Sang Geon Kim

College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University

Affiliated withSeoul National University

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 3	2017

Other Publications

Article	Year
Role of p90 ribosomal S6-kinase-1 in oltipraz-induced specific phosphorylation of CCAAT/enhancer binding protein-beta for GSTA2 gene transactivation. Molecular pharmacology\| PubMed ID: 16246908	2006
Potent inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by dibenzylbutyrolactone lignans through inhibition of I-kappaBalpha phosphorylation and of p65 nuclear tra... International immunopharmacology\| PubMed ID: 11789661	2002
Inhibition of dimethylnitrosamine-induced liver fibrosis by [5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione] (oltipraz) in rats: suppression of transforming growth factor-beta1 and tumor necr... Chemico-biological interactions\| PubMed ID: 11803029	2002
Identification of genes enhanced by protein-calorie malnutrition by differential display polymerase chain reaction (expression of fibrinogen B beta chain, B cell translocation gene 1 and thy... Molecular and cellular biochemistry\| PubMed ID: 11952159	2002
Alterations in cellular Ca(2+) and free iron pool by sulfur amino acid deprivation: the role of ferritin light chain down-regulation in prooxidant production. Biochemical pharmacology\| PubMed ID: 11992632	2002
Induction of microsomal epoxide hydrolase by sulfur amino acid deprivation via the pathway of C-Jun N-terminal kinase and its extracellular exposure during cell death. Free radical biology & medicine\| PubMed ID: 12008117	2002
JunB/AP-1 and NF-kappa B-mediated induction of nitric oxide synthase by bovine type I collagen in serum-stimulated murine macrophages. Nitric oxide : biology and chemistry\| PubMed ID: 12009850	2002
Increase in urea in conjunction with L-arginine metabolism in the liver leads to induction of cytochrome P450 2E1 (CYP2E1): the role of urea in CYP2E1 induction by acute renal failure. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 12019204	2002
Mechanism of the reduced elimination clearance of benzylpenicillin from cerebrospinal fluid in rats with intracisternal administration of lipopolysaccharide. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 12386127	2002
Phosphatidylinositol 3-kinase regulates nuclear translocation of NF-E2-related factor 2 through actin rearrangement in response to oxidative stress. Molecular pharmacology\| PubMed ID: 12391262	2002
Oltipraz regenerates cirrhotic liver through CCAAT/enhancer binding protein-mediated stellate cell inactivation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 12397085	2002
The anti-fibrogenic effect of a pharmaceutical composition of [5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione] (oltipraz) and dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-... Archives of pharmacal research\| PubMed ID: 12433201	2002
Peroxynitrite activates NF-E2-related factor 2/antioxidant response element through the pathway of phosphatidylinositol 3-kinase: the role of nitric oxide synthase in rat glutathione S-trans... Nitric oxide : biology and chemistry\| PubMed ID: 12446173	2002
Essential role of phosphatidylinositol 3-kinase-dependent CCAAT/enhancer binding protein beta activation in the induction of glutathione S-transferase by oltipraz. Journal of the National Cancer Institute\| PubMed ID: 12509401	2003
Hepatobiliary excretion of tributylmethylamonium in rats with lipopolysaccharide-induced acute inflammation. Archives of pharmacal research\| PubMed ID: 12510855	2002
Effect of nitric oxide on the sinusoidal uptake of organic cations and anions by isolated hepatocytes. Archives of pharmacal research\| PubMed ID: 12510858	2002
Effects of acute renal failure induced by uranyl nitrate on the pharmacokinetics of intravenous theophylline in rats: the role of CYP2E1 induction in 1,3-dimethyluric acid formation. The Journal of pharmacy and pharmacology\| PubMed ID: 12542900	2002
