Arnold Caplan

Department of Biology - Skeletal Research Center, Case Western Reserve University

Affiliated withCase Western Reserve University

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 7	2017

Other Publications

Article	Year
The STRO-1+ marrow cell population is multipotential. Cells, tissues, organs\| PubMed ID: 11731697	2002
Treatment of osteochondral defects with autologous bone marrow in a hyaluronan-based delivery vehicle. Tissue engineering\| PubMed ID: 12031121	2002
In vivo remodeling. Annals of the New York Academy of Sciences\| PubMed ID: 12081925	2002
In vivo remodeling: breakout session summary. Annals of the New York Academy of Sciences\| PubMed ID: 12081929	2002
Immunochemical and mechanical characterization of cartilage subtypes in rabbit. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society\| PubMed ID: 12133908	2002
Bioreactors mediate the effectiveness of tissue engineering scaffolds. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 12207008	2002
Repair of osteochondral defect with tissue-engineered two-phase composite material of injectable calcium phosphate and hyaluronan sponge. Tissue engineering\| PubMed ID: 12459061	2002
Age-related changes in the proteoglycans of human skin. Specific cleavage of decorin to yield a major catabolic fragment in adult skin. The Journal of biological chemistry\| PubMed ID: 12621051	2003
Embryonic development and the principles of tissue engineering. Novartis Foundation symposium\| PubMed ID: 12708647	2003
Production of a monoclonal antibody, DF-5, that identifies cells at the epithelial-mesenchymal interface in normal human skin. APN/CD13 is an epithelial-mesenchymal marker in skin. Experimental dermatology\| PubMed ID: 12823446	2003
Cytokines and glucocorticoids differentially regulate APN/CD13 and DPPIV/CD26 enzyme activities in cultured human dermal fibroblasts. Archives of dermatological research\| PubMed ID: 12861419	2003
Fibroblast heterogeneity: more than skin deep. Journal of cell science\| PubMed ID: 14754903	2004
Cellular interactions and bone healing responses to a novel porous tricalcium phosphate bone graft material. Orthopedics\| PubMed ID: 14763552	2004
Targeted delivery of progenitor cells for cartilage repair. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 15183428	2004
A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential. The Journal of experimental medicine\| PubMed ID: 15263023	2004
Generation of pluripotent stem cells and their differentiation to the chondrocytic phenotype. Methods in molecular medicine\| PubMed ID: 15280587	2004
Adult stem cell driven genesis of human-shaped articular condyle. Annals of biomedical engineering\| PubMed ID: 15298429	2004
Sustained Wnt protein expression in chondral constructs from mesenchymal stem cells. Journal of cellular physiology\| PubMed ID: 15389636	2005
Osteochondral defect repair by demineralized cortical bone matrix. Clinical orthopaedics and related research\| PubMed ID: 15480077	2004
FGF-2 enhances the mitotic and chondrogenic potentials of human adult bone marrow-derived mesenchymal stem cells. Journal of cellular physiology\| PubMed ID: 15521064	2005
Controlled release of hyaluronan oligomers from biodegradable polymeric microparticle carriers. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 15544873	2004
Tissue engineering of autologous cartilage grafts in three-dimensional in vitro macroaggregate culture system. Tissue engineering\| PubMed ID: 15684678	2004
Repair of osteochondral defects with hyaluronan- and polyester-based scaffolds. Osteoarthritis and cartilage\| PubMed ID: 15780643	2005
Effect of transforming growth factor beta 2 on marrow-infused foam poly(propylene fumarate) tissue-engineered constructs for the repair of critical-size cranial defects in rabbits. Tissue engineering\| PubMed ID: 15998232	2005
Review: mesenchymal stem cells: cell-based reconstructive therapy in orthopedics. Tissue engineering\| PubMed ID: 16144456	2005
A simple method for stem cell labeling with fluorine 18. Nuclear medicine and biology\| PubMed ID: 16243645	2005
Hyaluronan-based polymer scaffold modulates the expression of inflammatory and degradative factors in mesenchymal stem cells: Involvement of Cd44 and Cd54. Journal of cellular physiology\| PubMed ID: 16331675	2006
Mesenchymal stem cells as trophic mediators. Journal of cellular biochemistry\| PubMed ID: 16619257	2006
A rapid seeding technique for the assembly of large cell/scaffold composite constructs. Tissue engineering\| PubMed ID: 16889515	2006
