Zhang Zaijun

Institute of New Drug Research, jinan university

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 28	2017

Other Publications

Article	Year
Synthesis and preliminary antitumor activity evaluation of a DHA and doxorubicin conjugate. Bioorganic & medicinal chemistry letters\| PubMed ID: 16563756	2006
Synthesis and antitumor activity evaluations of albumin-binding prodrugs of CC-1065 analog. Bioorganic & medicinal chemistry\| PubMed ID: 18508273	2008
Antioxidative and thrombolytic TMP nitrone for treatment of ischemic stroke. Bioorganic & medicinal chemistry\| PubMed ID: 18790647	2008
Synthesis and evaluation of antibacterial activities of andrographolide analogues. European journal of medicinal chemistry\| PubMed ID: 19152987	2009
Hypoglycemic and beta cell protective effects of andrographolide analogue for diabetes treatment. Journal of translational medicine\| PubMed ID: 19607676	2009
Preventive effects of Flos Perariae (Gehua) water extract and its active ingredient puerarin in rodent alcoholism models. Chinese medicine\| PubMed ID: 20974012	2010
Synthesis and biological evaluations of novel apocynin analogues. European journal of medicinal chemistry\| PubMed ID: 21514981	2011
Eriocaulon buergerianum extract protects PC12 cells and neurons in zebrafish against 6-hydroxydopamine-induced damage. Chinese medicine\| PubMed ID: 21527031	2011
Bis(12)-hupyridone, a novel multifunctional dimer, promotes neuronal differentiation more potently than its monomeric natural analog huperzine A possibly through α7 nAChR. Brain research\| PubMed ID: 21665194	2011
Novel multi-functional nitrones for treatment of ischemic stroke. Bioorganic & medicinal chemistry\| PubMed ID: 22579617	2012
Baicalein protects against 6-OHDA-induced neurotoxicity through activation of Keap1/Nrf2/HO-1 and involving PKCα and PI3K/AKT signaling pathways. Journal of agricultural and food chemistry\| PubMed ID: 22838648	2012
Synthesis and preliminary anticancer evaluation of 10-hydroxycamptothecin analogs. Biological & pharmaceutical bulletin\| PubMed ID: 22863928	2012
Unexpected neuronal protection of SU5416 against 1-Methyl-4-phenylpyridinium ion-induced toxicity via inhibiting neuronal nitric oxide synthase. PloS one\| PubMed ID: 23049997	2012
The anti-cancer agent SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS. British journal of pharmacology\| PubMed ID: 23062100	2013
Anti-Lung-Cancer Activity and Liposome-Based Delivery Systems of β-Elemene. Evidence-based complementary and alternative medicine : eCAM\| PubMed ID: 23243436	2012
A novel Danshensu derivative confers cardioprotection via PI3K/Akt and Nrf2 pathways. International journal of cardiology\| PubMed ID: 23290949	2013
The novel tetramethylpyrazine bis-nitrone (TN-2) protects against MPTP/MPP+-induced neurotoxicity via inhibition of mitochondrial-dependent apoptosis. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 24233519	2014
Therapeutic effects of multifunctional tetramethylpyrazine nitrone on models of Parkinson's disease in vitro and in vivo. Biological & pharmaceutical bulletin\| PubMed ID: 24305623	2014
Neuroprotective effects of the andrographolide analogue AL-1 in the MPP⁺/MPTP-induced Parkinson's disease model in vitro and in mice. Pharmacology, biochemistry, and behavior\| PubMed ID: 24726706	2014
Protective effect of chinonin in MPTP-induced C57BL/6 mouse model of Parkinson's disease. Biological & pharmaceutical bulletin\| PubMed ID: 24871044	2014
Online two-dimensional porous graphitic carbon/reversed phase liquid chromatography platform applied to shotgun proteomics and glycoproteomics. Analytical chemistry\| PubMed ID: 25393709	2014
Inhibiting β-amyloid-associated Alzheimer's pathogenesis in vitro and in vivo by a multifunctional dimeric bis(12)-hupyridone derived from its natural analogue. Journal of molecular neuroscience : MN\| PubMed ID: 25407821	2015
A versatile reversed phase-strong cation exchange-reversed phase (RP-SCX-RP) multidimensional liquid chromatography platform for qualitative and quantitative shotgun proteomics. The Analyst\| PubMed ID: 25554751	2015
Pharmacokinetic and Metabolic Studies of ADTM: A Novel Danshensu Derivative Confers Cardioprotection by HPLC-UV and LC-MS/MS. Journal of chromatographic science\| PubMed ID: 25609599	2015
Andrographolide derivative AL-1 improves insulin resistance through down-regulation of NF-κB signalling pathway. British journal of pharmacology\| PubMed ID: 25712508	2015
Examining the neuroprotective effects of protocatechuic acid and chrysin on in vitro and in vivo models of Parkinson disease. Free radical biology & medicine\| PubMed ID: 25769424	2015
