Dorothee Weihrauch

Department of Anesthesiology, Medical College of Wisconsin

Affiliated withMedical College of Wisconsin

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 1	2017
Publication title Cited by 5	2021

Other Publications

Article	Year
Angiostatin inhibits coronary angiogenesis during impaired production of nitric oxide. Circulation\| PubMed ID: 11994253	2002
An intramyocardial catheter for repeated in vivo sampling of interstitial fluid. Journal of pharmacological and toxicological methods\| PubMed ID: 12459145	2002
Mechanism of preconditioning by isoflurane in rabbits: a direct role for reactive oxygen species. Anesthesiology\| PubMed ID: 12459675	2002
Reactive oxygen species modulate coronary wall shear stress and endothelial function during hyperglycemia. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 12543642	2003
Expression of VEGF and angiopoietins-1 and -2 during ischemia-induced coronary angiogenesis. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 12649074	2003
Mitochondrial adenosine triphosphate-regulated potassium channel opening acts as a trigger for isoflurane-induced preconditioning by generating reactive oxygen species. Anesthesiology\| PubMed ID: 12657856	2003
L-4F, an apolipoprotein A-1 mimetic, dramatically improves vasodilation in hypercholesterolemia and sickle cell disease. Circulation\| PubMed ID: 12732610	2003
N-acetylcysteine restores isoflurane-induced preconditioning against myocardial infarction during hyperglycemia. Anesthesiology\| PubMed ID: 12766647	2003
Reactive oxygen species are critical mediators of coronary collateral development in a canine model. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 12816750	2003
Angiostatin and matrix metalloprotease expression following ischemic acute renal failure. American journal of physiology. Renal physiology\| PubMed ID: 15075185	2004
Protein kinase C translocation and Src protein tyrosine kinase activation mediate isoflurane-induced preconditioning in vivo: potential downstream targets of mitochondrial adenosine triphosp... Anesthesiology\| PubMed ID: 15108965	2004
Chronic hyperglycemia attenuates coronary collateral development and impairs proliferative properties of myocardial interstitial fluid by production of angiostatin. Circulation\| PubMed ID: 15136506	2004
Autologous vascular smooth muscle cell-based myocardial gene therapy to induce coronary collateral growth. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 15277192	2004
Protein kinase C-epsilon primes the cardiac sarcolemmal adenosine triphosphate-sensitive potassium channel to modulation by isoflurane. Anesthesiology\| PubMed ID: 15277921	2004
Preconditioning by isoflurane is mediated by reactive oxygen species generated from mitochondrial electron transport chain complex III. Anesthesia and analgesia\| PubMed ID: 15502022	2004
Haptoglobin expression and activity during coronary collateralization. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 15550518	2005
Cardioprotection by volatile anesthetics. Vascular pharmacology\| PubMed ID: 15922257	2005
Role of endothelial nitric oxide synthase as a trigger and mediator of isoflurane-induced delayed preconditioning in rabbit myocardium. Anesthesiology\| PubMed ID: 15983459	2005
Morphine enhances isoflurane-induced postconditioning against myocardial infarction: the role of phosphatidylinositol-3-kinase and opioid receptors in rabbits. Anesthesia and analgesia\| PubMed ID: 16192500	2005
Isoflurane inhibits cardiac myocyte apoptosis during oxidative and inflammatory stress by activating Akt and enhancing Bcl-2 expression. Anesthesiology\| PubMed ID: 16249675	2005
Inhibition of mitochondrial permeability transition enhances isoflurane-induced cardioprotection during early reperfusion: the role of mitochondrial KATP channels. Anesthesia and analgesia\| PubMed ID: 16301224	2005
Role of Erk1/2, p70s6K, and eNOS in isoflurane-induced cardioprotection during early reperfusion in vivo. Canadian journal of anaesthesia = Journal canadien d'anesthesie\| PubMed ID: 16434759	2006
Inhibition of glycogen synthase kinase enhances isoflurane-induced protection against myocardial infarction during early reperfusion in vivo. Anesthesia and analgesia\| PubMed ID: 16632807	2006
The influence of B-cell lymphoma 2 protein, an antiapoptotic regulator of mitochondrial permeability transition, on isoflurane-induced and ischemic postconditioning in rabbits. Anesthesia and analgesia\| PubMed ID: 16632808	2006
Endothelium-derived microparticles inhibit human cardiac valve endothelial cell function. Shock (Augusta, Ga.)\| PubMed ID: 16721264	2006
Cardioprotection by volatile anesthetics: new applications for old drugs? Current opinion in anaesthesiology\| PubMed ID: 16829721	2006
Rosiglitazone antagonizes vascular endothelial growth factor signaling and nuclear factor of activated T cells activation in cardiac valve endothelium. Endothelium : journal of endothelial cell research\| PubMed ID: 16840174	2006