Toxic effects of gentamicin on marrow-derived human mesenchymal stem cells. Clinical orthopaedics and related research\| PubMed ID: 16906089	2006
Isolation of human marrow-derived mesenchymal stem cells. Experimental hematology\| PubMed ID: 17046583	2006
Isolation of rat marrow-derived mesenchymal stem cells. Experimental hematology\| PubMed ID: 17046584	2006
Clonal characterization of fibroblasts in the superficial layer of the adult human dermis. Cell and tissue research\| PubMed ID: 17093925	2007
Human mesenchymal stem cells signals regulate neural stem cell fate. Neurochemical research\| PubMed ID: 17191131	2007
Cartilage tissue engineering for laryngotracheal reconstruction: comparison of chondrocytes from three anatomic locations in the rabbit. Tissue engineering\| PubMed ID: 17394383	2007
Isolation and characterization of a population of immature dental pulp stem cells expressing OCT-4 and other embryonic stem cell markers. Cells, tissues, organs\| PubMed ID: 17409736	2006
Injectable biodegradable hydrogel composites for rabbit marrow mesenchymal stem cell and growth factor delivery for cartilage tissue engineering. Biomaterials\| PubMed ID: 17445882	2007
Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. Journal of cellular physiology\| PubMed ID: 17620285	2007
A self-assembled fibroblast-endothelial cell co-culture system that supports in vitro vasculogenesis by both human umbilical vein endothelial cells and human dermal microvascular endothelial... Cells, tissues, organs\| PubMed ID: 17657137	2007
Human dermal fibroblast subpopulations; differential interactions with vascular endothelial cells in coculture: nonsoluble factors in the extracellular matrix influence interactions. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society\| PubMed ID: 18318814	2008
Effect of dual growth factor delivery on chondrogenic differentiation of rabbit marrow mesenchymal stem cells encapsulated in injectable hydrogel composites. Journal of biomedical materials research. Part A\| PubMed ID: 18381637	2009
In search of the in vivo identity of mesenchymal stem cells. Stem cells (Dayton, Ohio)\| PubMed ID: 18566331	2008
Effects of initial seeding density and fluid perfusion rate on formation of tissue-engineered bone. Tissue engineering. Part A\| PubMed ID: 18620487	2008
Dexamethasone inhibition of confluence-induced apoptosis in human mesenchymal stem cells. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 18683880	2009
All MSCs are pericytes? Cell stem cell\| PubMed ID: 18786406	2008
MSC frequency correlates with blood vessel density in equine adipose tissue. Tissue engineering. Part A\| PubMed ID: 18847356	2009
In vitro dexamethasone pretreatment enhances bone formation of human mesenchymal stem cells in vivo. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 19137580	2009
Effect of swelling ratio of injectable hydrogel composites on chondrogenic differentiation of encapsulated rabbit marrow mesenchymal stem cells in vitro. Biomacromolecules\| PubMed ID: 19173557	2009
Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis. Glia\| PubMed ID: 19191336	2009
Influence of adult mesenchymal stem cells on in vitro vascular formation. Tissue engineering. Part A\| PubMed ID: 19196139	2009
New era of cell-based orthopedic therapies. Tissue engineering. Part B, Reviews\| PubMed ID: 19228082	2009
A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans. Nature medicine\| PubMed ID: 19234460	2009
Fibroblasts-a diverse population at the center of it all. International review of cell and molecular biology\| PubMed ID: 19584013	2009
Chondrogenesis of adult stem cells from adipose tissue and bone marrow: induction by growth factors and cartilage-derived matrix. Tissue engineering. Part A\| PubMed ID: 19715387	2010
Optimizing mesenchymal stem cell-based therapeutics. Current opinion in biotechnology\| PubMed ID: 19783424	2009
Fibroblast growth factor-2 enhances proliferation and delays loss of chondrogenic potential in human adult bone-marrow-derived mesenchymal stem cells. Tissue engineering. Part A\| PubMed ID: 19842915	2010
Mechanisms involved in the therapeutic properties of mesenchymal stem cells. Cytokine & growth factor reviews\| PubMed ID: 19926330	2009
Low oxygen tension during incubation periods of chondrocyte expansion is sufficient to enhance postexpansion chondrogenesis. Tissue engineering. Part A\| PubMed ID: 19958052	2010
In vitro generation of mechanically functional cartilage grafts based on adult human stem cells and 3D-woven poly(epsilon-caprolactone) scaffolds. Biomaterials\| PubMed ID: 20034665	2010
