Christian Grillon

Section on Neurobiology of Fear and Anxiety, National Institutes of Health (NIH)

Affiliated withNational Institutes of Health (NIH)

Research Area

Biography

Christian Grillon has not added Biography.
If you are Christian Grillon and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 7	2017

Other Publications

Article	Year
Benzodiazepines have no effect on fear-potentiated startle in humans. Psychopharmacology\| PubMed ID: 12021826	2002
Associative learning deficits increase symptoms of anxiety in humans. Biological psychiatry\| PubMed ID: 12022957	2002
Startle reactivity and anxiety disorders: aversive conditioning, context, and neurobiology. Biological psychiatry\| PubMed ID: 12437937	2002
Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans. Psychopharmacology\| PubMed ID: 12709777	2003
Emotional arousal does not affect delay eyeblink conditioning. Brain research. Cognitive brain research\| PubMed ID: 12880910	2003
A review of the modulation of the startle reflex by affective states and its application in psychiatry. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology\| PubMed ID: 12948786	2003
Effects of the beta-blocker propranolol on cued and contextual fear conditioning in humans. Psychopharmacology\| PubMed ID: 15007536	2004
A neuroimaging method for the study of threat in adolescents. Developmental psychobiology\| PubMed ID: 15027419	2003
Adaptive and maladaptive psychobiological responses to severe psychological stress: implications for the discovery of novel pharmacotherapy. Neuroscience and biobehavioral reviews\| PubMed ID: 15036934	2004
Fear conditioning in virtual reality contexts: a new tool for the study of anxiety. Biological psychiatry\| PubMed ID: 15158423	2004
Anxious responses to predictable and unpredictable aversive events. Behavioral neuroscience\| PubMed ID: 15506874	2004
Deficits in hippocampus-mediated Pavlovian conditioning in endogenous hypercortisolism. Biological psychiatry\| PubMed ID: 15576060	2004
Airpuff startle probes: an efficacious and less aversive alternative to white-noise. Biological psychology\| PubMed ID: 15620795	2005
Families at high and low risk for depression: a 3-generation study. Archives of general psychiatry\| PubMed ID: 15630070	2005
Electroencephalographic measures of regional hemispheric activity in offspring at risk for depressive disorders. Biological psychiatry\| PubMed ID: 15705347	2005
An investigation of prepulse inhibition in pediatric bipolar disorder. Bipolar disorders\| PubMed ID: 15762862	2005
Families at high and low risk for depression: a three-generation startle study. Biological psychiatry\| PubMed ID: 15860334	2005
Classical fear conditioning in the anxiety disorders: a meta-analysis. Behaviour research and therapy\| PubMed ID: 15885654	2005
Positron emission tomographic imaging of neural correlates of a fear acquisition and extinction paradigm in women with childhood sexual-abuse-related post-traumatic stress disorder. Psychological medicine\| PubMed ID: 15997600	2005
Cortisol and DHEA-S are associated with startle potentiation during aversive conditioning in humans. Psychopharmacology\| PubMed ID: 16052364	2006
Hydrocortisone impairs hippocampal-dependent trace eyeblink conditioning in post-traumatic stress disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 16123770	2006
Anticipation of public speaking in virtual reality reveals a relationship between trait social anxiety and startle reactivity. Biological psychiatry\| PubMed ID: 16325155	2006
The strong situation: a potential impediment to studying the psychobiology and pharmacology of anxiety disorders. Biological psychology\| PubMed ID: 16343731	2006
Sensation seeking and the aversive motivational system. Emotion (Washington, D.C.)\| PubMed ID: 16366744	2005
Brainstem correlates of defensive states in humans. Biological psychiatry\| PubMed ID: 16388780	2006
Using affect-modulated startle to study phenotypes of pediatric bipolar disorder. Bipolar disorders\| PubMed ID: 16403179	2005
The benzodiazepine alprazolam dissociates contextual fear from cued fear in humans as assessed by fear-potentiated startle. Biological psychiatry\| PubMed ID: 16631127	2006
Context conditioning and behavioral avoidance in a virtual reality environment: effect of predictability. Biological psychiatry\| PubMed ID: 16950216	2006
Attentional blink and prepulse inhibition of startle are positively correlated. Psychophysiology\| PubMed ID: 16965613	2006
A single dose of the selective serotonin reuptake inhibitor citalopram exacerbates anxiety in humans: a fear-potentiated startle study. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 16971899	2007
Reduction of trace but not delay eyeblink conditioning in panic disorder. The American journal of psychiatry\| PubMed ID: 17267792	2007
Luteal-phase accentuation of acoustic startle response in women with premenstrual dysphoric disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 17314917	2007