Gender-specificity of delayed preconditioning by isoflurane in rabbits: potential role of endothelial nitric oxide synthase. Anesthesia and analgesia\| PubMed ID: 16861402	2006
Extracellular signal-regulated kinases trigger isoflurane preconditioning concomitant with upregulation of hypoxia-inducible factor-1alpha and vascular endothelial growth factor expression i... Anesthesia and analgesia\| PubMed ID: 16861403	2006
Inhibition of apoptotic protein p53 lowers the threshold of isoflurane-induced cardioprotection during early reperfusion in rabbits. Anesthesia and analgesia\| PubMed ID: 17122210	2006
Efficient transgenic rat production by a lentiviral vector. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 17322424	2007
Effects of D-4F on vasodilation, oxidative stress, angiostatin, myocardial inflammation, and angiogenic potential in tight-skin mice. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 17496220	2007
Noble gases without anesthetic properties protect myocardium against infarction by activating prosurvival signaling kinases and inhibiting mitochondrial permeability transition in vivo. Anesthesia and analgesia\| PubMed ID: 17717207	2007
Diabetes abolishes sildenafil-induced cGMP-dependent protein kinase-I expression and cardioprotection. Journal of cardiovascular pharmacology\| PubMed ID: 18091584	2007
Telokin expression and the effect of hypoxia on its phosphorylation status in smooth muscle cells from small and large pulmonary arteries. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 18375742	2008
Histopathology of experimentally induced asthma in a murine model of sickle cell disease. Blood\| PubMed ID: 18579795	2008
Reactive oxygen species and mitochondrial adenosine triphosphate-regulated potassium channels mediate helium-induced preconditioning against myocardial infarction in vivo. Journal of cardiothoracic and vascular anesthesia\| PubMed ID: 18662630	2008
The mechanism of helium-induced preconditioning: a direct role for nitric oxide in rabbits. Anesthesia and analgesia\| PubMed ID: 18713880	2008
Inhibition of glycogen synthase kinase or the apoptotic protein p53 lowers the threshold of helium cardioprotection in vivo: the role of mitochondrial permeability transition. Anesthesia and analgesia\| PubMed ID: 18713881	2008
Role of heat shock protein 90 and endothelial nitric oxide synthase during early anesthetic and ischemic preconditioning. Anesthesiology\| PubMed ID: 19194158	2009
Morphine reduces the threshold of helium preconditioning against myocardial infarction: the role of opioid receptors in rabbits. Journal of cardiothoracic and vascular anesthesia\| PubMed ID: 19231239	2009
Mechanism of differential cardiovascular response to propofol in Dahl salt-sensitive, Brown Norway, and chromosome 13-substituted consomic rat strains: role of large conductance Ca2+ and vol... The Journal of pharmacology and experimental therapeutics\| PubMed ID: 19541907	2009
Depletion of calcium stores in injured sensory neurons: anatomic and functional correlates. Anesthesiology\| PubMed ID: 19602957	2009
Myocardial interstitial fluid inhibits proliferation and cardiomyocyte differentiation in pluripotent embryonic stem cells. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 19633209	2009
KATP channel subunits in rat dorsal root ganglia: alterations by painful axotomy. Molecular pain\| PubMed ID: 20102598	2010
Hyperglycemia adversely modulates endothelial nitric oxide synthase during anesthetic preconditioning through tetrahydrobiopterin- and heat shock protein 90-mediated mechanisms. Anesthesiology\| PubMed ID: 20124983	2010
Genetic deletion of apolipoprotein A-I increases airway hyperresponsiveness, inflammation, and collagen deposition in the lung. Journal of lipid research\| PubMed ID: 20498409	2010
Altered mitochondrial membrane potential, mass, and morphology in the mononuclear cells of humans with type 2 diabetes. Translational research : the journal of laboratory and clinical medicine\| PubMed ID: 20621033	2010
Abnormal fibrillin-1 expression and chronic oxidative stress mediate endothelial mesenchymal transition in a murine model of systemic sclerosis. American journal of physiology. Cell physiology\| PubMed ID: 21160034	2011
Store-operated Ca2+ entry in sensory neurons: functional role and the effect of painful nerve injury. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21389210	2011
Endothelial-cardiomyocyte crosstalk enhances pharmacological cardioprotection. Journal of molecular and cellular cardiology\| PubMed ID: 21791217	2011
Isoflurane differentially modulates mitochondrial reactive oxygen species production via forward versus reverse electron transport flow: implications for preconditioning. Anesthesiology\| PubMed ID: 21862887	2011
