: effect on wound healing and surgical outcome. Hernia : the journal of hernias and abdominal wall surgery\| PubMed ID: 17047884	2006
Influence of mast cells on outcome after heterotopic cardiac transplantation in rats. Transplant international : official journal of the European Society for Organ Transplantation\| PubMed ID: 17291219	2007
Significance of endothelial dysfunction in the pathogenesis of early and delayed radiation enteropathy. World journal of gastroenterology\| PubMed ID: 17589919	2007
Long-term prognosis in patients with severe late radiation enteropathy: a prospective cohort study. World journal of gastroenterology\| PubMed ID: 17659712	2007
Simvastatin ameliorates radiation enteropathy development after localized, fractionated irradiation by a protein C-independent mechanism. International journal of radiation oncology, biology, physics\| PubMed ID: 17674978	2007
Local administration of interleukin-11 ameliorates intestinal radiation injury in rats. Cancer research\| PubMed ID: 17909060	2007
Inactivation of thrombomodulin by ionizing radiation in a cell-free system: possible implications for radiation responses in vascular endothelium. Radiation research\| PubMed ID: 18363428	2008
Protection from adverse myocardial remodeling secondary to chronic volume overload in mast cell deficient rats. Journal of molecular and cellular cardiology\| PubMed ID: 18538342	2008
Involvement of heat shock factor 1 in statin-induced transcriptional upregulation of endothelial thrombomodulin. Circulation research\| PubMed ID: 18599869	2008
Prevention and treatment of functional and structural radiation injury in the rat heart by pentoxifylline and alpha-tocopherol. International journal of radiation oncology, biology, physics\| PubMed ID: 18632215	2008
Radiation damage to the gastrointestinal tract: mechanisms, diagnosis, and management. Current opinion in supportive and palliative care\| PubMed ID: 18660720	2007
Lactate stimulates vasculogenic stem cells via the thioredoxin system and engages an autocrine activation loop involving hypoxia-inducible factor 1. Molecular and cellular biology\| PubMed ID: 18710947	2008
Influence of endothelin 1 receptor inhibition on functional, structural and molecular changes in the rat heart after irradiation. Radiation research\| PubMed ID: 18763854	2008
Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis\| PubMed ID: 18832915	2008
Hyperbaric oxygen stimulates vasculogenic stem cell growth and differentiation in vivo. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 19023021	2009
Impact of vascular endothelial growth factor on skin graft survival in irradiated rats. Archives of facial plastic surgery\| PubMed ID: 19289683	2009
Determination of sample sizes for demonstrating efficacy of radiation countermeasures. Biometrics\| PubMed ID: 19432769	2010
Gamma-tocotrienol, a tocol antioxidant as a potent radioprotector. International journal of radiation biology\| PubMed ID: 19557601	2009
The somatostatin analog SOM230 (pasireotide) ameliorates injury of the intestinal mucosa and increases survival after total-body irradiation by inhibiting exocrine pancreatic secretion. Radiation research\| PubMed ID: 19580476	2009
gamma-Tocotrienol ameliorates intestinal radiation injury and reduces vascular oxidative stress after total-body irradiation by an HMG-CoA reductase-dependent mechanism. Radiation research\| PubMed ID: 19580495	2009
Oral PEG 15-20 protects the intestine against radiation: role of lipid rafts. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 19833862	2009
Selective deficiency of HIF-1alpha in myeloid cells influences secondary intention wound healing in mouse skin. In vivo (Athens, Greece)\| PubMed ID: 20023228	2009
Defining pelvic-radiation disease for the survivorship era. The Lancet. Oncology\| PubMed ID: 20149738	2010
Influence of sublethal total-body irradiation on immune cell populations in the intestinal mucosa. Radiation research\| PubMed ID: 20334519	2010
Animal models for medical countermeasures to radiation exposure. Radiation research\| PubMed ID: 20334528	2010
Sublethal total body irradiation leads to early cerebellar damage and oxidative stress. Current neurovascular research\| PubMed ID: 20334614	2010
Gamma-tocotrienol protects hematopoietic stem and progenitor cells in mice after total-body irradiation. Radiation research\| PubMed ID: 20518653	2010
Hematological targets of radiation damage. Current drug targets\| PubMed ID: 20583980	2010