Contextual-specificity of short-delay extinction in humans: renewal of fear-potentiated startle in a virtual environment. Learning & memory (Cold Spring Harbor, N.Y.)\| PubMed ID: 17412963	2007
Sensitivity to masked conditioned stimuli predicts conditioned response magnitude under masked conditions. Psychophysiology\| PubMed ID: 17433097	2007
Acute exposure to stress improves performance in trace eyeblink conditioning and spatial learning tasks in healthy men. Learning & memory (Cold Spring Harbor, N.Y.)\| PubMed ID: 17522023	2007
Comments on Fearful and sexual pictures not consciously seen modulate the startle reflex in human beings. Biological psychiatry\| PubMed ID: 17531204	2007
Fear-potentiated startle to threat, and prepulse inhibition among young adult nonsmokers, abstinent smokers, and nonabstinent smokers. Biological psychiatry\| PubMed ID: 17543892	2007
Cerebral blood flow in immediate and sustained anxiety. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17554005	2007
Neural responses to auditory stimulus deviance under threat of electric shock revealed by spatially-filtered magnetoencephalography. NeuroImage\| PubMed ID: 17566766	2007
Startle potentiation in rapidly alternating conditions of high and low predictability of threat. Biological psychology\| PubMed ID: 17644240	2007
Emotion regulation and potentiated startle across affective picture and threat-of-shock paradigms. Biological psychology\| PubMed ID: 17692453	2007
Acute stress potentiates anxiety in humans. Biological psychiatry\| PubMed ID: 17692829	2007
Elevated fear conditioning to socially relevant unconditioned stimuli in social anxiety disorder. The American journal of psychiatry\| PubMed ID: 18006874	2008
Models and mechanisms of anxiety: evidence from startle studies. Psychopharmacology\| PubMed ID: 18058089	2008
Fear conditioning in adolescents with anxiety disorders: results from a novel experimental paradigm. Journal of the American Academy of Child and Adolescent Psychiatry\| PubMed ID: 18174830	2008
Increased anxiety during anticipation of unpredictable but not predictable aversive stimuli as a psychophysiologic marker of panic disorder. The American journal of psychiatry\| PubMed ID: 18347001	2008
It is time to take a stand for medical research and against terrorism targeting medical scientists. Biological psychiatry\| PubMed ID: 18371494	2008
Generalization of conditioned fear-potentiated startle in humans: experimental validation and clinical relevance. Behaviour research and therapy\| PubMed ID: 18394587	2008
Contextual specificity of extinction of delay but not trace eyeblink conditioning in humans. Learning & memory (Cold Spring Harbor, N.Y.)\| PubMed ID: 18509111	2008
Human hippocampal and parahippocampal theta during goal-directed spatial navigation predicts performance on a virtual Morris water maze. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18524903	2008
Greater sustained anxiety but not phasic fear in women compared to men. Emotion (Washington, D.C.)\| PubMed ID: 18540756	2008
Contextual fear conditioning in humans: cortical-hippocampal and amygdala contributions. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18550763	2008
Modality-specific attention under imminent but not remote threat of shock: evidence from differential prepulse inhibition of startle. Psychological science\| PubMed ID: 18578853	2008
Two-week treatment with the selective serotonin reuptake inhibitor citalopram reduces contextual anxiety but not cued fear in healthy volunteers: a fear-potentiated startle study. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 18800069	2009
Increased anterior cingulate cortical activity in response to fearful faces: a neurophysiological biomarker that predicts rapid antidepressant response to ketamine. Biological psychiatry\| PubMed ID: 18822408	2009
Evoked amygdala responses to negative faces revealed by adaptive MEG beamformers. Brain research\| PubMed ID: 18930036	2008
Startle reactivity in children at risk for migraine. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology\| PubMed ID: 18951839	2008
Impaired discriminative fear-conditioning resulting from elevated fear responding to learned safety cues among individuals with panic disorder. Behaviour research and therapy\| PubMed ID: 19027893	2009
Increased anxiety during anticipation of unpredictable aversive stimuli in posttraumatic stress disorder but not in generalized anxiety disorder. Biological psychiatry\| PubMed ID: 19217076	2009
Working memory performance after acute exposure to the cold pressor stress in healthy volunteers. Neurobiology of learning and memory\| PubMed ID: 19340949	2009
Startle response in behaviorally inhibited adolescents with a lifetime occurrence of anxiety disorders. Journal of the American Academy of Child and Adolescent Psychiatry\| PubMed ID: 19454917	2009
D-cycloserine facilitation of fear extinction and exposure-based therapy might rely on lower-level, automatic mechanisms. Biological psychiatry\| PubMed ID: 19520359	2009
