Mitchell J. Weiss

Department of Hematology, St. Jude Children's Research Hospital

Affiliated withSt. Jude Children's Research Hospital

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 5	2017

Other Publications

Article	Year
An abundant erythroid protein that stabilizes free alpha-haemoglobin. Nature\| PubMed ID: 12066189	2002
Biophysical characterization of the alpha-globin binding protein alpha-hemoglobin stabilizing protein. The Journal of biological chemistry\| PubMed ID: 12192002	2002
Cooperative activities of hematopoietic regulators recruit RNA polymerase II to a tissue-specific chromatin domain. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12193659	2002
Formation of a tissue-specific histone acetylation pattern by the hematopoietic transcription factor GATA-1. Molecular and cellular biology\| PubMed ID: 12556492	2003
GATA-1-mediated proliferation arrest during erythroid maturation. Molecular and cellular biology\| PubMed ID: 12832487	2003
GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12857954	2003
Stress-induced apoptosis associated with null mutation of ADAR1 RNA editing deaminase gene. The Journal of biological chemistry\| PubMed ID: 14613934	2004
New insights into erythropoietin and epoetin alfa: mechanisms of action, target tissues, and clinical applications. The oncologist\| PubMed ID: 14671225	2003
Evaluation of alpha hemoglobin stabilizing protein (AHSP) as a genetic modifier in patients with beta thalassemia. Blood\| PubMed ID: 14715623	2004
Global regulation of erythroid gene expression by transcription factor GATA-1. Blood\| PubMed ID: 15297311	2004
Loss of alpha-hemoglobin-stabilizing protein impairs erythropoiesis and exacerbates beta-thalassemia. The Journal of clinical investigation\| PubMed ID: 15545996	2004
Molecular mechanism of AHSP-mediated stabilization of alpha-hemoglobin. Cell\| PubMed ID: 15550245	2004
Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1. Molecular cell\| PubMed ID: 15694345	2005
Structure of oxidized alpha-haemoglobin bound to AHSP reveals a protective mechanism for haem. Nature\| PubMed ID: 15931225	2005
Repression of c-kit and its downstream substrates by GATA-1 inhibits cell proliferation during erythroid maturation. Molecular and cellular biology\| PubMed ID: 16024808	2005
Early block to erythromegakaryocytic development conferred by loss of transcription factor GATA-1. Blood\| PubMed ID: 16144799	2006
GATA-1 and Oct-1 are required for expression of the human alpha-hemoglobin-stabilizing protein gene. The Journal of biological chemistry\| PubMed ID: 16186125	2005
Designer blood: creating hematopoietic lineages from embryonic stem cells. Blood\| PubMed ID: 16254136	2006
Megakaryocyte biology and related disorders. The Journal of clinical investigation\| PubMed ID: 16322777	2005
Role of alpha-hemoglobin-stabilizing protein in normal erythropoiesis and beta-thalassemia. Annals of the New York Academy of Sciences\| PubMed ID: 16339656	2005
Mitoferrin is essential for erythroid iron assimilation. Nature\| PubMed ID: 16511496	2006
Alpha-haemoglobin stabilising protein is a quantitative trait gene that modifies the phenotype of beta-thalassaemia. British journal of haematology\| PubMed ID: 16704446	2006
Biochemical fates of alpha hemoglobin bound to alpha hemoglobin-stabilizing protein AHSP. The Journal of biological chemistry\| PubMed ID: 16901899	2006
A novel haem-binding interface in the 22 kDa haem-binding protein p22HBP. Journal of molecular biology\| PubMed ID: 16905148	2006
Experimental validation of predicted mammalian erythroid cis-regulatory modules. Genome research\| PubMed ID: 17038566	2006
Assembly of recently translated full-length and C-terminal truncated human gamma-globin chains with a pool of alpha-globin chains to form Hb F in a cell-free system. Archives of biochemistry and biophysics\| PubMed ID: 17418086	2007
An erythroid chaperone that facilitates folding of alpha-globin subunits for hemoglobin synthesis. The Journal of clinical investigation\| PubMed ID: 17607360	2007
Diseased red blood cells topple iron balance. Nature medicine\| PubMed ID: 17828218	2007
Population analysis of the alpha hemoglobin stabilizing protein (AHSP) gene identifies sequence variants that alter expression and function. American journal of hematology\| PubMed ID: 17874450	2008
STAT1 promotes megakaryopoiesis downstream of GATA-1 in mice. The Journal of clinical investigation\| PubMed ID: 18060035	2007
A GATA-1-regulated microRNA locus essential for erythropoiesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18303114	2008
An iron responsive element-like stem-loop regulates alpha-hemoglobin-stabilizing protein mRNA. The Journal of biological chemistry\| PubMed ID: 18676996	2008
Trisomy 21 enhances human fetal erythro-megakaryocytic development. Blood\| PubMed ID: 18812473	2008
Transcriptional enhancement by GATA1-occupied DNA segments is strongly associated with evolutionary constraint on the binding site motif. Genome research\| PubMed ID: 18818370	2008
Chaperoning erythropoiesis. Blood\| PubMed ID: 19109556	2009