Hexosamine pathway activation and O-linked-N-acetylglucosamine: novel mediators of endothelial dysfunction in hyperglycemia and diabetes. Vascular pharmacology\| PubMed ID: 22289438	2012
Absence of type VI collagen paradoxically improves cardiac function, structure, and remodeling after myocardial infarction. Circulation research\| PubMed ID: 22343710	2012
Transient repetitive exposure to low level light therapy enhances collateral blood vessel growth in the ischemic hindlimb of the tight skin mouse. Photochemistry and photobiology\| PubMed ID: 23231468	2013
4F decreases IRF5 expression and activation in hearts of tight skin mice. PloS one\| PubMed ID: 23251680	2012
Intraganglionic AAV6 results in efficient and long-term gene transfer to peripheral sensory nervous system in adult rats. PloS one\| PubMed ID: 23613824	2013
Metal ions activate vascular endothelial cells and increase lymphocyte chemotaxis and binding. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 23629852	2013
Apolipoprotein A-1 mimetic D-4F enhances isoflurane-induced eNOS signaling and cardioprotection during acute hyperglycemia. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 23666677	2013
Far red/near infrared light treatment promotes femoral artery collateralization in the ischemic hindlimb. Journal of molecular and cellular cardiology\| PubMed ID: 23702287	2013
N-acetyl lysyltyrosylcysteine amide inhibits myeloperoxidase, a novel tripeptide inhibitor. Journal of lipid research\| PubMed ID: 23883583	2013
Inhibition of myeloperoxidase decreases vascular oxidative stress and increases vasodilatation in sickle cell disease mice. Journal of lipid research\| PubMed ID: 23956444	2013
Sigma-1 receptor expression in sensory neurons and the effect of painful peripheral nerve injury. Molecular pain\| PubMed ID: 24015960	2013
Porous ongrowth surfaces alter osteoblast maturation and mineralization. Journal of biomedical materials research. Part A\| PubMed ID: 24677492	2015
A novel path of improving heart function after infarction. Journal of molecular and cellular cardiology\| PubMed ID: 25944086	2015
Isoflurane favorably modulates guanosine triphosphate cyclohydrolase-1 and endothelial nitric oxide synthase during myocardial ischemia and reperfusion injury in rats. Anesthesiology\| PubMed ID: 26192027	2015
Alagebrium inhibits neointimal hyperplasia and restores distributions of wall shear stress by reducing downstream vascular resistance in obese and diabetic rats. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 26254329	2015
An IRF5 Decoy Peptide Reduces Myocardial Inflammation and Fibrosis and Improves Endothelial Cell Function in Tight-Skin Mice. PloS one\| PubMed ID: 27050551	2016
Lipid emulsion enhances cardiac performance after ischemia-reperfusion in isolated hearts from summer-active arctic ground squirrels. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology\| PubMed ID: 28364393	2017
Detection of TRPV4 channel current-like activity in Fawn Hooded hypertensive (FHH) rat cerebral arterial muscle cells. PloS one\| PubMed ID: 28472069	2017
Red/near infrared light stimulates release of an endothelium dependent vasodilator and rescues vascular dysfunction in a diabetes model. Free radical biology & medicine\| PubMed ID: 28935419	2017
Rationale and design of DUAL study: Doxycycline to Upgrade response in light chain (AL) amyloidosis (DUAL): A phase 2 pilot study of a two-pronged approach of prolonged doxycycline with plas... Contemporary clinical trials communications\| PubMed ID: 29696194	2017
Wavelength-dependence of vasodilation and NO release from S-nitrosothiols and dinitrosyl iron complexes by far red/near infrared light. Archives of biochemistry and biophysics\| PubMed ID: 29752896	2018
Corrigendum to "Red/near infrared light stimulates release of an endothelium dependent vasodilator and rescues vascular dysfunction in a diabetes model" [Free Radic. Biol. Med. 113:157-164]. Free radical biology & medicine\| PubMed ID: 30581102	2019
PPARγ-Independent Side Effects of Thiazolidinediones on Mitochondrial Redox State in Rat Isolated Hearts. Cells\| PubMed ID: 31968546	2020
Inhibition of myeloperoxidase increases revascularization and improves blood flow in a diabetic mouse model of hindlimb ischaemia. Diabetes & vascular disease research\| PubMed ID: 32223319	2020
Intralipid Increases Nitric Oxide Release from Human Endothelial Cells During Oxidative Stress. JPEN. Journal of parenteral and enteral nutrition\| PubMed ID: 32291784	2021
Adjuvant doxycycline to enhance anti-amyloid effects: Results from the dual phase 2 trial. EClinicalMedicine\| PubMed ID: 32529175	2020
Red light stimulates vasodilation through extracellular vesicle trafficking. Journal of photochemistry and photobiology. B, Biology\| PubMed ID: 34049180	2021
Electromagnetic energy (670 nm) stimulates vasodilation through activation of the large conductance potassium channel (BKCa). PloS one\| PubMed ID: 34610026	2021