Novel strategies to ameliorate radiation injury: a possible role for tetrahydrobiopterin. Current drug targets\| PubMed ID: 20583982	2010
Targets of potential radioprotective drugs. Current drug targets\| PubMed ID: 20583983	2010
Activation of protease activated receptor 2 by exogenous agonist exacerbates early radiation injury in rat intestine. International journal of radiation oncology, biology, physics\| PubMed ID: 20610041	2010
Skin graft take rates, granulation, and epithelialization: dependence on myeloid cell hypoxia-inducible factor 1alpha. Archives of otolaryngology--head & neck surgery\| PubMed ID: 20644069	2010
Reduction of radiation-induced vascular nitrosative stress by the vitamin E analog γ-tocotrienol: evidence of a role for tetrahydrobiopterin. International journal of radiation oncology, biology, physics\| PubMed ID: 20950957	2011
Decreasing the adverse effects of cancer therapy: National Cancer Institute guidance for the clinical development of radiation injury mitigators. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 21047979	2011
"Pelvic radiation disease": new understanding and new solutions for a new disease in the era of cancer survivorship. Scandinavian journal of gastroenterology\| PubMed ID: 21189094	2011
Development of a combined radiation and burn injury model. Journal of burn care & research : official publication of the American Burn Association\| PubMed ID: 21233728	2011
Pentoxifylline enhances the radioprotective properties of γ-tocotrienol: differential effects on the hematopoietic, gastrointestinal and vascular systems. Radiation research\| PubMed ID: 21388273	2011
IKKÎ² regulates the repair of DNA double-strand breaks induced by ionizing radiation in MCF-7 breast cancer cells. PloS one\| PubMed ID: 21490922	2011
Mechanisms underlying the radioprotective properties of γ-tocotrienol: comparative gene expression profiling in tocol-treated endothelial cells. Genes & nutrition\| PubMed ID: 21516479	2012
Preclinical evaluation of Som230 as a radiation mitigator in a mouse model: postexposure time window and mechanisms of action. Radiation research\| PubMed ID: 21529145	2011
Epithelial to mesenchymal transition (EMT) induced by bleomycin or TFG(b1)/EGF in murine induced pluripotent stem cell-derived alveolar Type II-like cells. Differentiation; research in biological diversity\| PubMed ID: 21596473	2011
Literature review and global consensus on management of acute radiation syndrome affecting nonhematopoietic organ systems. Disaster medicine and public health preparedness\| PubMed ID: 21986999	2011
First global consensus for evidence-based management of the hematopoietic syndrome resulting from exposure to ionizing radiation. Disaster medicine and public health preparedness\| PubMed ID: 21987000	2011
Î³-Tocotrienol protects against mitochondrial dysfunction and renal cell death. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 22040679	2012
Novel drugs to ameliorate gastrointestinal normal tissue radiation toxicity in clinical practice: what is emerging from the laboratory? Current opinion in supportive and palliative care\| PubMed ID: 22228028	2012
Statistical analysis of survival data from radiation countermeasure experiments. Radiation research\| PubMed ID: 22401302	2012
Procalcitonin as a predictive biomarker for total body irradiation-induced bacterial load and lethality in mice. Shock (Augusta, Ga.)\| PubMed ID: 22576002	2012
Inhibition of protease-activated receptor 1 ameliorates intestinal radiation mucositis in a preclinical rat model. International journal of radiation oncology, biology, physics\| PubMed ID: 22580123	2013
Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity. Nature medicine\| PubMed ID: 22729286	2012
Cardiac inflammation after local irradiation is influenced by the kallikrein-kinin system. Cancer research\| PubMed ID: 22865451	2012
Gamma-tocotrienol, a radiation prophylaxis agent, induces high levels of granulocyte colony-stimulating factor. International immunopharmacology\| PubMed ID: 23000517	2012
BMS-345541 sensitizes MCF-7 breast cancer cells to ionizing radiation by selective inhibition of homologous recombinational repair of DNA double-strand breaks. Radiation research\| PubMed ID: 23259762	2013
Laser capture microdissected mucosa versus whole tissue specimens for assessment of radiation-induced dynamic molecular and pathway changes in the small intestine. PloS one\| PubMed ID: 23341980	2013
