Ole Isacson

McLean Hospital, Harvard Medical School

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 7	2006
Publication title Cited by 1	2007

Other Publications

Article	Year
Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11782534	2002
Alzheimer's disease and Down's syndrome: roles of APP, trophic factors and ACh. Trends in neurosciences\| PubMed ID: 11814559	2002
Cortico-hippocampal APP and NGF levels are dynamically altered by cholinergic muscarinic antagonist or M1 agonist treatment in normal mice. The European journal of neuroscience\| PubMed ID: 11876777	2002
Analysis of different promoter systems for efficient transgene expression in mouse embryonic stem cell lines. Stem cells (Dayton, Ohio)\| PubMed ID: 11897870	2002
A direct role of the homeodomain proteins Phox2a/2b in noradrenaline neurotransmitter identity determination. Journal of neurochemistry\| PubMed ID: 11948255	2002
Herpes simplex virus/adeno-associated virus hybrid vectors for gene transfer to neurons. Preparation and use. Methods in molecular medicine\| PubMed ID: 11987795	2002
Models of repair mechanisms for future treatment modalities of Parkinson's disease. Brain research bulletin\| PubMed ID: 12031282	2002
Selective loss of 20S proteasome alpha-subunits in the substantia nigra pars compacta in Parkinson's disease. Neuroscience letters\| PubMed ID: 12095645	2002
Spatial memory testing decreases hippocampal amyloid precursor protein in young, but not aged, female rats. Neuroscience letters\| PubMed ID: 12123857	2002
Proteasome inhibition causes nigral degeneration with inclusion bodies in rats. Neuroreport\| PubMed ID: 12167769	2002
Regulation of dopamine cell type and transmitter function in fetal and stem cell transplantation for Parkinson's disease. Progress in brain research\| PubMed ID: 12432781	2002
Genetic engineering of mouse embryonic stem cells by Nurr1 enhances differentiation and maturation into dopaminergic neurons. The European journal of neuroscience\| PubMed ID: 12453046	2002
Altered proteasomal function in sporadic Parkinson's disease. Experimental neurology\| PubMed ID: 12504866	2003
Regional alterations in amyloid precursor protein and nerve growth factor across age in a mouse model of Down's syndrome. Neuroscience research\| PubMed ID: 12657457	2003
Toward full restoration of synaptic and terminal function of the dopaminergic system in Parkinson's disease by stem cells. Annals of neurology\| PubMed ID: 12666105	2003
Orphan nuclear receptor Nurr1 directly transactivates the promoter activity of the tyrosine hydroxylase gene in a cell-specific manner. Journal of neurochemistry\| PubMed ID: 12694388	2003
The production and use of cells as therapeutic agents in neurodegenerative diseases. The Lancet. Neurology\| PubMed ID: 12849120	2003
Mapping of brain function after MPTP-induced neurotoxicity in a primate Parkinson's disease model. NeuroImage\| PubMed ID: 14568476	2003
Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome. Hippocampus\| PubMed ID: 14750653	2003
Temporally induced Nurr1 can induce a non-neuronal dopaminergic cell type in embryonic stem cell differentiation. The European journal of neuroscience\| PubMed ID: 15016073	2004
Problems and solutions for circuits and synapses in Parkinson's disease. Neuron\| PubMed ID: 15260952	2004
Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease. Journal of neuroinflammation\| PubMed ID: 15285796	2004
Generalized brain and skin proteasome inhibition in Huntington's disease. Annals of neurology\| PubMed ID: 15349858	2004
Region-specific cell grafting into cervical and lumbar spinal cord in rat: a qualitative and quantitative stereological study. Experimental neurology\| PubMed ID: 15473986	2004
Intrastriatal transforming growth factor alpha delivery to a model of Parkinson's disease induces proliferation and migration of endogenous adult neural progenitor cells without differentiat... The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15483111	2004
Mapping dopamine function in primates using pharmacologic magnetic resonance imaging. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15509742	2004
The homeodomain transcription factor Pitx3 facilitates differentiation of mouse embryonic stem cells into AHD2-expressing dopaminergic neurons. Molecular and cellular neurosciences\| PubMed ID: 15691706	2005
