George K. Gittes

Department of Pediatric Surgery, Children's Hospital of Pittsburgh of UPMC

Affiliated withChildren's Hospital of Pittsburgh of UPMC University of Pittsburgh School of Medicine

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 1	2021
Publication title Cited by 1	2024

Other Publications

Article	Year
Defective pulmonary innervation and autonomic imbalance in congenital diaphragmatic hernia. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 22114150	2012
Intestinal epithelial Toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice. Gastroenterology\| PubMed ID: 22796522	2012
TGFβ receptor signaling is essential for inflammation-induced but not β-cell workload-induced β-cell proliferation. Diabetes\| PubMed ID: 23248173	2013
Hypoglycemia reduces vascular endothelial growth factor A production by pancreatic beta cells as a regulator of beta cell mass. The Journal of biological chemistry\| PubMed ID: 23378532	2013
Neurogenin3 activation is not sufficient to direct duct-to-beta cell transdifferentiation in the adult pancreas. The Journal of biological chemistry\| PubMed ID: 23867457	2013
α-Cells are dispensable in postnatal morphogenesis and maturation of mouse pancreatic islets. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 23982158	2013
Toll-like receptor 4-mediated endoplasmic reticulum stress in intestinal crypts induces necrotizing enterocolitis. The Journal of biological chemistry\| PubMed ID: 24519940	2014
Dynamic imaging of pancreatic nuclear factor κB (NF-κB) activation in live mice using adeno-associated virus (AAV) infusion and bioluminescence. The Journal of biological chemistry\| PubMed ID: 25802340	2015
Concise Review: New Insights Into the Role of Macrophages in β-Cell Proliferation. Stem cells translational medicine\| PubMed ID: 25900729	2015
Defective parasympathetic innervation is associated with airway branching abnormalities in experimental CDH. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 25934671	2015
The Role of ARF6 in Biliary Atresia. PloS one\| PubMed ID: 26379158	2015
Peroxisome Proliferator-activated Receptor-γ Coactivator 1-α (PGC1α) Protects against Experimental Murine Colitis. The Journal of biological chemistry\| PubMed ID: 26969166	2016
A synopsis of factors regulating beta cell development and beta cell mass. Cellular and molecular life sciences : CMLS\| PubMed ID: 27105622	2016
Epidermal Growth Factor Receptor Signaling Regulates β Cell Proliferation in Adult Mice. The Journal of biological chemistry\| PubMed ID: 27587395	2016
Forkhead Box Protein 1 (FoxO1) Inhibits Accelerated β Cell Aging in Pancreas-specific SMAD7 Mutant Mice. The Journal of biological chemistry\| PubMed ID: 28057752	2017
SMAD3/Stat3 Signaling Mediates β-Cell Epithelial-Mesenchymal Transition in Chronic Pancreatitis-Related Diabetes. Diabetes\| PubMed ID: 28775125	2017
GLP-1/Exendin-4 induces β-cell proliferation via the epidermal growth factor receptor. Scientific reports\| PubMed ID: 28831150	2017
Gcg knockin mice as a tool for genetic manipulation in pancreatic alpha cells. Diabetologia\| PubMed ID: 28884202	2017
Autophagy protects pancreatic beta cell mass and function in the setting of a high-fat and high-glucose diet. Scientific reports\| PubMed ID: 29180700	2017
Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes. Cell stem cell\| PubMed ID: 29304344	2018
Islet α-cell Inflammation Induced By NF-κB inducing kinase (NIK) Leads to Hypoglycemia, Pancreatitis, Growth Retardation, and Postnatal Death in Mice. Theranostics\| PubMed ID: 30613274	2018
Evidence of a developmental origin for β-cell heterogeneity using a dual lineage-tracing technology. Development (Cambridge, England)\| PubMed ID: 31160417	2019
Cellular Autophagy in Cells Plays a Role in the Maintenance of Islet Architecture. Journal of the Endocrine Society\| PubMed ID: 31620668	2019
SMAD7 enhances adult β-cell proliferation without significantly affecting β-cell function in mice. The Journal of biological chemistry\| PubMed ID: 32122971	2020
Biliary-Atresia-Associated Mannosidase-1-Alpha-2 Gene Regulates Biliary and Ciliary Morphogenesis and Laterality. Frontiers in physiology\| PubMed ID: 33192543	2020
TGF-beta isoform signaling regulates secondary transition and mesenchymal-induced endocrine development in the embryonic mouse pancreas. Developmental biology\| PubMed ID: 17418116	2007
Developmental biology of the pancreas: a comprehensive review. Developmental biology\| PubMed ID: 19013144	2009
