Irmgard Tegeder

Institute of Clinical Pharmacology, University Hospital Frankfurt

Affiliated withUniversity Hospital Frankfurt

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 4	2017

Other Publications

Article	Year
Drug interactions with patient-controlled analgesia. Clinical pharmacokinetics\| PubMed ID: 11825096	2002
Time course of 8-methoxypsoralen concentrations in skin and plasma after topical (bath and cream) and oral administration of 8-methoxypsoralen. Clinical pharmacology and therapeutics\| PubMed ID: 11907489	2002
Tissue distribution of imipenem in critically ill patients. Clinical pharmacology and therapeutics\| PubMed ID: 12011818	2002
The influence of inhibition of probenecid sensitive transporters on the central nervous system (CNS) uptake and the antinociceptive activity of morphine-6-glucuronide in rats. Neuroscience letters\| PubMed ID: 12165398	2002
Dual effects of spinally delivered 8-bromo-cyclic guanosine mono-phosphate (8-bromo-cGMP) in formalin-induced nociception in rats. Neuroscience letters\| PubMed ID: 12384231	2002
Increased CNS uptake and enhanced antinociception of morphine-6-glucuronide in rats after inhibition of P-glycoprotein. Journal of neurochemistry\| PubMed ID: 12423235	2002
Validation of a new fluorogenic real-time PCR assay for detection of CYP2C9 allelic variants and CYP2C9 allelic distribution in a German population. British journal of clinical pharmacology\| PubMed ID: 12445031	2002
Spatial distribution of 8-methoxypsoralen penetration into human skin after systemic or topical administration. British journal of clinical pharmacology\| PubMed ID: 12445034	2002
Opposite effects of rofecoxib on nuclear factor-kappaB and activating protein-1 activation. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 12604692	2003
Inhibition of cyclic guanosine 5'-monophosphate-dependent protein kinase I (PKG-I) in lumbar spinal cord reduces formalin-induced hyperalgesia and PKG upregulation. Nitric oxide : biology and chemistry\| PubMed ID: 12620371	2003
Peripheral opioid analgesia in experimental human pain models. Brain : a journal of neurology\| PubMed ID: 12690049	2003
G protein-independent G1 cell cycle block and apoptosis with morphine in adenocarcinoma cells: involvement of p53 phosphorylation. Cancer research\| PubMed ID: 12702572	2003
Cisplatin tumor concentrations after intra-arterial cisplatin infusion or embolization in patients with oral cancer. Clinical pharmacology and therapeutics\| PubMed ID: 12732842	2003
Activation of c-Jun-N-terminal-kinase is crucial for the induction of a cell cycle arrest in human colon carcinoma cells caused by flurbiprofen enantiomers. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 12759338	2003
Peripheral and central antihyperalgesic effects of diclofenac in a model of human inflammatory pain. Clinical pharmacology and therapeutics\| PubMed ID: 12891221	2003
Determination of 8-methoxypsoralen in human plasma, and microdialysates using liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences\| PubMed ID: 14643501	2003
Protein associated with Myc (PAM) is involved in spinal nociceptive processing. Journal of neurochemistry\| PubMed ID: 14756816	2004
Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14973199	2004
Specific Inhibition of IkappaB kinase reduces hyperalgesia in inflammatory and neuropathic pain models in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 14973242	2004
The calpain inhibitor MDL 28170 prevents inflammation-induced neurofilament light chain breakdown in the spinal cord and reduces thermal hyperalgesia. Pain\| PubMed ID: 15275793	2004
Opioids as modulators of cell death and survival--unraveling mechanisms and revealing new indications. Pharmacological reviews\| PubMed ID: 15317908	2004
Essential role of the synaptic vesicle protein synapsin II in formalin-induced hyperalgesia and glutamate release in the spinal cord. Pain\| PubMed ID: 15836980	2005
Comparative proteomic analysis of the rat spinal cord in inflammatory and neuropathic pain models. Neuroscience letters\| PubMed ID: 15896486	2005
Cardiovascular risk with cyclooxygenase inhibitors: general problem with substance specific differences? Naunyn-Schmiedeberg's archives of pharmacology\| PubMed ID: 16586083	2006
