Frank Reimann

Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge

Affiliated withWellcome Trust-MRC Institute of Metabolic Science, University of Cambridge

Research Area

Biology

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 30	2017

Other Publications

Article	Year
Limited impact on glucose homeostasis of leptin receptor deletion from insulin- or proglucagon-expressing cells. Molecular metabolism\| PubMed ID: 26413468	2015
Glucose-sensing in glucagon-like peptide-1-secreting cells. Diabetes\| PubMed ID: 12196469	2002
Sulfonylurea stimulation of insulin secretion. Diabetes\| PubMed ID: 12475777	2002
A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1. Lancet (London, England)\| PubMed ID: 12559865	2003
Analysis of the differential modulation of sulphonylurea block of beta-cell and cardiac ATP-sensitive K+ (K(ATP)) channels by Mg-nucleotides. The Journal of physiology\| PubMed ID: 12562963	2003
Differential selectivity of insulin secretagogues: mechanisms, clinical implications, and drug interactions. Journal of diabetes and its complications\| PubMed ID: 12623163	2003
A novel glucose-sensing mechanism contributing to glucagon-like peptide-1 secretion from the GLUTag cell line. Diabetes\| PubMed ID: 12716745	2003
A novel missense mutation in AE1 causing autosomal dominant distal renal tubular acidosis retains normal transport function but is mistargeted in polarized epithelial cells. The Journal of biological chemistry\| PubMed ID: 14734552	2004
Open to control--new hope for patients with neonatal diabetes. The New England journal of medicine\| PubMed ID: 15115828	2004
Constitutive Ras activity induces hippocampal hypertrophy and remodeling of pyramidal neurons in synRas mice. Journal of neuroscience research\| PubMed ID: 15352209	2004
Relapsing diabetes can result from moderately activating mutations in KCNJ11. Human molecular genetics\| PubMed ID: 15718250	2005
Mucolipin-1 is a lysosomal membrane protein required for intracellular lactosylceramide traffic. Traffic (Copenhagen, Denmark)\| PubMed ID: 16978393	2006
Sodium-coupled glucose cotransporters contribute to hypothalamic glucose sensing. Diabetes\| PubMed ID: 17130483	2006
An SCN9A channelopathy causes congenital inability to experience pain. Nature\| PubMed ID: 17167479	2006
No differences in mortality between users of pancreatic-specific and non-pancreatic-specific sulphonylureas: a cohort analysis. Diabetes, obesity & metabolism\| PubMed ID: 18093208	2008
Extrahepatic cholestasis increases liver stiffness (FibroScan) irrespective of fibrosis. Hepatology (Baltimore, Md.)\| PubMed ID: 18836992	2008
Dissociation between sensing and metabolism of glucose in sugar sensing neurones. The Journal of physiology\| PubMed ID: 18981030	2009
Nutritional regulation of glucagon-like peptide-1 secretion. The Journal of physiology\| PubMed ID: 19001044	2009
Glucose sensing in L cells: a primary cell study. Cell metabolism\| PubMed ID: 19041768	2008
Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects. The American journal of clinical nutrition\| PubMed ID: 19056578	2009
TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction. Nature genetics\| PubMed ID: 19079066	2009
Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants. Diabetes\| PubMed ID: 19542200	2009
Hypogonadotropic hypogonadism due to a novel missense mutation in the first extracellular loop of the neurokinin B receptor. The Journal of clinical endocrinology and metabolism\| PubMed ID: 19755480	2009
Molecular mechanisms underlying nutrient-stimulated incretin secretion. Expert reviews in molecular medicine\| PubMed ID: 20047700	2010
Increased liver stiffness in alcoholic liver disease: differentiating fibrosis from steatohepatitis. World journal of gastroenterology\| PubMed ID: 20180235	2010
Molecular mechanisms underlying nutrient detection by incretin-secreting cells. International dairy journal\| PubMed ID: 20204054	2010
Pain perception is altered by a nucleotide polymorphism in SCN9A. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20212137	2010
GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis. Cell metabolism\| PubMed ID: 20519125	2010
Leptin directly depolarizes preproglucagon neurons in the nucleus tractus solitarius: electrical properties of glucagon-like Peptide 1 neurons. Diabetes\| PubMed ID: 20522593	2010
Congenital insensitivity to pain: novel SCN9A missense and in-frame deletion mutations. Human mutation\| PubMed ID: 20635406	2010
Role of phosphodiesterase and adenylate cyclase isozymes in murine colonic glucagon-like peptide 1 secreting cells. British journal of pharmacology\| PubMed ID: 21054345	2011