The potential of mesenchymal stem cells for neural repair. Discovery medicine\| PubMed ID: 20350491	2010
What's in a name? Tissue engineering. Part A\| PubMed ID: 20412005	2010
Adult mesenchymal stem cells: an innovative therapeutic for lung diseases. Discovery medicine\| PubMed ID: 20423678	2010
Chondrogenesis and mineralization during in vitro culture of human mesenchymal stem cells on three-dimensional woven scaffolds. Tissue engineering. Part A\| PubMed ID: 20673022	2010
Human mesenchymal stem cells suppress chronic airway inflammation in the murine ovalbumin asthma model. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 20817776	2010
Topical delivery of mesenchymal stem cells and their function in wounds. Stem cell research & therapy\| PubMed ID: 20863417	2010
Age-related differences in human skin proteoglycans. Glycobiology\| PubMed ID: 20947661	2011
Defining human mesenchymal stem cell efficacy in vivo. Journal of inflammation (London, England)\| PubMed ID: 20974000	2010
Mesenchymal stem cells: mechanisms of inflammation. Annual review of pathology\| PubMed ID: 21073342	2011
2010 lifetime achievement award of Tissue Engineering and Regenerative Medicine International Society--north America: Arnold I. Caplan, Ph.D. Tissue engineering. Part A\| PubMed ID: 21128820	2011
Biological evaluation of a new C-xylopyranoside derivative (C-Xyloside) and its role in glycosaminoglycan biosynthesis. European journal of dermatology : EJD\| PubMed ID: 21609902	2011
PDGF in bone formation and regeneration: new insights into a novel mechanism involving MSCs. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 21618276	2011
The MSC: an injury drugstore. Cell stem cell\| PubMed ID: 21726829	2011
Nondestructive evaluation of hydrogel mechanical properties using ultrasound. Annals of biomedical engineering\| PubMed ID: 21773854	2011
Polybrene inhibits human mesenchymal stem cell proliferation during lentiviral transduction. PloS one\| PubMed ID: 21887340	2011
The creation of an in vitro adipose tissue that contains a vascular-adipocyte complex. Biomaterials\| PubMed ID: 21959010	2011
Stem cells in dental pulp of deciduous teeth. Tissue engineering. Part B, Reviews\| PubMed ID: 22032258	2012
Development of a peptide-targeted, myocardial ischemia-homing, mesenchymal stem cell. Journal of drug targeting\| PubMed ID: 22047107	2012
Proteoglycans of uterine fibroids and keloid scars: similarity in their proteoglycan composition. The Biochemical journal\| PubMed ID: 22257180	2012
Imaging stem cell differentiation for cell-based tissue repair. Methods in enzymology\| PubMed ID: 22341228	2012
Hepatocyte growth factor mediates mesenchymal stem cell–induced recovery in multiple sclerosis models. Nature neuroscience\| PubMed ID: 22610068	2012
Quantitative microscopy in murine models of lung inflammation. Analytical and quantitative cytology and histology\| PubMed ID: 22611751	2011
Scaling-up of dental pulp stem cells isolated from multiple niches. PloS one\| PubMed ID: 22768154	2012
The inhibition by interleukin 1 of MSC chondrogenesis and the development of biomechanical properties in biomimetic 3D woven PCL scaffolds. Biomaterials\| PubMed ID: 22999467	2012
Cell transplantation as an initiator of endogenous stem cell-based tissue repair. Current opinion in organ transplantation\| PubMed ID: 23111645	2012
Micrometer scale guidance of mesenchymal stem cells to form structurally oriented cartilage extracellular matrix. Tissue engineering. Part A\| PubMed ID: 23157410	2013
The effect of extended first passage culture on the proliferation and differentiation of human marrow-derived mesenchymal stem cells. Stem cells translational medicine\| PubMed ID: 23197807	2012
Efficient lentiviral transduction of human mesenchymal stem cells that preserves proliferation and differentiation capabilities. Stem cells translational medicine\| PubMed ID: 23283550	2012
Adult mesenchymal stem cells and the NO pathways. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23396846	2013
Growth, differentiation capacity, and function of mesenchymal stem cells expanded in serum-free medium developed via combinatorial screening. Experimental cell research\| PubMed ID: 23597555	2013
The effects of crosslinking of scaffolds engineered from cartilage ECM on the chondrogenic differentiation of MSCs. Biomaterials\| PubMed ID: 23642532	2013
MSCs: Delivery Routes and Engraftment, Cell-Targeting Strategies, and Immune Modulation. Stem cells international\| PubMed ID: 24000286	2013
Mesenchymal stem cells in tissue repair. Frontiers in immunology\| PubMed ID: 24027567	2013