Context-dependent neuronal differentiation and germ layer induction of Smad4-/- and Cripto-/- embryonic stem cells. Molecular and cellular neurosciences\| PubMed ID: 15737733	2005
Netrin-1 and slit-2 regulate and direct neurite growth of ventral midbrain dopaminergic neurons. Molecular and cellular neurosciences\| PubMed ID: 15737744	2005
Stem cells may reshape the prospect of Parkinson's disease therapy. Brain research. Molecular brain research\| PubMed ID: 15790528	2005
Abnormal APP, cholinergic and cognitive function in Ts65Dn Down's model mice. Experimental neurology\| PubMed ID: 15869949	2005
Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease. Brain : a journal of neurology\| PubMed ID: 15872020	2005
Cell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection. Human molecular genetics\| PubMed ID: 15888489	2005
Long-term survival of dopamine neurons derived from parthenogenetic primate embryonic stem cells (cyno-1) after transplantation. Stem cells (Dayton, Ohio)\| PubMed ID: 15941857	2005
Insights into Parkinson's disease models and neurotoxicity using non-invasive imaging. Toxicology and applied pharmacology\| PubMed ID: 15979668	2005
Stromal cell-derived inducing activity, Nurr1, and signaling molecules synergistically induce dopaminergic neurons from mouse embryonic stem cells. Stem cells (Dayton, Ohio)\| PubMed ID: 16123386	2006
Specific microRNAs modulate embryonic stem cell-derived neurogenesis. Stem cells (Dayton, Ohio)\| PubMed ID: 16357340	2006
Neural precursors derived from embryonic stem cells, but not those from fetal ventral mesencephalon, maintain the potential to differentiate into dopaminergic neurons after expansion in vitr... Stem cells (Dayton, Ohio)\| PubMed ID: 16543488	2006
Genetic selection of sox1GFP-expressing neural precursors removes residual tumorigenic pluripotent stem cells and attenuates tumor formation after transplantation. Journal of neurochemistry\| PubMed ID: 16696855	2006
Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits. Stem cells (Dayton, Ohio)\| PubMed ID: 16840550	2006
Neuroblast protuberances in the subventricular zone of the regenerative MRL/MpJ mouse. The Journal of comparative neurology\| PubMed ID: 16927265	2006
What are the long-term effects of neural grafting in patients with Huntington's disease? Nature clinical practice. Neurology\| PubMed ID: 16932607	2006
Enhanced yield of neuroepithelial precursors and midbrain-like dopaminergic neurons from human embryonic stem cells using the bone morphogenic protein antagonist noggin. Stem cells (Dayton, Ohio)\| PubMed ID: 17038668	2007
Transplanted dopamine neurons derived from primate ES cells preferentially innervate DARPP-32 striatal progenitors within the graft. The European journal of neuroscience\| PubMed ID: 17067292	2006
Selection of embryonic stem cell-derived enhanced green fluorescent protein-positive dopamine neurons using the tyrosine hydroxylase promoter is confounded by reporter gene expression in imm... Stem cells (Dayton, Ohio)\| PubMed ID: 17234989	2007
Proteasome activator enhances survival of Huntington's disease neuronal model cells. PloS one\| PubMed ID: 17327906	2007
Inhibition of the dopamine D1 receptor signaling by PSD-95. The Journal of biological chemistry\| PubMed ID: 17369255	2007
In vivo evidence of D3 dopamine receptor sensitization in parkinsonian primates and rodents with l-DOPA-induced dyskinesias. Neurobiology of disease\| PubMed ID: 17588764	2007
Markers and methods for cell sorting of human embryonic stem cell-derived neural cell populations. Stem cells (Dayton, Ohio)\| PubMed ID: 17588935	2007
Functional analysis of various promoters in lentiviral vectors at different stages of in vitro differentiation of mouse embryonic stem cells. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 17609656	2007
Immature and neurally differentiated mouse embryonic stem cells do not express a functional Fas/Fas ligand system. Stem cells (Dayton, Ohio)\| PubMed ID: 17615270	2007
An endogenous serine/threonine protein phosphatase inhibitor, G-substrate, reduces vulnerability in models of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17670978	2007
Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17726113	2007
Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease. PLoS medicine\| PubMed ID: 17760499	2007
Cell therapy and stem cells in animal models of motor neuron disorders. The European journal of neuroscience\| PubMed ID: 17897390	2007
