Ravi Salgia

Department of Medicine, University of Chicago

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 5	2011

Other Publications

Article	Year
Role of the hepatocyte growth factor receptor, c-Met, in oncogenesis and potential for therapeutic inhibition. Cytokine & growth factor reviews\| PubMed ID: 11750879	2002
Vascular endothelial growth factor-induced migration of multiple myeloma cells is associated with beta 1 integrin- and phosphatidylinositol 3-kinase-dependent PKC alpha activation. The Journal of biological chemistry\| PubMed ID: 11751905	2002
Modulation of the c-Met/hepatocyte growth factor pathway in small cell lung cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 11839685	2002
Differential expression and signaling of CBL and CBL-B in BCR/ABL transformed cells. Oncogene\| PubMed ID: 11857085	2002
A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migration. The Journal of biological chemistry\| PubMed ID: 11919182	2002
ATP6S1 elicits potent humoral responses associated with immune-mediated tumor destruction. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11983866	2002
Gemcitabine-induced radiation recall. International journal of radiation oncology, biology, physics\| PubMed ID: 12023144	2002
CD2 molecules redistribute to the uropod during T cell scanning: implications for cellular activation and immune surveillance. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12032326	2002
Flow cytometric determination of lipid peroxidation using fluoresceinated phosphoethanolamine. Methods in enzymology\| PubMed ID: 12125379	2002
Inhibition of epidermal growth factor receptor signaling in malignant pleural mesothelioma. Cancer research\| PubMed ID: 12234991	2002
Molecular alterations in lung cancer. Impact on prognosis. Methods in molecular medicine\| PubMed ID: 12407733	2003
Detection and analysis of lung cancer cells from body fluids using a rare event imaging system. Methods in molecular medicine\| PubMed ID: 12407757	2003
Regulation of cellular proliferation, cytoskeletal function, and signal transduction through CXCR4 and c-Kit in small cell lung cancer cells. Cancer research\| PubMed ID: 12414661	2002
Role of receptor tyrosine kinases in lung cancer. Methods in molecular medicine\| PubMed ID: 12415690	2003
Vaccination with irradiated autologous tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor augments antitumor immunity in some patients with metastatic non-sma... Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 12586798	2003
Use of temozolomide with other cytotoxic chemotherapy in the treatment of patients with recurrent brain metastases from lung cancer. The oncologist\| PubMed ID: 12604733	2003
Molecular and cellular biology of small cell lung cancer. Seminars in oncology\| PubMed ID: 12635090	2003
2-methoxyestradiol alters cell motility, migration, and adhesion. Blood\| PubMed ID: 12637335	2003
Circulating tumor cells and serum tumor biomarkers in small cell lung cancer. Anticancer research\| PubMed ID: 12683352	2003
Cell motility, adhesion, homing, and migration assays in the studies of tyrosine kinases. Methods in molecular medicine\| PubMed ID: 12710200	2003
Unusual problems in breast cancer and a rare lung cancer case. Case 4. Primary lymphoepithelioma-like carcinoma of the lung. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 12775751	2003
Small-cell cancers, and an unusual reaction to chemotherapy. Case 1. Extrapulmonary small-cell carcinoma arising in the prostate. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 12805344	2003
c-Met: structure, functions and potential for therapeutic inhibition. Cancer metastasis reviews\| PubMed ID: 12884908	2003
Recent advances in the molecular biology, diagnosis and novel therapies for various small blue cell tumors. Anticancer research\| PubMed ID: 12926079	2003
A novel small molecule met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase. Cancer research\| PubMed ID: 14500382	2003
Mechanisms of metastasis as related to receptor tyrosine kinases in small-cell lung cancer. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer\| PubMed ID: 14529091	2003
c-MET mutational analysis in small cell lung cancer: novel juxtamembrane domain mutations regulating cytoskeletal functions. Cancer research\| PubMed ID: 14559814	2003