Serial transplantation and long-term engraftment of intra-arterially delivered clonally derived mesenchymal stem cells to injured bone marrow. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 24067545	2014
Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine. Experimental & molecular medicine\| PubMed ID: 24232253	2013
Validating continuous digital light processing (cDLP) additive manufacturing accuracy and tissue engineering utility of a dye-initiator package. Biofabrication\| PubMed ID: 24429508	2014
Progressive approval: a proposal for a new regulatory pathway for regenerative medicine. Stem cells translational medicine\| PubMed ID: 24682285	2014
Chondrogenic differentiation of mesenchymal stem cells: challenges and unfulfilled expectations. Tissue engineering. Part B, Reviews\| PubMed ID: 24749845	2014
The role of CXCL12 and CCL7 chemokines in immune regulation, embryonic development, and tissue regeneration. Cytokine\| PubMed ID: 25034237	2014
Identification of a subpopulation of marrow MSC-derived medullary adipocytes that express osteoclast-regulating molecules: marrow adipocytes express osteoclast mediators. PloS one\| PubMed ID: 25302610	2014
Cancer stem cells: targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance. Cancer research\| PubMed ID: 25604264	2015
Adult mesenchymal stem cells and women's health. Menopause (New York, N.Y.)\| PubMed ID: 25608271	2015
Regenerative treatments to enhance orthopedic surgical outcome. PM & R : the journal of injury, function, and rehabilitation\| PubMed ID: 25864660	2015
Platelet-Derived Growth Factor BB Enhances Osteogenesis of Adipose-Derived But Not Bone Marrow-Derived Mesenchymal Stromal/Stem Cells. Stem cells (Dayton, Ohio)\| PubMed ID: 26013357	2015
Body Management: Mesenchymal Stem Cells Control the Internal Regenerator. Stem cells translational medicine\| PubMed ID: 26019227	2015
Mesenchymal Stem Cells: The Past, the Present, the Future. Cartilage\| PubMed ID: 26069532	2010
The MSC curtain that stops the immune system. Immunology letters\| PubMed ID: 26079607	2015
Mesenchymal stem cells regulate melanoma cancer cells extravasation to bone and liver at their perivascular niche. International journal of cancer\| PubMed ID: 26235173	2016
Adult Mesenchymal Stem Cells: When, Where, and How. Stem cells international\| PubMed ID: 26273305	2015
Mesenchymal stem cell therapy in a rat model of birth-trauma injury: functional improvements and biodistribution. International urogynecology journal\| PubMed ID: 26353846	2016
Proteoglycans in Leiomyoma and Normal Myometrium: Abundance, Steroid Hormone Control, and Implications for Pathophysiology. Reproductive sciences (Thousand Oaks, Calif.)\| PubMed ID: 26423601	2016
MSCs: The Sentinel and Safe-Guards of Injury. Journal of cellular physiology\| PubMed ID: 26565391	2016
Antimicrobial Properties of Mesenchymal Stem Cells: Therapeutic Potential for Cystic Fibrosis Infection, and Treatment. Stem cells international\| PubMed ID: 26925108	2016
Development of a Functional Biomarker for Use in Cell-Based Therapy Studies in Seropositive Rheumatoid Arthritis. Stem cells translational medicine\| PubMed ID: 27025689	2016
Mesenchymal Stem Cells in Lipogems, a Reverse Story: from Clinical Practice to Basic Science. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 27236668	2016
The 3Rs of Cell Therapy. Stem cells translational medicine\| PubMed ID: 27502516	2016
Growth Factor Dose Tuning for Bone Progenitor Cell Proliferation and Differentiation on Resorbable Poly(propylene fumarate) Scaffolds. Tissue engineering. Part C, Methods\| PubMed ID: 27558310	2016
The 3Rs of Cell Therapy. Stem cells translational medicine\| PubMed ID: 28170173	2017
New MSC: MSCs as pericytes are Sentinels and gatekeepers. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 28294393	2017
Mesenchymal Stem Cells: Time to Change the Name! Stem cells translational medicine\| PubMed ID: 28452204	2017
Not Missing the Future: A Call to Action for Investigating the Role of Regenerative Medicine Therapies in Pediatric/Adolescent Sports Injuries. Current sports medicine reports\| PubMed ID: 28498229	2017
Transcriptome-Wide Analyses of Human Neonatal Articular Cartilage and Human Mesenchymal Stem Cell-Derived Cartilage Provide a New Molecular Target for Evaluating Engineered Cartilage. Tissue engineering. Part A\| PubMed ID: 28602122	2017
Non-destructive/non-invasive imaging evaluation of cellular differentiation progression during in vitro MSC-derived chondrogenesis. Tissue engineering. Part A\| PubMed ID: 28825369	2017