Fulvio Mavilio

Center for Genome Research, University of Modena and Reggio Emilia

Affiliated withUniversity of Modena and Reggio Emilia Généthon

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2017

Other Publications

Article	Year
Muscle-derived hematopoietic stem cells are hematopoietic in origin. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11830662	2002
Transcriptional targeting of lentiviral vectors by long terminal repeat enhancer replacement. Journal of virology\| PubMed ID: 11907239	2002
Myogenic stem cells from the bone marrow: a therapeutic alternative for muscular dystrophy? Neuromuscular disorders : NMD\| PubMed ID: 12206789	2002
The choice of a suitable lentivirus vector: transcriptional targeting. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 12824618	2003
The future of gene therapy. Nature\| PubMed ID: 14985734	2004
Site-specific integration of functional transgenes into the human genome by adeno/AAV hybrid vectors. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 15451450	2004
Stem cell plasticity: time for a reappraisal? Haematologica\| PubMed ID: 15749669	2005
Competitive engraftment of hematopoietic stem cells genetically modified with a truncated erythropoietin receptor. Human gene therapy\| PubMed ID: 15916484	2005
Gene therapy approaches for epidermolysis bullosa. Clinics in dermatology\| PubMed ID: 16023940	2005
T Lymphocytes transduced with a lentiviral vector expressing F12-Vif are protected from HIV-1 infection in an APOBEC3G-independent manner. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 16039909	2005
Retroviral vector integration deregulates gene expression but has no consequence on the biology and function of transplanted T cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16432223	2006
Gene therapy in combination with tissue engineering to treat epidermolysis bullosa. Expert opinion on biological therapy\| PubMed ID: 16548763	2006
Site-specific integration into the human genome: ready for clinical application? Rejuvenation research\| PubMed ID: 17105384	2006
Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells. Nature medicine\| PubMed ID: 17115047	2006
Hot spots of retroviral integration in human CD34+ hematopoietic cells. Blood\| PubMed ID: 17507662	2007
C/EBPdelta regulates cell cycle and self-renewal of human limbal stem cells. The Journal of cell biology\| PubMed ID: 17562792	2007
Long-term engraftment of single genetically modified human epidermal holoclones enables safety pre-assessment of cutaneous gene therapy. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 17579576	2007
Multilineage hematopoietic reconstitution without clonal selection in ADA-SCID patients treated with stem cell gene therapy. The Journal of clinical investigation\| PubMed ID: 17671653	2007
Role of CD34 antigen in myeloid differentiation of human hematopoietic progenitor cells. Stem cells (Dayton, Ohio)\| PubMed ID: 18192237	2008
Towards a gene therapy clinical trial for epidermolysis bullosa. Reviews on recent clinical trials\| PubMed ID: 18473966	2006
Genetic modification of somatic stem cells. The progress, problems and prospects of a new therapeutic technology. EMBO reports\| PubMed ID: 18578029	2008
Correction of laminin-5 deficiency in human epidermal stem cells by transcriptionally targeted lentiviral vectors. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 18813277	2008
PPARdelta is a ligand-dependent negative regulator of vitamin D3-induced monocyte differentiation. Carcinogenesis\| PubMed ID: 19056929	2009
Tracking gene-modified T cells in vivo. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19110640	2009
Transcription factor binding sites are genetic determinants of retroviral integration in the human genome. PloS one\| PubMed ID: 19238208	2009
Transcriptional enhancers induce insertional gene deregulation independently from the vector type and design. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 19293778	2009
Integration of retroviral vectors induces minor changes in the transcriptional activity of T cells from ADA-SCID patients treated with gene therapy. Blood\| PubMed ID: 19652199	2009
Comprehensive genomic access to vector integration in clinical gene therapy. Nature medicine\| PubMed ID: 19966782	2009
Gene therapy: back on track? EMBO reports\| PubMed ID: 20118988	2010
Correction of beta-thalassemia major by gene transfer in haematopoietic progenitors of pediatric patients. EMBO molecular medicine\| PubMed ID: 20665635	2010
High-definition mapping of retroviral integration sites identifies active regulatory elements in human multipotent hematopoietic progenitors. Blood\| PubMed ID: 20864581	2010
