Christopher N. Boddy

Department of Chemistry and Biomolecular Sciences, University of Ottawa

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2017

Other Publications

Article	Year
Does CIP Nomenclature Adequately Handle Molecules with Multiple Stereoelements? A Case Study of Vancomycin and Cognates We would like to thank Professor Dieter Hellwinkel for pointing out to... Angewandte Chemie (International ed. in English)\| PubMed ID: 11241596	2001
Atropselective macrocyclization of diaryl ether ring systems: application to the synthesis of vancomycin model systems. Journal of the American Chemical Society\| PubMed ID: 12197747	2002
Epothilone C macrolactonization and hydrolysis are catalyzed by the isolated thioesterase domain of epothilone polyketide synthase. Journal of the American Chemical Society\| PubMed ID: 12643694	2003
Understanding substrate specificity of polyketide synthase modules by generating hybrid multimodular synthases. The Journal of biological chemistry\| PubMed ID: 12923197	2003
Precursor-directed biosynthesis of epothilone in Escherichia coli. Journal of the American Chemical Society\| PubMed ID: 15198579	2004
Sweetening cyclic peptide libraries. Chemistry & biology\| PubMed ID: 15610840	2004
Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli. Nature chemical biology\| PubMed ID: 16799553	2006
The thioesterase domain from the pimaricin and erythromycin biosynthetic pathways can catalyze hydrolysis of simple thioester substrates. Bioorganic & medicinal chemistry letters\| PubMed ID: 17428661	2007
Sialic acid and N-acyl sialic acid analog production by fermentation of metabolically and genetically engineered Escherichia coli. Organic & biomolecular chemistry\| PubMed ID: 17551639	2007
A new mechanism for benzopyrone formation in aromatic polyketide biosynthesis. Journal of the American Chemical Society\| PubMed ID: 17625867	2007
Orthogonal ligation: a three piece assembly of a PNA-peptide-PNA conjugate. Chemical communications (Cambridge, England)\| PubMed ID: 18688310	2008
Examining the role of hydrogen bonding interactions in the substrate specificity for the loading step of polyketide synthase thioesterase domains. Biochemistry\| PubMed ID: 18850723	2008
Biomimetic transannular oxa-conjugate addition approach to the 2,6-disubstituted dihydropyran of laulimalide yields an unprecedented transannular oxetane. The Journal of organic chemistry\| PubMed ID: 19159194	2009
Polyketide synthase thioesterases catalyze rapid hydrolysis of peptidyl thioesters. Bioorganic & medicinal chemistry letters\| PubMed ID: 19188064	2009
A thioesterase from an iterative fungal polyketide synthase shows macrocyclization and cross coupling activity and may play a role in controlling iterative cycling through product offloading... Biochemistry\| PubMed ID: 19530704	2009
Heterologous expression of the oxytetracycline biosynthetic pathway in Myxococcus xanthus. Applied and environmental microbiology\| PubMed ID: 20208031	2010
Reinvestigation of coenzyme Q10 isolation from Sporidiobolus johnsonii. Chemistry & biodiversity\| PubMed ID: 21674778	2011
6-Deoxyerythronolide B synthase thioesterase-catalyzed macrocyclization is highly stereoselective. Organic letters\| PubMed ID: 22519860	2012
Non-canonical regioisomerizations and a 'Diels-Alderase' are likely essential in the biosynthesis of spiculoic acid A. Bioorganic & medicinal chemistry letters\| PubMed ID: 22801647	2012
ClusterMine360: a database of microbial PKS/NRPS biosynthesis. Nucleic acids research\| PubMed ID: 23104377	2013
Gene PA2449 is essential for glycine metabolism and pyocyanin biosynthesis in Pseudomonas aeruginosa PAO1. Journal of bacteriology\| PubMed ID: 23457254	2013
Alternative Sigma Factor Over-Expression Enables Heterologous Expression of a Type II Polyketide Biosynthetic Pathway in Escherichia coli. PloS one\| PubMed ID: 23724102	2013
Biosynthesis of ebelactone A: isotopic tracer, advanced precursor and genetic studies reveal a thioesterase-independent cyclization to give a polyketide β-lactone. The Journal of antibiotics\| PubMed ID: 23801186	2013
The role of transcription in heterologous expression of polyketides in bacterial hosts. Natural product reports\| PubMed ID: 24061690	2013
Bioinformatics tools for genome mining of polyketide and non-ribosomal peptides. Journal of industrial microbiology & biotechnology\| PubMed ID: 24174214	2014
Habitat-specific type I polyketide synthases in soils and street sediments. Journal of industrial microbiology & biotechnology\| PubMed ID: 24241933	2014
Elucidation of gephyronic acid biosynthetic pathway revealed unexpected SAM-dependent methylations. Journal of natural products\| PubMed ID: 24298873	2013
Genetic analysis of the assimilation of C5-dicarboxylic acids in Pseudomonas aeruginosa PAO1. Journal of bacteriology\| PubMed ID: 24794562	2014
Salvadenosine, a 5'-deoxy-5'-(methylthio) nucleoside from the Bahamian tunicate Didemnum sp. The Journal of organic chemistry\| PubMed ID: 25284474	2014
An evolutionary model encompassing substrate specificity and reactivity of type I polyketide synthase thioesterases. Chembiochem : a European journal of chemical biology\| PubMed ID: 25354333	2014
Resorcylic acid lactone biosynthesis relies on a stereotolerant macrocyclizing thioesterase. Organic letters\| PubMed ID: 25372311	2014
Modulation of antifreeze activity and the effect upon post-thaw HepG2 cell viability after cryopreservation. Cryobiology\| PubMed ID: 25595636	2015
Polyketide synthase and non-ribosomal peptide synthetase thioesterase selectivity: logic gate or a victim of fate? Natural product reports\| PubMed ID: 25642666	2016
Draft Genome Sequence of Streptomyces sp. Strain PBH53, Isolated from an Urban Environment. Genome announcements\| PubMed ID: 26227608	2015
Thermoplasmonic ssDNA Dynamic Release from Gold Nanoparticles Examined with Advanced Fluorescence Microscopy. The journal of physical chemistry letters\| PubMed ID: 26263158	2015
Towards a characterization of the structural determinants of specificity in the macrocyclizing thioesterase for deoxyerythronolide B biosynthesis. Biochimica et biophysica acta\| PubMed ID: 26592346	2016
Diastereoseletive Transannular Oxa-Conjugate Addition Generates the 2,6-cis-Disubstituted Tetrahydropyran of Neopeltolide. The Journal of organic chemistry\| PubMed ID: 26675500	2016
The Use of ClusterMine360 for the Analysis of Polyketide and Nonribosomal Peptide Biosynthetic Pathways. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 26831712	2016
First-in-class small molecule potentiators of cancer virotherapy. Scientific reports\| PubMed ID: 27226390	2016
Total Biosynthesis of Legionaminic Acid, a Bacterial Sialic Acid Analogue. Angewandte Chemie (International ed. in English)\| PubMed ID: 27538580	2016
Portable, On-Demand Biomolecular Manufacturing. Cell\| PubMed ID: 27662092	2016
Natural products: Mapping an amazing thicket. Nature chemical biology\| PubMed ID: 27984578	2016
Sampling Terrestrial Environments for Bacterial Polyketides. Molecules (Basel, Switzerland)\| PubMed ID: 28468277	2017