Han Yifan

Department of Applied Biology and Chemistry Technology, The Hong Kong Polytechnic University

Affiliated withThe Hong Kong Polytechnic University International Joint Laboratory (SYSU-PolyU HK) of Novel Anti-Dementia Drugs of Guangdong

Research Area

Neuroscience

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 28	2017

Other Publications

Article	Year
SP600125, a new JNK inhibitor, protects dopaminergic neurons in the MPTP model of Parkinson's disease. Neuroscience research\| PubMed ID: 14741394	2004
Minocycline prevents glutamate-induced apoptosis of cerebellar granule neurons by differential regulation of p38 and Akt pathways. Journal of neurochemistry\| PubMed ID: 15569265	2004
Activity deprivation-dependent induction of the proapoptotic BH3-only protein Bim is independent of JNK/c-Jun activation during apoptosis in cerebellar granule neurons. Neuroscience letters\| PubMed ID: 15664113	2005
Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors. The Journal of biological chemistry\| PubMed ID: 15710623	2005
Identification of a novel Wee1 isoform. Biochimica et biophysica acta\| PubMed ID: 15804487	2005
Effects of a memory enhancing peptide on cognitive abilities of brain-lesioned mice: additivity with huperzine A and relative potency to tacrine. Journal of peptide science : an official publication of the European Peptide Society\| PubMed ID: 15942937	2006
Neuroprotection via inhibition of nitric oxide synthase by bis(7)-tacrine. Neuroreport\| PubMed ID: 16543809	2006
Impact of growth kinetics on morphology and pore structure of TiO2-one-pot synthesis of macroporous TiO2 microspheres. Inorganic chemistry\| PubMed ID: 16749824	2006
Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels. Journal of neurochemistry\| PubMed ID: 16771827	2006
Extracellular signal-regulated kinases are not involved in activity-dependent survival or apoptosis in cerebellar granule neurons. Neuroscience letters\| PubMed ID: 16973276	2006
Alkylene tether-length dependent gamma-aminobutyric acid type A receptor competitive antagonism by tacrine dimers. Neuropharmacology\| PubMed ID: 17056074	2007
Synergistic neuroprotection by bis(7)-tacrine via concurrent blockade of N-methyl-D-aspartate receptors and neuronal nitric-oxide synthase. Molecular pharmacology\| PubMed ID: 17299028	2007
Inhibition of glycogen synthase kinase-3beta protects dopaminergic neurons from MPTP toxicity. Neuropharmacology\| PubMed ID: 17517424	2007
Mitochondrial proteomic analysis and characterization of the intracellular mechanisms of bis(7)-tacrine in protecting against glutamate-induced excitotoxicity in primary cultured neurons. Journal of proteome research\| PubMed ID: 17530875	2007
Novel dimeric bis(7)-tacrine proton-dependently inhibits NMDA-activated currents. Biochemical and biophysical research communications\| PubMed ID: 17655827	2007
Promising anti-Alzheimer's dimer bis(7)-tacrine reduces beta-amyloid generation by directly inhibiting BACE-1 activity. Biochemical and biophysical research communications\| PubMed ID: 18039469	2008
Mecamylamine prevents neuronal apoptosis induced by glutamate and low potassium via differential anticholinergic-independent mechanisms. Neuropharmacology\| PubMed ID: 18222492	2008
Maternal low-level lead exposure reduces the expression of PSA-NCAM and the activity of sialyltransferase in the hippocampi of neonatal rat pups. Neurotoxicology\| PubMed ID: 18499259	2008
Bis(7)-tacrine, a promising anti-Alzheimer's dimer, affords dose- and time-dependent neuroprotection against transient focal cerebral ischemia. Neuroscience letters\| PubMed ID: 18515007	2008
Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin. Neuroscience letters\| PubMed ID: 18583042	2008
Novel anti-Alzheimer's dimer Bis(7)-cognitin: cellular and molecular mechanisms of neuroprotection through multiple targets. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 19110209	2009
p38 and ERK, but not JNK, are involved in copper-induced apoptosis in cultured cerebellar granule neurons. Biochemical and biophysical research communications\| PubMed ID: 19138669	2009
Promising multifunctional anti-Alzheimer's dimer bis(7)-Cognitin acting as an activator of protein kinase C regulates activities of alpha-secretase and BACE-1 concurrently. European journal of pharmacology\| PubMed ID: 19765582	2009
Senkyunolides reduce hydrogen peroxide-induced oxidative damage in human liver HepG2 cells via induction of heme oxygenase-1. Chemico-biological interactions\| PubMed ID: 19961840	2010
