Baruch Minke

Baruch Minke

Department of Medical Neurobiology, Hebrew University

Affiliated withHebrew University

Research Area

Biography

Baruch Minke is a professor in the Department of Medical Neurobiology at the Faculty of Medicine and in the Edmond and Lily Safra Center for Brain Sciences (ELSC) of the Hebrew University in Jerusalem, Israel. He received his B.Sc. degree in physiology and biochemistry, M.Sc. degree in Physiology and Ph.D. degree in physiology and biophysics from the Hebrew University of Jerusalem, Israel.

During Dr. Minke post-doctoral training at Purdue University, IN USA, he has learned from Prof. William L. Pak the great power of genetics and molecular genetics and combined this approach to his electrophysiological and biochemical studies of phototransduction in the fruit fly Drosophila melanogaster. He was a visiting research professor at the Max-Planck-Institut für Biologische Kybernetik in Tübingen, Germany and at the Department of Neurosciences, The Johns Hopkins University School of Medicine, Baltimore, MD USA. He has been a Member of the Editorial Board of several International Journals. As a result of his studies on phototransduction in Drosophila he co-discovered a new type of ion channel, which he designated the Transient Receptor Potential (TRP) channel. He investigated the biophysical and biochemical properties of TRP channels in the Drosophila eyes and identified biochemically and electro-physiologically together with Prof. Zvi Selinger, phospholipase C as a crucial component of the Drosophila TRP signaling pathway. The channel function of the Drosophila TRP protein was first demonstrated by Dr. Roger Hardie from Cambridge University together with Dr. Minke.

Dr. Minke received a Fulbright Scholarship (1973), a research fund for excellent researcher from the Wolf Foundation (1985), the Prince of Asturias Award for Technical and Scientific Research together with the 2021 Nobel laureate Dr. David Julius (2010) and the EMET prize in Brain Research (2010). His current research program encompasses using Drosophila mutants as well as the first identified human mutation in the TRPV1 channel.

JoVE Journal Publications

ArticleTotal : 3
Year
Electrophysiological Method for Whole-cell Voltage Clamp Recordings from <em>Drosophila</em> Photoreceptors
Publication title

Cited by 3

2017
2022
2023

Other Publications

Article
Year
Calmodulin regulation of light adaptation and store-operated dark current in Drosophila photoreceptors.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 9159171

1997
Novel mechanism of massive photoreceptor degeneration caused by mutations in the trp gene of Drosophila.

The Journal of neuroscience : the official journal of the Society for Neuroscience| PubMed ID: 10632594

2000
Metabolic stress reversibly activates the Drosophila light-sensitive channels TRP and TRPL in vivo.

The Journal of neuroscience : the official journal of the Society for Neuroscience| PubMed ID: 10908615

2000
A common mechanism underlies vertebrate calcium signaling and Drosophila phototransduction.

The Journal of neuroscience : the official journal of the Society for Neuroscience| PubMed ID: 11306615

2001
TRP channel proteins and signal transduction.

Physiological reviews| PubMed ID: 11917094

2002
2002
2003
The TRP calcium channel and retinal degeneration.

Advances in experimental medicine and biology| PubMed ID: 12596945

2002
2003
2004
Novel dominant rhodopsin mutation triggers two mechanisms of retinal degeneration and photoreceptor desensitization.

The Journal of neuroscience : the official journal of the Society for Neuroscience| PubMed ID: 15014127

2004
2005
2005
2006
Insights on TRP channels from in vivo studies in Drosophila.

Annual review of physiology| PubMed ID: 16460287

2006
2006
TRP channels and Ca2+ signaling.

Cell calcium| PubMed ID: 16806461

2006
2007
Translocation of Gq alpha mediates long-term adaptation in Drosophila photoreceptors.

The Journal of neuroscience : the official journal of the Society for Neuroscience| PubMed ID: 17522302

2007
2009
Membrane lipid modulations remove divalent open channel block from TRP-like and NMDA channels.

The Journal of neuroscience : the official journal of the Society for Neuroscience| PubMed ID: 19244513

2009
2009
Drosophila photoreceptors and signaling mechanisms.

Frontiers in cellular neuroscience| PubMed ID: 19623243

2009
Constitutive activity of the human TRPML2 channel induces cell degeneration.

The Journal of biological chemistry| PubMed ID: 19940139

2010
Cellular functions of transient receptor potential channels.

The international journal of biochemistry & cell biology| PubMed ID: 20399884

2010
2010
2010
2010
Cell biology. Rhodopsin as thermosensor?

Science (New York, N.Y.)| PubMed ID: 21393531

2011
2011
2012
Phospholipase C-mediated suppression of dark noise enables single-photon detection in Drosophila photoreceptors.

The Journal of neuroscience : the official journal of the Society for Neuroscience| PubMed ID: 22357856

2012
2012
2012
2012
Compartmentalization and Ca2+ buffering are essential for prevention of light-induced retinal degeneration.

The Journal of neuroscience : the official journal of the Society for Neuroscience| PubMed ID: 23077055

2012
2013
2015
Functional cooperation between the IP3 receptor and phospholipase C secures the high sensitivity to light of Drosophila photoreceptors in vivo.

The Journal of neuroscience : the official journal of the Society for Neuroscience| PubMed ID: 25673847

2015
2017
The Phosphorylation State of the Drosophila TRP Channel Modulates the Frequency Response to Oscillating Light In Vivo.

The Journal of neuroscience : the official journal of the Society for Neuroscience| PubMed ID: 28314815

2017
2017
2017
2018
2019
2019
2021
2022
2022
Nociception and pain in humans lacking a functional TRPV1 channel.

The Journal of clinical investigation| PubMed ID: 36454632

2023
Electroretinogram (ERG) Recordings from .

Bio-protocol| PubMed ID: 36590848

2015