finite-element-analysis-model-for-assessing-expansion-patterns-from

Finite Element Analysis Model for Assessing Expansion Patterns from Surgically Assisted Rapid Palatal Expansion

Surgically assisted rapid palatal expansion (SARPE) was introduced to release bony resistance to facilitate skeletal expansion in skeletally mature ...

University of Pennsylvania

This study evaluated changes in methemoglobin and oxygen saturation concentrations after the administration of recommended doses of 14% benzocaine alone or 14% benzocaine combined with 2% tetracaine.

Lack of Methemoglobin Elevations After Topical Applications of Benzocaine Alone or Benzocaine Plus Tetracaine to the Oral Mucosa.

In vitro whole-organism screens of Trypanosoma brucei with representative examples of brain-penetrant microtubule (MT)-stabilizing agents identified lethal triazolopyrimidines and phenylpyrimidines with sub-micromolar potency. In mammalian cells, these antiproliferative compounds disrupt MT integrity and decrease total tubulin levels. Their parasiticidal potency, combined with their generally favorable pharmacokinetic properties, which include oral bioavailability and brain penetration, suggest that these compounds are potential leads against human African trypanosomiasis.

Brain-Penetrant Triazolopyrimidine and Phenylpyrimidine Microtubule Stabilizers as Potential Leads to Treat Human African Trypanosomiasis.

CTY-5339A is an investigational topical anesthetic spray containing 14% benzocaine/2% tetracaine in a metered canister. Each spray delivers ∼0.2 mL of solution. This double-blind, randomized, crossover study compared the local anesthetic effect of CTY-5339A versus 14% benzocaine alone by using 2 quantitative sensory threshold experimental pain paradigms on the maxillary gingiva: pin prick test pain intensity (PPT PI) and heat pain threshold (HPT).

A Proof-of-concept Study Using Quantitative Sensory Threshold Analysis to Compare Two Intraoral Topical Anesthetics.

The purpose of this study was to quantify trainee contributions to the Journal of Oral and Maxillofacial Surgery (JOMS).

A 15-Year Review of Trainee Contributions to the Journal of Oral and Maxillofacial Surgery.

The Potential of EHR Defaults to Reduce Postoperative Dental Opioid Prescriptions.

Applying Behavioral Economics to Address COVID-19 Fear Among Oral and Maxillofacial Surgery Patients.

Pediatric-Antiresorptive Use: Should We Intervene on Third Molars Early?

The scope of oral and maxillofacial surgery treatment and care is very broad, from dentoalveolar surgery, to pathology and reconstruction, to treatment of craniofacial deformities. The effective surgical treatment of patients requires appropriate and accurate diagnostic imaging. The various imaging modalities used in oral and maxillofacial surgery are typically for diagnostic and treatment planning purposes. With the improvements of three-dimensional imaging and software programs, surgical treatment and care have been enhanced with patient-specific guides, hardware, and implants. This article discusses the various imaging modalities used for a variety of typical oral and maxillofacial surgery procedures.

Imaging in Oral and Maxillofacial Surgery.

Opioid-induced hyperalgesia, a paradoxical increase in pain sensitivity associated with ongoing opioid use, may worsen the postoperative pain experience. This pilot study examined the effect of chronic opioid use on pain responses in patients undergoing a standardized dental surgery.

Preoperative and Postoperative Hyperalgesia in Dental Patients on Chronic Opioid Therapy: A Pilot Study.

Surgically assisted rapid palatal expansion (SARPE) is often performed to correct the transverse deficiency in the maxilla for skeletally mature patients. However, there is little consensus on the sagittal and vertical displacement of the maxilla after SARPE. This systematic review aims to analyze the position changes of the maxilla in the sagittal and vertical dimensions after the completion of SARPE. Registered with PROSPERO (registration number: CRD42022312103), this study complied with the 2020 PRISMA guideline and was conducted on 21 January 2023. Original studies were screened from MEDLINE (PubMed), Elsevier (SCOPUS), and Cochrane, and supplemented by hand-searching. Cephalometric changes of skeletal vertical and sagittal measurements were the focus. A fixed-effects model was applied in R for meta-analysis. After applying inclusion and exclusion criteria, seven articles were included in the final review. Four studies had a high risk of bias, and the other three had a medium risk of bias. Meta-analysis revealed that the SNA angle increased by 0.50° ± 0.08° (95% confidence interval, 0.33° to 0.66°), and the SN-PP angle increased by 0.60° ± 0.09° (95% confidence interval, 0.41° to 0.79°) after SARPE. In summary, the maxilla displayed statistically significant forward and clockwise downward movement after SARPE. However, the amounts were small and might not be clinically significant. Due to the high risk of bias of included studies, our results must be taken cautiously. Future studies are needed to discern the effects of direction and angulation of the osteotomies of SARPE on the displacement of the maxilla.

Article	Year
Lack of Methemoglobin Elevations After Topical Applications of Benzocaine Alone or Benzocaine Plus Tetracaine to the Oral Mucosa. Clinical therapeutics\| PubMed ID: 28943117	2017
Brain-Penetrant Triazolopyrimidine and Phenylpyrimidine Microtubule Stabilizers as Potential Leads to Treat Human African Trypanosomiasis. ChemMedChem\| PubMed ID: 29969537	2018
A Proof-of-concept Study Using Quantitative Sensory Threshold Analysis to Compare Two Intraoral Topical Anesthetics. Clinical therapeutics\| PubMed ID: 30660443	2019
A 15-Year Review of Trainee Contributions to the Journal of Oral and Maxillofacial Surgery. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons\| PubMed ID: 30738062	2019
The Potential of EHR Defaults to Reduce Postoperative Dental Opioid Prescriptions. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons\| PubMed ID: 32173332	2020
Applying Behavioral Economics to Address COVID-19 Fear Among Oral and Maxillofacial Surgery Patients. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons\| PubMed ID: 33460562	2021
Pediatric-Antiresorptive Use: Should We Intervene on Third Molars Early? Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons\| PubMed ID: 34051154	2021
Imaging in Oral and Maxillofacial Surgery. Dental clinics of North America\| PubMed ID: 34051927	2021
Preoperative and Postoperative Hyperalgesia in Dental Patients on Chronic Opioid Therapy: A Pilot Study. Anesthesia progress\| PubMed ID: 36995960	2023
Sagittal and Vertical Changes of the Maxilla after Surgically Assisted Rapid Palatal Expansion: A Systematic Review and Meta-Analysis. Journal of clinical medicine\| PubMed ID: 37240593	2023

Steven Wang

Biography

JoVE Journal Publications

Other Publications