Impaired spatial navigation in pediatric anxiety. Journal of child psychology and psychiatry, and allied disciplines\| PubMed ID: 19594834	2009
Phasic vs sustained fear in rats and humans: role of the extended amygdala in fear vs anxiety. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 19693004	2010
Overgeneralization of conditioned fear as a pathogenic marker of panic disorder. The American journal of psychiatry\| PubMed ID: 19917595	2010
Anterior cingulate desynchronization and functional connectivity with the amygdala during a working memory task predict rapid antidepressant response to ketamine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 20393460	2010
Abnormal hippocampal functioning and impaired spatial navigation in depressed individuals: evidence from whole-head magnetoencephalography. The American journal of psychiatry\| PubMed ID: 20439387	2010
Effect of acute psychological stress on prefrontal GABA concentration determined by proton magnetic resonance spectroscopy. The American journal of psychiatry\| PubMed ID: 20634372	2010
Development of anxiety: the role of threat appraisal and fear learning. Depression and anxiety\| PubMed ID: 20734364	2011
Becoming the center of attention in social anxiety disorder: startle reactivity to a virtual audience during speech anticipation. The Journal of clinical psychiatry\| PubMed ID: 21034683	2011
Phasic and sustained fear in humans elicits distinct patterns of brain activity. NeuroImage\| PubMed ID: 21111828	2011
Acute hydrocortisone treatment increases anxiety but not fear in healthy volunteers: a fear-potentiated startle study. Biological psychiatry\| PubMed ID: 21277566	2011
Distinct neural signatures of threat learning in adolescents and adults. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21368210	2011
Anxiety overrides the blocking effects of high perceptual load on amygdala reactivity to threat-related distractors. Neuropsychologia\| PubMed ID: 21376745	2011
Measuring anxious responses to predictable and unpredictable threat in children and adolescents. Journal of experimental child psychology\| PubMed ID: 21440905	2011
The effect of induced anxiety on cognition: threat of shock enhances aversive processing in healthy individuals. Cognitive, affective & behavioral neuroscience\| PubMed ID: 21484411	2011
In the face of fear: anxiety sensitizes defensive responses to fearful faces. Psychophysiology\| PubMed ID: 21824155	2011
The adaptive threat bias in anxiety: amygdala-dorsomedial prefrontal cortex coupling and aversive amplification. NeuroImage\| PubMed ID: 22178453	2012
Anxiety, a benefit and detriment to cognition: behavioral and magnetoencephalographic evidence from a mixed-saccade task. Brain and cognition\| PubMed ID: 22289426	2012
Describing the interplay between anxiety and cognition: from impaired performance under low cognitive load to reduced anxiety under high load. Psychophysiology\| PubMed ID: 22332819	2012
Testing the effects of Δ9-THC and D-cycloserine on extinction of conditioned fear in humans. Journal of psychopharmacology (Oxford, England)\| PubMed ID: 22351380	2012
Assessing fear and anxiety in humans using the threat of predictable and unpredictable aversive events (the NPU-threat test). Nature protocols\| PubMed ID: 22362158	2012
Through the eyes of anxiety: Dissecting threat bias via emotional-binocular rivalry. Emotion (Washington, D.C.)\| PubMed ID: 22390706	2012
Distinct contributions of human hippocampal theta to spatial cognition and anxiety. Hippocampus\| PubMed ID: 22467298	2012
Acute tryptophan depletion increases translational indices of anxiety but not fear: serotonergic modulation of the bed nucleus of the stria terminalis? Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 22491355	2012
Synaptic potentiation is critical for rapid antidepressant response to ketamine in treatment-resistant major depression. Biological psychiatry\| PubMed ID: 22521148	2012
Enhanced discrimination between threatening and safe contexts in high-anxious individuals. Biological psychology\| PubMed ID: 23384512	2013
Stress increases aversive prediction error signal in the ventral striatum. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23401511	2013
Passive avoidance is linked to impaired fear extinction in humans. Learning & memory (Cold Spring Harbor, N.Y.)\| PubMed ID: 23427168	2013
The impact of induced anxiety on response inhibition. Frontiers in human neuroscience\| PubMed ID: 23471118	2013
The complex interaction between anxiety and cognition: insight from spatial and verbal working memory. Frontiers in human neuroscience\| PubMed ID: 23542914	2013
The role of serotonin in the neurocircuitry of negative affective bias: serotonergic modulation of the dorsal medial prefrontal-amygdala 'aversive amplification' circuit. NeuroImage\| PubMed ID: 23583742	2013
The impact of anxiety upon cognition: perspectives from human threat of shock studies. Frontiers in human neuroscience\| PubMed ID: 23730279	2013
