analyzing-cell-surface-adhesion-remodeling-response-to-mechanical

Analyzing Cell Surface Adhesion Remodeling in Response to Mechanical Tension Using Magnetic Beads

Mechanosensitive cell surface adhesion complexes allow cells to sense the mechanical properties of their surroundings. Recent studies have identified both ...

Centre de recherche UGA - INSERM U1209 - CNRS UMR

Cells are constantly adjusting to the mechanical properties of their surroundings, operating a complex mechanochemical feedback, which hinges on mechanotransduction mechanisms. Whereas adhesion structures have been shown to play a central role in mechanotransduction, it now emerges that the nucleus may act as a mechanosensitive structure. Here, we review recent advances demonstrating that mechanical stress emanating from the cytoskeleton can activate pathways in the nucleus which eventually impact both its structure and the transcriptional machinery.

Under Pressure: Mechanical Stress Management in the Nucleus.

As the largest and stiffest organelle in the cell, the nucleus can be subjected to significant forces generated by the cytoskeleton to adjust its shape and position, and accommodate the cellular machinery during cell migration, differentiation or division. As it was anticipated, recent work showed that mechanosensitive mechanisms exist in the nucleus and regulate its structure and function in response to mechanical force. While the molecular mechanisms that mediate this response are only beginning to be elucidated, the nuclear envelope seems to play a central role in this process. Here, we review these nuclear mechanosensitive mechanisms and highlight their functional homology with those located at the cell surface. Additionally, we discuss how these nuclear envelope mechanisms function during adhesion and migration, and how they participate in cytoskeletal organization, via direct physical contact or signaling event regulation.

Article	Year
Under Pressure: Mechanical Stress Management in the Nucleus. Cells\| PubMed ID: 27314389	2016
Mechanotransduction via the nuclear envelope: a distant reflection of the cell surface. Current opinion in cell biology\| PubMed ID: 27876470	2016

Julien Aureille

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