Motoi Ohba

Institute of Molecular Oncology, Showa Medical University

Affiliated withShowa Medical University Showa University

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 4	2017
Publication title Cited by 3	2019

Other Publications

Article	Year
Induction of differentiation in normal human keratinocytes by adenovirus-mediated introduction of the eta and delta isoforms of protein kinase C. Molecular and cellular biology\| PubMed ID: 9710604	1998
Phorbol ester-induced G1 arrest in BALB/MK-2 mouse keratinocytes is mediated by delta and eta isoforms of protein kinase C. Japanese journal of cancer research : Gann\| PubMed ID: 9914781	1998
Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCalpha. The Journal of biological chemistry\| PubMed ID: 11584014	2002
Activation of protein kinase C zeta induces serine phosphorylation of VAMP2 in the GLUT4 compartment and increases glucose transport in skeletal muscle. Molecular and cellular biology\| PubMed ID: 11604519	2001
Phosphorylation-dependent regulation of phospholipase D2 by protein kinase C delta in rat Pheochromocytoma PC12 cells. The Journal of biological chemistry\| PubMed ID: 11744693	2002
Requirement of Ca(2+) and PKCdelta for Janus kinase 2 activation by angiotensin II: involvement of PYK2. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 11818507	2002
Lysophosphatidylcholine inhibits insulin-induced Akt activation through protein kinase C-alpha in vascular smooth muscle cells. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 11882599	2002
Protein kinase Cdelta amplifies ceramide formation via mitochondrial signaling in prostate cancer cells. The Journal of clinical investigation\| PubMed ID: 11901191	2002
Dual regulation of phospholipase D1 by protein kinase C alpha in vivo. Biochemical and biophysical research communications\| PubMed ID: 12074591	2002
Novel protein kinase C isoforms regulate human keratinocyte differentiation by activating a p38 delta mitogen-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alp... The Journal of biological chemistry\| PubMed ID: 12080077	2002
Enhancement of anchorage-independent growth of human pancreatic carcinoma MIA PaCa-2 cells by signaling from protein kinase C to mitogen-activated protein kinase. Molecular carcinogenesis\| PubMed ID: 12203369	2002
Ligand-independent trans-activation of the platelet-derived growth factor receptor by reactive oxygen species requires protein kinase C-delta and c-Src. The Journal of biological chemistry\| PubMed ID: 12226102	2002
Localization of phospholipase D1 to caveolin-enriched membrane via palmitoylation: implications for epidermal growth factor signaling. Molecular biology of the cell\| PubMed ID: 12429840	2002
Thrombin rapidly induces protein kinase D phosphorylation, and protein kinase C delta mediates the activation. The Journal of biological chemistry\| PubMed ID: 12431976	2003
Protein kinase C eta (PKC eta): its involvement in keratinocyte differentiation. Journal of biochemistry\| PubMed ID: 12473186	2002
Distinct mechanisms of receptor and nonreceptor tyrosine kinase activation by reactive oxygen species in vascular smooth muscle cells: role of metalloprotease and protein kinase C-delta. Molecular and cellular biology\| PubMed ID: 12588978	2003
Insulin-induced Akt activation is inhibited by angiotensin II in the vasculature through protein kinase C-alpha. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 12623995	2003
The eta isoform of protein kinase C inhibits UV-induced activation of caspase-3 in normal human keratinocytes. Biochemical and biophysical research communications\| PubMed ID: 12646210	2003
PKCdelta inhibits PKCalpha-mediated activation of phospholipase D1 in a manner independent of its protein kinase activity. FEBS letters\| PubMed ID: 14596936	2003
Differential regulation of alpha6beta4 integrin by PKC isoforms in murine skin keratinocytes. Biochemical and biophysical research communications\| PubMed ID: 14715240	2004
PKCalpha mediates TGFbeta-induced growth inhibition of human keratinocytes via phosphorylation of S100C/A11. The Journal of cell biology\| PubMed ID: 15051732	2004
Transcriptional and post-transcriptional regulation of the PKC delta gene by etoposide in L1210 murine leukemia cells: implication of PKC delta autoregulation. Journal of molecular biology\| PubMed ID: 15223313	2004
Role of CPI-17 in the regulation of endothelial cytoskeleton. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 15234908	2004