Pathophysiology and treatment of pain in joint disease. Advanced drug delivery reviews\| PubMed ID: 16626837	2006
GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nature medicine\| PubMed ID: 17057711	2006
Reliable screening for a pain-protective haplotype in the GTP cyclohydrolase 1 gene (GCH1) through the use of 3 or fewer single nucleotide polymorphisms. Clinical chemistry\| PubMed ID: 17363416	2007
Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors. Nature neuroscience\| PubMed ID: 17558404	2007
The impact of CREB and its phosphorylation at Ser142 on inflammatory nociception. Biochemical and biophysical research communications\| PubMed ID: 17692820	2007
Low-dose methotrexate reduces peripheral nerve injury-evoked spinal microglial activation and neuropathic pain behavior in rats. Pain\| PubMed ID: 18215468	2008
Cysteine-rich protein 2, a novel downstream effector of cGMP/cGMP-dependent protein kinase I-mediated persistent inflammatory pain. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18256252	2008
Ro5-4864 promotes neonatal motor neuron survival and nerve regeneration in adult rats. The European journal of neuroscience\| PubMed ID: 18333964	2008
Reduced hyperalgesia in homozygous carriers of a GTP cyclohydrolase 1 haplotype. European journal of pain (London, England)\| PubMed ID: 18374612	2008
Clinical genetics of functionally mild non-coding GTP cyclohydrolase 1 (GCH1) polymorphisms modulating pain and cardiovascular risk. Mutation research\| PubMed ID: 18515178	2008
GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function. Journal of the American College of Cardiology\| PubMed ID: 18598896	2008
Genetic deletion of synapsin II reduces neuropathic pain due to reduced glutamate but increased GABA in the spinal cord dorsal horn. Pain\| PubMed ID: 18701217	2008
cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18716216	2008
Comparison of nociceptive behavior in prostaglandin E, F, D, prostacyclin and thromboxane receptor knockout mice. European journal of pain (London, England)\| PubMed ID: 18938093	2009
Current evidence for a modulation of low back pain by human genetic variants. Journal of cellular and molecular medicine\| PubMed ID: 19228264	2009
No NO, no pain? The role of nitric oxide and cGMP in spinal pain processing. Trends in neurosciences\| PubMed ID: 19414201	2009
Genetic modulation of the pharmacological treatment of pain. Pharmacology & therapeutics\| PubMed ID: 19615406	2009
Analgesic efficacy of tramadol, pregabalin and ibuprofen in menthol-evoked cold hyperalgesia. Pain\| PubMed ID: 19762153	2009
Inhibitor kappaB Kinase beta deficiency in primary nociceptive neurons increases TRP channel sensitivity. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19828806	2009
R-flurbiprofen reduces neuropathic pain in rodents by restoring endogenous cannabinoids. PloS one\| PubMed ID: 20498712	2010
Inter-strain differences of serotonergic inhibitory pain control in inbred mice. Molecular pain\| PubMed ID: 20977736	2010
Opioid-mediated drug actions cannot be concluded from naloxone induced reversal of anti-nociceptive effects in behavioural tests only. European journal of pain (London, England)\| PubMed ID: 21070957	2010
Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice. The Journal of clinical investigation\| PubMed ID: 21383497	2011
SNO-ing at the nociceptive synapse? Pharmacological reviews\| PubMed ID: 21436345	2011
Nerve injury evoked loss of latexin expression in spinal cord neurons contributes to the development of neuropathic pain. PloS one\| PubMed ID: 21572518	2011
Progranulin contributes to endogenous mechanisms of pain defense after nerve injury in mice. Journal of cellular and molecular medicine\| PubMed ID: 21645236	2012
Emerging country pharmacology: a 10-year perspective from Naunyn-Schmiedeberg's Archives of Pharmacology. Naunyn-Schmiedeberg's archives of pharmacology\| PubMed ID: 21656233	2011
CNGA3: a target of spinal nitric oxide/cGMP signaling and modulator of inflammatory pain hypersensitivity. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21813679	2011
The protein kinase IKKε is a potential target for the treatment of inflammatory hyperalgesia. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21813779	2011
Gα(q/11) signaling tonically modulates nociceptor function and contributes to activity-dependent sensitization. Pain\| PubMed ID: 22071319	2012
Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity. PLoS biology\| PubMed ID: 22427743	2012
Inhibitor kappa B kinase beta dependent cytokine upregulation in nociceptive neurons contributes to nociceptive hypersensitivity after sciatic nerve injury. The journal of pain : official journal of the American Pain Society\| PubMed ID: 22564672	2012
Protein S-nitrosylation and denitrosylation in the mouse spinal cord upon injury of the sciatic nerve. Journal of proteomics\| PubMed ID: 22588120	2012
Inhibition of GTP cyclohydrolase reduces cancer pain in mice and enhances analgesic effects of morphine. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 22706600	2012
Inhibition of GTP cyclohydrolase attenuates tumor growth by reducing angiogenesis and M2-like polarization of tumor associated macrophages. International journal of cancer\| PubMed ID: 22753274	2013
Author's reply to Kapoor S. GTP cyclohydrolase and cancer pain. International journal of cancer\| PubMed ID: 23011772	2013
Peripheral nerve injury produces a sustained shift in the balance between glutamate release and uptake in the dorsal horn of the spinal cord. Pain\| PubMed ID: 23021150	2012
Anandamide deficiency and heightened neuropathic pain in aged mice. Neuropharmacology\| PubMed ID: 23597506	2013
Dichotomy of CCL21 and CXCR3 in nerve injury-evoked and autoimmunity-evoked hyperalgesia. Brain, behavior, and immunity\| PubMed ID: 23643685	2013
Exogenous delta⁹-tetrahydrocannabinol influences circulating endogenous cannabinoids in humans. Journal of clinical psychopharmacology\| PubMed ID: 23899642	2013
Hypoxia-inducible factor 1 regulates heat and cold pain sensitivity and persistence. Antioxidants & redox signaling\| PubMed ID: 24144405	2014
Learning and memory with neuropathic pain: impact of old age and progranulin deficiency. Frontiers in behavioral neuroscience\| PubMed ID: 24319417	2013
R-flurbiprofen attenuates experimental autoimmune encephalomyelitis in mice. EMBO molecular medicine\| PubMed ID: 25269445	2014
"Disease modifying nutricals" for multiple sclerosis. Pharmacology & therapeutics\| PubMed ID: 25435020	2015
Regulation of circulating endocannabinoids associated with cancer and metastases in mice and humans. Oncoscience\| PubMed ID: 25594019	2014
Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway. Neuron\| PubMed ID: 26087165	2015
COX-2-Derived Prostaglandin E2 Produced by Pyramidal Neurons Contributes to Neurovascular Coupling in the Rodent Cerebral Cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 26311764	2015
Redoxins in peripheral neurons after sciatic nerve injury. Free radical biology & medicine\| PubMed ID: 26456799	2015
Molecular cause and functional impact of altered synaptic lipid signaling due to a prg-1 gene SNP. EMBO molecular medicine\| PubMed ID: 26671989	2015
Expression and regulation of redoxins at nociceptive signaling sites after sciatic nerve injury in mice. Data in brief\| PubMed ID: 26693520	2015
Endocannabinoids as Guardians of Metastasis. International journal of molecular sciences\| PubMed ID: 26875980	2016
Tetrahydrobiopterin Attenuates DSS-evoked Colitis in Mice by Rebalancing Redox and Lipid Signalling. Journal of Crohn's & colitis\| PubMed ID: 26928964	2016
Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy. Neurobiology of disease\| PubMed ID: 27629805	2016
Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling. Molecular neurodegeneration\| PubMed ID: 27770818	2016
Progranulin protects against exaggerated axonal injury and astrogliosis following traumatic brain injury. Glia\| PubMed ID: 27778404	2017
Yeast-2-Hybrid data file showing progranulin interactions in human fetal brain and bone marrow libraries. Data in brief\| PubMed ID: 27921076	2016
Data file of a deep proteome analysis of the prefrontal cortex in aged mice with progranulin deficiency or neuronal overexpression of progranulin. Data in brief\| PubMed ID: 27921079	2016
Redox-guided axonal regrowth requires cyclic GMP dependent protein kinase 1: Implication for neuropathic pain. Redox biology\| PubMed ID: 27978504	2017
R-Flurbiprofen Traps Prostaglandins within Cells by Inhibition of Multidrug Resistance-Associated Protein-4. International journal of molecular sciences\| PubMed ID: 28042832	2016