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Transcanalicular Diode Laser-assisted Dacryocystorhinostomy for the Treatment of Primary Acquired Nasolacrimal Duct Obstruction

Today&#39;s gold standard in the treatment of infrasaccal primary acquired nasolacrimal duct obstruction (PANDO) is external dacryocystorhinostomy (DCR), ...

University of Cologne

To study the clinicopathological characteristics, diagnosis and differential diagnosis of hypopharyngeal carcinosarcoma.

[Clinicopathological characteristics of hypopharyngeal carcinosarcoma].

To study the clinical and pathological features of pilomatricoma.

[Pilomatricoma: a retrospective study of 399 cases].

Previous research suggested that the biofilm of Staphylococcus aureus contributes greatly to the recalcitrant nature of chronic rhinosinusitis (CRS). However, the lack of a simple and stable animal model limited further study in this field. The aim of this study was to create a convenient animal model of S. aureus biofilms in the maxillary sinus of rabbit.

A simple animal model of Staphylococcus aureus biofilm in sinusitis.

Staphylococcus aureus biofilms contribute significantly to the recalcitrant nature of chronic rhinosinusitis. In previous studies, it has been shown that silk fibroin-nano silver solution can eliminate S. aureus biofilms in vitro, which suggests a potential role of this novel agent in the treatment of biofilm-associated diseases, such as sinusitis.

Efficacy of silk fibroin-nano silver against Staphylococcus aureus biofilms in a rabbit model of sinusitis.

The biocompatibility and in vivo degradation rate of biomaterials represent critical control points in the long-term success of scaffolds for tissue restoration. In this study, new three-dimensional (3D) regenerated silk fibroin scaffolds (RSFs) were prepared by the freezing-defrosting procedure, and then were implanted beneath the dorsal skin of rats. This study aims to develop a kinetic semi-quantitative approach to assess in vivo degradation rate and biocompatibility of this kind of RSFs with different pore sizes for the first time, and to evaluate the relationship between the biodegradation and tissue responses by measuring the thickness of residual scaffolds, fibrous capsules and infiltrated tissues through integrated techniques of histology, optical imaging and image analysis. Our results showed that scaffolds with both pore sizes (74.35±10.84μm and 139.23±44.93μm, respectively) were well tolerated by host animals and pore size was found to be the rate limiting factor to the biodegradation in the subcutaneous implantation model. In addition, the biodegradation of RSFs was inflammation-mediated to a certain degree and fibroblasts may play a critical role in this process. Overall, such semi-quantitative approach was demonstrated to be a simple and effective method to assess the in vivo degradation rate, and the prepared RSFs were presented to have promising potential in tissue engineering applications.

Article	Year
[Clinicopathological characteristics of hypopharyngeal carcinosarcoma]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery\| PubMed ID: 23898616	2013
[Pilomatricoma: a retrospective study of 399 cases]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery\| PubMed ID: 24617004	2013
A simple animal model of Staphylococcus aureus biofilm in sinusitis. American journal of rhinology & allergy\| PubMed ID: 24717948	2014
Efficacy of silk fibroin-nano silver against Staphylococcus aureus biofilms in a rabbit model of sinusitis. International journal of nanomedicine\| PubMed ID: 28435269	2017
A simple semi-quantitative approach studying the in vivo degradation of regenerated silk fibroin scaffolds with different pore sizes. Materials science & engineering. C, Materials for biological applications\| PubMed ID: 28629003	2017
Statin Use in Patients with Aneurysmal Subarachnoid Hemorrhage May not Significantly Reduce the Occurrence of Delayed Ischemic Neurological Deficit. World neurosurgery\| PubMed ID: 28732423	2017

Yongwei Guo

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