Relaxation effect of a novel Danshensu/tetramethylpyrazine derivative on rat mesenteric arteries. European journal of pharmacology\| PubMed ID: 25952729	2015
Novel anti-thrombotic agent for modulation of protein disulfide isomerase family member ERp57 for prophylactic therapy. Scientific reports\| PubMed ID: 26037049	2015
Corrigendum: Novel anti-thrombotic agent for modulation of protein disulfide isomerase family member ERp57 for prophylactic therapy. Scientific reports\| PubMed ID: 26329261	2015
Fully automated multidimensional reversed-phase liquid chromatography with tandem anion/cation exchange columns for simultaneous global endogenous tyrosine nitration detection, integral memb... Analytical chemistry\| PubMed ID: 26335518	2015
Indirubin-3-Oxime Effectively Prevents 6OHDA-Induced Neurotoxicity in PC12 Cells via Activating MEF2D Through the Inhibition of GSK3β. Journal of molecular neuroscience : MN\| PubMed ID: 26346600	2015
Online coupling of hydrophilic interaction/strong cation exchange/reversed-phase liquid chromatography with porous graphitic carbon liquid chromatography for simultaneous proteomics and N-gl... Journal of chromatography. A\| PubMed ID: 26362810	2015
Protective effects of andrographolide derivative AL-1 on high glucose-induced oxidative stress in RIN-m cells. Current pharmaceutical design\| PubMed ID: 26391852	2016
Protective Effect of Edaravone in Primary Cerebellar Granule Neurons against Iodoacetic Acid-Induced Cell Injury. Oxidative medicine and cellular longevity\| PubMed ID: 26557222	2015
Sunitinib, a Clinically Used Anticancer Drug, Is a Potent AChE Inhibitor and Attenuates Cognitive Impairments in Mice. ACS chemical neuroscience\| PubMed ID: 27046396	2016
Multifunction of Chrysin in Parkinson's Model: Anti-Neuronal Apoptosis, Neuroprotection via Activation of MEF2D, and Inhibition of Monoamine Oxidase-B. Journal of agricultural and food chemistry\| PubMed ID: 27245668	2016
Discovery, Synthesis, and Functional Characterization of a Novel Neuroprotective Natural Product from the Fruit of Alpinia oxyphylla for use in Parkinson's Disease Through LC/MS-Based Multiv... Journal of proteome research\| PubMed ID: 27246451	2016
Potent Protection Against MPP(+)-Induced Neurotoxicity via Activating Transcription Factor MEF2D by a Novel Derivative of Naturally Occurring Danshensu/Tetramethylpyrazine. Neuromolecular medicine\| PubMed ID: 27277280	2016
Design, synthesis and evaluation of novel dual monoamine-cholinesterase inhibitors as potential treatment for Alzheimer's disease. Neuropharmacology\| PubMed ID: 27318273	2016
Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3β and the ERK Pathway. Cellular and molecular neurobiology\| PubMed ID: 27412761	2017
Andrographolide derivative AL-1 ameliorates TNBS-induced colitis in mice: involvement of NF-кB and PPAR-γ signaling pathways. Scientific reports\| PubMed ID: 27435110	2016
Neuroprotection against glutamate-induced excitotoxicity and induction of neurite outgrowth by T-006, a novel multifunctional derivative of tetramethylpyrazine in neuronal cell models. Neurochemistry international\| PubMed ID: 27445088	2016
Tetramethylpyrazine Nitrone Improves Neurobehavioral Functions and Confers Neuroprotection on Rats with Traumatic Brain Injury. Neurochemical research\| PubMed ID: 27452038	2016
Design, Synthesis, and Biological Evaluation of Novel Tetramethylpyrazine Derivatives as Potential Neuroprotective Agents. Chemical & pharmaceutical bulletin\| PubMed ID: 27746410	2017
Tetramethylpyrazine nitrone, a multifunctional neuroprotective agent for ischemic stroke therapy. Scientific reports\| PubMed ID: 27841332	2016
Characterization of the Molecular Mechanisms Underlying the Chronic Phase of Stroke in a Cynomolgus Monkey Model of Induced Cerebral Ischemia. Journal of proteome research\| PubMed ID: 28102082	2017
Neuroprotective Effects and Mechanisms of Action of Multifunctional Agents Targeting Free Radicals, Monoamine Oxidase B and Cholinesterase in Parkinson's Disease Model. Journal of molecular neuroscience : MN\| PubMed ID: 28144826	2017
Tetramethylpyrazine nitrone protects retinal ganglion cells against N-methyl-d-aspartate-induced excitotoxicity. Journal of neurochemistry\| PubMed ID: 28160291	2017
Neuroprotective and axonal outgrowth-promoting effects of tetramethylpyrazine nitrone in chronic cerebral hypoperfusion rats and primary hippocampal neurons exposed to hypoxia. Neuropharmacology\| PubMed ID: 28342896	2017
Synthesis and Biological Evaluation of Danshensu and Tetramethylpyrazine Conjugates as Cardioprotective Agents. Chemical & pharmaceutical bulletin\| PubMed ID: 28381679	2017