p53 and Bcl-2 in small cell-lung cancer. Clinical lung cancer\| PubMed ID: 14609449	2003
Phase II study of imatinib in patients with small cell lung cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 14676110	2003
Small cell lung cancer: from molecular biology to novel therapeutics. Journal of experimental therapeutics & oncology\| PubMed ID: 14678519	2003
Targeted molecules in small cell lung cancer. Seminars in oncology\| PubMed ID: 14981588	2004
Targeting c-Kit mutations: basic science to novel therapies. Leukemia research\| PubMed ID: 15036937	2004
Reliable and sensitive identification of occult tumor cells using the improved rare event imaging system. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 15131038	2004
Haptoglobin alpha-subunit and hepatocyte growth factor can potentially serve as serum tumor biomarkers in small cell lung cancer. Anticancer research\| PubMed ID: 15154618	2004
Therapeutic targeting of the receptor tyrosine kinase Met. Cancer treatment and research\| PubMed ID: 15164876	2004
Integrin-dependent protein tyrosine phosphorylation is a key regulatory event in collagen-IV-mediated adhesion and proliferation of human lung tumor cell line, Calu-1. The Annals of thoracic surgery\| PubMed ID: 15276495	2004
Receptor tyrosine kinases and inhibitors in lung cancer. TheScientificWorldJournal\| PubMed ID: 15349502	2004
Activation of the PI3K/mTOR pathway by BCR-ABL contributes to increased production of reactive oxygen species. Blood\| PubMed ID: 15486067	2005
Modulation of c-Kit/SCF pathway leads to alterations in topoisomerase-I activity in small cell lung cancer. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer\| PubMed ID: 15511212	2004
The role of ephrins and Eph receptors in cancer. Cytokine & growth factor reviews\| PubMed ID: 15561600	2004
Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer. Cancer research\| PubMed ID: 15735036	2005
A selective small molecule c-MET Inhibitor, PHA665752, cooperates with rapamycin. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 15788682	2005
Novel therapies in lung cancer. Hematology/oncology clinics of North America\| PubMed ID: 15833410	2005
c-Met as a target for human cancer and characterization of inhibitors for therapeutic intervention. Cancer letters\| PubMed ID: 15922853	2005
Therapeutic targeting of receptor tyrosine kinases in lung cancer. Expert opinion on therapeutic targets\| PubMed ID: 15948672	2005
Expression of Siva-1 protein or its putative amphipathic helical region enhances cisplatin-induced apoptosis in breast cancer cells: effect of elevated levels of BCL-2. Cancer research\| PubMed ID: 15958577	2005
Molecular biology of malignant mesothelioma: a review. Hematology/oncology clinics of North America\| PubMed ID: 16325120	2005
Functional analysis of c-Met/hepatocyte growth factor pathway in malignant pleural mesothelioma. Cancer research\| PubMed ID: 16397249	2006
Gefitinib response of erlotinib-refractory lung cancer involving meninges--role of EGFR mutation. Nature clinical practice. Oncology\| PubMed ID: 16407879	2006
Diffuse alveolar damage after a single dose of topotecan in a patient with pulmonary fibrosis and small cell lung cancer. Lung cancer (Amsterdam, Netherlands)\| PubMed ID: 16949700	2006
Epidermal growth factor receptor mutations and susceptibility to targeted therapy in lung cancer. Respirology (Carlton, Vic.)\| PubMed ID: 17052295	2006
c-Met inhibition. Clinical advances in hematology & oncology : H&O\| PubMed ID: 17143251	2006
Epidermal growth factor receptor - mediated signal transduction in the development and therapy of gliomas. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 17189397	2006
A review of topoisomerase inhibition in lung cancer. Cancer biology & therapy\| PubMed ID: 17224634	2006
A phase I study of pemetrexed, carboplatin, and concurrent radiotherapy in patients with locally advanced or metastatic non-small cell lung or esophageal cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 17255273	2007
Lung carcinoma in African Americans. Nature clinical practice. Oncology\| PubMed ID: 17259932	2007
c-Met and hepatocyte growth factor: potential as novel targets in cancer therapy. Current oncology reports\| PubMed ID: 17288874	2007
