Ulrich Dirnagl

Department for Experimental Neurology, Center for Stroke Research Berlin, Charité Universitätsmedizin

Affiliated withCenter for Stroke Research Berlin, Charité Universitätsmedizin

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 190	2011

Other Publications

Article	Year
Endothelin-1 potently induces LeÃ£o's cortical spreading depression in vivo in the rat: a model for an endothelial trigger of migrainous aura? Brain : a journal of neurology\| PubMed ID: 11834596	2002
Desferrioxamine induces delayed tolerance against cerebral ischemia in vivo and in vitro. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 11973424	2002
Rosuvastatin, a new HMG-CoA reductase inhibitor, upregulates endothelial nitric oxide synthase and protects from ischemic stroke in mice. Brain research\| PubMed ID: 12031849	2002
Tolerance against ischemic neuronal injury can be induced by volatile anesthetics and is inducible NO synthase dependent. Stroke; a journal of cerebral circulation\| PubMed ID: 12105371	2002
Serial analysis of gene expression identifies metallothionein-II as major neuroprotective gene in mouse focal cerebral ischemia. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12122050	2002
Isoflurane induced prolonged protection against cerebral ischemia in mice: a redox sensitive mechanism? Neuroreport\| PubMed ID: 12167768	2002
Triptans reduce the inflammatory response in bacterial meningitis. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 12172384	2002
Bone marrow-derived progenitor cells modulate vascular reendothelialization and neointimal formation: effect of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 12377731	2002
Ischemia triggered by red blood cell products in the subarachnoid space is inhibited by nimodipine administration or moderate volume expansion/hemodilution in rats. Neurosurgery\| PubMed ID: 12445352	2002
Focal laminar cortical MR signal abnormalities after subarachnoid hemorrhage. Annals of neurology\| PubMed ID: 12447937	2002
Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: evidence from an in vitro model. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12451129	2002
Withdrawal of statin treatment abrogates stroke protection in mice. Stroke; a journal of cerebral circulation\| PubMed ID: 12574574	2003
Ischemia and stroke. Advances in experimental medicine and biology\| PubMed ID: 12575832	2002
Role of NAD(P)H:quinone oxidoreductase in the progression of neuronal cell death in vitro and following cerebral ischaemia in vivo. Journal of neurochemistry\| PubMed ID: 12603827	2003
Ischemic tolerance and endogenous neuroprotection. Trends in neurosciences\| PubMed ID: 12744841	2003
Neuronal activity-induced changes of local cerebral microvascular blood oxygenation in the rat: effect of systemic hyperoxia or hypoxia. Brain research\| PubMed ID: 12763601	2003
Estrogen increases bone marrow-derived endothelial progenitor cell production and diminishes neointima formation. Circulation\| PubMed ID: 12810616	2003
Improved protocol for SAGE tag-to-gene allocation. BioTechniques\| PubMed ID: 12813889	2003
Hypoxia-induced stroke tolerance in the mouse is mediated by erythropoietin. Stroke; a journal of cerebral circulation\| PubMed ID: 12829864	2003
Bone marrow-derived cells expressing green fluorescent protein under the control of the glial fibrillary acidic protein promoter do not differentiate into astrocytes in vitro and in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12832523	2003
Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation. The Journal of experimental medicine\| PubMed ID: 12939340	2003
Cerebrovascular vasodilation to extraluminal acidosis occurs via combined activation of ATP-sensitive and Ca2+-activated potassium channels. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 14526233	2003
Mechanisms of stroke protection by physical activity. Annals of neurology\| PubMed ID: 14595647	2003
Ischemia triggered by spreading neuronal activation is induced by endothelin-1 and hemoglobin in the subarachnoid space. Annals of neurology\| PubMed ID: 14595648	2003
A fluorescence-based method to assess plasma protein extravasation in rat dura mater using confocal laser scanning microscopy. Brain research. Brain research protocols\| PubMed ID: 14613808	2003
Selective neuronal vulnerability following mild focal brain ischemia in the mouse. Brain pathology (Zurich, Switzerland)\| PubMed ID: 14655751	2003
ET-1 induces cortical spreading depression via activation of the ETA receptor/phospholipase C pathway in vivo. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 14656702	2004