Neural substrates of classically conditioned fear-generalization in humans: a parametric fMRI study. Social cognitive and affective neuroscience\| PubMed ID: 23748500	2014
Response to learned threat: An FMRI study in adolescent and adult anxiety. The American journal of psychiatry\| PubMed ID: 23929092	2013
Major depression is not associated with blunting of aversive responses; evidence for enhanced anxious anticipation. PloS one\| PubMed ID: 23951057	2013
Generalized anxiety disorder is associated with overgeneralization of classically conditioned fear. Biological psychiatry\| PubMed ID: 24001473	2014
Developmental investigation of fear-potentiated startle across puberty. Biological psychology\| PubMed ID: 24334108	2014
Evidence of MAOA genotype involvement in spatial ability in males. Behavioural brain research\| PubMed ID: 24671068	2014
Increased fear-potentiated startle in major depressive disorder patients with lifetime history of suicide attempt. Journal of affective disorders\| PubMed ID: 24767002	2014
Understanding placebo and nocebo responses for pain management. Current pain and headache reports\| PubMed ID: 24771206	2014
Sustained anxiety increases amygdala-dorsomedial prefrontal coupling: a mechanism for maintaining an anxious state in healthy adults. Journal of psychiatry & neuroscience : JPN\| PubMed ID: 24886788	2014
Pain and placebo in pediatrics: a comprehensive review of laboratory and clinical findings. Pain\| PubMed ID: 25180010	2014
The CRH1 antagonist GSK561679 increases human fear but not anxiety as assessed by startle. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 25430779	2015
Oxytocin and vasopressin modulate risk-taking. Physiology & behavior\| PubMed ID: 25446228	2015
fMRI functional connectivity applied to adolescent neurodevelopment. Annual review of clinical psychology\| PubMed ID: 25581237	2015
Mental fatigue impairs emotion regulation. Emotion (Washington, D.C.)\| PubMed ID: 25706833	2015
Towards a mechanistic understanding of pathological anxiety: the dorsal medial prefrontal-amygdala 'aversive amplification' circuit in unmedicated generalized and social anxiety disorders. The lancet. Psychiatry\| PubMed ID: 25722962	2014
Effect of attention control on sustained attention during induced anxiety. Cognition & emotion\| PubMed ID: 25899613	2016
Resting state connectivity of the bed nucleus of the stria terminalis at ultra-high field. Human brain mapping\| PubMed ID: 26178381	2015
Vasopressin Boosts Placebo Analgesic Effects in Women: A Randomized Trial. Biological psychiatry\| PubMed ID: 26321018	2016
Effect of anxiety on behavioural pattern separation in humans. Cognition & emotion\| PubMed ID: 26480349	2017
Interaction of threat and verbal working memory in adolescents. Psychophysiology\| PubMed ID: 26589772	2016
Age and Social Context Modulate the Effect of Anxiety on Risk-taking in Pediatric Samples. Journal of abnormal child psychology\| PubMed ID: 26659306	2016
Abnormal decision-making in generalized anxiety disorder: Aversion of risk or stimulus-reinforcement impairment? Psychiatry research\| PubMed ID: 26822065	2016
Induced-anxiety differentially disrupts working memory in generalized anxiety disorder. BMC psychiatry\| PubMed ID: 26976146	2016
Anxiety Patients Show Reduced Working Memory Related dlPFC Activation During Safety and Threat. Depression and anxiety\| PubMed ID: 27110997	2017
Striatum on the anxiety map: Small detours into adolescence. Brain research\| PubMed ID: 27276526	2017
The neural basis of improved cognitive performance by threat of shock. Social cognitive and affective neuroscience\| PubMed ID: 27369069	2016
Working memory maintenance is sufficient to reduce state anxiety. Psychophysiology\| PubMed ID: 27434207	2016
The effects of methylphenidate and propranolol on the interplay between induced-anxiety and working memory. Psychopharmacology\| PubMed ID: 27492789	2016
Gain in Translation: Is It Time for Thigmotaxis Studies in Humans? Biological psychiatry\| PubMed ID: 27499012	2016
Prediction Error Representation in Individuals With Generalized Anxiety Disorder During Passive Avoidance. The American journal of psychiatry\| PubMed ID: 27631963	2017
Altered Pain Perception and Fear-Learning Deficits in Subjects With Posttraumatic Stress Disorder. The journal of pain : official journal of the American Pain Society\| PubMed ID: 27641312	2016
Anxiety-mediated facilitation of behavioral inhibition: Threat processing and defensive reactivity during a go/no-go task. Emotion (Washington, D.C.)\| PubMed ID: 27642657	2017
Resting state connectivity of the human habenula at ultra-high field. NeuroImage\| PubMed ID: 27780778	2017
Intrinsic functional connectivity of the central nucleus of the amygdala and bed nucleus of the stria terminalis. NeuroImage\| PubMed ID: 28392491	2017
Threat of shock increases excitability and connectivity of the intraparietal sulcus. eLife\| PubMed ID: 28555565	2017