Holger Wille

Centre for Prions and Protein Folding Diseases & Department of Biochemistry, University of Alberta

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2017

Other Publications

Article	Year
Molecular modeling of the misfolded insulin subunit and amyloid fibril. Biophysical journal\| PubMed ID: 20006956	2009
Structural studies of the scrapie prion protein by electron crystallography. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11891310	2002
Cytosolic prion protein in neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12904479	2003
Evidence for assembly of prions with left-handed beta-helices into trimers. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15155909	2004
Engineering a 2D protein-DNA crystal. Angewandte Chemie (International ed. in English)\| PubMed ID: 15828044	2005
Assembly of natural and recombinant prion protein into fibrils. Biological chemistry\| PubMed ID: 16006244	2005
Human prions and plasma lipoproteins. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16849426	2006
Influence of water, fat, and glycerol on the mechanism of thermal prion inactivation. The Journal of biological chemistry\| PubMed ID: 17878157	2007
Electron crystallography of the scrapie prion protein complexed with heavy metals. Archives of biochemistry and biophysics\| PubMed ID: 17935686	2007
Small-molecule aggregates inhibit amyloid polymerization. Nature chemical biology\| PubMed ID: 18223646	2008
Mechanisms of prion protein assembly into amyloid. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18268326	2008
Genes contributing to prion pathogenesis. The Journal of general virology\| PubMed ID: 18559949	2008
Conformational diversity of wild-type Tau fibrils specified by templated conformation change. The Journal of biological chemistry\| PubMed ID: 19010781	2009
Cryo-immunogold electron microscopy for prions: toward identification of a conversion site. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19020041	2008
Surface charge of polyoxometalates modulates polymerization of the scrapie prion protein. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19223590	2009
Evolutionary descent of prion genes from the ZIP family of metal ion transporters. PloS one\| PubMed ID: 19784368	2009
Natural and synthetic prion structure from X-ray fiber diffraction. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19805070	2009
Design and construction of diverse mammalian prion strains. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19915150	2009
Colloid formation by drugs in simulated intestinal fluid. Journal of medicinal chemistry\| PubMed ID: 20426472	2010
Family reunion--the ZIP/prion gene family. Progress in neurobiology\| PubMed ID: 21163327	2011
In vitro conversion and seeded fibrillization of posttranslationally modified prion protein. Biological chemistry\| PubMed ID: 21476870	2011
Self-assembling small molecules form nanofibrils that bind procaspase-3 to promote activation. Journal of the American Chemical Society\| PubMed ID: 22066605	2011
Spontaneous generation of anchorless prions in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22160704	2011
Protease-resistant prions selectively decrease Shadoo protein. PLoS pathogens\| PubMed ID: 22163178	2011
Prion uptake in the gut: identification of the first uptake and replication sites. PLoS pathogens\| PubMed ID: 22216002	2011
Degradation of fungal prion HET-s(218-289) induces formation of a generic amyloid fold. Biophysical journal\| PubMed ID: 22677387	2012
Plasma membrane invaginations containing clusters of full-length PrPSc are an early form of prion-associated neuropathology in vivo. Neurobiology of aging\| PubMed ID: 23481568	2013
The ZIP5 ectodomain co-localizes with PrP and may acquire a PrP-like fold that assembles into a dimer. PloS one\| PubMed ID: 24039764	2013
The structure of the infectious prion protein: experimental data and molecular models. Prion\| PubMed ID: 24583975	2014
The structure of human prions: from biology to structural models-considerations and pitfalls. Viruses\| PubMed ID: 25333467	2014
Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation. EMBO molecular medicine\| PubMed ID: 25661904	2015
Subcellular distribution of the prion protein in sickness and in health. Virus research\| PubMed ID: 25683509	2015
Mechanism of scrapie prion precipitation with phosphotungstate anions. ACS chemical biology\| PubMed ID: 25695325	2015
Structural studies of truncated forms of the prion protein PrP. Biophysical journal\| PubMed ID: 25809267	2015
Deer Prion Proteins Modulate the Emergence and Adaptation of Chronic Wasting Disease Strains. Journal of virology\| PubMed ID: 26423950	2015
Toll-like receptor-mediated immune response inhibits prion propagation. Glia\| PubMed ID: 26880394	2016
The Detection of Infectious Prions: In Vitro Conversion Assays Change the (Folding) Landscape. The Journal of molecular diagnostics : JMD\| PubMed ID: 27020948	2016
Secretory pathway retention of mutant prion protein induces p38-MAPK activation and lethal disease in mice. Scientific reports\| PubMed ID: 27117504	2016
A Neuronal Culture System to Detect Prion Synaptotoxicity. PLoS pathogens\| PubMed ID: 27227882	2016
Neuroinvasion of α-Synuclein Prionoids after Intraperitoneal and Intraglossal Inoculation. Journal of virology\| PubMed ID: 27489279	2016
The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy. PLoS pathogens\| PubMed ID: 27606840	2016