Dysexecutive syndrome after mild cerebral ischemia? Mice learn normally but have deficits in strategy switching. Stroke; a journal of cerebral circulation\| PubMed ID: 14671235	2004
Preventive antibacterial treatment improves the general medical and neurological outcome in a mouse model of stroke. Stroke; a journal of cerebral circulation\| PubMed ID: 14684767	2004
Neuronal gelsolin prevents apoptosis by enhancing actin depolymerization. Molecular and cellular neurosciences\| PubMed ID: 14962741	2004
HMG-CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis. Journal of neurochemistry\| PubMed ID: 15030386	2004
Impaired vascular reactivity of isolated rat middle cerebral artery after cortical spreading depression in vivo. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 15129184	2004
Tyrosine kinase inhibition reduces inflammation in the acute stage of experimental pneumococcal meningitis. Infection and immunity\| PubMed ID: 15155632	2004
Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase. The Journal of clinical investigation\| PubMed ID: 15199406	2004
Pathophysiology of stroke: lessons from animal models. Metabolic brain disease\| PubMed ID: 15554412	2004
Angiotensin AT2 receptor protects against cerebral ischemia-induced neuronal injury. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 15665034	2005
Circulating monocytic cells infiltrate layers of anterograde axonal degeneration where they transform into microglia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 15671154	2005
Neuroprotective effects of atorvastatin against glutamate-induced excitotoxicity in primary cortical neurones. Journal of neurochemistry\| PubMed ID: 15748157	2005
Neuroprotective role of astrocytes in cerebral ischemia: focus on ischemic preconditioning. Glia\| PubMed ID: 15846804	2005
Role of glial cells in cerebral ischemia. Glia\| PubMed ID: 15846807	2005
Increased extracellular K+ concentration reduces the efficacy of N-methyl-D-aspartate receptor antagonists to block spreading depression-like depolarizations and spreading ischemia. Stroke; a journal of cerebral circulation\| PubMed ID: 15879337	2005
Ion changes in spreading ischaemia induce rat middle cerebral artery constriction in the absence of NO. Brain : a journal of neurology\| PubMed ID: 15901647	2005
Central nervous system injury-induced immune deficiency syndrome. Nature reviews. Neuroscience\| PubMed ID: 16163382	2005
Partial antagonistic effect of adenosine on inverse coupling between spreading neuronal activation and cerebral blood flow in rats. Neurocritical care\| PubMed ID: 16174901	2004
Nitric oxide modulates calcium entry through P/Q-type calcium channels and N-methyl-d-aspartate receptors in rat cortical neurons. Brain research\| PubMed ID: 16274675	2005
Effects of parecoxib on plasma protein extravasation and c-fos expression in the rat. Headache\| PubMed ID: 16492237	2006
Bench to bedside: the quest for quality in experimental stroke research. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 16525413	2006
Improved reperfusion and neuroprotection by creatine in a mouse model of stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 16773141	2007
Stroke research priorities for the next decade--A representative view of the European scientific community. Cerebrovascular diseases (Basel, Switzerland)\| PubMed ID: 16790993	2006
Impaired cerebrovascular reactivity after cortical spreading depression in rats: Restoration by nitric oxide or cGMP. Experimental neurology\| PubMed ID: 16920100	2006
Stroke propagates bacterial aspiration to pneumonia in a model of cerebral ischemia. Stroke; a journal of cerebral circulation\| PubMed ID: 16946159	2006
Noninvasive near-infrared imaging of fluorochromes within the brain of live mice: an in vivo phantom study. Molecular imaging\| PubMed ID: 16954033	2006
Tracking of systemically administered mononuclear cells in the ischemic brain by high-field magnetic resonance imaging. NeuroImage\| PubMed ID: 16973381	2006
Roller culture of free-floating retinal slices: a new system of organotypic cultures of adult rat retina. Ophthalmic research\| PubMed ID: 16974126	2006
Functional imaging with laser speckle contrast analysis: vascular compartment analysis and correlation with laser Doppler flowmetry and somatosensory evoked potentials. Brain research\| PubMed ID: 17030028	2006
Physical activity improves long-term stroke outcome via endothelial nitric oxide synthase-dependent augmentation of neovascularization and cerebral blood flow. Circulation research\| PubMed ID: 17038638	2006
