Francisco Ciruela

Unitat de Farmacologia, Universitat de Barcelona, L'Hospitalet de Llobregat

Affiliated withUniversitat de Barcelona, L'Hospitalet de Llobregat Universitat de Barcelona

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 6	2017

Other Publications

Article	Year
Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12189203	2002
Ligand-induced caveolae-mediated internalization of A1 adenosine receptors: morphological evidence of endosomal sorting and receptor recycling. Experimental cell research\| PubMed ID: 12681288	2003
Regulation of heptaspanning-membrane-receptor function by dimerization and clustering. Trends in biochemical sciences\| PubMed ID: 12765835	2003
The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin. The Journal of biological chemistry\| PubMed ID: 12837758	2003
Metabotropic glutamate type 1alpha receptor localizes in low-density caveolin-rich plasma membrane fractions. Journal of neurochemistry\| PubMed ID: 12887677	2003
Adenosine A2A-dopamine D2 receptor-receptor heteromerization: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer. The Journal of biological chemistry\| PubMed ID: 12933819	2003
Homodimerization of adenosine A2A receptors: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer. Journal of neurochemistry\| PubMed ID: 14720222	2004
Group I metabotropic glutamate receptors mediate a dual role of glutamate in T cell activation. The Journal of biological chemistry\| PubMed ID: 15184389	2004
Adenosine A2A-dopamine D2 receptor-receptor heteromers. Targets for neuro-psychiatric disorders. Parkinsonism & related disorders\| PubMed ID: 15196504	2004
Combining mass spectrometry and pull-down techniques for the study of receptor heteromerization. Direct epitope-epitope electrostatic interactions between adenosine A2A and dopamine D2 recep... Analytical chemistry\| PubMed ID: 15362892	2004
Mutual regulation between metabotropic glutamate type 1alpha receptor and caveolin proteins: from traffick to constitutive activity. Experimental cell research\| PubMed ID: 15383311	2004
Adenosine receptor-mediated modulation of dopamine release in the nucleus accumbens depends on glutamate neurotransmission and N-methyl-D-aspartate receptor stimulation. Journal of neurochemistry\| PubMed ID: 15525341	2004
Dimer-based model for heptaspanning membrane receptors. Trends in biochemical sciences\| PubMed ID: 15951182	2005
Role of electrostatic interaction in receptor-receptor heteromerization. Journal of molecular neuroscience : MN\| PubMed ID: 16012186	2005
Partners for adenosine A1 receptors. Journal of molecular neuroscience : MN\| PubMed ID: 16012195	2005
Heptaspanning membrane receptors and cytoskeletal/scaffolding proteins: focus on adenosine, dopamine, and metabotropic glutamate receptor function. Journal of molecular neuroscience : MN\| PubMed ID: 16012201	2005
Role of adenosine in the control of homosynaptic plasticity in striatal excitatory synapses. Journal of integrative neuroscience\| PubMed ID: 16385640	2005
Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16481441	2006
The two-state dimer receptor model: a general model for receptor dimers. Molecular pharmacology\| PubMed ID: 16501032	2006
Heteromeric nicotinic acetylcholine-dopamine autoreceptor complexes modulate striatal dopamine release. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 16710311	2007
Working memory deficits in transgenic rats overexpressing human adenosine A2A receptors in the brain. Neurobiology of learning and memory\| PubMed ID: 16824773	2007
Adenosine A2A receptors are expressed in human atrial myocytes and modulate spontaneous sarcoplasmic reticulum calcium release. Cardiovascular research\| PubMed ID: 17014834	2006
Glutamate released by dendritic cells as a novel modulator of T cell activation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17082582	2006
Actin-binding protein alpha-actinin-1 interacts with the metabotropic glutamate receptor type 5b and modulates the cell surface expression and function of the receptor. The Journal of biological chemistry\| PubMed ID: 17311919	2007
Striatal adenosine A2A and cannabinoid CB1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 17356572	2007