Glutamine triggers and potentiates glucagon-like peptide-1 secretion by raising cytosolic Ca2+ and cAMP. Endocrinology\| PubMed ID: 21209017	2011
CCK stimulation of GLP-1 neurons involves α1-adrenoceptor-mediated increase in glutamatergic synaptic inputs. Diabetes\| PubMed ID: 21885869	2011
Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. Nature medicine\| PubMed ID: 22037645	2011
Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion. Diabetes\| PubMed ID: 22124465	2012
Nutrient detection by incretin hormone secreting cells. Physiology & behavior\| PubMed ID: 22182802	2012
Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2. Diabetes\| PubMed ID: 22190648	2012
Intestinal sensing of nutrients. Handbook of experimental pharmacology\| PubMed ID: 22249821	2012
G-protein-coupled receptors in intestinal chemosensation. Cell metabolism\| PubMed ID: 22482725	2012
Overlap of endocrine hormone expression in the mouse intestine revealed by transcriptional profiling and flow cytometry. Endocrinology\| PubMed ID: 22685263	2012
Neurochemical characterization of body weight-regulating leptin receptor neurons in the nucleus of the solitary tract. Endocrinology\| PubMed ID: 22869346	2012
PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice. The Journal of clinical investigation\| PubMed ID: 23093780	2012
The G protein-coupled receptor family C group 6 subtype A (GPRC6A) receptor is involved in amino acid-induced glucagon-like peptide-1 secretion from GLUTag cells. The Journal of biological chemistry\| PubMed ID: 23269670	2013
Molecular mechanisms of incretin hormone secretion. Current opinion in pharmacology\| PubMed ID: 24035446	2013
Oligopeptides stimulate glucagon-like peptide-1 secretion in mice through proton-coupled uptake and the calcium-sensing receptor. Diabetologia\| PubMed ID: 24045836	2013
A tag to track short chain fatty acid sensors. Endocrinology\| PubMed ID: 24058154	2013
Generation of L cells in mouse and human small intestine organoids. Diabetes\| PubMed ID: 24130334	2014
Towards the harnessing of gut feelings. Current opinion in pharmacology\| PubMed ID: 24140240	2013
Identification and characterization of GLP-1 receptor-expressing cells using a new transgenic mouse model. Diabetes\| PubMed ID: 24296712	2014
Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes. Cell metabolism\| PubMed ID: 24315372	2013
Fructose stimulates GLP-1 but not GIP secretion in mice, rats, and humans. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 24525020	2014
Insulin-like peptide 5 is an orexigenic gastrointestinal hormone. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25028498	2014
LKB1 and AMPK differentially regulate pancreatic β-cell identity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 25070369	2014
GLP-1 receptor stimulation of the lateral parabrachial nucleus reduces food intake: neuroanatomical, electrophysiological, and behavioral evidence. Endocrinology\| PubMed ID: 25116706	2014
Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers. Nature\| PubMed ID: 25141178	2014
Reversible changes in pancreatic islet structure and function produced by elevated blood glucose. Nature communications\| PubMed ID: 25145789	2014
Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression. The Journal of physiology\| PubMed ID: 25172946	2014
The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in mice. Disease models & mechanisms\| PubMed ID: 25190708	2014
The role of gut endocrine cells in control of metabolism and appetite. Experimental physiology\| PubMed ID: 25210110	2014
Stimulation of GLP-1 secretion downstream of the ligand-gated ion channel TRPA1. Diabetes\| PubMed ID: 25325736	2015
Clocking up GLP-1: considering intestinal rhythms in the incretin effect. Diabetes\| PubMed ID: 25342730	2014
The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo. Cell metabolism\| PubMed ID: 25453189	2014
Bacterial metabolite indole modulates incretin secretion from intestinal enteroendocrine L cells. Cell reports\| PubMed ID: 25456122	2014
Targeting development of incretin-producing cells increases insulin secretion. The Journal of clinical investigation\| PubMed ID: 25500886	2015
Gut chemosensing mechanisms. The Journal of clinical investigation\| PubMed ID: 25664852	2015
Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion. The Biochemical journal\| PubMed ID: 25731850	2015
Activation of the GLP-1 receptors in the nucleus of the solitary tract reduces food reward behavior and targets the mesolimbic system. PloS one\| PubMed ID: 25793511	2015
LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia. Molecular metabolism\| PubMed ID: 25830091	2015