Hepatocyte growth factor activates CCAAT enhancer binding protein and cell replication via PI3-kinase pathway. Hepatology (Baltimore, Md.)\| PubMed ID: 12601366	2003
Thrombin induces nitric-oxide synthase via Galpha12/13-coupled protein kinase C-dependent I-kappaBalpha phosphorylation and JNK-mediated I-kappaBalpha degradation. The Journal of biological chemistry\| PubMed ID: 12606553	2003
Potentiation of lipopolysaccharide-inducible cyclooxygenase 2 expression by C2-ceramide via c-Jun N-terminal kinase-mediated activation of CCAAT/enhancer binding protein beta in macrophages. Molecular pharmacology\| PubMed ID: 12606757	2003
Activation of CCAAT/enhancer-binding protein beta by 2'-amino-3'-methoxyflavone (PD98059) leads to the induction of glutathione S-transferase A2. Carcinogenesis\| PubMed ID: 12663507	2003
Effects of cysteine on the pharmacokinetics of intravenous 2-(allylthio)pyrazine, a new chemoprotective agent, in rats with protein-calorie malnutrition. International journal of pharmaceutics\| PubMed ID: 12672597	2003
Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-alpha and COX-2 expression by sauchinone effects on I-kappaBalpha phosphorylation, C/EBP and AP-1 activation. British journal of pharmacology\| PubMed ID: 12746218	2003
Effects of acute renal failure on the pharmacokinetics of chlorzoxazone in rats. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 12756212	2003
Effects of recombinant human growth hormone on the pharmacokinetics of intravenous chlorzoxazone in rats with acute renal failure induced by uranyl nitrate. Life sciences\| PubMed ID: 12757833	2003
The suppressed expression and functional activity of hepatic P-glycoprotein in rats with protein-calorie malnutrition. Journal of pharmaceutical sciences\| PubMed ID: 12820137	2003
Cadmium-induced non-apoptotic cell death mediated by oxidative stress under the condition of sulfhydryl deficiency. Toxicology letters\| PubMed ID: 12927350	2003
Oltipraz inhibits 3-methylcholanthrene induction of CYP1A1 by CCAAT/enhancer-binding protein activation. The Journal of biological chemistry\| PubMed ID: 12941938	2003
2-Oxo-3,23-isopropylidene-asiatate (AS2006A), a wound-healing asiatate derivative, exerts anti-inflammatory effect by apoptosis of macrophages. International immunopharmacology\| PubMed ID: 12946439	2003
Ginsenoside Rg3 inhibits phenylephrine-induced vascular contraction through induction of nitric oxide synthase. British journal of pharmacology\| PubMed ID: 14534150	2003
Pharmacokinetic interaction between oltipraz and dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate (DDB) after single intravenous and oral administration to rats... The Journal of pharmacy and pharmacology\| PubMed ID: 14604467	2003
Effects of colchicine on liver functions of cirrhotic rats: beneficial effects result from stellate cell inactivation and inhibition of TGF beta1 expression. Chemico-biological interactions\| PubMed ID: 14726149	2004
Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14764898	2004
Cytoprotective effects of Glycyrrhizae radix extract and its active component liquiritigenin against cadmium-induced toxicity (effects on bad translocation and cytochrome c-mediated PARP cle... Toxicology\| PubMed ID: 15033546	2004
Transactivation of the PPAR-responsive enhancer module in chemopreventive glutathione S-transferase gene by the peroxisome proliferator-activated receptor-gamma and retinoid X receptor heter... Cancer research\| PubMed ID: 15150131	2004
Ceramide negatively regulates glutathione S-transferase gene transactivation via repression of hepatic nuclear factor-1 that is degraded by the ubiquitin proteasome system. Molecular pharmacology\| PubMed ID: 15155840	2004
