Yossef Av-Gay

Department of Medicine, University of British Columbia

Affiliated withUniversity of British Columbia

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 15	2017

Other Publications

Article	Year
Expression and localization of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA. Research in microbiology\| PubMed ID: 12066895	2002
Evidence that plant-like genes in Chlamydia species reflect an ancestral relationship between Chlamydiaceae, cyanobacteria, and the chloroplast. Genome research\| PubMed ID: 12176923	2002
Mycothiol-deficient Mycobacterium smegmatis mutants are hypersensitive to alkylating agents, free radicals, and antibiotics. Antimicrobial agents and chemotherapy\| PubMed ID: 12384335	2002
Identification and characterization of a diamide sensitive mutant of Mycobacterium smegmatis. FEMS microbiology letters\| PubMed ID: 12670676	2003
Inactivation of mshB, a key gene in the mycothiol biosynthesis pathway in Mycobacterium smegmatis. Microbiology (Reading, England)\| PubMed ID: 12724395	2003
The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA). Journal of bacteriology\| PubMed ID: 12754249	2003
The crystal structure of 1-D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) from Mycobacterium tuberculosis reveals a zinc hydrolase with a lactate dehydrogenase... The Journal of biological chemistry\| PubMed ID: 12958317	2003
Kinome analysis of host response to mycobacterial infection: a novel technique in proteomics. Infection and immunity\| PubMed ID: 14500469	2003
Characterization of Mycobacterium tuberculosis mycothiol S-conjugate amidase. Biochemistry\| PubMed ID: 14556638	2003
The Mycobacterium tuberculosis ino1 gene is essential for growth and virulence. Molecular microbiology\| PubMed ID: 14763976	2004
Development of a liposome formulation of ethambutol. Antimicrobial agents and chemotherapy\| PubMed ID: 15105152	2004
The Mycobacterium tuberculosis protein serine/threonine kinase PknG is linked to cellular glutamate/glutamine levels and is important for growth in vivo. Molecular microbiology\| PubMed ID: 15186418	2004
Targeted mutagenesis of the Mycobacterium smegmatis mca gene, encoding a mycothiol-dependent detoxification protein. Journal of bacteriology\| PubMed ID: 15342574	2004
Screening of Compounds Toxicity against Human Monocytic cell line-THP-1 by Flow Cytometry. Biological procedures online\| PubMed ID: 15472722	2004
Thiol specific oxidative stress response in Mycobacteria. FEMS microbiology letters\| PubMed ID: 16006064	2005
Mycobacterial manipulation of the host cell. FEMS microbiology reviews\| PubMed ID: 16040149	2005
Deletion of the Mycobacterium tuberculosis pknH gene confers a higher bacillary load during the chronic phase of infection in BALB/c mice. Journal of bacteriology\| PubMed ID: 16077122	2005
Mycobacterium bovis BCG attenuates surface expression of mature class II molecules through IL-10-dependent inhibition of cathepsin S. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16210638	2005
In vitro properties of antimicrobial bromotyrosine alkaloids. Journal of medical microbiology\| PubMed ID: 16533988	2006
Purification and characterization of Mycobacterium tuberculosis 1D-myo-inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase, MshB, a mycothiol biosynthetic enzyme. Protein expression and purification\| PubMed ID: 16630724	2006
Mycothiol-dependent mycobacterial response to oxidative stress. FEBS letters\| PubMed ID: 16643903	2006
Mycobacterium tuberculosis transporter MmpL7 is a potential substrate for kinase PknD. Biochemical and biophysical research communications\| PubMed ID: 16879801	2006
Mycobacterium avium subsp. paratuberculosis PtpA is an endogenous tyrosine phosphatase secreted during infection. Infection and immunity\| PubMed ID: 16982836	2006
Mycothiol-dependent proteins in actinomycetes. FEMS microbiology reviews\| PubMed ID: 17286835	2007
Novel substrates of Mycobacterium tuberculosis PknH Ser/Thr kinase. Biochemical and biophysical research communications\| PubMed ID: 17286964	2007
Innate protection of Mycobacterium smegmatis against the antimicrobial activity of nitric oxide is provided by mycothiol. Antimicrobial agents and chemotherapy\| PubMed ID: 17638697	2007
