murine-full-thickness-skin-transplantation

Murine Full-thickness Skin Transplantation

Murine full-thickness skin transplantation is a well-established in vivo model to study alloimmune response and graft rejection. Despite its limited ...

Johns Hopkins University School of Medicine

Abstract 11: the role of donor antigen persistance in maintaining immune tolerance to a vascularized composite allograft.

Broader clinical application of reconstructive hand and face transplantation is hindered by the need for lifelong immunosuppression for allograft maintenance. In this review, we summarize various cell-based approaches to tolerance induction currently under investigation in both clinical and pre-clinical models to alleviate the need for chronic immunosuppression. These include strategies to induce mixed hematopoietic chimerism, therapy with T and B regulatory cells, regulatory macrophages, tolerogenic dendritic cells, and mesenchymal stem cells. The vascularized, intragraft bone components inherent to reconstructive transplants serve as a continuous source of donor-derived hematopoietic cells, and make hand and face transplants uniquely well suited for cell-based approaches to tolerance that may ultimately tilt the risk-benefit balance for these life-changing, but not life-saving, procedures.

Article	Year
Abstract 11: the role of donor antigen persistance in maintaining immune tolerance to a vascularized composite allograft. Plastic and reconstructive surgery\| PubMed ID: 25942122	2014
Exploring cell-based tolerance strategies for hand and face transplantation. Expert review of clinical immunology\| PubMed ID: 26289376	2015

Madeline Fryer

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