c-Met overexpression is a prognostic factor in ovarian cancer and an effective target for inhibition of peritoneal dissemination and invasion. Cancer research\| PubMed ID: 17308108	2007
Tyrosine kinase mutations in human cancer. Current molecular medicine\| PubMed ID: 17311534	2007
Activation of HGF/c-Met pathway contributes to the reactive oxygen species generation and motility of small cell lung cancer cells. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 17322284	2007
Key signaling pathways and targets in lung cancer therapy. Clinical lung cancer\| PubMed ID: 17382025	2007
c-Met is a potentially new therapeutic target for treatment of human melanoma. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 17404109	2007
Biomarker discovery in lung cancer--promises and challenges of clinical proteomics. Mass spectrometry reviews\| PubMed ID: 17407130	2007
A selective small molecule inhibitor of c-Met, PHA665752, inhibits tumorigenicity and angiogenesis in mouse lung cancer xenografts. Cancer research\| PubMed ID: 17440059	2007
Preclinical studies of the proteasome inhibitor bortezomib in malignant pleural mesothelioma. Cancer chemotherapy and pharmacology\| PubMed ID: 17522864	2008
Chemotherapy and high dose radiotherapy followed by resection for locally advanced nonsmall cell lung cancers. American journal of clinical oncology\| PubMed ID: 17551302	2007
Lysophosphatidic acid modulates c-Met redistribution and hepatocyte growth factor/c-Met signaling in human bronchial epithelial cells through PKC delta and E-cadherin. Cellular signalling\| PubMed ID: 17689924	2007
CD44 regulates hepatocyte growth factor-mediated vascular integrity. Role of c-Met, Tiam1/Rac1, dynamin 2, and cortactin. The Journal of biological chemistry\| PubMed ID: 17702746	2007
Non-receptor tyrosine kinase inhibitors in lung cancer. Anti-cancer agents in medicinal chemistry\| PubMed ID: 18045058	2007
Paxillin is a target for somatic mutations in lung cancer: implications for cell growth and invasion. Cancer research\| PubMed ID: 18172305	2008
Randomized phase II Study of carboplatin and etoposide with or without the bcl-2 antisense oligonucleotide oblimersen for extensive-stage small-cell lung cancer: CALGB 30103. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 18281659	2008
C. elegans as a model organism for in vivo screening in cancer: effects of human c-Met in lung cancer affect C. elegans vulva phenotypes. Cancer biology & therapy\| PubMed ID: 18340114	2008
Efficacy and safety of bevacizumab plus erlotinib for patients with recurrent ovarian, primary peritoneal, and fallopian tube cancer: a trial of the Chicago, PMH, and California Phase II Con... Gynecologic oncology\| PubMed ID: 18423560	2008
Review of clinic trials: agents targeting c-Met. Reviews on recent clinical trials\| PubMed ID: 18473999	2007
Vitamin D receptor expression in normal, premalignant, and malignant human lung tissue. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 18483332	2008
Erlotinib plus bevacizumab in previously treated patients with malignant pleural mesothelioma. Cancer\| PubMed ID: 18543326	2008
Concerted potent humoral immune responses to autoantigens are associated with tumor destruction and favorable clinical outcomes without autoimmunity. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 18559611	2008
MET as a target for treatment of chest tumors. Lung cancer (Amsterdam, Netherlands)\| PubMed ID: 18672314	2009
Expression and mutational analysis of MET in human solid cancers. Genes, chromosomes & cancer\| PubMed ID: 18709663	2008
Phase I trial of erlotinib-based multimodality therapy for inoperable stage III non-small cell lung cancer. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer\| PubMed ID: 18758303	2008
Protein kinase C beta in malignant pleural mesothelioma. Anti-cancer drugs\| PubMed ID: 18765998	2008
EGFR-targeted therapeutics: focus on SCCHN and NSCLC. TheScientificWorldJournal\| PubMed ID: 18836658	2008
FYN is overexpressed in human prostate cancer. BJU international\| PubMed ID: 18990162	2009
Stamp out lung cancer. Journal of carcinogenesis\| PubMed ID: 19008566	2008
Lymphatic vessel density is not associated with lymph node metastasis in non-small cell lung carcinoma. Archives of pathology & laboratory medicine\| PubMed ID: 19061284	2008