Lipoamide dehydrogenase mediates retention of coronin-1 on BCG vacuoles, leading to arrest in phagosome maturation. Journal of cell science\| PubMed ID: 17652161	2007
Comparative analysis of mutants in the mycothiol biosynthesis pathway in Mycobacterium smegmatis. Biochemical and biophysical research communications\| PubMed ID: 17826740	2007
Mycobacterium bovis bacillus Calmette-Guérin secreting active cathepsin S stimulates expression of mature MHC class II molecules and antigen presentation in human macrophages. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17911599	2007
Mycobacterium smegmatis biofilm formation and sliding motility are affected by the serine/threonine protein kinase PknF. FEMS microbiology letters\| PubMed ID: 18031532	2008
Molecular cloning and biochemical characterization of a serine threonine protein kinase, PknL, from Mycobacterium tuberculosis. Protein expression and purification\| PubMed ID: 18276158	2008
Mycobacterium tuberculosis virulence is mediated by PtpA dephosphorylation of human vacuolar protein sorting 33B. Cell host & microbe\| PubMed ID: 18474358	2008
Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis. Molecular microbiology\| PubMed ID: 18651841	2008
Gaseous nitric oxide bactericidal activity retained during intermittent high-dose short duration exposure. Nitric oxide : biology and chemistry\| PubMed ID: 18789393	2009
The serine/threonine protein kinase PknI controls the growth of Mycobacterium tuberculosis upon infection. FEMS microbiology letters\| PubMed ID: 19341393	2009
Mycobacterium tuberculosis PtkA is a novel protein tyrosine kinase whose substrate is PtpA. The Biochemical journal\| PubMed ID: 19366344	2009
Glutathione disulfide and S-nitrosoglutathione detoxification by Mycobacterium tuberculosis thioredoxin system. FEBS letters\| PubMed ID: 19737561	2009
Protein kinase and phosphatase signaling in Mycobacterium tuberculosis physiology and pathogenesis. Biochimica et biophysica acta\| PubMed ID: 19766738	2010
Slow release of nitric oxide from charged catheters and its effect on biofilm formation by Escherichia coli. Antimicrobial agents and chemotherapy\| PubMed ID: 19884372	2010
Inositol monophosphate phosphatase genes of Mycobacterium tuberculosis. BMC microbiology\| PubMed ID: 20167072	2010
Synthesis, characterization, and evaluation of antimicrobial and cytotoxic effect of silver and titanium nanoparticles. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 20215045	2010
Inhibition of Mycobacterium tuberculosis tyrosine phosphatase PtpA by synthetic chalcones: kinetics, molecular modeling, toxicity and effect on growth. Bioorganic & medicinal chemistry\| PubMed ID: 20462762	2010
Convergence of Ser/Thr and two-component signaling to coordinate expression of the dormancy regulon in Mycobacterium tuberculosis. The Journal of biological chemistry\| PubMed ID: 20630871	2010
Antimycobacterial activity of UDP-galactopyranose mutase inhibitors. International journal of antimicrobial agents\| PubMed ID: 20678902	2010
MmpS4 promotes glycopeptidolipids biosynthesis and export in Mycobacterium smegmatis. Molecular microbiology\| PubMed ID: 21062372	2010
Antibacterial and cytotoxic activities of the sesquiterpene lactones cnicin and onopordopicrin. Natural product communications\| PubMed ID: 21425665	2011
Precise null deletion mutations of the mycothiol synthesis genes reveal their role in isoniazid and ethionamide resistance in Mycobacterium smegmatis. Antimicrobial agents and chemotherapy\| PubMed ID: 21502624	2011
Synergistic drug combinations for tuberculosis therapy identified by a novel high-throughput screen. Antimicrobial agents and chemotherapy\| PubMed ID: 21576426	2011
Antimicrobial, anti-inflammatory, antiparasitic, and cytotoxic activities of Galium mexicanum. Journal of ethnopharmacology\| PubMed ID: 21586319	2011
Coresistance to isoniazid and ethionamide maps to mycothiol biosynthetic genes in Mycobacterium bovis. Antimicrobial agents and chemotherapy\| PubMed ID: 21709101	2011
