Mak Shinghung

Department of Applied Biology and Chemistry Technology, The Hong Kong Polytechnic University

Affiliated withThe Hong Kong Polytechnic University

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 28	2017

Other Publications

Article	Year
Promising multifunctional anti-Alzheimer's dimer bis(7)-Cognitin acting as an activator of protein kinase C regulates activities of alpha-secretase and BACE-1 concurrently. European journal of pharmacology\| PubMed ID: 19765582	2009
Preventing Hâ‚‚Oâ‚‚-induced apoptosis in cerebellar granule neurons by regulating the VEGFR-2/Akt signaling pathway using a novel dimeric antiacetylcholinesterase bis(12)-hupyridone. Brain research\| PubMed ID: 21315693	2011
Protection against 1-methyl-4-phenylpyridinium ion (MPP+)-induced apoptosis by water extract of ginseng (Panax ginseng C.A. Meyer) in SH-SY5Y cells. Journal of ethnopharmacology\| PubMed ID: 21349320	2011
Bis(12)-hupyridone, a novel multifunctional dimer, promotes neuronal differentiation more potently than its monomeric natural analog huperzine A possibly through α7 nAChR. Brain research\| PubMed ID: 21665194	2011
PI3-K/Akt and ERK pathways activated by VEGF play opposite roles in MPP+-induced neuronal apoptosis. Neurochemistry international\| PubMed ID: 21781996	2011
Tacrine(2)-ferulic acid, a novel multifunctional dimer, attenuates 6-hydroxydopamine-induced apoptosis in PC12 cells by activating Akt pathway. Neurochemistry international\| PubMed ID: 21939707	2011
Unexpected neuronal protection of SU5416 against 1-Methyl-4-phenylpyridinium ion-induced toxicity via inhibiting neuronal nitric oxide synthase. PloS one\| PubMed ID: 23049997	2012
The anti-cancer agent SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS. British journal of pharmacology\| PubMed ID: 23062100	2013
Bis(12)-hupyridone, a novel acetylcholinesterase inhibitor, protects against glutamate-induced neuronal excitotoxicity via activating α7 nicotinic acetylcholine receptor/phosphoinositide 3-k... Chemico-biological interactions\| PubMed ID: 23085120	2013
Bis(propyl)-cognitin protects against glutamate-induced neuro-excitotoxicity via concurrent regulation of NO, MAPK/ERK and PI3-K/Akt/GSK3β pathways. Neurochemistry international\| PubMed ID: 23357479	2013
Synergistic inhibition on acetylcholinesterase by the combination of berberine and palmatine originally isolated from Chinese medicinal herbs. Journal of molecular neuroscience : MN\| PubMed ID: 24793543	2014
Inhibiting β-amyloid-associated Alzheimer's pathogenesis in vitro and in vivo by a multifunctional dimeric bis(12)-hupyridone derived from its natural analogue. Journal of molecular neuroscience : MN\| PubMed ID: 25407821	2015
Reduced Expression of P2Y2 Receptor and Acetylcholinesterase at Neuromuscular Junction of P2Y1 Receptor Knock-out Mice. Journal of molecular neuroscience : MN\| PubMed ID: 26036470	2015
Substantial Neuroprotective and Neurite Outgrowth-Promoting Activities by Bis(propyl)-cognitin via the Activation of Alpha7-nAChR, a Promising Anti-Alzheimer's Dimer. ACS chemical neuroscience\| PubMed ID: 26147504	2015
Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin. Scientific reports\| PubMed ID: 26194093	2015
Indirubin-3-Oxime Effectively Prevents 6OHDA-Induced Neurotoxicity in PC12 Cells via Activating MEF2D Through the Inhibition of GSK3β. Journal of molecular neuroscience : MN\| PubMed ID: 26346600	2015
Tanshinone II A, a multiple target neuroprotectant, promotes caveolae-dependent neuronal differentiation. European journal of pharmacology\| PubMed ID: 26363255	2015
Sunitinib, a Clinically Used Anticancer Drug, Is a Potent AChE Inhibitor and Attenuates Cognitive Impairments in Mice. ACS chemical neuroscience\| PubMed ID: 27046396	2016
Potent Protection Against MPP(+)-Induced Neurotoxicity via Activating Transcription Factor MEF2D by a Novel Derivative of Naturally Occurring Danshensu/Tetramethylpyrazine. Neuromolecular medicine\| PubMed ID: 27277280	2016
Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3β and the ERK Pathway. Cellular and molecular neurobiology\| PubMed ID: 27412761	2017
Neuroprotection against glutamate-induced excitotoxicity and induction of neurite outgrowth by T-006, a novel multifunctional derivative of tetramethylpyrazine in neuronal cell models. Neurochemistry international\| PubMed ID: 27445088	2016