Endothelin-1-induced spreading depression in rats is associated with a microarea of selective neuronal necrosis. Experimental biology and medicine (Maywood, N.J.)\| PubMed ID: 17259327	2007
Stroke-induced immunodepression: experimental evidence and clinical relevance. Stroke; a journal of cerebral circulation\| PubMed ID: 17261736	2007
Neuroprotective effects of the beta-carboline abecarnil studied in cultured cortical neurons and organotypic retinal cultures. Neuropharmacology\| PubMed ID: 17449066	2007
Phosphatidylinositol 3-Akt-kinase-dependent phosphorylation of p21(Waf1/Cip1) as a novel mechanism of neuroprotection by glucocorticoids. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17460069	2007
Protection from brain damage and bacterial infection in murine stroke by the novel caspase-inhibitor Q-VD-OPH. Experimental neurology\| PubMed ID: 17585906	2007
Sulfonylureas improve outcome in patients with type 2 diabetes and acute ischemic stroke. Stroke; a journal of cerebral circulation\| PubMed ID: 17673715	2007
Inducible nitric oxide synthase does not mediate brain damage after transient focal cerebral ischemia in mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 17851454	2008
Cellular immunodepression preceding infectious complications after acute ischemic stroke in humans. Cerebrovascular diseases (Basel, Switzerland)\| PubMed ID: 18033958	2008
Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach. Stroke; a journal of cerebral circulation\| PubMed ID: 18239164	2008
Doxorubicin induces biphasic neurotoxicity to rat cortical neurons. Neurotoxicology\| PubMed ID: 18258305	2008
Improving outcome after stroke: overcoming the translational roadblock. Cerebrovascular diseases (Basel, Switzerland)\| PubMed ID: 18292653	2008
Nitric oxide modulates spreading depolarization threshold in the human and rodent cortex. Stroke; a journal of cerebral circulation\| PubMed ID: 18309156	2008
Hypothermia effects on neurovascular coupling and cerebral metabolic rate of oxygen. NeuroImage\| PubMed ID: 18343160	2008
Endogenous neuroprotection: mitochondria as gateways to cerebral preconditioning? Neuropharmacology\| PubMed ID: 18402985	2008
Preventive antibacterial therapy in acute ischemic stroke: a randomized controlled trial. PloS one\| PubMed ID: 18478129	2008
5,7-Dihydroxitryptamine toxicity to serotonergic neurons in serum free raphe cultures. European journal of pharmacology\| PubMed ID: 18519135	2008
Evidence for the efficacy of NXY-059 in experimental focal cerebral ischaemia is confounded by study quality. Stroke; a journal of cerebral circulation\| PubMed ID: 18635842	2008
In vivo imaging of the inflammatory receptor CD40 after cerebral ischemia using a fluorescent antibody. Stroke; a journal of cerebral circulation\| PubMed ID: 18635859	2008
Good laboratory practice: preventing introduction of bias at the bench. Stroke; a journal of cerebral circulation\| PubMed ID: 18703798	2009
The ischemic cascade and mediators of ischemic injury. Handbook of clinical neurology / edited by P.J. Vinken and G.W. Bruyn\| PubMed ID: 18790268	2009
Reprint: Good laboratory practice: preventing introduction of bias at the bench. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 18797473	2009
Fluorescence tomography technique optimized for noninvasive imaging of the mouse brain. Journal of biomedical optics\| PubMed ID: 19021319	2008
Reprint: Good laboratory practice: preventing introduction of bias at the bench. International journal of stroke : official journal of the International Stroke Society\| PubMed ID: 19236488	2009
Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use. Lancet neurology\| PubMed ID: 19296922	2009
Effects of the PDE5-inhibitor vardenafil in a mouse stroke model. Brain research\| PubMed ID: 19368809	2009
In vivo near-infrared fluorescence imaging of matrix metalloproteinase activity after cerebral ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 19417756	2009
Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage. Brain : a journal of neurology\| PubMed ID: 19420089	2009
Near-infrared fluorescence imaging with fluorescently labeled albumin: a novel method for non-invasive optical imaging of blood-brain barrier impairment after focal cerebral ischemia in mice... Journal of neuroscience methods\| PubMed ID: 19427539	2009
Stroke research at a road block: the streets from adversity should be paved with meta-analysis and good laboratory practice. British journal of pharmacology\| PubMed ID: 19664136	2009
Pharmacological uncoupling of activation induced increases in CBF and CMRO2. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 19794398	2010