Induction of cyclooxygenase-2 by bovine type I collagen in macrophages via C/EBP and CREB activation by multiple cell signaling pathways. Biochemical pharmacology\| PubMed ID: 15163555	2004
Synthesis and anti-inflammatory effects of novel pimarane diterpenoid analogs. Bioorganic & medicinal chemistry letters\| PubMed ID: 15177458	2004
Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-alpha inhibition. International immunopharmacology\| PubMed ID: 15313439	2004
Ceramide, an apoptotic rheostat, inhibits CCAAT/enhancer binding protein-beta and NF-E2-related factor-2 activation: the role in glutathione S-transferase A2 gene repression. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 15319326	2004
PKC downstream of Pl3-kinase regulates peroxynitrite formation for Nrf2-mediated GSTA2 induction. Archives of pharmacal research\| PubMed ID: 15357004	2004
Hyaluronic acid inhibits adhesion of hepatic stellate cells in spite of its stimulation of DNA synthesis. Tissue & cell\| PubMed ID: 15385147	2004
Deprenyl, a therapeutic agent for Parkinson's disease, inhibits arsenic toxicity potentiated by GSH depletion via inhibition of JNK activation. Journal of toxicology and environmental health. Part A\| PubMed ID: 15513899	2004
Lack of therapeutic improvement of liver fibrosis in rats by dexamethasone in spite of ascites amelioration. Chemico-biological interactions\| PubMed ID: 15766921	2005
Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPbeta TAD and Nrf2 Neh4/5: role of SMRT recruited to GR in GSTA2 gene repression. Molecular and cellular biology\| PubMed ID: 15870285	2005
Bovine type I collagen inhibits Raw264.7 cell proliferation through phosphoinositide 3-kinase- and mitogen-activated protein kinase-dependent down-regulation of cyclins D1, A and B1. Biochimica et biophysica acta\| PubMed ID: 15878397	2005
meso-dihydroguaiaretic acid from Machilus thunbergii down-regulates TGF-beta1 gene expression in activated hepatic stellate cells via inhibition of AP-1 activity. Planta medica\| PubMed ID: 15931574	2005
Garlic oil and DDB, comprised in a pharmaceutical composition for the treatment of patients with viral hepatitis, prevents acute liver injuries potentiated by glutathione deficiency in rats. Chemico-biological interactions\| PubMed ID: 15950962	2005
Enhanced CCAAT/enhancer-binding protein beta-liver-enriched inhibitory protein production by Oltipraz, which accompanies CUG repeat-binding protein-1 (CUGBP1) RNA-binding protein activation,... Molecular pharmacology\| PubMed ID: 15961673	2005
Pharmacokinetics of theophylline in diabetes mellitus rats: induction of CYP1A2 and CYP2E1 on 1,3-dimethyluric acid formation. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences\| PubMed ID: 15985363	2005
Repression by oxidative stress of iNOS and cytokine gene induction in macrophages results from AP-1 and NF-kappaB inhibition mediated by B cell translocation gene-1 activation. Free radical biology & medicine\| PubMed ID: 16274887	2005
NO signaling in ARE-mediated gene expression. Methods in enzymology\| PubMed ID: 16291243	2005
G-protein signaling in iNOS gene expression. Methods in enzymology\| PubMed ID: 16291247	2005
Molecular mechanism of nrf2 activation by oxidative stress. Antioxidants & redox signaling\| PubMed ID: 16356128	2005
Peroxisome proliferator-activated receptor-gamma and retinoic acid X receptor alpha represses the TGFbeta1 gene via PTEN-mediated p70 ribosomal S6 kinase-1 inhibition: role for Zf9 dephospho... Molecular pharmacology\| PubMed ID: 16611854	2006
Expression of microsomal epoxide hydrolase is elevated in Alzheimer's hippocampus and induced by exogenous beta-amyloid and trimethyl-tin. The European journal of neuroscience\| PubMed ID: 16630050	2006
Liquiritigenin, an aglycone of liquiritin in Glycyrrhizae radix, prevents acute liver injuries in rats induced by acetaminophen with or without buthionine sulfoximine. Chemico-biological interactions\| PubMed ID: 16647697	2006