Neurotransmitter receptor heteromers and their integrative role in 'local modules': the striatal spine module. Brain research reviews\| PubMed ID: 17408563	2007
The neuronal Ca(2+) -binding protein 2 (NECAB2) interacts with the adenosine A(2A) receptor and modulates the cell surface expression and function of the receptor. Molecular and cellular neurosciences\| PubMed ID: 17689978	2007
Functional relevance of neurotransmitter receptor heteromers in the central nervous system. Trends in neurosciences\| PubMed ID: 17692396	2007
Old and new ways to calculate the affinity of agonists and antagonists interacting with G-protein-coupled monomeric and dimeric receptors: the receptor-dimer cooperativity index. Pharmacology & therapeutics\| PubMed ID: 17935788	2007
The coexistence of multiple receptors in a single nerve terminal provides evidence for pre-synaptic integration. Journal of neurochemistry\| PubMed ID: 17944874	2007
Adenosine A1-A2A receptor heteromers: new targets for caffeine in the brain. Frontiers in bioscience : a journal and virtual library\| PubMed ID: 17981720	2008
Adenosine receptor heteromers and their integrative role in striatal function. TheScientificWorldJournal\| PubMed ID: 17982579	2007
Light resonance energy transfer-based methods in the study of G protein-coupled receptor oligomerization. BioEssays : news and reviews in molecular, cellular and developmental biology\| PubMed ID: 18081019	2008
Cell type-specific subunit composition of G protein-gated potassium channels in the cerebellum. Journal of neurochemistry\| PubMed ID: 18088366	2008
Detection of heteromerization of more than two proteins by sequential BRET-FRET. Nature methods\| PubMed ID: 18587404	2008
Fluorescence-based methods in the study of protein-protein interactions in living cells. Current opinion in biotechnology\| PubMed ID: 18602005	2008
Detection of higher-order G protein-coupled receptor oligomers by a combined BRET-BiFC technique. FEBS letters\| PubMed ID: 18675812	2008
Plasma membrane diffusion of G protein-coupled receptor oligomers. Biochimica et biophysica acta\| PubMed ID: 18691614	2008
Detection of heteromers formed by cannabinoid CB1, dopamine D2, and adenosine A2A G-protein-coupled receptors by combining bimolecular fluorescence complementation and bioluminescence energy... TheScientificWorldJournal\| PubMed ID: 18956124	2008
Metabotropic glutamate type 5, dopamine D2 and adenosine A2a receptors form higher-order oligomers in living cells. Journal of neurochemistry\| PubMed ID: 19344374	2009
Subcellular compartment-specific molecular diversity of pre- and post-synaptic GABA-activated GIRK channels in Purkinje cells. Journal of neurochemistry\| PubMed ID: 19558451	2009
The association of metabotropic glutamate receptor type 5 with the neuronal Ca2+-binding protein 2 modulates receptor function. Journal of neurochemistry\| PubMed ID: 19694902	2009
Adenosine receptors interacting proteins (ARIPs): Behind the biology of adenosine signaling. Biochimica et biophysica acta\| PubMed ID: 19883624	2010
A serine point mutation in the adenosine A2AR C-terminal tail reduces receptor heteromerization and allosteric modulation of the dopamine D2R. Biochemical and biophysical research communications\| PubMed ID: 20197060	2010
Impaired M(3) muscarinic acetylcholine receptor signal transduction through blockade of binding of multiple proteins to its third intracellular loop. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology\| PubMed ID: 20332620	2010
The metabotropic glutamate receptor mGlu7 activates phospholipase C, translocates munc-13-1 protein, and potentiates glutamate release at cerebrocortical nerve terminals. The Journal of biological chemistry\| PubMed ID: 20375012	2010
The M(5) muscarinic acetylcholine receptor third intracellular loop regulates receptor function and oligomerization. Biochimica et biophysica acta\| PubMed ID: 20398705	2010
On the expanding terminology in the GPCR field: the meaning of receptor mosaics and receptor heteromers. Journal of receptor and signal transduction research\| PubMed ID: 20429829	2010
Histamine H3 receptor activation potentiates peripheral opioid-mediated antinociception: substance P role in peripheral inflammation in mice. European journal of pharmacology\| PubMed ID: 20435034	2010