Protein kinase Cdelta mediates lysophosphatidic acid-induced NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells. The Journal of biological chemistry\| PubMed ID: 15280372	2004
Decay-accelerating factor induction on vascular endothelium by vascular endothelial growth factor (VEGF) is mediated via a VEGF receptor-2 (VEGF-R2)- and protein kinase C-alpha/epsilon (PKCa... The Journal of biological chemistry\| PubMed ID: 15284224	2004
Angiotensin II-induced protein kinase D activation is regulated by protein kinase Cdelta and mediated via the angiotensin II type 1 receptor in vascular smooth muscle cells. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 15499041	2004
Protein kinase Calpha is implicated in cholecystokinin-induced activation of 70-kd S6 kinase in AR42J cells. Pancreas\| PubMed ID: 15632699	2005
Novel functions of the phospholipase D2-Phox homology domain in protein kinase Czeta activation. Molecular and cellular biology\| PubMed ID: 15798205	2005
A role for proteinase-activated receptor 2 and PKC-epsilon in thrombin-mediated induction of decay-accelerating factor on human endothelial cells. American journal of physiology. Cell physiology\| PubMed ID: 16079188	2005
Pituitary adenylate cyclase-activating polypeptide-induced differentiation of embryonic neural stem cells into astrocytes is mediated via the beta isoform of protein kinase C. Journal of neuroscience research\| PubMed ID: 17022039	2006
Activation of protein kinase Czeta mediates luteinizing hormone- or forskolin-induced NGFI-B expression in preovulatory granulosa cells of rat ovary. Molecular and cellular endocrinology\| PubMed ID: 17416458	2007
A protein kinase Cepsilon-anti-apoptotic kinase signaling complex protects human vascular endothelial cells against apoptosis through induction of Bcl-2. The Journal of biological chemistry\| PubMed ID: 17785460	2007
Protein kinase C alpha and zeta differentially regulate death-inducing signaling complex formation in cigarette smoke extract-induced apoptosis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18354190	2008
Functional characterization of IL-17F as a selective neutrophil attractant in psoriasis. The Journal of investigative dermatology\| PubMed ID: 18830271	2009
Lysophosphatidylcholine activates adipocyte glucose uptake and lowers blood glucose levels in murine models of diabetes. The Journal of biological chemistry\| PubMed ID: 19815546	2009
Activation of proteinase-activated receptor 2 stimulates soluble vascular endothelial growth factor receptor 1 release via epidermal growth factor receptor transactivation in endothelial cel... Hypertension\| PubMed ID: 20124108	2010
Protein kinase C delta and eta differently regulate the expression of loricrin and Jun family proteins in human keratinocytes. Biochemical and biophysical research communications\| PubMed ID: 20184865	2010
B lymphocyte-induced maturation protein 1 is a novel target gene of aryl hydrocarbon receptor. Journal of dermatological science\| PubMed ID: 20478695	2010
Vascular endothelial tight junctions and barrier function are disrupted by 15(S)-hydroxyeicosatetraenoic acid partly via protein kinase C ε-mediated zona occludens-1 phosphorylation at threo... The Journal of biological chemistry\| PubMed ID: 24338688	2014
Silver Nanoscale Hexagonal Column Chips for Detecting Cell-free DNA and Circulating Nucleosomes in Cancer Patients. Scientific reports\| PubMed ID: 25994878	2015
Acquired Resistance Mechanisms to Combination Met-TKI/EGFR-TKI Exposure in Met-Amplified EGFR-TKI-Resistant Lung Adenocarcinoma Harboring an Activating EGFR Mutation. Molecular cancer therapeutics\| PubMed ID: 27612490	2016
Distinct Afatinib Resistance Mechanisms Identified in Lung Adenocarcinoma Harboring an EGFR Mutation. Molecular cancer research : MCR\| PubMed ID: 28289161	2017
Up-regulation of Syndecan-4 contributes to TGF-β1-induced epithelial to mesenchymal transition in lung adenocarcinoma A549 cells. Biochemistry and biophysics reports\| PubMed ID: 28955801	2016
Molecular-Targeted Therapies for Epidermal Growth Factor Receptor and Its Resistance Mechanisms. International journal of molecular sciences\| PubMed ID: 29140271	2017
and Amplifications Mediate Resistance to Rociletinib and Osimertinib in Acquired Afatinib-Resistant NSCLC Harboring Exon 19 Deletion/T790M in . Molecular cancer therapeutics\| PubMed ID: 30322949	2019
Receptor Tyrosine Kinase-Targeted Cancer Therapy. International journal of molecular sciences\| PubMed ID: 30404198	2018