Differential effects of the oxidized metabolites of oltipraz on the activation of CCAAT/enhancer binding protein-beta and NF-E2-related factor-2 for GSTA2 gene induction. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 16714377	2006
A novel iNOS and COX-2 inhibitor from the aerial parts of Rodgersia podophylla. Bioorganic & medicinal chemistry letters\| PubMed ID: 16784852	2006
Effects of glucose supplementation on the pharmacokinetics of intravenous chlorzoxazone in rats with water deprivation for 72 h. Life sciences\| PubMed ID: 16914164	2006
Activating transcription factor 2 mediates matrix metalloproteinase-2 transcriptional activation induced by p38 in breast epithelial cells. Cancer research\| PubMed ID: 17079470	2006
Inhibition of TGFbeta1-mediated PAI-1 induction by oltipraz through selective interruption of Smad 3 activation. Cytokine\| PubMed ID: 17095240	2006
Galpha12 specifically regulates COX-2 induction by sphingosine 1-phosphate. Role for JNK-dependent ubiquitination and degradation of IkappaBalpha. The Journal of biological chemistry\| PubMed ID: 17098744	2007
PI3K, RSK, and mTOR signal networks for the GST gene regulation. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 17122411	2007
Identifying drugs needing pharmacogenetic monitoring in a Korean hospital. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists\| PubMed ID: 17215467	2007
G alpha 12/13 basally regulates p53 through Mdm4 expression. Molecular cancer research : MCR\| PubMed ID: 17510313	2007
The potent protective effect of wild ginseng (Panax ginseng C.A. Meyer) against benzo[alpha]pyrene-induced toxicity through metabolic regulation of CYP1A1 and GSTs. Journal of ethnopharmacology\| PubMed ID: 17590295	2007
Role of Galpha12 and Galpha13 as novel switches for the activity of Nrf2, a key antioxidative transcription factor. Molecular and cellular biology\| PubMed ID: 17591699	2007
Combined metadoxine and garlic oil treatment efficaciously abrogates alcoholic steatosis and CYP2E1 induction in rat liver with restoration of AMPK activity. Chemico-biological interactions\| PubMed ID: 17606256	2007
Induction of glutathione transferase in insulin-like growth factor type I receptor-overexpressed hepatoma cells. Molecular pharmacology\| PubMed ID: 17615245	2007
Metformin prevents an adaptive increase in GSH and induces apoptosis under the conditions of GSH deficiency in H4IIE cells. Journal of toxicology and environmental health. Part A\| PubMed ID: 17654257	2007
Functional induction of P-glycoprotein in the blood-brain barrier of streptozotocin-induced diabetic rats: evidence for the involvement of nuclear factor-kappaB, a nitrosative stress-sensiti... Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 17664251	2007
Identification of a novel class of dithiolethiones that prevent hepatic insulin resistance via the adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway. Hepatology (Baltimore, Md.)\| PubMed ID: 17668885	2007
3,3'-Diindolylmethane suppresses the inflammatory response to lipopolysaccharide in murine macrophages. The Journal of nutrition\| PubMed ID: 18156398	2008
Abrogation of hyperosmotic impairment of insulin signaling by a novel class of 1,2-dithiole-3-thiones through the inhibition of S6K1 activation. Molecular pharmacology\| PubMed ID: 18252807	2008
Isoliquiritigenin suppresses cocaine-induced extracellular dopamine release in rat brain through GABA(B) receptor. European journal of pharmacology\| PubMed ID: 18495107	2008
A Novel Mechanism of PPARgamma Regulation of TGFbeta1: Implication in Cancer Biology. PPAR research\| PubMed ID: 18615188	2008
Regulation of thymus-dependent and thymus-independent production of immunoglobulin G subclasses by Galpha12 and Galpha13. Journal of molecular signaling\| PubMed ID: 18620589	2008