Proteomic characterization of the cellular response to chemopreventive triterpenoid astragaloside IV in human hepatocellular carcinoma cell line HepG2. International journal of oncology\| PubMed ID: 20126993	2010
Human cytomegalovirus induces caspase-dependent apoptosis of megakaryocytic CHRF-288-11 cells by activating the JNK pathway. International journal of hematology\| PubMed ID: 20376580	2010
Pathologically activated neuroprotection via uncompetitive blockade of N-methyl-D-aspartate receptors with fast off-rate by novel multifunctional dimer bis(propyl)-cognitin. The Journal of biological chemistry\| PubMed ID: 20404346	2010
Preventing Hâ‚‚Oâ‚‚-induced apoptosis in cerebellar granule neurons by regulating the VEGFR-2/Akt signaling pathway using a novel dimeric antiacetylcholinesterase bis(12)-hupyridone. Brain research\| PubMed ID: 21315693	2011
Protection against 1-methyl-4-phenylpyridinium ion (MPP+)-induced apoptosis by water extract of ginseng (Panax ginseng C.A. Meyer) in SH-SY5Y cells. Journal of ethnopharmacology\| PubMed ID: 21349320	2011
Bis(12)-hupyridone, a novel multifunctional dimer, promotes neuronal differentiation more potently than its monomeric natural analog huperzine A possibly through α7 nAChR. Brain research\| PubMed ID: 21665194	2011
Pharmacological induction of leukotriene B4-12-hydroxydehydrogenase suppresses the oncogenic transformation of human hepatoma HepG2 cells. International journal of oncology\| PubMed ID: 21687936	2011
PI3-K/Akt and ERK pathways activated by VEGF play opposite roles in MPP+-induced neuronal apoptosis. Neurochemistry international\| PubMed ID: 21781996	2011
Tacrine(2)-ferulic acid, a novel multifunctional dimer, attenuates 6-hydroxydopamine-induced apoptosis in PC12 cells by activating Akt pathway. Neurochemistry international\| PubMed ID: 21939707	2011
Neuroprotection against excitotoxic and ischemic insults by bis(12)-hupyridone, a novel anti-acetylcholinesterase dimer, possibly via acting on multiple targets. Brain research\| PubMed ID: 21978549	2011
Potential roles of PI3K/Akt and Nrf2-Keap1 pathways in regulating hormesis of Z-ligustilide in PC12 cells against oxygen and glucose deprivation. Neuropharmacology\| PubMed ID: 22146407	2012
Acetylcholinesterase is associated with apoptosis in Î² cells and contributes to insulin-dependent diabetes mellitus pathogenesis. Acta biochimica et biophysica Sinica\| PubMed ID: 22236578	2012
Tacrine-6-Ferulic Acid, a Novel Multifunctional Dimer, Inhibits Amyloid-Î²-Mediated Alzheimer's Disease-Associated Pathogenesis In Vitro and In Vivo. PloS one\| PubMed ID: 22384101	2012
Z-ligustilide potentiates the cytotoxicity of dopamine in rat dopaminergic PC12 cells. Neurotoxicity research\| PubMed ID: 22451226	2012
Baicalein protects against 6-OHDA-induced neurotoxicity through activation of Keap1/Nrf2/HO-1 and involving PKCα and PI3K/AKT signaling pathways. Journal of agricultural and food chemistry\| PubMed ID: 22838648	2012
Activation of transcription factor MEF2D by bis(3)-cognitin protects dopaminergic neurons and ameliorates Parkinsonian motor defects. The Journal of biological chemistry\| PubMed ID: 22891246	2012
Unexpected neuronal protection of SU5416 against 1-Methyl-4-phenylpyridinium ion-induced toxicity via inhibiting neuronal nitric oxide synthase. PloS one\| PubMed ID: 23049997	2012
The anti-cancer agent SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS. British journal of pharmacology\| PubMed ID: 23062100	2013
Bis(12)-hupyridone, a novel acetylcholinesterase inhibitor, protects against glutamate-induced neuronal excitotoxicity via activating α7 nicotinic acetylcholine receptor/phosphoinositide 3-k... Chemico-biological interactions\| PubMed ID: 23085120	2013
Bis(propyl)-cognitin protects against glutamate-induced neuro-excitotoxicity via concurrent regulation of NO, MAPK/ERK and PI3-K/Akt/GSK3β pathways. Neurochemistry international\| PubMed ID: 23357479	2013
Sulfur-oxidizing bacteria dominate the microbial diversity shift during the pyrite and low-grade pyrolusite bioleaching process. Journal of bioscience and bioengineering\| PubMed ID: 23673133	2013
The novel tetramethylpyrazine bis-nitrone (TN-2) protects against MPTP/MPP+-induced neurotoxicity via inhibition of mitochondrial-dependent apoptosis. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 24233519	2014
Synergistic inhibition on acetylcholinesterase by the combination of berberine and palmatine originally isolated from Chinese medicinal herbs. Journal of molecular neuroscience : MN\| PubMed ID: 24793543	2014