Mrp-8 and -14 mediate CNS injury in focal cerebral ischemia. Biochimica et biophysica acta\| PubMed ID: 19835955	2009
Neurovascular coupling in rat brain operates independent of hemoglobin deoxygenation. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 20040927	2010
If you have the science, we have the journal! Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 20046196	2010
Statistics in experimental cerebrovascular research-comparison of two groups with a continuous outcome variable. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 20051976	2010
Membrane attack complex inhibitor CD59a protects against focal cerebral ischemia in mice. Journal of neuroinflammation\| PubMed ID: 20202211	2010
Elevating intracranial pressure reverses the decrease in deoxygenated hemoglobin and abolishes the post-stimulus overshoot upon somatosensory activation in rats. NeuroImage\| PubMed ID: 20420930	2010
CD93/AA4.1: a novel regulator of inflammation in murine focal cerebral ischemia. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20439917	2010
Statistics in experimental cerebrovascular research: comparison of more than two groups with a continuous outcome variable. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 20571520	2010
Fighting publication bias: introducing the Negative Results section. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 20596038	2010
Oxygen maps in the brain. Nature methods\| PubMed ID: 20805799	2010
Determination of the brain-blood partition coefficient for water in mice using MRI. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 20842161	2010
Pathophysiological interference with neurovascular coupling - when imaging based on hemoglobin might go blind. Frontiers in neuroenergetics\| PubMed ID: 20953238	2010
Effect of 3,4-methylenedioxyamphetamine on dendritic spine dynamics in rat neocortical neurons--involvement of heat shock protein 27. Brain research\| PubMed ID: 21075084	2011
Immune responses after acute ischemic stroke or myocardial infarction. International journal of cardiology\| PubMed ID: 21078527	2010
Hypothermia for Stroke: call to action 2010. International journal of stroke : official journal of the International Stroke Society\| PubMed ID: 21086713	2010
Pericytes in capillaries are contractile in vivo, but arterioles mediate functional hyperemia in the mouse brain. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21135230	2010
Systematic survey of the design, statistical analysis, and reporting of studies published in the 2008 volume of the Journal of Cerebral Blood Flow and Metabolism. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 21157472	2011
Improving the quality of biomedical research: guidelines for reporting experiments involving animals. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 21206506	2011
Visualization of cell death in mice with focal cerebral ischemia using fluorescent annexin A5, propidium iodide, and TUNEL staining. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 21245871	2011
Non-invasive surface-stripping for epifluorescence small animal imaging. Biomedical optics express\| PubMed ID: 21258449	2010
IL-1Î² stimulates COX-2 dependent PGEâ‚‚ synthesis and CGRP release in rat trigeminal ganglia cells. PloS one\| PubMed ID: 21394197	2011
Non-resolving aspects of acute inflammation after spinal cord injury (SCI): indices and resolution plateau. Brain pathology (Zurich, Switzerland)\| PubMed ID: 21418368	2011
Stroke and the immune system: from pathophysiology to new therapeutic strategies. Lancet neurology\| PubMed ID: 21511199	2011
Rotation of Editorial Board Members and new publication formats. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 21587269	2011
Acute pathophysiological processes after ischaemic and traumatic brain injury. Best practice & research. Clinical anaesthesiology\| PubMed ID: 21619862	2010
Protective conditioning of the brain: expressway or roadblock? The Journal of physiology\| PubMed ID: 21708907	2011
SUMO2/3 conjugation is an endogenous neuroprotective mechanism. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 21863037	2011
Body weight after stroke: lessons from the obesity paradox. Stroke; a journal of cerebral circulation\| PubMed ID: 21960580	2011
Visualizing cell death in experimental focal cerebral ischemia: promises, problems, and perspectives. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 22086195	2012
Mitochondrial hexokinase II (HKII) and phosphoprotein enriched in astrocytes (PEA15) form a molecular switch governing cellular fate depending on the metabolic state. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22233811	2012