An integrated view on the role of receptor mosaics at perisynaptic level: focus on adenosine A(2A), dopamine D(2), cannabinoid CB(1), and metabotropic glutamate mGlu(5) receptors. Journal of receptor and signal transduction research\| PubMed ID: 20524778	2010
Lighting up multiprotein complexes: lessons from GPCR oligomerization. Trends in biotechnology\| PubMed ID: 20542584	2010
The changing world of G protein-coupled receptors: from monomers to dimers and receptor mosaics with allosteric receptor-receptor interactions. Journal of receptor and signal transduction research\| PubMed ID: 20684666	2010
G protein-coupled receptor oligomerization for what? Journal of receptor and signal transduction research\| PubMed ID: 20718634	2010
Evidence for oligomerization between GABAB receptors and GIRK channels containing the GIRK1 and GIRK3 subunits. The European journal of neuroscience\| PubMed ID: 20846323	2010
Dopamine D2 and 5-hydroxytryptamine 5-HT(₂A) receptors assemble into functionally interacting heteromers. Biochemical and biophysical research communications\| PubMed ID: 20888323	2010
Bioinformatics and mathematical modelling in the study of receptor-receptor interactions and receptor oligomerization: focus on adenosine receptors. Biochimica et biophysica acta\| PubMed ID: 20888789	2011
Characterization of the A2AR-D2R interface: focus on the role of the C-terminal tail and the transmembrane helices. Biochemical and biophysical research communications\| PubMed ID: 21040702	2010
G-protein-coupled receptor heteromer dynamics. Journal of cell science\| PubMed ID: 21123619	2010
Muscarinic receptor family interacting proteins: role in receptor function. Journal of neuroscience methods\| PubMed ID: 21134400	2011
Abnormal calcium handling in atrial fibrillation is linked to up-regulation of adenosine A2A receptors. European heart journal\| PubMed ID: 21177700	2011
On the existence of a possible A2A-D2-β-Arrestin2 complex: A2A agonist modulation of D2 agonist-induced β-arrestin2 recruitment. Journal of molecular biology\| PubMed ID: 21256133	2011
Fentanyl-trazodone-paracetamol triple drug combination: multimodal analgesia in a mouse model of visceral pain. Pharmacology, biochemistry, and behavior\| PubMed ID: 21296105	2011
Adenosine receptor containing oligomers: their role in the control of dopamine and glutamate neurotransmission in the brain. Biochimica et biophysica acta\| PubMed ID: 21316336	2011
Dopamine D4 receptor oligomerization--contribution to receptor biogenesis. The FEBS journal\| PubMed ID: 21320289	2011
Caffeine improves attention deficit in neonatal 6-OHDA lesioned rats, an animal model of attention deficit hyperactivity disorder (ADHD). Neuroscience letters\| PubMed ID: 21362462	2011
Adenosine receptors. Biochimica et biophysica acta\| PubMed ID: 21444000	2011
Agonist-induced formation of FGFR1 homodimers and signaling differ among members of the FGF family. Biochemical and biophysical research communications\| PubMed ID: 21621521	2011
Molecular mechanisms of MLC1 and GLIALCAM mutations in megalencephalic leukoencephalopathy with subcortical cysts. Human molecular genetics\| PubMed ID: 21624973	2011
Moonlighting characteristics of G protein-coupled receptors: focus on receptor heteromers and relevance for neurodegeneration. IUBMB life\| PubMed ID: 21698749	2011
Agonist-specific voltage sensitivity at the dopamine D2S receptor--molecular determinants and relevance to therapeutic ligands. Neuropharmacology\| PubMed ID: 21752340	2011
G protein-coupled receptors interacting proteins: towards the druggable interactome. Current drug targets\| PubMed ID: 21777189	2012
An update on adenosine A2A receptors as drug target in Parkinson's disease. CNS & neurological disorders drug targets\| PubMed ID: 21838670	2011
Possible new targets for GPCR modulation: allosteric interactions, plasma membrane domains, intercellular transfer and epigenetic mechanisms. Journal of receptor and signal transduction research\| PubMed ID: 21929287	2011
GABAB receptors-associated proteins: potential drug targets in neurological disorders? Current drug targets\| PubMed ID: 22023408	2012
Fibroblast growth factor receptor 1- 5-hydroxytryptamine 1A heteroreceptor complexes and their enhancement of hippocampal plasticity. Biological psychiatry\| PubMed ID: 22035699	2012