Inhibiting β-amyloid-associated Alzheimer's pathogenesis in vitro and in vivo by a multifunctional dimeric bis(12)-hupyridone derived from its natural analogue. Journal of molecular neuroscience : MN\| PubMed ID: 25407821	2015
Synthesis, biological activity, and biopharmaceutical characterization of tacrine dimers as acetylcholinesterase inhibitors. International journal of pharmaceutics\| PubMed ID: 25445524	2014
Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD. Bioorganic & medicinal chemistry letters\| PubMed ID: 25597007	2015
An analysis of chemical ingredients network of Chinese herbal formulae for the treatment of coronary heart disease. PloS one\| PubMed ID: 25658855	2015
Examining the neuroprotective effects of protocatechuic acid and chrysin on in vitro and in vivo models of Parkinson disease. Free radical biology & medicine\| PubMed ID: 25769424	2015
Silk-based biomaterials in biomedical textiles and fiber-based implants. Advanced healthcare materials\| PubMed ID: 25772248	2015
PLU-1/JARID1B overexpression predicts proliferation properties in head and neck squamous cell carcinoma. Oncology reports\| PubMed ID: 25777981	2015
A Novel Danshensu Derivative Prevents Cardiac Dysfunction and Improves the Chemotherapeutic Efficacy of Doxorubicin in Breast Cancer Cells. Journal of cellular biochemistry\| PubMed ID: 26058377	2016
Substantial Neuroprotective and Neurite Outgrowth-Promoting Activities by Bis(propyl)-cognitin via the Activation of Alpha7-nAChR, a Promising Anti-Alzheimer's Dimer. ACS chemical neuroscience\| PubMed ID: 26147504	2015
Bis(propyl)-cognitin Prevents β-amyloid-induced Memory Deficits as Well as Synaptic Formation and Plasticity Impairments via the Activation of PI3-K Pathway. Molecular neurobiology\| PubMed ID: 26160762	2016
Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin. Scientific reports\| PubMed ID: 26194093	2015
Indirubin-3-Oxime Effectively Prevents 6OHDA-Induced Neurotoxicity in PC12 Cells via Activating MEF2D Through the Inhibition of GSK3β. Journal of molecular neuroscience : MN\| PubMed ID: 26346600	2015
Tanshinone II A, a multiple target neuroprotectant, promotes caveolae-dependent neuronal differentiation. European journal of pharmacology\| PubMed ID: 26363255	2015
In Vitro and in Vivo Anticancer Activity of Pardaxin against Proliferation and Growth of Oral Squamous Cell Carcinoma. Marine drugs\| PubMed ID: 26703631	2015
Miracle Fruit (Synsepalum dulcificum) Exhibits as a Novel Anti-Hyperuricaemia Agent. Molecules (Basel, Switzerland)\| PubMed ID: 26821007	2016
Plant Natural Product Formononetin Protects Rat Cardiomyocyte H9c2 Cells against Oxygen Glucose Deprivation and Reoxygenation via Inhibiting ROS Formation and Promoting GSK-3β Phosphorylatio... Oxidative medicine and cellular longevity\| PubMed ID: 27034732	2016
Sunitinib, a Clinically Used Anticancer Drug, Is a Potent AChE Inhibitor and Attenuates Cognitive Impairments in Mice. ACS chemical neuroscience\| PubMed ID: 27046396	2016
Gallic acid-l-leucine (GAL) conjugate enhances macrophage phagocytosis via inducing leukotriene B4 12-hydroxydehydrogenase (LTB4DH) expression. Molecular immunology\| PubMed ID: 27148819	2016
Multifunction of Chrysin in Parkinson's Model: Anti-Neuronal Apoptosis, Neuroprotection via Activation of MEF2D, and Inhibition of Monoamine Oxidase-B. Journal of agricultural and food chemistry\| PubMed ID: 27245668	2016
Potent Protection Against MPP(+)-Induced Neurotoxicity via Activating Transcription Factor MEF2D by a Novel Derivative of Naturally Occurring Danshensu/Tetramethylpyrazine. Neuromolecular medicine\| PubMed ID: 27277280	2016
Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3β and the ERK Pathway. Cellular and molecular neurobiology\| PubMed ID: 27412761	2017
Neuroprotection against glutamate-induced excitotoxicity and induction of neurite outgrowth by T-006, a novel multifunctional derivative of tetramethylpyrazine in neuronal cell models. Neurochemistry international\| PubMed ID: 27445088	2016
Discovery of novel rivastigmine-hydroxycinnamic acid hybrids as multi-targeted agents for Alzheimer's disease. European journal of medicinal chemistry\| PubMed ID: 27736684	2017
Inhibition of AGEs/RAGE/Rho/ROCK pathway suppresses non-specific neuroinflammation by regulating BV2 microglial M1/M2 polarization through the NF-κB pathway. Journal of neuroimmunology\| PubMed ID: 28284330	2017
L-F001, a novel multifunctional ROCK inhibitor, suppresses neuroinflammation in vitro and in vivo: Involvement of NF-κB inhibition and Nrf2 pathway activation. European journal of pharmacology\| PubMed ID: 28320516	2017