Kensuke Osada

Department of Bioengineering, The University of Tokyo

Affiliated withThe University of Tokyo the university of tokyo

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 4	2017

Other Publications

Article	Year
Poly(ethylene glycol) Crowding as Critical Factor To Determine pDNA Packaging Scheme into Polyplex Micelles for Enhanced Gene Expression. Biomacromolecules\| PubMed ID: 27990798	2017
A synthetic block copolymer regulates S1 nuclease fragmentation of supercoiled plasmid DNA. Angewandte Chemie (International ed. in English)\| PubMed ID: 15880738	2005
Semipermeable polymer vesicle (PICsome) self-assembled in aqueous medium from a pair of oppositely charged block copolymers: physiologically stable micro-/nanocontainers of water-soluble mac... Journal of the American Chemical Society\| PubMed ID: 16669639	2006
Encapsulation of myoglobin in PEGylated polyion complex vesicles made from a pair of oppositely charged block ionomers: a physiologically available oxygen carrier. Angewandte Chemie (International ed. in English)\| PubMed ID: 17628476	2007
Charge-conversional polyionic complex micelles-efficient nanocarriers for protein delivery into cytoplasm. Angewandte Chemie (International ed. in English)\| PubMed ID: 19294716	2009
Polymeric micelles from poly(ethylene glycol)-poly(amino acid) block copolymer for drug and gene delivery. Journal of the Royal Society, Interface\| PubMed ID: 19364722	2009
Polyplex nanomicelle promotes hydrodynamic gene introduction to skeletal muscle. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 20043959	2010
Quantized folding of plasmid DNA condensed with block catiomer into characteristic rod structures promoting transgene efficacy. Journal of the American Chemical Society\| PubMed ID: 20712309	2010
Polyplex micelles prepared from ω-cholesteryl PEG-polycation block copolymers for systemic gene delivery. Biomaterials\| PubMed ID: 20932567	2011
Enhanced endosomal escape of siRNA-incorporating hybrid nanoparticles from calcium phosphate and PEG-block charge-conversional polymer for efficient gene knockdown with negligible cytotoxici... Biomaterials\| PubMed ID: 21272932	2011
Enhanced in vivo Magnetic Resonance Imaging of Tumors by PEGylated Iron-Oxide-Gold Core-Shell Nanoparticles with Prolonged Blood Circulation Properties. Macromolecular rapid communications\| PubMed ID: 21567561	2010
Combination of chondroitin sulfate and polyplex micelles from Poly(ethylene glycol)-poly{N'-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} block copolymer for prolonged in vivo gene transfectio... Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 21571018	2011
Effect of polymer structure on micelles formed between siRNA and cationic block copolymer comprising thiols and amidines. Biomacromolecules\| PubMed ID: 21863796	2011
Enhanced gene expression promoted by the quantized folding of pDNA within polyplex micelles. Biomaterials\| PubMed ID: 21993237	2012
PEGylated polyplex with optimized PEG shielding enhances gene introduction in lungs by minimizing inflammatory responses. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 22334020	2012
Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic anti-angiogenic gene therapy for fibrotic pancreatic tumors. Biomaterials\| PubMed ID: 22444644	2012
Effective transgene expression without toxicity by intraperitoneal administration of PEG-detachable polyplex micelles in mice with peritoneal dissemination. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 22484197	2012
Targeted polymeric micelles for siRNA treatment of experimental cancer by intravenous injection. ACS nano\| PubMed ID: 22575090	2012
Pancreatic cancer therapy by systemic administration of VEGF siRNA contained in calcium phosphate/charge-conversional polymer hybrid nanoparticles. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 22580114	2012
NanoPARCEL: a method for controlling cellular behavior with external light. Chemical communications (Cambridge, England)\| PubMed ID: 22798992	2012
Bioactive polymeric metallosomes self-assembled through block copolymer-metal complexation. Journal of the American Chemical Society\| PubMed ID: 22834643	2012
In vivo messenger RNA introduction into the central nervous system using polyplex nanomicelle. PloS one\| PubMed ID: 23418537	2013
Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors. Biomaterials\| PubMed ID: 24439417	2014
Three-layered polyplex micelle as a multifunctional nanocarrier platform for light-induced systemic gene transfer. Nature communications\| PubMed ID: 24694458	2014
Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors. Biomaterials\| PubMed ID: 24720877	2014
Bundled assembly of helical nanostructures in polymeric micelles loaded with platinum drugs enhancing therapeutic efficiency against pancreatic tumor. ACS nano\| PubMed ID: 24927216	2014
Intraperitoneal administration of a tumor-associated antigen SART3, CD40L, and GM-CSF gene-loaded polyplex micelle elicits a vaccine effect in mouse tumor models. PloS one\| PubMed ID: 25013909	2014
A tadpole-shaped gene carrier with distinct phase segregation in a ternary polymeric micelle. Soft matter\| PubMed ID: 25711768	2015
Feasibility of a subcutaneously administered block/homo-mixed polyplex micelle as a carrier for DNA vaccination in a mouse tumor model. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 25819159	2015
Ternary polyplex micelles with PEG shells and intermediate barrier to complexed DNA cores for efficient systemic gene delivery. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 25912408	2015
Toroidal Packaging of pDNA into Block Ionomer Micelles Exerting Promoted in Vivo Gene Expression. Biomacromolecules\| PubMed ID: 26226080	2015
Rod-to-Globule Transition of pDNA/PEG-Poly(l-Lysine) Polyplex Micelles Induced by a Collapsed Balance Between DNA Rigidity and PEG Crowdedness. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 26426541	2016
Enhanced target recognition of nanoparticles by cocktail PEGylation with chains of varying lengths. Chemical communications (Cambridge, England)\| PubMed ID: 26658952	2016
Polyplex Micelles with Double-Protective Compartments of Hydrophilic Shell and Thermoswitchable Palisade of Poly(oxazoline)-Based Block Copolymers for Promoted Gene Transfection. Biomacromolecules\| PubMed ID: 26682466	2016
Systemic delivery of messenger RNA for the treatment of pancreatic cancer using polyplex nanomicelles with a cholesterol moiety. Biomaterials\| PubMed ID: 26763736	2016
Influence of RNA Strand Rigidity on Polyion Complex Formation with Block Catiomers. Macromolecular rapid communications\| PubMed ID: 26765970	2016
Polyplex micelle installing intracellular self-processing functionalities without free catiomers for safe and efficient systemic gene therapy through tumor vasculature targeting. Biomaterials\| PubMed ID: 27835820	2017
Happy Birthday Kataoka-sensei! Macromolecular bioscience\| PubMed ID: 28079310	2017
Effect of shear stress on structure and function of polyplex micelles from poly(ethylene glycol)-poly(l-lysine) block copolymers as systemic gene delivery carrier. Biomaterials\| PubMed ID: 28254691	2017
Block Copolymer Micellization as a Protection Strategy for DNA Origami. Angewandte Chemie (International ed. in English)\| PubMed ID: 28295864	2017