PAX5 is expressed in small-cell lung cancer and positively regulates c-Met transcription. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 19139719	2009
Synergism of EGFR and c-Met pathways, cross-talk and inhibition, in non-small cell lung cancer. Journal of carcinogenesis\| PubMed ID: 19240370	2008
The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma. Cancer research\| PubMed ID: 19318576	2009
MET pathway as a therapeutic target. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer\| PubMed ID: 19333071	2009
Role of c-Met in cancer: emphasis on lung cancer. Seminars in oncology\| PubMed ID: 19393836	2009
PAX6 is expressed in pancreatic cancer and actively participates in cancer progression through activation of the MET tyrosine kinase receptor gene. The Journal of biological chemistry\| PubMed ID: 19651775	2009
Ethnic differences and functional analysis of MET mutations in lung cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 19723643	2009
Melanoma proteoglycan modifies gene expression to stimulate tumor cell motility, growth, and epithelial-to-mesenchymal transition. Cancer research\| PubMed ID: 19738072	2009
Novel targets for therapeutic agents in small cell lung cancer. Journal of the National Comprehensive Cancer Network : JNCCN\| PubMed ID: 19777705	2004
Biomarkers in lung cancer: from early detection to novel therapeutics and decision making. Biomarkers in medicine\| PubMed ID: 19802373	2008
MET, HGF, EGFR, and PXN gene copy number in lung cancer using DNA extracts from FFPE archival samples and prognostic significance. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer\| PubMed ID: 19817696	2009
MET receptor tyrosine kinase. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer\| PubMed ID: 19861919	2009
The role of EGFR inhibition in the treatment of non-small cell lung cancer. The oncologist\| PubMed ID: 19892771	2009
MET/PKCbeta expression correlate with metastasis and inhibition is synergistic in lung cancer. Journal of carcinogenesis\| PubMed ID: 19955662	2009
PAX3 and SOX10 activate MET receptor expression in melanoma. Pigment cell & melanoma research\| PubMed ID: 20067553	2010
CBL is frequently altered in lung cancers: its relationship to mutations in MET and EGFR tyrosine kinases. PloS one\| PubMed ID: 20126411	2010
MET molecular mechanisms and therapies in lung cancer. Cell adhesion & migration\| PubMed ID: 20139696	2010
The role of chemokine receptor CXCR4 in lung cancer. Cancer biology & therapy\| PubMed ID: 20147779	2010
Fyn: a novel molecular target in cancer. Cancer\| PubMed ID: 20151426	2010
Methylnaltrexone potentiates the anti-angiogenic effects of mTOR inhibitors. Journal of angiogenesis research\| PubMed ID: 20298531	2010
EphA2 mutation in lung squamous cell carcinoma promotes increased cell survival, cell invasion, focal adhesions, and mammalian target of rapamycin activation. The Journal of biological chemistry\| PubMed ID: 20360610	2010
The MET axis as a therapeutic target. Update on cancer therapeutics\| PubMed ID: 20368753	2009
Phase II study of amrubicin as second-line therapy in patients with platinum-refractory small-cell lung cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 20385980	2010
DIFFERENTIAL SERUM LEVEL OF SPECIFIC HAPTOGLOBIN ISOFORMS IN SMALL CELL LUNG CANCER. Current proteomics\| PubMed ID: 20526421	2010
Novel oncogenic mutations of CBL in human acute myeloid leukemia that activate growth and survival pathways depend on increased metabolism. The Journal of biological chemistry\| PubMed ID: 20622007	2010
Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. The New England journal of medicine\| PubMed ID: 20979469	2010
Expression patterns of PAX5, c-Met, and paxillin in neuroendocrine tumors of the lung. Archives of pathology & laboratory medicine\| PubMed ID: 21043826	2010
Paxillin expression and amplification in early lung lesions of high-risk patients, lung adenocarcinoma and metastatic disease. Journal of clinical pathology\| PubMed ID: 21045234	2011
Rapid and dramatic radiographic and clinical response to an ALK inhibitor (crizotinib, PF02341066) in an ALK translocation-positive patient with non-small cell lung cancer. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer\| PubMed ID: 21102269	2010
The novel role of the mu opioid receptor in lung cancer progression: a laboratory investigation. Anesthesia and analgesia\| PubMed ID: 21156980	2011