Metabolomic changes in gastrointestinal tissues after whole body radiation in a murine model. Molecular bioSystems\| PubMed ID: 23403731	2013
Mobilization of progenitor cells into peripheral blood by gamma-tocotrienol: a promising radiation countermeasure. International immunopharmacology\| PubMed ID: 23415908	2013
Effects of radiation on the epidermal growth factor receptor pathway in the heart. International journal of radiation biology\| PubMed ID: 23488537	2013
Characterization of transgenic Gfrp knock-in mice: implications for tetrahydrobiopterin in modulation of normal tissue radiation responses. Antioxidants & redox signaling\| PubMed ID: 23521531	2014
PARP1 is required for chromosomal translocations. Blood\| PubMed ID: 23568489	2013
Effects of late administration of pentoxifylline and tocotrienols in an image-guided rat model of localized heart irradiation. PloS one\| PubMed ID: 23894340	2013
Combined radiation and burn injury results in exaggerated early pulmonary inflammation. Radiation research\| PubMed ID: 23899376	2013
Pharmacological induction of transforming growth factor-beta1 in rat models enhances radiation injury in the intestine and the heart. PloS one\| PubMed ID: 23936211	2013
Gamma tocotrienol, a potent radioprotector, preferentially upregulates expression of anti-apoptotic genes to promote intestinal cell survival. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association\| PubMed ID: 23941772	2013
Luis Felipe Fajardo L-G, MD, 1927-2013. Radiation research\| PubMed ID: 23964607	2013
A novel technique for image-guided local heart irradiation in the rat. Technology in cancer research & treatment\| PubMed ID: 24000983	2014
Radiation induced bowel injury: a neglected problem. Lancet (London, England)\| PubMed ID: 24067489	2013
Practical advice on calculating confidence intervals for radioprotection effects and reducing animal numbers in radiation countermeasure experiments. Radiation research\| PubMed ID: 24164553	2013
Oral interleukin 11 as a countermeasure to lethal total-body irradiation in a murine model. Radiation research\| PubMed ID: 24219324	2013
Roles of sensory nerves in the regulation of radiation-induced structural and functional changes in the heart. International journal of radiation oncology, biology, physics\| PubMed ID: 24331664	2014
Ionizing radiation-induced responses: where free radical chemistry meets redox biology and medicine. Antioxidants & redox signaling\| PubMed ID: 24354361	2014
Radiation-induced alterations in mitochondria of the rat heart. Radiation research\| PubMed ID: 24568130	2014
Bone marrow transplantation helps restore the intestinal mucosal barrier after total body irradiation in mice. Radiation research\| PubMed ID: 24568131	2014
Toward development of interleukin-11 as a medical countermeasure for use in radiological/nuclear emergencies. Digestive diseases and sciences\| PubMed ID: 24591015	2014
Radiation lethality potentiation in total body irradiated mice by a commonly prescribed proton pump inhibitor, Pantoprazole sodium. International journal of radiation biology\| PubMed ID: 24646079	2014
Molecular dynamics guided design of tocoflexol: a new radioprotectant tocotrienol with enhanced bioavailability. Drug development research\| PubMed ID: 24648045	2014
Radiation enteropathy--pathogenesis, treatment and prevention. Nature reviews. Gastroenterology & hepatology\| PubMed ID: 24686268	2014
C/EBPδ deficiency sensitizes mice to ionizing radiation-induced hematopoietic and intestinal injury. PloS one\| PubMed ID: 24747529	2014
Liver metabolomics reveals increased oxidative stress and fibrogenic potential in gfrp transgenic mice in response to ionizing radiation. Journal of proteome research\| PubMed ID: 24824572	2014
Palmitoylethanolamide regulates development of intestinal radiation injury in a mast cell-dependent manner. Digestive diseases and sciences\| PubMed ID: 24848354	2014
Synergistic radioprotection by gamma-tocotrienol and pentoxifylline: role of cAMP signaling. ISRN radiology\| PubMed ID: 24959559	2013
Whole-body proton irradiation causes long-term damage to hematopoietic stem cells in mice. Radiation research\| PubMed ID: 25635345	2015
A tocotrienol-enriched formulation protects against radiation-induced changes in cardiac mitochondria without modifying late cardiac function or structure. Radiation research\| PubMed ID: 25710576	2015
Thrombomodulin contributes to gamma tocotrienol-mediated lethality protection and hematopoietic cell recovery in irradiated mice. PloS one\| PubMed ID: 25860286	2015
