David K Cole

Division of Infection and Immunity and Systems Immunity Research Institute, Cardiff University

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 7	2017

Other Publications

Article	Year
Basis for fusion inhibition by peptides: analysis of the heptad repeat regions of the fusion proteins from Nipah and Hendra viruses, newly emergent zoonotic paramyxoviruses. Biochemical and biophysical research communications\| PubMed ID: 14975752	2004
Following the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors. Biochemical and biophysical research communications\| PubMed ID: 15158473	2004
Crystallization and preliminary crystallographic analysis of the fusion core from two new zoonotic paramyxoviruses, Nipah virus and Hendra virus. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 15159588	2004
SARS coronavirus induces apoptosis in Vero E6 cells. Journal of medical virology\| PubMed ID: 15170624	2004
Complex assembly, crystallization and preliminary X-ray crystallographic studies of MHC H-2Kd complexed with an HBV-core nonapeptide. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 15272181	2004
Biochemical, biophysical and preliminary X-ray crystallographic analyses of the fusion core of Sendai virus F protein. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 15333939	2004
Construct design, biophysical, and biochemical characterization of the fusion core from mouse hepatitis virus (a coronavirus) spike protein. Protein expression and purification\| PubMed ID: 15477089	2004
Characterization of the heptad repeat regions, HR1 and HR2, and design of a fusion core structure model of the spike protein from severe acute respiratory syndrome (SARS) coronavirus. Biochemistry\| PubMed ID: 15518555	2004
CD8: adhesion molecule, co-receptor and immuno-modulator. Cellular & molecular immunology\| PubMed ID: 16212893	2004
Crystal structure of HLA-A*2402 complexed with a telomerase peptide. European journal of immunology\| PubMed ID: 16323248	2006
Crystallization and preliminary X-ray structural studies of a high-affinity CD8alphaalpha co-receptor to pMHC. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 16511019	2005
Computational design and crystal structure of an enhanced affinity mutant human CD8 alphaalpha coreceptor. Proteins\| PubMed ID: 17243170	2007
Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor. European journal of immunology\| PubMed ID: 17273992	2007
Human TCR-binding affinity is governed by MHC class restriction. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17442956	2007
Different T cell receptor affinity thresholds and CD8 coreceptor dependence govern cytotoxic T lymphocyte activation and tetramer binding properties. The Journal of biological chemistry\| PubMed ID: 17540778	2007
T cell receptor engagement of peptide-major histocompatibility complex class I does not modify CD8 binding. Molecular immunology\| PubMed ID: 18243322	2008
Detection of low avidity CD8(+) T cell populations with coreceptor-enhanced peptide-major histocompatibility complex class I tetramers. Journal of immunological methods\| PubMed ID: 18675271	2008
Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor. Nature medicine\| PubMed ID: 18997777	2008
Tricks with tetramers: how to get the most from multimeric peptide-MHC. Immunology\| PubMed ID: 19125886	2009
Germ line-governed recognition of a cancer epitope by an immunodominant human T-cell receptor. The Journal of biological chemistry\| PubMed ID: 19605354	2009
Peptide-major histocompatibility complex dimensions control proximal kinase-phosphatase balance during T cell activation. The Journal of biological chemistry\| PubMed ID: 19628870	2009
ELISPOT and functional T cell analyses using HLA mono-specific target cells. Journal of immunological methods\| PubMed ID: 19729014	2009
T cell receptor cross-reactivity directed by antigen-dependent tuning of peptide-MHC molecular flexibility. Immunity\| PubMed ID: 20064447	2009
MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20190139	2010
Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20639478	2010
Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection. PLoS pathogens\| PubMed ID: 21124993	2010
Real time detection of peptide-MHC dissociation reveals that improvement of primary MHC-binding residues can have a minimal, or no, effect on stability. Molecular immunology\| PubMed ID: 21130497	2011
Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21677135	2011
Correlation of in situ mechanosensitive responses of the Moraxella catarrhalis adhesin UspA1 with fibronectin and receptor CEACAM1 binding. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21876142	2011
The multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cells. Journal of leukocyte biology\| PubMed ID: 21954283	2011
Structural and biophysical determinants of αβ T-cell antigen recognition. Immunology\| PubMed ID: 22044041	2012
Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes. Nature immunology\| PubMed ID: 22245737	2012
Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4⁺ T-cell repertoire selection. Nature communications\| PubMed ID: 22314361	2012
TCR/pMHC Optimized Protein crystallization Screen. Journal of immunological methods\| PubMed ID: 22705983	2012
The molecular determinants of CD8 co-receptor function. Immunology\| PubMed ID: 22804746	2012
Human β-cell killing by autoreactive preproinsulin-specific CD8 T cells is predominantly granule-mediated with the potency dependent upon T-cell receptor avidity. Diabetes\| PubMed ID: 22936177	2013
T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. The Journal of biological chemistry\| PubMed ID: 22952231	2012
Minimal conformational plasticity enables TCR cross-reactivity to different MHC class II heterodimers. Scientific reports\| PubMed ID: 22953050	2012
Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood\| PubMed ID: 23255554	2013
T-cell receptor specificity maintained by altered thermodynamics. The Journal of biological chemistry\| PubMed ID: 23698002	2013
Increased Peptide Contacts Govern High Affinity Binding of a Modified TCR Whilst Maintaining a Native pMHC Docking Mode. Frontiers in immunology\| PubMed ID: 23805144	2013
Re-Directing CD4(+) T Cell Responses with the Flanking Residues of MHC Class II-Bound Peptides: The Core is Not Enough. Frontiers in immunology\| PubMed ID: 23847615	2013
Cellular-level versus receptor-level response threshold hierarchies in T-cell activation. Frontiers in immunology\| PubMed ID: 24046768	2013
T-cell receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions. The Journal of biological chemistry\| PubMed ID: 24196962	2014
The versatility of the αβ T-cell antigen receptor. Protein science : a publication of the Protein Society\| PubMed ID: 24375592	2014
Molecular basis of a dominant T cell response to an HIV reverse transcriptase 8-mer epitope presented by the protective allele HLA-B*51:01. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 24600035	2014
Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance. Cell\| PubMed ID: 25284152	2014
Recurrence of melanoma following T cell treatment: continued antigen expression in a tumor that evades T cell recruitment. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 25363716	2015
Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRs. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 25452566	2015
Structural basis for ineffective T-cell responses to MHC anchor residue-improved "heteroclitic" peptides. European journal of immunology\| PubMed ID: 25471691	2015
Naive CD8⁺ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics. Immunology and cell biology\| PubMed ID: 25801351	2015
A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape. Retrovirology\| PubMed ID: 25808313	2015
The ultimate mix and match: making sense of HLA alleles and peptide repertoires. Immunology and cell biology\| PubMed ID: 25823993	2015
The promise of γδ T cells and the γδ T cell receptor for cancer immunotherapy. Cellular & molecular immunology\| PubMed ID: 25864915	2015
More tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimers. Immunology\| PubMed ID: 26076649	2015
Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptide. The Journal of biological chemistry\| PubMed ID: 26085090	2015
Enhanced Detection of Antigen-Specific CD4+ T Cells Using Altered Peptide Flanking Residue Peptide-MHC Class II Multimers. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 26553072	2015
Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy. Scientific reports\| PubMed ID: 26758806	2016
T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones. Journal of immunological methods\| PubMed ID: 26826277	2016
A Molecular Switch Abrogates Glycoprotein 100 (gp100) T-cell Receptor (TCR) Targeting of a Human Melanoma Antigen. The Journal of biological chemistry\| PubMed ID: 26917722	2016
Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity. The Journal of clinical investigation\| PubMed ID: 27183389	2016
Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity. The Journal of clinical investigation\| PubMed ID: 27525441	2016
Structural Mechanism Underpinning Cross-reactivity of a CD8+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase. The Journal of biological chemistry\| PubMed ID: 27903649	2017