Antibacterial activity, inflammatory response, coagulation and cytotoxicity effects of silver nanoparticles. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 21718674	2012
Comparative efficacy of commercially available and emerging antimicrobial urinary catheters against bacteriuria caused by E. coli in vitro. Urology\| PubMed ID: 21820571	2011
Antimicrobial activities of sesquiterpene lactones and inositol derivatives from Hymenoxys robusta. Phytochemistry\| PubMed ID: 21963130	2011
The mycobacterial transcriptional regulator whiB7 gene links redox homeostasis and intrinsic antibiotic resistance. The Journal of biological chemistry\| PubMed ID: 22069311	2012
Mycobacterium tuberculosis protein tyrosine phosphatase (PtpA) excludes host vacuolar-H+-ATPase to inhibit phagosome acidification. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22087003	2011
A phase I clinical study of inhaled nitric oxide in healthy adults. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society\| PubMed ID: 22520076	2012
Nitazoxanide stimulates autophagy and inhibits mTORC1 signaling and intracellular proliferation of Mycobacterium tuberculosis. PLoS pathogens\| PubMed ID: 22589723	2012
Antimicrobial, anti-inflammatory, antiparasitic, and cytotoxic activities of Laennecia confusa. TheScientificWorldJournal\| PubMed ID: 22623891	2012
Mycobacterium tuberculosis modulators of the macrophage's cellular events. Microbes and infection\| PubMed ID: 22841679	2012
Chemical constituents, anti-inflammatory and antioxidant activities of bark extracts from Prunus tucumanensis Lillo. Natural product research\| PubMed ID: 22889184	2013
Mycobacterium tuberculosis-secreted phosphatases: from pathogenesis to targets for TB drug development. Trends in microbiology\| PubMed ID: 23084287	2013
Disruption of the serine/threonine protein kinase H affects phthiocerol dimycocerosates synthesis in Mycobacterium tuberculosis. Microbiology (Reading, England)\| PubMed ID: 23412844	2013
Antimicrobial activity, cytotoxicity and inflammatory response of novel plastics embedded with silver nanoparticles. Future microbiology\| PubMed ID: 23464375	2013
Gaseous nitric oxide reduces influenza infectivity in vitro. Nitric oxide : biology and chemistry\| PubMed ID: 23562771	2013
Mycobacterium tuberculosis nucleoside diphosphate kinase inactivates small GTPases leading to evasion of innate immunity. PLoS pathogens\| PubMed ID: 23874203	2013
Microbial protein-tyrosine kinases. The Journal of biological chemistry\| PubMed ID: 24554699	2014
Mycobacterium tuberculosis promotes anti-apoptotic activity of the macrophage by PtpA protein-dependent dephosphorylation of host GSK3α. The Journal of biological chemistry\| PubMed ID: 25187516	2014
Phosphorylation control of protein tyrosine phosphatase A activity in Mycobacterium tuberculosis. FEBS letters\| PubMed ID: 25535696	2015
Immunoevasion and immunosuppression of the macrophage by Mycobacterium tuberculosis. Immunological reviews\| PubMed ID: 25703562	2015
Regulation of Ergothioneine Biosynthesis and Its Effect on Mycobacterium tuberculosis Growth and Infectivity. The Journal of biological chemistry\| PubMed ID: 26229105	2015
Phosphorylation of Mycobacterium tuberculosis protein tyrosine kinase A PtkA by Ser/Thr protein kinases. Biochemical and biophysical research communications\| PubMed ID: 26417687	2015
Development of an Intracellular Screen for New Compounds Able To Inhibit Mycobacterium tuberculosis Growth in Human Macrophages. Antimicrobial agents and chemotherapy\| PubMed ID: 26503663	2015
Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium tuberculosis. Cell reports\| PubMed ID: 26774486	2016
Intracellular Growth of Bacterial Pathogens: The Role of Secreted Effector Proteins in the Control of Phagocytosed Microorganisms. Microbiology spectrum\| PubMed ID: 27337278	2015
Aminorifamycins and Sporalactams Produced in Culture by a Micromonospora sp. Isolated from a Northeastern-Pacific Marine Sediment Are Potent Antibiotics. Organic letters\| PubMed ID: 28164711	2017
Epigenetic Phosphorylation Control of Mycobacterium tuberculosis Infection and Persistence. Microbiology spectrum\| PubMed ID: 28281439	2017