Neural precursors derived from human embryonic stem cells maintain long-term proliferation without losing the potential to differentiate into all three neural lineages, including dopaminergi... Journal of neurochemistry\| PubMed ID: 17944878	2008
Neuroinflammation mediated by IL-1beta increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease. Journal of neuroinflammation\| PubMed ID: 18304357	2008
Recent advances in cell-based therapy for Parkinson disease. Neurosurgical focus\| PubMed ID: 18341409	2008
Embryonic stem cell-derived Pitx3-enhanced green fluorescent protein midbrain dopamine neurons survive enrichment by fluorescence-activated cell sorting and function in an animal model of Pa... Stem cells (Dayton, Ohio)\| PubMed ID: 18388307	2008
Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18391196	2008
Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years. Nature medicine\| PubMed ID: 18391961	2008
Nociceptin/orphanin FQ receptor blockade attenuates MPTP-induced parkinsonism. Neurobiology of disease\| PubMed ID: 18413287	2008
Fate mapping and lineage analyses demonstrate the production of a large number of striatal neuroblasts after transforming growth factor alpha and noggin striatal infusions into the dopamine-... Stem cells (Dayton, Ohio)\| PubMed ID: 18556510	2008
Compensatory changes in the ubiquitin-proteasome system, brain-derived neurotrophic factor and mitochondrial complex II/III in YAC72 and R6/2 transgenic mice partially model Huntington's dis... Human molecular genetics\| PubMed ID: 18640989	2008
Parthenogenetic dopamine neurons from primate embryonic stem cells restore function in experimental Parkinson's disease. Brain : a journal of neurology\| PubMed ID: 18669499	2008
ALS model glia can mediate toxicity to motor neurons derived from human embryonic stem cells. Cell stem cell\| PubMed ID: 19041769	2008
Future of cell and gene therapies for Parkinson's disease. Annals of neurology\| PubMed ID: 19127583	2008
Axon guidance and synaptic maintenance: preclinical markers for neurodegenerative disease and therapeutics. Trends in neurosciences\| PubMed ID: 19162339	2009
PSD-95 uncouples dopamine-glutamate interaction in the D1/PSD-95/NMDA receptor complex. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19261890	2009
Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell\| PubMed ID: 19269371	2009
Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19295143	2009
The blood-brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates--evidence from in vivo neuroimaging studies. Neurobiology of disease\| PubMed ID: 19501164	2009
Lack of functional relevance of isolated cell damage in transplants of Parkinson's disease patients. Journal of neurology\| PubMed ID: 19711122	2009
CD15, CD24, and CD29 define a surface biomarker code for neural lineage differentiation of stem cells. Stem cells (Dayton, Ohio)\| PubMed ID: 19725119	2009
Molecular and cellular determinants for generating ES-cell derived dopamine neurons for cell therapy. Advances in experimental medicine and biology\| PubMed ID: 19731556	2009
No evidence for disease-like processes in fetal transplants. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19805203	2009
Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway. Cell stem cell\| PubMed ID: 19951692	2009
Isolation and culture of ventral mesencephalic precursor cells and dopaminergic neurons from rodent brains. Current protocols in stem cell biology\| PubMed ID: 19960452	2009
Cell therapy ahead for Parkinson's disease. Science (New York, N.Y.)\| PubMed ID: 19965408	2009
Functional enhancement and protection of dopaminergic terminals by RAB3B overexpression. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20007772	2009
High regulatability favors genetic selection in SLC18A2, a vesicular monoamine transporter essential for life. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 20181938	2010
The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons. Brain : a journal of neurology\| PubMed ID: 20573704	2010
Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic ... Molecular and cellular neurosciences\| PubMed ID: 20603216	2010
The hAPP-YAC transgenic model has elevated UPS activity in the frontal cortex similar to Alzheimer's disease and Down's syndrome. Journal of neurochemistry\| PubMed ID: 20698932	2010
Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20798034	2010