Compound C inhibits clonal expansion of preadipocytes by increasing p21 level irrespectively of AMPK inhibition. Archives of biochemistry and biophysics\| PubMed ID: 18721791	2008
The identification of C/EBPbeta as a transcription factor necessary for the induction of MAPK phosphatase-1 by toll-like receptor-4 ligand. Archives of biochemistry and biophysics\| PubMed ID: 18761321	2008
Drug-induced hyperbilirubinemia and the clinical influencing factors. Drug metabolism reviews\| PubMed ID: 18821100	2008
A novel mitogen-activated protein kinase phosphatase-1 and glucocorticoid receptor (GR) interacting protein-1-dependent combinatorial mechanism of gene transrepression by GR. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 18945810	2009
Inhibition of arachidonic acid and iron-induced mitochondrial dysfunction and apoptosis by oltipraz and novel 1,2-dithiole-3-thione congeners. Molecular pharmacology\| PubMed ID: 18945820	2009
Liquiritigenin, a flavonoid aglycone from licorice, has a choleretic effect and the ability to induce hepatic transporters and phase-II enzymes. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 19074639	2009
Oxidized metabolites of oltipraz exert cytoprotective effects against arachidonic acid through AMP-activated protein kinase-dependent cellular antioxidant effect and mitochondrial protection... Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 19299524	2009
Role of adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway in repression of liver X receptor-alpha-dependent lipogenic gene induction and hepatic steatosis by... Hepatology (Baltimore, Md.)\| PubMed ID: 19378344	2009
Oltipraz promotion of liver regeneration after partial hepatectomy: The role of PI3-kinase-dependent C/EBPbeta and cyclin E regulation. Archives of pharmacal research\| PubMed ID: 19407981	2009
Galpha13 regulates methacholine-induced contraction of bronchial smooth muscle via phosphorylation of MLC20. Biochemical pharmacology\| PubMed ID: 19426687	2009
H89, an inhibitor of PKA and MSK, inhibits cyclic-AMP response element binding protein-mediated MAPK phosphatase-1 induction by lipopolysaccharide. Inflammation research : official journal of the European Histamine Research Society ... [et al.]\| PubMed ID: 19547917	2009
Therapeutic potential of dithiolethiones for hepatic diseases. Pharmacology & therapeutics\| PubMed ID: 19563826	2009
Metadoxine, an ion-pair of pyridoxine and L-2-pyrrolidone-5-carboxylate, blocks adipocyte differentiation in association with inhibition of the PKA-CREB pathway. Archives of biochemistry and biophysics\| PubMed ID: 19607801	2009
Efficacy of sauchinone as a novel AMPK-activating lignan for preventing iron-induced oxidative stress and liver injury. Free radical biology & medicine\| PubMed ID: 19616619	2009
Resveratrol protects mitochondria against oxidative stress through AMP-activated protein kinase-mediated glycogen synthase kinase-3beta inhibition downstream of poly(ADP-ribose)polymerase-LK... Molecular pharmacology\| PubMed ID: 19620254	2009
A special issue edited by Dr. Louis J. Ignarro, A Nobel Prize Laureate. Archives of pharmacal research\| PubMed ID: 19727600	2009
Oltipraz and dithiolethione congeners inhibit hypoxia-inducible factor-1alpha activity through p70 ribosomal S6 kinase-1 inhibition and H2O2-scavenging effect. Molecular cancer therapeutics\| PubMed ID: 19789218	2009
Inhibition of SREBP-1c-mediated hepatic steatosis and oxidative stress by sauchinone, an AMPK-activating lignan in Saururus chinensis. Free radical biology & medicine\| PubMed ID: 20005944	2010
AMPK-mediated GSK3beta inhibition by isoliquiritigenin contributes to protecting mitochondria against iron-catalyzed oxidative stress. Biochemical pharmacology\| PubMed ID: 20026081	2010
The G12 family proteins upregulate matrix metalloproteinase-2 via p53 leading to human breast cell invasion. Breast cancer research and treatment\| PubMed ID: 20044778	2010
