Linda Partridge

Institute of Healthy Ageing, University College London - UCL

Affiliated withUniversity College London - UCL

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 17	2011

Other Publications

Article	Year
A mortality cost of virginity at older ages in female Mediterranean fruit flies. Experimental gerontology\| PubMed ID: 11830353	2002
Dietary restriction in long-lived dwarf flies. Science (New York, N.Y.)\| PubMed ID: 11951037	2002
Mechanisms of ageing: public or private? Nature reviews. Genetics\| PubMed ID: 11972154	2002
Genome-wide transcript profiles in aging and calorically restricted Drosophila melanogaster. Current biology : CB\| PubMed ID: 12007414	2002
The evolution of longevity. Current biology : CB\| PubMed ID: 12194832	2002
A lethal side-effect. Nature\| PubMed ID: 12198525	2002
Different cell size and cell number contribution in two newly established and one ancient body size cline of Drosophila subobscura. Evolution; international journal of organic evolution\| PubMed ID: 12703946	2003
Rapid laboratory evolution of adult wing area in Drosophila melanogaster in response to humidity. Evolution; international journal of organic evolution\| PubMed ID: 12778562	2003
Life history response of Mediterranean fruit flies to dietary restriction. Aging cell\| PubMed ID: 12882344	2002
Interpreting interactions between treatments that slow aging. Aging cell\| PubMed ID: 12882347	2002
The sex peptide of Drosophila melanogaster: female post-mating responses analyzed by using RNA interference. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12893873	2003
Demography of dietary restriction and death in Drosophila. Science (New York, N.Y.)\| PubMed ID: 14500985	2003
Superoxide and hydrogen peroxide production by Drosophila mitochondria. Free radical biology & medicine\| PubMed ID: 14556858	2003
Testing for asymmetrical gene flow in a Drosophila melanogaster body-size cline. Genetics\| PubMed ID: 14573478	2003
QTL mapping reveals a striking coincidence in the positions of genomic regions associated with adaptive variation in body size in parallel clines of Drosophila melanogaster on different cont... Evolution; international journal of organic evolution\| PubMed ID: 14686541	2003
Sex differences in the effect of dietary restriction on life span and mortality rates in female and male Drosophila melanogaster. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 14718480	2004
Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science (New York, N.Y.)\| PubMed ID: 15192154	2004
Lifespan extension by dietary restriction in female Drosophila melanogaster is not caused by a reduction in vitellogenesis or ovarian activity. Experimental gerontology\| PubMed ID: 15236760	2004
Lack of correlation between mitochondrial reactive oxygen species production and life span in Drosophila. Annals of the New York Academy of Sciences\| PubMed ID: 15247051	2004
Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogaster. Experimental gerontology\| PubMed ID: 15288688	2004
The interaction between FOXO and SIRT1: tipping the balance towards survival. Trends in cell biology\| PubMed ID: 15308206	2004
Computational analysis of alpha-helical membrane protein structure: implications for the prediction of 3D structural models. Protein engineering, design & selection : PEDS\| PubMed ID: 15388845	2004
Genetic variation for total fitness in Drosophila melanogaster: complex yet replicable patterns. Genetics\| PubMed ID: 15545656	2005
Dietary restriction, mortality trajectories, risk and damage. Mechanisms of ageing and development\| PubMed ID: 15610760	2005
Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15708981	2005
Sex and death: what is the connection? Cell\| PubMed ID: 15734679	2005
Insulin signaling is necessary for vitellogenesis in Drosophila melanogaster independent of the roles of juvenile hormone and ecdysteroids: female sterility of the chico1 insulin signaling m... Journal of insect physiology\| PubMed ID: 15890189	2005
Dietary restriction in Drosophila. Mechanisms of ageing and development\| PubMed ID: 15935441	2005
Counting the calories: the role of specific nutrients in extension of life span by food restriction. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 15972601	2005
Calories do not explain extension of life span by dietary restriction in Drosophila. PLoS biology\| PubMed ID: 16000018	2005
Isogenic autosomes to be applied in optimal screening for novel mutants with viable phenotypes in Drosophila melanogaster. Journal of neurogenetics\| PubMed ID: 16024440	2005
Diet, metabolism and lifespan in Drosophila. Experimental gerontology\| PubMed ID: 16137851	2005
Science fact and the SENS agenda. What can we reasonably expect from ageing research? EMBO reports\| PubMed ID: 16264422	2005