In Vitro Toxicity and Epigenotoxicity of Different Types of Ambient Particulate Matter. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 26342214	2015
Tocotrienol-Rich Fraction from Rice Bran Demonstrates Potent Radiation Protection Activity. Evidence-based complementary and alternative medicine : eCAM\| PubMed ID: 26425129	2015
Novel Use of Proteomic Profiles in a Convex-Hull Ensemble Classifier to Predict Gynecological Cancer Patients' Susceptibility to Gastrointestinal Mucositis as Side Effect of Radiation Therap... Journal of proteomics & bioinformatics\| PubMed ID: 26430350	2015
Total Body Irradiation in the "Hematopoietic" Dose Range Induces Substantial Intestinal Injury in Non-Human Primates. Radiation research\| PubMed ID: 26495870	2015
Combined exposure to protons and (56)Fe leads to overexpression of Il13 and reactivation of repetitive elements in the mouse lung. Life sciences in space research\| PubMed ID: 26553631	2015
Use of biomarkers for assessing radiation injury and efficacy of countermeasures. Expert review of molecular diagnostics\| PubMed ID: 26568096	2016
Gene expression profiling in non-human primate jejunum, ileum and colon after total-body irradiation: a comparative study of segment-specific molecular and cellular responses. BMC genomics\| PubMed ID: 26589571	2015
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice. Nature medicine\| PubMed ID: 26657143	2016
EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair. PLoS genetics\| PubMed ID: 26684013	2015
Segmental Differences in Radiation-Induced Alterations of Tight Junction-Related Proteins in Non-Human Primate Jejunum, Ileum and Colon. Radiation research\| PubMed ID: 26720804	2016
Space radiation and cardiovascular disease risk. World journal of cardiology\| PubMed ID: 26730293	2015
Timing of the loss of Pten protein determines disease severity in a mouse model of myeloid malignancy. Blood\| PubMed ID: 26764354	2016
Particle Beam may have Higher Effectiveness in Treating Chemo-resistant Cancers than Low-LET Photon Beam Therapy. Research & reviews, journal of pharmacy and pharmaceutical sciences\| PubMed ID: 26779544	2015
Modulation of Radiation Response by the Tetrahydrobiopterin Pathway. Antioxidants (Basel, Switzerland)\| PubMed ID: 26785338	2015
James William Osborne, PhD 1928-2015. Radiation research\| PubMed ID: 26890300	2016
Radioprotective Efficacy of Gamma-Tocotrienol in Nonhuman Primates. Radiation research\| PubMed ID: 26930378	2016
A priming dose of protons alters the early cardiac cellular and molecular response to (56)Fe irradiation. Life sciences in space research\| PubMed ID: 26948008	2016
A Quantitative Proteomic Analysis of Urine from Gamma-Irradiated Non-Human Primates. Journal of proteomics & bioinformatics\| PubMed ID: 26962295	2016
Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart. Mutation research\| PubMed ID: 26963372	2016
Gamma-Tocotrienol Modulates Radiation-Induced MicroRNA Expression in Mouse Spleen. Radiation research\| PubMed ID: 27128741	2016
γ-Tocotrienol as a Promising Countermeasure for Acute Radiation Syndrome: Current Status. International journal of molecular sciences\| PubMed ID: 27153057	2016
The Vitamin E Analog Gamma-Tocotrienol (GT3) Suppresses Radiation-Induced Cytogenetic Damage. Pharmaceutical research\| PubMed ID: 27216753	2016
Low Doses of Oxygen Ion Irradiation Cause Acute Damage to Hematopoietic Cells in Mice. PloS one\| PubMed ID: 27367604	2016
Densely ionizing radiation affects DNA methylation of selective LINE-1 elements. Environmental research\| PubMed ID: 27419368	2016
Recombinant Thrombomodulin (Solulin) Ameliorates Early Intestinal Radiation Toxicity in a Preclinical Rat Model. Radiation research\| PubMed ID: 27459702	2016
Minipigs as models in drug discovery. Expert opinion on drug discovery\| PubMed ID: 27546211	2016
Loss of C/EBPδ enhances IR-induced cell death by promoting oxidative stress and mitochondrial dysfunction. Free radical biology & medicine\| PubMed ID: 27554969	2016
Synthesis of (2R,8' S,3' E)-δ-tocodienol, a tocoflexol family member designed to have a superior pharmacokinetic profile compared to δ-tocotrienol. Tetrahedron\| PubMed ID: 27773949	2016
The Vitamin E Analog Gamma-Tocotrienol (GT3) and Statins Synergistically Up-Regulate Endothelial Thrombomodulin (TM). International journal of molecular sciences\| PubMed ID: 27869747	2016
Effects of ionizing radiation on the heart. Mutation research\| PubMed ID: 27919338	2016