Antioxidant and mitochondrial protective effects of oxidized metabolites of oltipraz. Expert opinion on drug metabolism & toxicology\| PubMed ID: 20095791	2010
The NRF2-heme oxygenase-1 system modulates cyclosporin A-induced epithelial-mesenchymal transition and renal fibrosis. Free radical biology & medicine\| PubMed ID: 20096777	2010
Synergistic hepatotoxicity of N,N-dimethylformamide with carbon tetrachloride in association with endoplasmic reticulum stress. Chemico-biological interactions\| PubMed ID: 20097184	2010
Protective effects of magnesium lithospermate B against diabetic atherosclerosis via Nrf2-ARE-NQO1 transcriptional pathway. Atherosclerosis\| PubMed ID: 20172524	2010
Galpha12 is critical for TCR-induced IL-2 production and differentiation of T helper 2 and T helper 17 cells. Biochemical and biophysical research communications\| PubMed ID: 20233578	2010
Ajoene, a stable garlic by-product, has an antioxidant effect through Nrf2-mediated glutamate-cysteine ligase induction in HepG2 cells and primary hepatocytes. The Journal of nutrition\| PubMed ID: 20463144	2010
Simultaneous quantitative monitoring of drug-induced caspase cascade pathways in carcinoma cells. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 20473412	2010
G(alpha)12/13 inhibition enhances the anticancer effect of bortezomib through PSMB5 downregulation. Carcinogenesis\| PubMed ID: 20478922	2010
Ajoene, a stable garlic by-product, inhibits high fat diet-induced hepatic steatosis and oxidative injury through LKB1-dependent AMPK activation. Antioxidants & redox signaling\| PubMed ID: 20560786	2011
Negligible effect of oral garlic oil on the oral absorption of pyridoxine in metadoxine in rats. Archives of pharmacal research\| PubMed ID: 20661709	2010
Inhibition of LXRα-dependent steatosis and oxidative injury by liquiritigenin, a licorice flavonoid, as mediated with Nrf2 activation. Antioxidants & redox signaling\| PubMed ID: 20677908	2011
AMPK-associated signaling to bridge the gap between fuel metabolism and hepatocyte viability. World journal of gastroenterology\| PubMed ID: 20698033	2010
AMPK-Dependent Metabolic Regulation by PPAR Agonists. PPAR research\| PubMed ID: 20814441	2010
Inhibition of liver X receptor-α-dependent hepatic steatosis by isoliquiritigenin, a licorice antioxidant flavonoid, as mediated by JNK1 inhibition. Free radical biology & medicine\| PubMed ID: 20840863	2010
Transactivation of genes encoding for phase II enzymes and phase III transporters by phytochemical antioxidants. Molecules (Basel, Switzerland)\| PubMed ID: 20877225	2010
E-cadherin antagonizes transforming growth factor β1 gene induction in hepatic stellate cells by inhibiting RhoA-dependent Smad3 phosphorylation. Hepatology (Baltimore, Md.)\| PubMed ID: 20890948	2010
Nrf2-mediated liver protection by sauchinone, an antioxidant lignan, from acetaminophen toxicity through the PKCδ-GSK3β pathway. British journal of pharmacology\| PubMed ID: 21039417	2011
G(alpha)12/13 induction of CYR61 in association with arteriosclerotic intimal hyperplasia: effect of sphingosine-1-phosphate. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 21212405	2011
Phenethyl isothiocyanate inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammatory responses in mouse skin. Journal of medicinal food\| PubMed ID: 21303260	2011
Toll-like receptor modulators: a patent review (2006-2010). Expert opinion on therapeutic patents\| PubMed ID: 21406035	2011
Hemin, an iron-binding porphyrin, inhibits HIF-1α induction through its binding with heat shock protein 90. International journal of cancer\| PubMed ID: 21413014	2012
Oltipraz therapy in patients with liver fibrosis or cirrhosis: a randomized, double-blind, placebo-controlled phase II trial. The Journal of pharmacy and pharmacology\| PubMed ID: 21492164	2011