Genome-wide gene expression in response to parasitoid attack in Drosophila. Genome biology\| PubMed ID: 16277749	2005
Patterns of diversity and linkage disequilibrium within the cosmopolitan inversion In(3R)Payne in Drosophila melanogaster are indicative of coadaptation. Genetics\| PubMed ID: 16322502	2006
The effects of exogenous antioxidants on lifespan and oxidative stress resistance in Drosophila melanogaster. Mechanisms of ageing and development\| PubMed ID: 16442589	2006
The effect of dietary restriction on mitochondrial protein density and flight muscle mitochondrial morphology in Drosophila. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 16456193	2006
Flight activity, mortality rates, and lipoxidative damage in Drosophila. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 16510857	2006
No extension of lifespan by ablation of germ line in Drosophila. Proceedings. Biological sciences / The Royal Society\| PubMed ID: 16627279	2006
Beyond the evolutionary theory of ageing, from functional genomics to evo-gero. Trends in ecology & evolution\| PubMed ID: 16769434	2006
Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in mice. Physiological genomics\| PubMed ID: 16882887	2006
Superoxide dismutase activities in long-lived Drosophila melanogaster females: chico1 genotypes and dietary dilution. Biogerontology\| PubMed ID: 17103233	2007
A functioning ovary is not required for sex peptide to reduce receptivity to mating in D. melanogaster. Journal of insect physiology\| PubMed ID: 17303161	2007
Comment by Matthew Piper, William Mair, Linda Partridge on Min, K.J., Flatt, T., Kulaots, I., Tatar, M. (2006) "Counting calories in Drosophila dietary restriction"Exp. Gerontology, doi:10.1... Experimental gerontology\| PubMed ID: 17317064	2007
Role of insulin-like signalling in Drosophila lifespan. Trends in biochemical sciences\| PubMed ID: 17412594	2007
Dietary restriction in Drosophila: delayed aging or experimental artefact? PLoS genetics\| PubMed ID: 17465680	2007
Dynamics of the action of dFOXO on adult mortality in Drosophila. Aging cell\| PubMed ID: 17465980	2007
No influence of Indy on lifespan in Drosophila after correction for genetic and cytoplasmic background effects. PLoS genetics\| PubMed ID: 17571923	2007
Correcting for sequence biases in present/absent calls. Genome biology\| PubMed ID: 17594492	2007
Estimation and correction of non-specific binding in a large-scale spike-in experiment. Genome biology\| PubMed ID: 17594493	2007
Mapping regions within cosmopolitan inversion In(3R)Payne associated with natural variation in body size in Drosophila melanogaster. Genetics\| PubMed ID: 17603103	2007
Evolutionary conservation of regulated longevity assurance mechanisms. Genome biology\| PubMed ID: 17612391	2007
Some highlights of research on aging with invertebrates, 2006-2007. Aging cell\| PubMed ID: 17725687	2007
Antagonizing Methuselah to extend life span. Genome biology\| PubMed ID: 17764591	2007
Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans. Mechanisms of ageing and development\| PubMed ID: 17875315	2007
Brief carbon dioxide exposure blocks heat hardening but not cold acclimation in Drosophila melanogaster. Journal of insect physiology\| PubMed ID: 17884085	2008
Optimization of dietary restriction protocols in Drosophila. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 17921418	2007
Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 17928362	2008
Benchmarks for ageing studies. Nature\| PubMed ID: 17994065	2007
Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response. Aging cell\| PubMed ID: 18241326	2008
Pitfalls of measuring feeding rate in the fruit fly Drosophila melanogaster. Nature methods\| PubMed ID: 18309307	2008
Stress-response hormesis and aging: "that which does not kill us makes us stronger". Cell metabolism\| PubMed ID: 18316025	2008
Toward a control theory analysis of aging. Annual review of biochemistry\| PubMed ID: 18318658	2008
Feeding, fecundity and lifespan in female Drosophila melanogaster. Proceedings. Biological sciences / The Royal Society\| PubMed ID: 18430646	2008
Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis". Science (New York, N.Y.)\| PubMed ID: 18497277	2008
New model of health promotion and disease prevention for the 21st century. BMJ (Clinical research ed.)\| PubMed ID: 18614506	2008
Stage debut for the elusive Drosophila insulin-like growth factor binding protein. Journal of biology\| PubMed ID: 18620552	2008
Some highlights of research on aging with invertebrates, 2008. Aging cell\| PubMed ID: 18631320	2008
Endocrine regulation of aging and reproduction in Drosophila. Molecular and cellular endocrinology\| PubMed ID: 18682271	2009
Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs. PloS one\| PubMed ID: 19005568	2008
Effect of a standardised dietary restriction protocol on multiple laboratory strains of Drosophila melanogaster. PloS one\| PubMed ID: 19119322	2009
Insulin/IGF-like signalling, the central nervous system and aging. The Biochemical journal\| PubMed ID: 19159343	2009
Expression of human uncoupling protein-3 in Drosophila insulin-producing cells increases insulin-like peptide (DILP) levels and shortens lifespan. Experimental gerontology\| PubMed ID: 19385039	2009
Longevity of Indy mutant Drosophila not attributable to Indy mutation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19435842	2009
Quantification of food intake in Drosophila. PloS one\| PubMed ID: 19557170	2009
Some highlights of research on aging with invertebrates, 2009. Aging cell\| PubMed ID: 19558590	2009
Invertebrate models of age-related muscle degeneration. Biochimica et biophysica acta\| PubMed ID: 19563864	2009
Chemical changes in aging Drosophila melanogaster. Age (Dordrecht, Netherlands)\| PubMed ID: 19585275	2009
The endosymbiont Wolbachia increases insulin/IGF-like signalling in Drosophila. Proceedings. Biological sciences / The Royal Society\| PubMed ID: 19692410	2009
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science (New York, N.Y.)\| PubMed ID: 19797661	2009
Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila. Nature\| PubMed ID: 19956092	2009
The new biology of ageing. Philosophical transactions of the Royal Society of London. Series B, Biological sciences\| PubMed ID: 20008392	2010
A Drosophila insulin-like peptide promotes growth during nonfeeding states. Developmental cell\| PubMed ID: 20059956	2009
Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell metabolism\| PubMed ID: 20074526	2010
DILP-producing median neurosecretory cells in the Drosophila brain mediate the response of lifespan to nutrition. Aging cell\| PubMed ID: 20156206	2010
Molecular evolution and functional characterization of Drosophila insulin-like peptides. PLoS genetics\| PubMed ID: 20195512	2010
Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk. PLoS genetics\| PubMed ID: 20333234	2010
Biomarkers of aging in Drosophila. Aging cell\| PubMed ID: 20367621	2010
Extending healthy life span--from yeast to humans. Science (New York, N.Y.)\| PubMed ID: 20395504	2010
Insulin signalling regulates remating in female Drosophila. Proceedings. Biological sciences / The Royal Society\| PubMed ID: 20739318	2011
Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease. PLoS genetics\| PubMed ID: 20824130	2010
Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network. Experimental gerontology\| PubMed ID: 20849947	2011
Some highlights of research on aging with invertebrates, 2010. Aging cell\| PubMed ID: 21078113	2011
Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor. Aging cell\| PubMed ID: 21108726	2011
The new science of ageing. Philosophical transactions of the Royal Society of London. Series B, Biological sciences\| PubMed ID: 21115524	2011
Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1. PloS one\| PubMed ID: 21283571	2011
Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix. Cell metabolism\| PubMed ID: 21356523	2011
Molecular basis of adaptive shift in body size in Drosophila melanogaster: functional and sequence analyses of the Dca gene. Molecular biology and evolution\| PubMed ID: 21393605	2011
A longer and healthier life with TOR down-regulation: genetics and drugs. Biochemical Society transactions\| PubMed ID: 21428920	2011
dFOXO-independent effects of reduced insulin-like signaling in Drosophila. Aging cell\| PubMed ID: 21443682	2011
Unraveling the biological roles of reactive oxygen species. Cell metabolism\| PubMed ID: 21459321	2011
Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling. Molecular systems biology\| PubMed ID: 21694719	2011
Dietary restriction and aging: a unifying perspective. Cell metabolism\| PubMed ID: 21803286	2011
Death and dessert: nutrient signalling pathways and ageing. Current opinion in cell biology\| PubMed ID: 21835601	2011
Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature\| PubMed ID: 21938067	2011
The bicoid stability factor controls polyadenylation and expression of specific mitochondrial mRNAs in Drosophila melanogaster. PLoS genetics\| PubMed ID: 22022283	2011
Current developments at Philosophical Transactions of the Royal Society B. Philosophical transactions of the Royal Society of London. Series B, Biological sciences\| PubMed ID: 22106421	2012
A double whammy for aging? Rapamycin extends lifespan and inhibits cancer in inbred female mice. Cell cycle (Georgetown, Tex.)\| PubMed ID: 22186783	2012