Submembrane ATP and Ca2+ kinetics in α-cells: unexpected signaling for glucagon secretion. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 25911612	2015
Novel SCN9A mutations underlying extreme pain phenotypes: unexpected electrophysiological and clinical phenotype correlations. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25995458	2015
Transcriptional regulator PRDM12 is essential for human pain perception. Nature genetics\| PubMed ID: 26005867	2015
Effect of reducing portion size at a compulsory meal on later energy intake, gut hormones, and appetite in overweight adults. Obesity (Silver Spring, Md.)\| PubMed ID: 26054049	2015
Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells. Nature communications\| PubMed ID: 26134028	2015
Lipid derivatives activate GPR119 and trigger GLP-1 secretion in primary murine L-cells. Peptides\| PubMed ID: 26144594	2016
High fat diet impairs the function of glucagon-like peptide-1 producing L-cells. Peptides\| PubMed ID: 26145551	2016
Signalling pathways involved in the detection of peptones by murine small intestinal enteroendocrine L-cells. Peptides\| PubMed ID: 26215048	2016
Corrigendum: Transcriptional regulator PRDM12 is essential for human pain perception. Nature genetics\| PubMed ID: 26220135	2015
A Transcriptome-Led Exploration of Molecular Mechanisms Regulating Somatostatin-Producing D-Cells in the Gastric Epithelium. Endocrinology\| PubMed ID: 26241122	2015
Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein-Coupled Bile Acid Receptors. Endocrinology\| PubMed ID: 26280129	2015
Can encapsulated glutamine increase GLP-1 secretion, improve glucose tolerance, and reduce meal size in healthy volunteers? A randomised, placebo-controlled, cross-over trial. Lancet (London, England)\| PubMed ID: 26312890	2015
The effect of bariatric surgery on gastrointestinal and pancreatic peptide hormones. Peptides\| PubMed ID: 26344355	2016
Enteroendocrine Cells: Chemosensors in the Intestinal Epithelium. Annual review of physiology\| PubMed ID: 26442437	2016
GLP1- and GIP-producing cells rarely overlap and differ by bombesin receptor-2 expression and responsiveness. The Journal of endocrinology\| PubMed ID: 26483393	2016
Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain. Molecular metabolism\| PubMed ID: 26500843	2015
The effect of encapsulated glutamine on gut peptide secretion in human volunteers. Peptides\| PubMed ID: 26541888	2016
Galanin inhibits GLP-1 and GIP secretion via the GAL1 receptor in enteroendocrine L and K cells. British journal of pharmacology\| PubMed ID: 26661062	2016
G protein-coupled receptors as new therapeutic targets for type 2 diabetes. Diabetologia\| PubMed ID: 26661410	2016
Peptide production and secretion in GLUTag, NCI-H716, and STC-1 cells: a comparison to native L-cells. Journal of molecular endocrinology\| PubMed ID: 26819328	2016
Stimulation of incretin secreting cells. Therapeutic advances in endocrinology and metabolism\| PubMed ID: 26885360	2016
The incretin hormone glucagon-like peptide 1 increases mitral cell excitability by decreasing conductance of a voltage-dependent potassium channel. The Journal of physiology\| PubMed ID: 26931093	2016
Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance. PloS one\| PubMed ID: 27010458	2016
Role of enteroendocrine L-cells in arginine vasopressin-mediated inhibition of colonic anion secretion. The Journal of physiology\| PubMed ID: 27037495	2016
Preproglucagon neurons in the hindbrain have IL-6 receptor-α and show Ca2+ influx in response to IL-6. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 27097661	2016
Mechanisms underlying glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 secretion. Journal of diabetes investigation\| PubMed ID: 27186350	2016
Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets. Diabetologia\| PubMed ID: 27390011	2016
Angiotensin II Type 1 Receptor-Dependent GLP-1 and PYY Secretion in Mice and Humans. Endocrinology\| PubMed ID: 27447725	2016
Functional and Molecular Adaptations of Enteroendocrine L-Cells in Male Obese Mice Are Associated With Preservation of Pancreatic α-Cell Function and Prevention of Hyperglycemia. Endocrinology\| PubMed ID: 27547850	2016
Gut Hormone Regulation and Secretion via FFA1 and FFA4. Handbook of experimental pharmacology\| PubMed ID: 27873089	2017
Scaling it down: new in vitro tools to get the balance right. The Biochemical journal\| PubMed ID: 28008090	2017
Glucagon-Like Peptide 1 and Its Analogs Act in the Dorsal Raphe and Modulate Central Serotonin to Reduce Appetite and Body Weight. Diabetes\| PubMed ID: 28057699	2017
Signalling in the gut endocrine axis. Physiology & behavior\| PubMed ID: 28257936	2017