Nrf2 inhibits LXRα-dependent hepatic lipogenesis by competing with FXR for acetylase binding. Antioxidants & redox signaling\| PubMed ID: 21504366	2011
Farnesoid X receptor activation by chenodeoxycholic acid induces detoxifying enzymes through AMP-activated protein kinase and extracellular signal-regulated kinase 1/2-mediated phosphorylati... Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 21596890	2011
Sphingosine 1-phosphate regulates matrix metalloproteinase-9 expression and breast cell invasion through S1P3-Gαq coupling. Journal of cell science\| PubMed ID: 21652634	2011
DA6034 promotes gastric epithelial cell migration and wound-healing through the mTOR pathway. Journal of gastroenterology and hepatology\| PubMed ID: 21793913	2012
Rimonabant, a cannabinoid receptor type 1 inverse agonist, inhibits hepatocyte lipogenesis by activating liver kinase B1 and AMP-activated protein kinase axis downstream of Gα i/o inhibition... Molecular pharmacology\| PubMed ID: 21803969	2011
Effects of poloxamer 407-induced hyperlipidemia on the pharmacokinetics of carbamazepine and its 10,11-epoxide metabolite in rats: Impact of decreased expression of both CYP3A1/2 and microso... European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology\| PubMed ID: 22137858	2012
Hypoxia-inducible factor-1α inhibition by a pyrrolopyrazine metabolite of oltipraz as a consequence of microRNAs 199a-5p and 20a induction. Carcinogenesis\| PubMed ID: 22223846	2012
FXR Protects Hepatocytes from Injury by Repressing miR-199a-3p, which Increases Levels of LKB1. Gastroenterology\| PubMed ID: 22265968	2012
E-cadherin inhibits nuclear accumulation of Nrf2: implications for chemoresistance of cancer cells. Journal of cell science\| PubMed ID: 22302998	2012
Fyn inhibition by cycloalkane-fused 1,2-dithiole-3-thiones enhances antioxidant capacity and protects mitochondria from oxidative injury. Molecular pharmacology\| PubMed ID: 22474169	2012
Enhanced antioxidant effect of prenylated polyphenols as Fyn inhibitor. Free radical biology & medicine\| PubMed ID: 22771471	2012
Decrease of microRNA-122 causes hepatic insulin resistance by inducing protein tyrosine phosphatase 1B, which is reversed by licorice flavonoid. Hepatology (Baltimore, Md.)\| PubMed ID: 22807119	2012
Roles of toll-like receptors in cancer: a double-edged sword for defense and offense. Archives of pharmacal research\| PubMed ID: 22941474	2012
Efficacy and tolerability of diphenyl-dimethyldicarboxylate plus garlic oil in patients with chronic hepatitis. International journal of clinical pharmacology and therapeutics\| PubMed ID: 22943930	2012
Clinical outcomes of occupational exposure to n,n-dimethylformamide: perspectives from experimental toxicology. Safety and health at work\| PubMed ID: 22953193	2011
An active metabolite of oltipraz (M2) increases mitochondrial fuel oxidation and inhibits lipogenesis in the liver by dually activating AMPK. British journal of pharmacology\| PubMed ID: 23145499	2013
Design, synthesis, and biological evaluation of novel deguelin-based heat shock protein 90 (HSP90) inhibitors targeting proliferation and angiogenesis. Journal of medicinal chemistry\| PubMed ID: 23186287	2012
The role of sphingolipids in drug metabolism and transport. Expert opinion on drug metabolism & toxicology\| PubMed ID: 23289866	2013
Structural requirements within protoporphyrin IX in the inhibition of heat shock protein 90. Chemico-biological interactions\| PubMed ID: 23624237	2013
The gep proto-oncogene Gα12 mediates LPA-stimulated activation of CREB in ovarian cancer cells. Cellular signalling\| PubMed ID: 24055910	2014
Applications of genetically modified tools to safety assessment in drug development. Toxicological research\| PubMed ID: 24278499	2010
SIRT1 activation by methylene blue, a repurposed drug, leads to AMPK-mediated inhibition of steatosis and steatohepatitis. European journal of pharmacology\| PubMed ID: 24486702	2014