Dissecting the conserved NPxxY motif of the M3 muscarinic acetylcholine receptor: critical role of Asp-7.49 for receptor signaling and multiprotein complex formation. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology\| PubMed ID: 22178951	2011
Synergistic interaction between fentanyl and a tramadol: paracetamol combination on the inhibition of nociception in mice. Journal of pharmacological sciences\| PubMed ID: 22302020	2012
A modification of the split-tobacco etch virus method for monitoring interactions between membrane proteins in mammalian cells. Analytical biochemistry\| PubMed ID: 22342621	2012
On the role of volume transmission and receptor-receptor interactions in social behaviour: focus on central catecholamine and oxytocin neurons. Brain research\| PubMed ID: 22373652	2012
The existence of FGFR1-5-HT1A receptor heterocomplexes in midbrain 5-HT neurons of the rat: relevance for neuroplasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22553035	2012
G protein-coupled receptor oligomerization and brain integration: focus on adenosinergic transmission. Brain research\| PubMed ID: 22575562	2012
Extrasynaptic neurotransmission in the modulation of brain function. Focus on the striatal neuronal-glial networks. Frontiers in physiology\| PubMed ID: 22675301	2012
Fluorescence resonance energy transfer-based technologies in the study of protein-protein interactions at the cell surface. Methods (San Diego, Calif.)\| PubMed ID: 22683304	2012
Transcriptional profiling of striatal neurons in response to single or concurrent activation of dopamine D2, adenosine A(2A) and metabotropic glutamate type 5 receptors: focus on beta-synucl... Gene\| PubMed ID: 22892378	2012
Molecular determinants of A2AR-D2R allosterism: role of the intracellular loop 3 of the D2R. Journal of neurochemistry\| PubMed ID: 22924752	2012
On the existence and function of galanin receptor heteromers in the central nervous system. Frontiers in endocrinology\| PubMed ID: 23112793	2012
G protein-coupled receptor heterodimerization in the brain. Methods in enzymology\| PubMed ID: 23351745	2013
The Parkinson's disease-associated GPR37 receptor-mediated cytotoxicity is controlled by its intracellular cysteine-rich domain. Journal of neurochemistry\| PubMed ID: 23398388	2013
A new interpretative paradigm for Conformational Protein Diseases. Current protein & peptide science\| PubMed ID: 23441893	2013
Ras-association domain of sorting Nexin 27 is critical for regulating expression of GIRK potassium channels. PloS one\| PubMed ID: 23536889	2013
The type II cGMP dependent protein kinase regulates GluA1 levels at the plasma membrane of developing cerebellar granule cells. Biochimica et biophysica acta\| PubMed ID: 23545413	2013
Dopamine D(2) receptor-mediated modulation of adenosine A(2A) receptor agonist binding within the A(2A)R/D(2)R oligomer framework. Neurochemistry international\| PubMed ID: 23619397	2013
Preface. In cells. Progress in molecular biology and translational science\| PubMed ID: 23663984	2013
Guanosine behind the scene. Journal of neurochemistry\| PubMed ID: 23815178	2013
β-Adrenergic receptors activate exchange protein directly activated by cAMP (Epac), translocate Munc13-1, and enhance the Rab3A-RIM1α interaction to potentiate glutamate release at cerebroco... The Journal of biological chemistry\| PubMed ID: 24036110	2013
Moonlighting proteins and protein-protein interactions as neurotherapeutic targets in the G protein-coupled receptor field. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 24105074	2014
Predicting the antinociceptive efficacy of σ(1) receptor ligands by a novel receptor fluorescence resonance energy transfer (FRET) based biosensor. Journal of medicinal chemistry\| PubMed ID: 24354313	2014
Striatal adenosine A2A receptor expression is controlled by S-adenosyl-L-methionine-mediated methylation. Purinergic signalling\| PubMed ID: 24943396	2014
Portraying G protein-coupled receptors with fluorescent ligands. ACS chemical biology\| PubMed ID: 25010291	2014
Deciphering G protein-coupled receptor biology with fluorescence-based methods. Current pharmaceutical biotechnology\| PubMed ID: 25213309	2014