Multicenter phase II trial of Motexafin gadolinium and pemetrexed for second-line treatment in patients with non-small cell lung cancer. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer\| PubMed ID: 21289521	2011
Functional EGFR germline polymorphisms may confer risk for EGFR somatic mutations in non-small cell lung cancer, with a predominant effect on exon 19 microdeletions. Cancer research\| PubMed ID: 21292812	2011
Fyn is downstream of the HGF/MET signaling axis and affects cellular shape and tropism in PC3 cells. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 21364031	2011
Role of protein kinase C Î² and vascular endothelial growth factor receptor in malignant pleural mesothelioma: Therapeutic implications and the usefulness of Caenorhabditis elegans model org... Journal of carcinogenesis\| PubMed ID: 21383961	2011
Personalized treatment of lung cancer. Seminars in oncology\| PubMed ID: 21421117	2011
Takotsubo cardiomyopathy in a patient with squamous cell esophageal carcinoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 21519014	2011
RON (MST1R) is a novel prognostic marker and therapeutic target for gastroesophageal adenocarcinoma. Cancer biology & therapy\| PubMed ID: 21543897	2011
Phase 2 trial of Linifanib (ABT-869) in patients with advanced non-small cell lung cancer. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer\| PubMed ID: 21597387	2011
Proteomic characterization of non-small cell lung cancer in a comprehensive translational thoracic oncology database. Journal of clinical bioinformatics\| PubMed ID: 21603121	2011
Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 21606412	2011
An E3 ubiquitin ligase: c-Cbl: a new therapeutic target of lung cancer. Cancer\| PubMed ID: 21607942	2011
Crizotinib (PF02341066)、双间充质上皮过渡 (MET) 和间变性淋巴瘤激酶（ALK&#x... Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer\| PubMed ID: 21623265	2011
Autotaxin induces lung epithelial cell migration through lysoPLD activity-dependent and -independent pathways. The Biochemical journal\| PubMed ID: 21696367	2011
Novel functional germline variants in the VEGF receptor 2 gene and their effect on gene expression and microvessel density in lung cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 21712447	2011
Bortezomib for patients with advanced-stage bronchioloalveolar carcinoma: a California Cancer Consortium Phase II study (NCI 7003). Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer\| PubMed ID: 21716143	2011
Prognostic significance of angiogenesis and angiogenic growth factors in nonsmall cell lung cancer. Cancer\| PubMed ID: 21858799	2011
The role of the c-Met pathway in lung cancer and the potential for targeted therapy. Therapeutic advances in medical oncology\| PubMed ID: 21904579	2011
Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis. The lancet oncology\| PubMed ID: 21933749	2011
Prognostic value of metabolic tumor burden on 18F-FDG PET in nonsurgical patients with non-small cell lung cancer. European journal of nuclear medicine and molecular imaging\| PubMed ID: 21946983	2012
Inhibition of MET receptor tyrosine kinase and its ligand hepatocyte growth factor. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer\| PubMed ID: 22005540	2011
MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 22042947	2011
Role of MetMAb (OA-5D5) in c-MET active lung malignancies. Expert opinion on biological therapy\| PubMed ID: 22047509	2011
Targeted and Cytotoxic Therapy in Coordinated Sequence (TACTICS): Erlotinib, Bevacizumab, and Standard Chemotherapy for Non-Small-Cell Lung Cancer, A Phase II Trial. Clinical lung cancer\| PubMed ID: 22100149	2011
Characterization of NOL7 gene point mutations, promoter methylation, and protein expression in cervical cancer. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists\| PubMed ID: 22123719	2012
MET and phosphorylated MET as potential biomarkers in lung cancer. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer\| PubMed ID: 22181983	2011
Hypofractionated Image-Guided Radiation Therapy for Patients with Limited Volume Metastatic Non-small Cell Lung Cancer. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer\| PubMed ID: 22198429	2012
Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 22321727	2012