Analysis of human alpha globin gene mutations that impair binding to the alpha hemoglobin stabilizing protein. Blood\| PubMed ID: 19349619	2009
Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate. Blood\| PubMed ID: 19491391	2009
The role of alpha-hemoglobin stabilizing protein in redox chemistry, denaturation, and hemoglobin assembly. Antioxidants & redox signaling\| PubMed ID: 19659437	2010
Stem cells unscramble yolk sac hematopoiesis. Blood\| PubMed ID: 19696206	2009
A cis-proline in alpha-hemoglobin stabilizing protein directs the structural reorganization of alpha-hemoglobin. The Journal of biological chemistry\| PubMed ID: 19706593	2009
Mammalian casein kinase 1alpha and its leishmanial ortholog regulate stability of IFNAR1 and type I interferon signaling. Molecular and cellular biology\| PubMed ID: 19805514	2009
LRF is an essential downstream target of GATA1 in erythroid development and regulates BIM-dependent apoptosis. Developmental cell\| PubMed ID: 19853566	2009
Erythroid GATA1 function revealed by genome-wide analysis of transcription factor occupancy, histone modifications, and mRNA expression. Genome research\| PubMed ID: 19887574	2009
Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis. Molecular cell\| PubMed ID: 19941827	2009
Getting by with a little help from our friends. Current opinion in pediatrics\| PubMed ID: 20068412	2010
MicroRNAs in erythropoiesis. Current opinion in hematology\| PubMed ID: 20216213	2010
miR-451 protects against erythroid oxidant stress by repressing 14-3-3zeta. Genes & development\| PubMed ID: 20679398	2010
MicroRNA expression in maturing murine megakaryocytes. Blood\| PubMed ID: 20720187	2010
Analysis of alpha hemoglobin stabilizing protein overexpression in murine β-thalassemia. American journal of hematology\| PubMed ID: 20815047	2010
AHSP (α-haemoglobin-stabilizing protein) stabilizes apo-α-haemoglobin in a partially folded state. The Biochemical journal\| PubMed ID: 20860551	2010
Protein quality control during erythropoiesis and hemoglobin synthesis. Hematology/oncology clinics of North America\| PubMed ID: 21075281	2010
Identification of distal cis-regulatory elements at mouse mitoferrin loci using zebrafish transgenesis. Molecular and cellular biology\| PubMed ID: 21248200	2011
A hemoglobin variant associated with neonatal cyanosis and anemia. The New England journal of medicine\| PubMed ID: 21561349	2011
Dynamics of the epigenetic landscape during erythroid differentiation after GATA1 restoration. Genome research\| PubMed ID: 21795386	2011
Functional regulation of pre-B-cell leukemia homeobox interacting protein 1 (PBXIP1/HPIP) in erythroid differentiation. The Journal of biological chemistry\| PubMed ID: 22187427	2012
A new 'Linc' between noncoding RNAs and blood development. Genes & development\| PubMed ID: 22190456	2011
Insights into hemoglobin assembly through in vivo mutagenesis of α-hemoglobin stabilizing protein. The Journal of biological chemistry\| PubMed ID: 22287545	2012
Kinetics of α-globin binding to α-hemoglobin stabilizing protein (AHSP) indicate preferential stabilization of hemichrome folding intermediate. The Journal of biological chemistry\| PubMed ID: 22298770	2012
Loss of the miR-144/451 cluster impairs ischaemic preconditioning-mediated cardioprotection by targeting Rac-1. Cardiovascular research\| PubMed ID: 22354898	2012
Integrated protein quality-control pathways regulate free α-globin in murine β-thalassemia. Blood\| PubMed ID: 22427201	2012
Self-renewing endodermal progenitor lines generated from human pluripotent stem cells. Cell stem cell\| PubMed ID: 22482503	2012
CD19 is a major B cell receptor-independent activator of MYC-driven B-lymphomagenesis. The Journal of clinical investigation\| PubMed ID: 22546857	2012
SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models. Blood\| PubMed ID: 22611153	2012
What's in a name? The Journal of clinical investigation\| PubMed ID: 22706300	2012
An encyclopedia of mouse DNA elements (Mouse ENCODE). Genome biology\| PubMed ID: 22889292	2012
α-Hemoglobin-stabilizing protein is a sensitive and specific marker of erythroid precursors. The American journal of surgical pathology\| PubMed ID: 22982896	2012
Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23045701	2012
Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23045704	2012
miR-451 regulates dendritic cell cytokine responses to influenza infection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23169590	2012
α-Hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of α-subunits of human HbA with hydrogen peroxide. The Journal of biological chemistry\| PubMed ID: 23264625	2013
Hemoglobin variants: biochemical properties and clinical correlates. Cold Spring Harbor perspectives in medicine\| PubMed ID: 23388674	2013
The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis. Blood\| PubMed ID: 23426945	2013
The calcineurin-NFAT pathway negatively regulates megakaryopoiesis. Blood\| PubMed ID: 23446734	2013