Gα12gep oncogene inhibits FOXO1 in hepatocellular carcinoma as a consequence of miR-135b and miR-194 dysregulation. Cellular signalling\| PubMed ID: 24631529	2014
Mitigation of carbon tetrachloride-induced hepatic injury by methylene blue, a repurposed drug, is mediated by dual inhibition of GSK3β downstream of PKA. British journal of pharmacology\| PubMed ID: 24641162	2014
Discovery of an integrative network of microRNAs and transcriptomics changes for acute kidney injury. Kidney international\| PubMed ID: 24759152	2014
microRNA-148a dysregulation discriminates poor prognosis of hepatocellular carcinoma in association with USP4 overexpression. Oncotarget\| PubMed ID: 24798342	2014
Autophagy and microRNA dysregulation in liver diseases. Archives of pharmacal research\| PubMed ID: 25015129	2014
Specific oligopeptides in fermented soybean extract inhibit NF-κB-dependent iNOS and cytokine induction by toll-like receptor ligands. Journal of medicinal food\| PubMed ID: 25184943	2014
Increase of miR-199a-5p by protoporphyrin IX, a photocatalyzer, directly inhibits E2F3, sensitizing mesenchymal tumor cells to anti-cancer agents. Oncotarget\| PubMed ID: 25714015	2015
Tacrolimus therapy causes hepatotoxicity in patients with a history of liver disease. International journal of clinical pharmacology and therapeutics\| PubMed ID: 25740263	2015
Phlda3, a urine-detectable protein, causes p53 accumulation in renal tubular cells injured by cisplatin. Cell biology and toxicology\| PubMed ID: 25809501	2015
Phytochemical regulation of Fyn and AMPK signaling circuitry. Archives of pharmacal research\| PubMed ID: 25951818	2015
Gα12 overexpressed in hepatocellular carcinoma reduces microRNA-122 expression via HNF4α inactivation, which causes c-Met induction. Oncotarget\| PubMed ID: 25965999	2015
PHLDA3 overexpression in hepatocytes by endoplasmic reticulum stress via IRE1-Xbp1s pathway expedites liver injury. Gut\| PubMed ID: 25966993	2016
Etoposide Induces Necrosis Through p53-Mediated Antiapoptosis in Human Kidney Proximal Tubule Cells. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 26259609	2015
Endoplasmic Reticulum Stress in Hepatic Stellate Cells Promotes Liver Fibrosis via PERK-Mediated Degradation of HNRNPA1 and Up-regulation of SMAD2. Gastroenterology\| PubMed ID: 26435271	2016
A load of mice to hypergravity causes AMPKα repression with liver injury, which is overcome by preconditioning loads via Nrf2. Scientific reports\| PubMed ID: 26493041	2015
Molecular network of HCC aggressiveness. Oncoscience\| PubMed ID: 26682240	2015
Synthesis and biological evaluation of 1,2-dithiol-3-thiones and pyrrolo[1,2-a]pyrazines as novel hypoxia inducible factor-1 (HIF-1) inhibitor. Bioorganic & medicinal chemistry\| PubMed ID: 27157007	2016
AMPK Facilitates Nuclear Accumulation of Nrf2 by Phosphorylating at Serine 550. Molecular and cellular biology\| PubMed ID: 27161318	2016
Higher plasma bilirubin predicts veno-occlusive disease in early childhood undergoing hematopoietic stem cell transplantation with cyclosporine. World journal of transplantation\| PubMed ID: 27358786	2016
Farnesoid X receptor as a regulator of fuel consumption and mitochondrial function. Archives of pharmacal research\| PubMed ID: 27515052	2016
Corrigendum: A load of mice to hypergravity causes AMPKα repression with liver injury, which is overcome by preconditioning loads via Nrf2. Scientific reports\| PubMed ID: 27703208	2016
miRNA-324, a potential therapeutic target for paracetamol-induced liver injury. Stem cell investigation\| PubMed ID: 27868049	2016
Binge Alcohol Intake After Hypergravity Stress Sustainably Decreases AMPK and Transcription Factors Necessary for Hepatocyte Survival. Alcoholism, clinical and experimental research\| PubMed ID: 27901267	2017
Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt. Nature communications\| PubMed ID: 28004654	2016