Photomodulation of G protein-coupled adenosine receptors by a novel light-switchable ligand. Bioconjugate chemistry\| PubMed ID: 25248077	2014
Uncovering caffeine's adenosine A2A receptor inverse agonism in experimental parkinsonism. ACS chemical biology\| PubMed ID: 25268872	2014
Coassembly and coupling of SK2 channels and mGlu5 receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25355231	2014
Untangling dopamine-adenosine receptor-receptor assembly in experimental parkinsonism in rats. Disease models & mechanisms\| PubMed ID: 25398851	2015
Evidence for the existence of FGFR1-5-HT1A heteroreceptor complexes in the midbrain raphe 5-HT system. Biochemical and biophysical research communications\| PubMed ID: 25485703	2015
Adenosine A1 receptor activation modulates N-methyl-d-aspartate (NMDA) preconditioning phenotype in the brain. Behavioural brain research\| PubMed ID: 25557798	2015
GPCR oligomerization analysis by means of BRET and dFRAP. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 25563182	2015
The role of parkinson's disease-associated receptor GPR37 in the hippocampus: functional interplay with the adenosinergic system. Journal of neurochemistry\| PubMed ID: 25824528	2015
Adenosine A2A receptor-mediated control of pilocarpine-induced tremulous jaw movements is Parkinson's disease-associated GPR37 receptor-dependent. Behavioural brain research\| PubMed ID: 25862943	2015
Lighting up G protein-coupled purinergic receptors with engineered fluorescent ligands. Neuropharmacology\| PubMed ID: 25890205	2015
Enhancement of the FGFR1 signaling in the FGFR1-5-HT1A heteroreceptor complex in midbrain raphe 5-HT neuron systems. Relevance for neuroplasticity and depression. Biochemical and biophysical research communications\| PubMed ID: 25957476	2015
Visualizing G Protein-Coupled Receptor-Receptor Interactions in Brain Using Proximity Ligation In Situ Assay. Current protocols in cell biology\| PubMed ID: 26061241	2015
Facilitated Anion Transport Induces Hyperpolarization of the Cell Membrane That Triggers Differentiation and Cell Death in Cancer Stem Cells. Journal of the American Chemical Society\| PubMed ID: 26632983	2015
Membrane omega-3 fatty acids modulate the oligomerisation kinetics of adenosine A2A and dopamine D2 receptors. Scientific reports\| PubMed ID: 26796668	2016
Presynaptic P2X1-3 and α3-containing nicotinic receptors assemble into functionally interacting ion channels in the rat hippocampus. Neuropharmacology\| PubMed ID: 26801076	2016
Genetic blockade of adenosine A2A receptors induces cognitive impairments and anatomical changes related to psychotic symptoms in mice. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology\| PubMed ID: 27133030	2016
The Exonuclease Trex2 Shapes Psoriatic Phenotype. The Journal of investigative dermatology\| PubMed ID: 27365293	2016
The Guanine-Based Purinergic System: The Tale of An Orphan Neuromodulation. Frontiers in pharmacology\| PubMed ID: 27378923	2016
Investigation of LRRC8-Mediated Volume-Regulated Anion Currents in Xenopus Oocytes. Biophysical journal\| PubMed ID: 27705766	2016
Parkinson's disease-associated GPR37 receptor regulates cocaine-mediated synaptic depression in corticostriatal synapses. Neuroscience letters\| PubMed ID: 28007645	2017
Singular Location and Signaling Profile of Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Dorsal Striatum. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 28102227	2017
Calcium modulates calmodulin/α-actinin 1 interaction with and agonist-dependent internalization of the adenosine A2A receptor. Biochimica et biophysica acta\| PubMed ID: 28130124	2017
Exploring Drug-Receptor Interaction Kinetics: Lessons from a Sigma-1 Receptor Transmembrane Biosensor. Frontiers in pharmacology\| PubMed ID: 28144220	2017
Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals. ACS central science\| PubMed ID: 28149957	2017
Synthesis and Characterization of a New Bivalent Ligand Combining Caffeine and Docosahexaenoic Acid. Molecules (Basel, Switzerland)\| PubMed ID: 28264466	2017
Systematic protein-protein interaction mapping for clinically relevant human GPCRs. Molecular systems biology\| PubMed ID: 28298427	2017
Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator. eLife\| PubMed ID: 28395733	2017