Being too inclusive about synuclein inclusions. Nature medicine\| PubMed ID: 20823871	2010
Global gene expression profiling of somatic motor neuron populations with different vulnerability identify molecules and pathways of degeneration and protection. Brain : a journal of neurology\| PubMed ID: 20826431	2010
The Toll-like receptor-3 agonist polyinosinic:polycytidylic acid triggers nigrostriatal dopaminergic degeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21123556	2010
Functions of the nigrostriatal dopaminergic synapse and the use of neurotransplantation in Parkinson's disease. Journal of neurology\| PubMed ID: 21544566	2011
Development of histocompatible primate-induced pluripotent stem cells for neural transplantation. Stem cells (Dayton, Ohio)\| PubMed ID: 21608081	2011
Oct4-induced reprogramming is required for adult brain neural stem cell differentiation into midbrain dopaminergic neurons. PloS one\| PubMed ID: 21655272	2011
Opportunities for neurorestorative therapies in PD using iPS and stem cells. RinshÅ shinkeigaku = Clinical neurology\| PubMed ID: 21921494	2010
Transcript expression levels of full-length alpha-synuclein and its three alternatively spliced variants in Parkinson's disease brain regions and in a transgenic mouse model of alpha-synucle... Molecular and cellular neurosciences\| PubMed ID: 22155155	2012
Using stem cells and iPS cells to discover new treatments for Parkinson's disease. Parkinsonism & related disorders\| PubMed ID: 22166414	2012
Clinical translation of stem cells in neurodegenerative disorders. Cell stem cell\| PubMed ID: 22305565	2012
Viral and inflammatory triggers of neurodegenerative diseases. Science translational medicine\| PubMed ID: 22344685	2012
α-Synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits. Neurobiology of disease\| PubMed ID: 22549133	2012
Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease. Science translational medicine\| PubMed ID: 22764206	2012
The search for genetic mouse models of prodromal Parkinson's disease. Experimental neurology\| PubMed ID: 22819262	2012
Creation of an open-access, mutation-defined fibroblast resource for neurological disease research. PloS one\| PubMed ID: 22952635	2012
Stem cells for Parkinson's disease: advancing science but protecting patients. Movement disorders : official journal of the Movement Disorder Society\| PubMed ID: 23032987	2012
Characterization and criteria of embryonic stem and induced pluripotent stem cells for a dopamine replacement therapy. Progress in brain research\| PubMed ID: 23195423	2012
Improved cell therapy protocols for Parkinson's disease based on differentiation efficiency and safety of hESC-, hiPSC-, and non-human primate iPSC-derived dopaminergic neurons. Stem cells (Dayton, Ohio)\| PubMed ID: 23666606	2013
LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction. Neurobiology of disease\| PubMed ID: 24148854	2014
Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease. Neurobiology of disease\| PubMed ID: 24388974	2014
Advances in stem-cell--generated transplantation therapy for Parkinson's disease. Expert opinion on biological therapy\| PubMed ID: 24437368	2014
Motor impairments, striatal degeneration, and altered dopamine-glutamate interplay in mice lacking PSD-95. Journal of neurogenetics\| PubMed ID: 24702501	2014
Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease. Human molecular genetics\| PubMed ID: 24728190	2014
Widespread neuron-specific transgene expression in brain and spinal cord following synapsin promoter-driven AAV9 neonatal intracerebroventricular injection. Neuroscience letters\| PubMed ID: 24882721	2014
ALS-associated peripherin spliced transcripts form distinct protein inclusions that are neuroprotective against oxidative stress. Experimental neurology\| PubMed ID: 24907400	2014
Long-term health of dopaminergic neuron transplants in Parkinson's disease patients. Cell reports\| PubMed ID: 24910427	2014
Successful Function of Autologous iPSC-Derived Dopamine Neurons following Transplantation in a Non-Human Primate Model of Parkinson's Disease. Cell stem cell\| PubMed ID: 25732245	2015
A Nurr1 Agonist Causes Neuroprotection in a Parkinson's Disease Lesion Model Primed with the Toll-Like Receptor 3 dsRNA Inflammatory Stimulant Poly(I:C). PloS one\| PubMed ID: 25815475	2015
Sorting the wheat from the chaff in dopamine neuron-based cell therapies. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25848026	2015