Reciprocal expression and signaling of TLR4 and TLR9 in the pathogenesis and treatment of necrotizing enterocolitis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19109197	2009
Assessing vesicoureteral reflux in live inbred mice via ultrasound with a microbubble contrast agent. American journal of physiology. Renal physiology\| PubMed ID: 21325495	2011
Amniotic fluid inhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22733781	2012
No evidence for β cell neogenesis in murine adult pancreas. The Journal of clinical investigation\| PubMed ID: 23619362	2013
Pancreatic duct cells as a source of VEGF in mice. Diabetologia\| PubMed ID: 24535231	2014
M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24639504	2014
Renal blood flow and oxygenation drive nephron progenitor differentiation. American journal of physiology. Renal physiology\| PubMed ID: 24920757	2014
Pancreatic cell tracing, lineage tagging and targeted genetic manipulations in multiple cell types using pancreatic ductal infusion of adeno-associated viral vectors and/or cell-tagging dyes... Nature protocols\| PubMed ID: 25356582	2014
Intraislet Pancreatic Ducts Can Give Rise to Insulin-Positive Cells. Endocrinology\| PubMed ID: 26505114	2016
Multiple roles for TGFβ receptor type II in regulating the pancreatic response in acute pancreatitis. The Journal of pathology\| PubMed ID: 26608971	2016
Transient Suppression of TGFβ Receptor Signaling Facilitates Human Islet Transplantation. Endocrinology\| PubMed ID: 26872091	2016
PNA lectin for purifying mouse acinar cells from the inflamed pancreas. Scientific reports\| PubMed ID: 26884345	2016
Targeted inhibition of pancreatic acinar cell calcineurin is a novel strategy to prevent post-ERCP pancreatitis. Cellular and molecular gastroenterology and hepatology\| PubMed ID: 28090570	2017
Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion. The Journal of clinical investigation\| PubMed ID: 29106387	2017
Placental growth factor in beta cells plays an essential role in gestational beta-cell growth. BMJ open diabetes research & care\| PubMed ID: 32144129	2020
Intra-Amniotic Sildenafil Treatment Promotes Lung Growth and Attenuates Vascular Remodeling in an Experimental Model of Congenital Diaphragmatic Hernia. Fetal diagnosis and therapy\| PubMed ID: 32663823	2020
Glucagon Resistance and Decreased Susceptibility to Diabetes in a Model of Chronic Hyperglucagonemia. Diabetes\| PubMed ID: 33239450	2021
Chemical pancreatectomy treats chronic pancreatitis while preserving endocrine function in preclinical models. The Journal of clinical investigation\| PubMed ID: 33351784	2021
Insulin-positive ductal cells do not migrate into preexisting islets during pregnancy. Experimental & molecular medicine\| PubMed ID: 33820959	2021
Chitinase-3-like 1 protein complexes modulate macrophage-mediated immune suppression in glioblastoma. The Journal of clinical investigation\| PubMed ID: 34228644	2021
Mechanisms of Impaired Lung Development and Ciliation in Mannosidase-1-Alpha-2 () Mutants. Frontiers in physiology\| PubMed ID: 34366878	2021
Polarized macrophages promote gestational beta cell growth through extracellular signal-regulated kinase 5 signalling. Diabetes, obesity & metabolism\| PubMed ID: 35546452	2022
Ionizable lipid nanoparticles deliver mRNA to pancreatic β cells via macrophage-mediated gene transfer. Science advances\| PubMed ID: 36706177	2023
Bone-marrow derived cells do not contribute to new beta-cells in the inflamed pancreas. Frontiers in immunology\| PubMed ID: 36733483	2023
A neurodevelopmental epigenetic programme mediated by SMARCD3-DAB1-Reelin signalling is hijacked to promote medulloblastoma metastasis. Nature cell biology\| PubMed ID: 36849558	2023
Intra-amniotic sildenafil administration in rabbits: Safety, pharmacokinetics, organ distribution and histologic evaluation. Toxicology and applied pharmacology\| PubMed ID: 37080362	2023
Time-dependent effects of endogenous hyperglucagonemia on glucose homeostasis and hepatic glucagon action. JCI insight\| PubMed ID: 37140984	2023
Intra-amniotic sildenafil treatment improves lung blood flow and pulmonary hypertension in congenital diaphragmatic hernia rats. Frontiers in bioengineering and biotechnology\| PubMed ID: 37545896	2023
Intra-Amniotic Sildenafil and Rosiglitazone Late in Gestation Ameliorate the Pulmonary Hypertension Phenotype in Congenital Diaphragmatic Hernia. Journal of pediatric surgery\| PubMed ID: 38350773	2024