High-definition mapping of retroviral integration sites defines the fate of allogeneic T cells after donor lymphocyte infusion. PloS one\| PubMed ID: 21203516	2010
Correction of murine SCID-X1 by lentiviral gene therapy using a codon-optimized IL2RG gene and minimal pretransplant conditioning. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21750532	2011
Site-specific integration by the adeno-associated virus rep protein. Current gene therapy\| PubMed ID: 21827397	2011
Insertion sites in engrafted cells cluster within a limited repertoire of genomic areas after gammaretroviral vector gene therapy. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21862999	2011
Preclinical corrective gene transfer in xeroderma pigmentosum human skin stem cells. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 22068429	2012
Estimated comparative integration hotspots identify different behaviors of retroviral gene transfer vectors. PLoS computational biology\| PubMed ID: 22144885	2011
The GATA1-HS2 enhancer allows persistent and position-independent expression of a β-globin transgene. PloS one\| PubMed ID: 22164220	2011
Gene therapy of skin adhesion disorders (mini review). Current pharmaceutical biotechnology\| PubMed ID: 22250710	2012
Alternative splicing caused by lentiviral integration in the human genome. Methods in enzymology\| PubMed ID: 22365773	2012
Lentiviral vector integration in the human genome induces alternative splicing and generates aberrant transcripts. The Journal of clinical investigation\| PubMed ID: 22523069	2012
Gene therapies need new development models. Nature\| PubMed ID: 23038429	2012
IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors. Blood\| PubMed ID: 23160470	2013
Mechanisms of retroviral integration and mutagenesis. Human gene therapy\| PubMed ID: 23330935	2013
Translating the genomics revolution: the need for an international gene therapy consortium for monogenic diseases. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 23369965	2013
Deletion of the LTR enhancer/promoter has no impact on the integration profile of MLV vectors in human hematopoietic progenitors. PloS one\| PubMed ID: 23383272	2013
Nup153 and Nup98 bind the HIV-1 core and contribute to the early steps of HIV-1 replication. Virology\| PubMed ID: 23523133	2013
Genotoxic signature in cord blood cells of newborns exposed in utero to a Zidovudine-based antiretroviral combination. The Journal of infectious diseases\| PubMed ID: 23559464	2013
Targeted gene addition in human epithelial stem cells by zinc-finger nuclease-mediated homologous recombination. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 23760447	2013
RD2-MolPack-Chim3, a packaging cell line for stable production of lentiviral vectors for anti-HIV gene therapy. Human gene therapy methods\| PubMed ID: 23767932	2013
Gene therapy prolongs survival and restores function in murine and canine models of myotubular myopathy. Science translational medicine\| PubMed ID: 24452262	2014
Repairing without cutting: a safer alternative to gene correction? Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 24691177	2014
Genome-wide analysis of alpharetroviral integration in human hematopoietic stem/progenitor cells. Genes\| PubMed ID: 24840152	2014
Genomic analysis of Sleeping Beauty transposon integration in human somatic cells. PloS one\| PubMed ID: 25390293	2014
Perspectives on best practices for gene therapy programs. Human gene therapy\| PubMed ID: 25654329	2015
A single epidermal stem cell strategy for safe ex vivo gene therapy. EMBO molecular medicine\| PubMed ID: 25724200	2015
Nuclear architecture dictates HIV-1 integration site selection. Nature\| PubMed ID: 25731161	2015
Outcomes following gene therapy in patients with severe Wiskott-Aldrich syndrome. JAMA\| PubMed ID: 25898053	2015
Genome-Wide Definition of Promoter and Enhancer Usage during Neural Induction of Human Embryonic Stem Cells. PloS one\| PubMed ID: 25978676	2015
Dynamic Transcriptional and Epigenetic Regulation of Human Epidermal Keratinocyte Differentiation. Stem cell reports\| PubMed ID: 27050947	2016
Transcriptional, epigenetic and retroviral signatures identify regulatory regions involved in hematopoietic lineage commitment. Scientific reports\| PubMed ID: 27095295	2016
Efficacy and biodistribution analysis of intracerebroventricular administration of an optimized scAAV9-SMN1 vector in a mouse model of spinal muscular atrophy. Molecular therapy. Methods & clinical development\| PubMed ID: 27652289	2016
Systemic AAV8-Mediated Gene Therapy Drives Whole-Body Correction of Myotubular Myopathy in Dogs. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 28237839	2017