Patient-derived induced pluripotent stem cells recapitulate hematopoietic abnormalities of juvenile myelomonocytic leukemia. Blood\| PubMed ID: 23620576	2013
Long noncoding RNAs in biology and hematopoiesis. Blood\| PubMed ID: 23645840	2013
α-Hemoglobin-stabilizing protein (AHSP) perturbs the proximal heme pocket of oxy-α-hemoglobin and weakens the iron-oxygen bond. The Journal of biological chemistry\| PubMed ID: 23696640	2013
Congenital dyserythropoietic anemias: III's a charm. Blood\| PubMed ID: 23744492	2013
Ribosomal and hematopoietic defects in induced pluripotent stem cells derived from Diamond Blackfan anemia patients. Blood\| PubMed ID: 23744582	2013
Clonal genetic and hematopoietic heterogeneity among human-induced pluripotent stem cell lines. Blood\| PubMed ID: 23940280	2013
Development of acute megakaryoblastic leukemia in Down syndrome is associated with sequential epigenetic changes. Blood\| PubMed ID: 23980066	2013
Lineage and species-specific long noncoding RNAs during erythro-megakaryocytic development. Blood\| PubMed ID: 24497530	2014
Iron-laden macrophage in autoimmune disease. Blood\| PubMed ID: 24605366	2014
Erythro-megakaryocytic transcription factors associated with hereditary anemia. Blood\| PubMed ID: 24652993	2014
Personalized platelet transfusions: one step closer to the clinic. Cell stem cell\| PubMed ID: 24702993	2014
Immune hemolytic anemia with drug-induced antibodies to carboplatin and vincristine in a pediatric patient with an optic pathway glioma. Transfusion\| PubMed ID: 24860959	2014
miR-451 deficiency is associated with altered endometrial fibrinogen alpha chain expression and reduced endometriotic implant establishment in an experimental mouse model. PloS one\| PubMed ID: 24937656	2014
Post-translational transformation of methionine to aspartate is catalyzed by heme iron and driven by peroxide: a novel subunit-specific mechanism in hemoglobin. The Journal of biological chemistry\| PubMed ID: 24939847	2014
Update on the diagnosis and management of thalassemia. Clinical advances in hematology & oncology : H&O\| PubMed ID: 25000317	2014
Hematopoietic differentiation of pluripotent stem cells in culture. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 25062629	2014
Trim58 degrades Dynein and regulates terminal erythropoiesis. Developmental cell\| PubMed ID: 25241935	2014
Dynamic shifts in occupancy by TAL1 are guided by GATA factors and drive large-scale reprogramming of gene expression during hematopoiesis. Genome research\| PubMed ID: 25319994	2014
Divergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis. Genome research\| PubMed ID: 25319996	2014
A comparative encyclopedia of DNA elements in the mouse genome. Nature\| PubMed ID: 25409824	2014
Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia. Blood\| PubMed ID: 25490895	2015
MicroRNA-486-5p is an erythroid oncomiR of the myeloid leukemias of Down syndrome. Blood\| PubMed ID: 25533034	2015
Pluripotent stem cells reveal erythroid-specific activities of the GATA1 N-terminus. The Journal of clinical investigation\| PubMed ID: 25621499	2015
Dynamics of GATA1 binding and expression response in a GATA1-induced erythroid differentiation system. Genomics data\| PubMed ID: 25729644	2015
Anemia: progress in molecular mechanisms and therapies. Nature medicine\| PubMed ID: 25742458	2015
Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells. The Journal of clinical investigation\| PubMed ID: 25961454	2015
Occupancy by key transcription factors is a more accurate predictor of enhancer activity than histone modifications or chromatin accessibility. Epigenetics & chromatin\| PubMed ID: 25984238	2015
Dysregulation of the Transforming Growth Factor β Pathway in Induced Pluripotent Stem Cells Generated from Patients with Diamond Blackfan Anemia. PloS one\| PubMed ID: 26258650	2015
The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development. Molecular and cellular biology\| PubMed ID: 26527618	2015
Targeted Application of Human Genetic Variation Can Improve Red Blood Cell Production from Stem Cells. Cell stem cell\| PubMed ID: 26607381	2016
Amelioration of murine sickle cell disease by nonablative conditioning and γ-globin gene-corrected bone marrow cells. Molecular therapy. Methods & clinical development\| PubMed ID: 26665131	2015
Unlinking an lncRNA from Its Associated cis Element. Molecular cell\| PubMed ID: 27041223	2016
Welcoming a new age for gene therapy in hematology. Blood\| PubMed ID: 27053534	2016
Pharmacogenetics for Safe Codeine Use in Sickle Cell Disease. Pediatrics\| PubMed ID: 27335380	2016
The severity of hereditary porphyria is modulated by the porphyrin exporter and Lan antigen ABCB6. Nature communications\| PubMed ID: 27507172	2016
A genome-editing strategy to treat β-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition. Nature medicine\| PubMed ID: 27525524	2016
miR-144 attenuates the host response to influenza virus by targeting the TRAF6-IRF7 signaling axis. PLoS pathogens\| PubMed ID: 28380049	2017
UBE2O remodels the proteome during terminal erythroid differentiation. Science (New York, N.Y.)\| PubMed ID: 28774900	2017